AutismKB 2.0

Annotation Detail for EVI2A


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Basic Information Top
Gene Symbol:EVI2A ( EVDA,EVI-2A,EVI2 )
Gene Full Name: ecotropic viral integration site 2A
Band: 17q11.2
Quick LinksEntrez ID:2123; OMIM: 158380; Uniprot ID:EVI2A_HUMAN; ENSEMBL ID: ENSG00000126860; HGNC ID: 3499
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C026114 2-xylene 2-xylene results in increased expression of EVI2A mRNAincreases expression 20359517
D000082 Acetaminophen Acetaminophen affects the expression of EVI2A mRNAaffects expression 17562736
D001554 Benzene Benzene results in increased expression of EVI2A mRNAincreases expression 20359517
D004041 Dietary Fats Dietary Fats results in decreased expression of EVI2A mRNAdecreases expression 18042831
D004958 Estradiol Estradiol affects the expression of EVI2A mRNAaffects expression 14699072
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of EVI2A mRNAaffects cotreatment|increases expression 17942748
C004912 ethylbenzene ethylbenzene results in increased expression of EVI2A mRNAincreases expression 20359517
D008752 Methylene Chloride Methylene Chloride results in increased expression of EVI2A mRNAincreases expression 20359517
C041786 palm oil palm oil results in decreased expression of EVI2A mRNAdecreases expression 18042831
D011374 Progesterone Progesterone results in increased expression of EVI2A mRNAincreases expression 18070364
D020849 Raloxifene [Raloxifene co-treated with ESR2 protein] results in decreased expression of EVI2A mRNAaffects cotreatment|decreases expression 19059307
D013629 Tamoxifen [Tamoxifen co-treated with ESR2 protein] results in decreased expression of EVI2A mRNAaffects cotreatment|decreases expression 19059307
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of EVI2A mRNAdecreases expression 17101203
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of EVI2A mRNAaffects cotreatment|increases expression 17942748
D014050 Toluene Toluene results in increased expression of EVI2A mRNAincreases expression 20359517
D014241 Trichloroethylene Trichloroethylene results in increased expression of EVI2A mRNAincreases expression 20359517
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.6114745880
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.9011752688 14514962 15322242
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.0017505938
MESH:D000230 Adenocarcinoma Estradiol 4.2411473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.2414692618
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.4316835633
MESH:D000419 Albuminuria Raloxifene 4.6317308373 17451421
MESH:D000544 Alzheimer Disease Raloxifene 2.5515800139
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.9711748828
MESH:D000741 Anemia, Aplastic Benzene 4.3911369114 14761424 17661222
MESH:D000799 Angioedema Acetaminophen 3.9110982225
MESH:D001161 Arteriosclerosis Dietary Fats 10.0515238619
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 10.0511256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.6815885639
MESH:D001321 Autistic Disorder Acetaminophen 1.4218445737
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.0712125929
MESH:D001836 Body Weight Changes 2-xylene 12.317457028
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 12.3115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.7815746008
MESH:D001855 Bone Marrow Diseases Benzene 5.2916183116
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.4017868700
MESH:D001930 Brain Injuries Progesterone 11.1115665606 15380490 15845082
MESH:D001930 Brain Injuries Raloxifene 11.1116580743
MESH:D001943 Breast Neoplasms Benzene 5.8711921183 17162533
MESH:D001943 Breast Neoplasms Dietary Fats 5.8720435547
MESH:D001943 Breast Neoplasms Estradiol 5.8712948864 17289903 16675129 19861407 14630087 17261762 18497071 17018787
MESH:D001943 Breast Neoplasms Methylene Chloride 5.8715986119
MESH:D001943 Breast Neoplasms Progesterone 5.8717614352 15562024 16175315
MESH:D001943 Breast Neoplasms Raloxifene 5.8717440819 17893378 16837676 15758505 15775269 15572757 17242785 16912660 17049068 17952589 17595753 17261762
MESH:D001943 Breast Neoplasms Tamoxifen 5.8720859285 11161223 18425577 19155303 17049068 19244106 20065188 19142967 19410462 19189210 19487384 17893378 17261762 19221464 19289846 18855134 16273361 20135344 19288272 19189212 20390343 19011961 19103187 15565566 17242785 16818667 21138602 16202921 19059307 18815881 18984771 19066611 20005174 20544844 17440819 19084267 19115204 18351453 16873071 15668708 21152245 18821012 19200415 18997820 18629630
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 5.8720435547
MESH:D001943 Breast Neoplasms Trichloroethylene 5.8715986119
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.5116111702
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.8216835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.5519066611
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.543084413
MESH:D006528 Carcinoma, Hepatocellular Estradiol 4.5416924424
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 4.5416924424
MESH:D002295 Carcinoma, Transitional Cell Raloxifene 9.5917572228
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 9.5917572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3818850075 18670907 16120746
MESH:D002318 Cardiovascular Diseases Raloxifene 3.4615775269
MESH:D002386 Cataract Acetaminophen 2.6010977129
MESH:D002471 Cell Transformation, Neoplastic Estradiol 2.7918566989
MESH:D002547 Cerebral Palsy Toluene 5.909294310
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.1916835633
MESH:D002779 Cholestasis Ethinyl Estradiol 2.8917333356 17681005 17110522 16105132 11677210 16919318 15861022
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.118697196 12621046 15340226 16354765 15668235
MESH:D003072 Cognition Disorders Raloxifene 4.6615800139
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.0814669216 17141729
MESH:D019465 Craniofacial Abnormalities Benzene 3.9915643154
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 3.9920055451 15322242 10048152
MESH:D019465 Craniofacial Abnormalities Toluene 3.999294310
MESH:D003643 Death Toluene 5.736431079
MESH:D003711 Demyelinating Diseases Tamoxifen 4.4019031437
MESH:D003865 Depressive Disorder, Major Raloxifene 4.1917474826
MESH:D003872 Dermatitis Benzene 4.8115902427
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6717107852
MESH:D003928 Diabetic Nephropathies Estradiol 15.1719279558
MESH:D003928 Diabetic Nephropathies Raloxifene 15.1717308373 15920148 17451421
MESH:D003928 Diabetic Nephropathies Tamoxifen 15.1719279558
MESH:D003929 Diabetic Neuropathies Progesterone 4.5317187935
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.3317522070 10663392 11421492 18713872 12958197 12705907 19420014 14725611 14986274 16781746 16081117 12153990 12594235 11739529 15968718 2444490 19164858 12540782 19085960 14550746 11461765 10774834 11287661 19923254 16177239 19370779 19739265 17562736 19416960 11529661 10915739 16485898 17906064 11743745 16227642 12392966 11834606 15619225 18071297 16393943 16109766
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 6.3320420201
MESH:D056486 Drug-Induced Liver Injury Trichloroethylene 6.337120509
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.1619426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.7811462148
MESH:D050171 Dyslipidemias Dietary Fats 3.4718367378
MESH:D004487 Edema Raloxifene 6.9515860553
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.9512711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.9618230668 16714409 15322242
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 22.2612538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 22.2617692515
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Raloxifene 22.2615845917
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 22.2619031437
MESH:D016889 Endometrial Neoplasms Estradiol 7.4519148513 11473722 18566989
MESH:D016889 Endometrial Neoplasms Tamoxifen 7.4517893378 19155303 20544844 16202921
MESH:D004715 Endometriosis Progesterone 9.0216134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 9.0210568697 9294722
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0311564622
MESH:D005234 Fatty Liver Dietary Fats 19.0518296743 19004024 17967931 19551842
MESH:D005234 Fatty Liver Ethinyl Estradiol 19.0515345470
MESH:D005234 Fatty Liver Raloxifene 19.0517473493
MESH:D005234 Fatty Liver Tamoxifen 19.0519224547 14986274
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.2516709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.5011858732
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.5814745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.2319069698
MESH:D005355 Fibrosis Dietary Fats 8.7618296743
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 8.7620067830
MESH:D005756 Gastritis Acetaminophen 3.7416983495
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.6610696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.3411294989 10048152
MESH:D006331 Heart Diseases Raloxifene 3.5511110106
MESH:D006402 Hematologic Diseases Benzene 4.6916183116
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.3611000095
MESH:D006529 Hepatomegaly 2-xylene 9.157457028 7457013
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 9.1515340226 16120746 12621046
MESH:D006558 Herpes Genitalis Estradiol 5.0915709030
MESH:D019584 Hot Flashes Estradiol 3.8117088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.1116959395 16354765 18606429 15340226 8697196
MESH:D006930 Hyperalgesia Acetaminophen 2.7216870215
MESH:D006937 Hypercholesterolemia Dietary Fats 3.6221332399
MESH:D006949 Hyperlipidemias Dietary Fats 3.6521332399
MESH:D006973 Hypertension Benzene 8.7717940673
MESH:D006973 Hypertension Raloxifene 8.7717577099 15787275
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 8.7718670907 18850075
MESH:D007021 Hypospadias Ethinyl Estradiol 3.8516945680 16569931
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.4415869954
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.4912013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.5017937319
MESH:D007249 Inflammation Dietary Fats 12.0820412841
MESH:D007249 Inflammation Progesterone 12.0815869954
MESH:D007249 Inflammation Tamoxifen 12.0819457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 12.0812878042 12200463
MESH:D007333 Insulin Resistance Dietary Fats 7.4311836018 18457598
MESH:D007333 Insulin Resistance Estradiol 7.4316393666 16627594
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.3616580747
MESH:D007674 Kidney Diseases Acetaminophen 5.9412587719 15629191
MESH:D007674 Kidney Diseases Estradiol 5.9415618244
MESH:D007680 Kidney Neoplasms Estradiol 7.4615610895
MESH:D007680 Kidney Neoplasms Tamoxifen 7.4618625569
MESH:D007889 Leiomyoma Raloxifene 4.5316973256
MESH:D007938 Leukemia Benzene 3.4014694614 18335105 15935818 17119257
MESH:D007951 Leukemia, Myeloid Benzene 4.3517506065
MESH:D015470 Leukemia, Myeloid, Acute Benzene 2.7019478238
MESH:D008064 Lipidoses Tamoxifen 3.1715342952 17567588
MESH:D008103 Liver Cirrhosis Dietary Fats 2.8918296743
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 3.4514659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 3.4518564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.4512878042
MESH:D008107 Liver Diseases Acetaminophen 1.6319784758 16611625 12969438 19460945 19014921 16610002 11587558 12587719
MESH:D017114 Liver Failure, Acute Acetaminophen 3.2617185352 16871587
MESH:D008113 Liver Neoplasms Tamoxifen 4.4316684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 4.4316984957
MESH:D008114 Liver Neoplasms, Experimental Benzene 10.1512562636
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 10.1512151625
MESH:D008114 Liver Neoplasms, Experimental Trichloroethylene 10.157955063
MESH:D017563 Lung Diseases, Interstitial Benzene 4.8714698565
MESH:D008175 Lung Neoplasms Benzene 4.9612562636
MESH:D008175 Lung Neoplasms Methylene Chloride 4.9615172992
MESH:D008175 Lung Neoplasms Tamoxifen 4.9618625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 4.9611884234 19555203
MESH:D008223 Lymphoma Benzene 3.7517119257 17584886
MESH:D015674 Mammary Neoplasms, Animal Benzene 10.2412562636
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 10.2419428831
MESH:D008325 Mammary Neoplasms, Experimental Benzene 14.4511921183
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 14.4511807958 16891317 17203775 11408345
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 14.4511408345 17203775
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 14.4511731420 19196723 14580682 16827153 19196722
MESH:D020149 Manganese Poisoning Estradiol 12.8619453300
MESH:D020149 Manganese Poisoning Tamoxifen 12.8619453300
MESH:D008545 Melanoma Tamoxifen 1.8819393235 12393984
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.2315990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.6119513568
MESH:D008607 Mental Retardation Toluene 3.669294310
MESH:D018200 Mixed Tumor, Mullerian Raloxifene 5.6215863610
MESH:D019957 Motor Skills Disorders Toluene 5.279294310
MESH:D009101 Multiple Myeloma Benzene 7.6817119195
MESH:D009101 Multiple Myeloma Raloxifene 7.6816497877
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.0412213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 3.3016810080
MESH:D009232 Myxoma Raloxifene 5.6216343187
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.5519393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.5219410462
MESH:D009369 Neoplasms Trichloroethylene 3.5611911487
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.0619189210 19200415 19196722
MESH:D009389 Neovascularization, Pathologic Estradiol 3.7817289903
MESH:D009421 Nervous System Malformations Estradiol 9.5916427766 11399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 9.5914600291
MESH:D009436 Neural Tube Defects Benzene 3.6915643154
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.8918514411
MESH:D009765 Obesity Dietary Fats 2.2921332399 19632207 17217161 11836018 20132043 18457598 20518802 18674790 16723640
MESH:D009784 Occupational Diseases Benzene 4.2115727169 17479406 15935809 17178637 16737584 15576619 15612468 17119257 15913788
MESH:D010024 Osteoporosis Raloxifene 3.4119059307 17882678 15775268
MESH:D015663 Osteoporosis, Postmenopausal Raloxifene 4.2617823083 15758505 17893378 15579764
MESH:D010051 Ovarian Neoplasms Benzene 8.0212562636
MESH:D010051 Ovarian Neoplasms Estradiol 8.0219401270
MESH:D010051 Ovarian Neoplasms Progesterone 8.0216525653 17393432
MESH:D010146 Pain Acetaminophen 2.4116870215
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.7211578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.3112520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.5918163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.2411399792 11896295 11222880 11118676
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.9120887781
MESH:D011471 Prostatic Neoplasms Estradiol 2.5916740699
MESH:D011471 Prostatic Neoplasms Raloxifene 2.5915731164 16536755 16220300
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.5915067354
MESH:D011537 Pruritus Ethinyl Estradiol 3.3615861022 16919318
MESH:D011693 Purpura Raloxifene 5.6215770314
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.8718990726
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.8618045962
MESH:D012640 Seizures Toluene 3.746431079 9294310
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.0516192470
MESH:D013088 Spermatocele Ethinyl Estradiol 11.7716709447
MESH:D013088 Spermatocele Tamoxifen 11.7716709447
MESH:D013119 Spinal Cord Injuries Progesterone 11.0415862959 16503802
MESH:D013119 Spinal Cord Injuries Tamoxifen 11.0419457130
MESH:D013274 Stomach Neoplasms Benzene 2.4212562636
MESH:D020521 Stroke Raloxifene 3.8416837676
MESH:D013733 Testicular Diseases Toluene 5.0110048760 10514026
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.6511994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.1815669648
MESH:D013953 Thymus Neoplasms Benzene 5.0110850423
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.9612697716
MESH:D013978 Tibial Fractures Estradiol 13.9219048282
MESH:D013978 Tibial Fractures Raloxifene 13.9219048282
MESH:D001749 Urinary Bladder Neoplasms Raloxifene 5.2617572228
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 5.2616712894 8653321 17572228
MESH:D014581 Urticaria Acetaminophen 3.0110982225
MESH:D014594 Uterine Neoplasms Benzene 9.6912562636
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 9.6914692618
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.6612125929
MESH:D054556 Venous Thromboembolism Raloxifene 5.2716837676
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.5714671159 15869587
MESH:D014846 Vulvar Neoplasms Raloxifene 5.6216343187
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.3115886252
MESH:D015430 Weight Gain Dietary Fats 3.7616723640
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA27913
    • No data
    Releated disease ID Related disease Name
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    No data
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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