AutismKB 2.0

Annotation Detail for EVI2B


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Basic Information Top
Gene Symbol:EVI2B ( D17S376,EVDB )
Gene Full Name: ecotropic viral integration site 2B
Band: 17q11.2
Quick LinksEntrez ID:2124; OMIM: 158381; Uniprot ID:EVI2B_HUMAN; ENSEMBL ID: ENSG00000185862; HGNC ID: 3500
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D001104 Arbutin Arbutin results in decreased expression of EVI2B mRNAdecreases expression 17103032
D004052 Diethylnitrosamine Diethylnitrosamine results in increased expression of EVI2B mRNAincreases expression 17942915
D004052 Diethylnitrosamine MET protein inhibits the reaction [Diethylnitrosamine results in increased expression of EVI2B mRNA]decreases reaction|increases expression 17942915
D002117 Calcitriol Calcitriol results in increased expression of EVI2B mRNAincreases expression 12875902
C056507 gemcitabine gemcitabine results in decreased expression of EVI2B mRNAdecreases expression 17039268
D014212 Tretinoin Tretinoin results in increased expression of EVI2B mRNAincreases expression 12875902
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000236 Adenoma Diethylnitrosamine 3.036695378 10737359
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 4.4419061943 19052882 16434500 17162532 18056438 17620307
MESH:D000505 Alopecia Tretinoin 3.9015955085
MESH:D001169 Arthritis, Experimental Tretinoin 3.2816412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.3316292516
MESH:D001249 Asthma Tretinoin 2.4316456186
MESH:D001471 Barrett Esophagus Tretinoin 4.8416935849
MESH:D001778 Blood Coagulation Disorders Tretinoin 3.9816206674 16197459
MESH:D001943 Breast Neoplasms Calcitriol 2.0711237771
MESH:D001943 Breast Neoplasms Diethylnitrosamine 2.0717474063
MESH:D001943 Breast Neoplasms gemcitabine 2.0717039268 18382427
MESH:D001943 Breast Neoplasms Tretinoin 2.0716166294 16443354 16873071
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 5.1316813970
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.7716168501
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 3.1720512989 19919837 16935385 19052882 16698587 18785209 16569478 17173139 20727157 19171122 16830150 16502159 20214788 17055752 18978308 16878318 16540662 18210153 20935162 18506893 18494052 18788625 20432363 19519916 19383236 19335982 19107877 19701751 20524982 3581430 20007298 3084413 16807293 16288022 19418558 19394651 10737359 20084675 20101231 10672840 17162532 19539802 18665156 16328049 18971187 17761372 19822196 20514400 11831363 17978847 16779866 19208518 16681979 17138121 18691550 18393292 17428255 18056438 21159647
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 3.171917145
MESH:D002294 Carcinoma, Squamous Cell Calcitriol 5.0511237771
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 5.0516051514 16096774
MESH:D002386 Cataract Tretinoin 3.2817460283
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 3.092727394 17174075 21159647 7505956
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 5.1316129372
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 4.0119052882
MESH:D002822 Choriocarcinoma Tretinoin 5.7716461808
MESH:D002972 Cleft Palate Tretinoin 2.799407595
MESH:D003092 Colitis Tretinoin 4.1917035595
MESH:D019465 Craniofacial Abnormalities Tretinoin 1.839142499 10589399 8800419 17551590 9125849 16925845 9224671 14991402 9211117 9664655
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 2.2520387270
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 2.1319107877
MESH:D004489 Edema, Cardiac Tretinoin 5.0818230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Calcitriol 4.3715138306
MESH:D016889 Endometrial Neoplasms Tretinoin 3.3216569247
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.7316302075
MESH:D005124 Eye Abnormalities Tretinoin 3.849664655 16938888
MESH:D005234 Fatty Liver Diethylnitrosamine 3.5620387270 21071580
MESH:D005355 Fibrosis Tretinoin 3.9917994277
MESH:D005909 Glioblastoma Tretinoin 3.2217312396
MESH:D006258 Head and Neck Neoplasms Tretinoin 3.4116096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.7716084493
MESH:D006330 Heart Defects, Congenital Tretinoin 3.059664655 14991402
MESH:D006930 Hyperalgesia Tretinoin 3.5016870215
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 5.0516778211
MESH:D007249 Inflammation Diethylnitrosamine 2.5318785209
MESH:D007410 Intestinal Diseases Tretinoin 4.2517994277
MESH:D007569 Jaw Abnormalities Tretinoin 4.2717551590 15992940
MESH:D007938 Leukemia Tretinoin 2.9217143497
MESH:D007951 Leukemia, Myeloid Tretinoin 4.0716482212 16932348 19285840
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.1219850784 16294345 17596541
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.3716331271 16823087 19225113 17294898 16140955 12679006 16935935 16788101 17217047 17506722 17301526 19075265 17107899 17649720 16766008 19035177 17368321 17712046 19029980 17361223 17339181 9834237 15748426 16891316 19642359
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.559224671
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 2.9918522880 18407596 18665156 19638242 20032147
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 1.8116248980 18397230
MESH:D008107 Liver Diseases Diethylnitrosamine 2.1617034775
MESH:D008113 Liver Neoplasms Diethylnitrosamine 2.3420101389 15885732 18754104 19833225 18644402 19256749 20137499 2862719 10737359 19427195 18648771 9163691 19426721 19551842 12771043 16942905 21047994 20118626 19812893 18978307 19690152 20501860 20492335 19090486 21278145 2422723 12112319 19642983 19638242 21071580 20405173 19073162 15175105 19294768 20452335 19254457 19499222 19255062 20583210 21167192 19850985 19996281 18977376 20434301
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 2.8316267830 18308698 18079962 18282651 18544905 16842330 17942915 17854601 18775883 9362446 3124819 19519916 19539802 18164116 19009564 18253720 17174075 21159647 2563599 18093689 19126423 19004024
MESH:D008175 Lung Neoplasms Diethylnitrosamine 1.7620512841 20970405 6695378 21163286
MESH:D008527 Medulloblastoma Tretinoin 2.9017453147
MESH:D008545 Melanoma Tretinoin 1.9816752155
MESH:D008591 Meningomyelocele Tretinoin 4.9116940565
MESH:D009190 Myelodysplastic Syndromes Tretinoin 3.2617596541
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.683581430 9029167
MESH:D009369 Neoplasms Tretinoin 2.5516946489 16594593
MESH:D009421 Nervous System Malformations Tretinoin 4.229125849
MESH:D009436 Neural Tube Defects Tretinoin 3.279142499
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 3.6520387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.7320387270
MESH:D010051 Ovarian Neoplasms Tretinoin 2.4316936753
MESH:D010146 Pain Tretinoin 3.2016870215
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 9.3616540662
MESH:D010190 Pancreatic Neoplasms gemcitabine 9.3618992248 11504793 18383843 16929163 17440100
MESH:D010190 Pancreatic Neoplasms Tretinoin 9.3615976015
MESH:D011230 Precancerous Conditions Diethylnitrosamine 3.882563599
MESH:D011470 Prostatic Hyperplasia Calcitriol 5.3215572423
MESH:D011471 Prostatic Neoplasms Calcitriol 3.4916644109 16289102 18247401 15754350 12479363
MESH:D011507 Proteinuria Tretinoin 4.0116636307
MESH:D011625 Pterygium Tretinoin 5.3316723453
MESH:D012208 Rhabdomyosarcoma Tretinoin 4.5016116481 16283617
MESH:D012878 Skin Neoplasms Tretinoin 2.7516467112
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 2.4818456281
MESH:D013274 Stomach Neoplasms Tretinoin 2.4817261132
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 8.097505956
MESH:D013964 Thyroid Neoplasms Tretinoin 8.0917045167 16026305
MESH:D014062 Tongue Neoplasms Tretinoin 4.1416051514
MESH:D014376 Tuberculosis Tretinoin 3.4316040207
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 4.0216129372
MESH:D014604 Uveal Neoplasms Tretinoin 5.2216752155
MESH:D014820 Vitiligo Tretinoin 4.5016761959
MESH:D009396 Wilms Tumor Tretinoin 4.2916287080
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA27914
    • No data
    Releated disease ID Related disease Name
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    No data
    Drug Bank Top

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    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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