AutismKB 2.0

Annotation Detail for EYA2


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Basic Information Top
Gene Symbol:EYA2 ( EAB1,MGC10614 )
Gene Full Name: eyes absent homolog 2 (Drosophila)
Band: 20q13.12
Quick LinksEntrez ID:2139; OMIM: 601654; Uniprot ID:EYA2_HUMAN; ENSEMBL ID: ENSG00000064655; HGNC ID: 3520
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1859Ovarian cancer
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000643 Ammonium Chloride Ammonium Chloride affects the expression of EYA2 mRNAaffects expression 16483693
D016572 Cyclosporine Cyclosporine results in decreased expression of EYA2 mRNAdecreases expression 20106945
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of EYA2 mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of EYA2 mRNAaffects cotreatment|increases expression 17942748
D005419 Flavonoids Flavonoids results in decreased expression of EYA2 mRNAdecreases expression 18035473
D009151 Mustard Gas Mustard Gas results in decreased expression of EYA2 mRNAdecreases expression 15674843
D010656 Phenylephrine EYA2 protein inhibits the reaction [Phenylephrine results in increased expression of MYH7 protein]decreases reaction|increases expression 17327491
D010656 Phenylephrine EYA2 protein inhibits the reaction [Phenylephrine results in increased expression of NPPA protein]decreases reaction|increases expression 17327491
C009166 retinol acetate retinol acetate results in increased expression of EYA2 mRNAincreases expression 16772331
D012643 Selenium Selenium results in increased expression of EYA2 mRNAincreases expression 19244175
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of EYA2 mRNAaffects cotreatment|increases expression 17942748
D014212 Tretinoin Tretinoin results in increased expression of EYA2 mRNAincreases expression 16604517
D014810 Vitamin E Vitamin E results in increased expression of EYA2 mRNAincreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.0411752688 14514962 15322242
MESH:D000138 Acidosis Ammonium Chloride 3.7518287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.1617505938
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8414692618
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.5716835633
MESH:D000505 Alopecia Tretinoin 3.7315955085
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.0811748828
MESH:D001145 Arrhythmias, Cardiac Phenylephrine 4.2417460149
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.6411256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 7.4815885639
MESH:D001169 Arthritis, Experimental Tretinoin 7.4816412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.2916292516
MESH:D001249 Asthma Mustard Gas 5.1110378619
MESH:D001249 Asthma Tretinoin 5.1116456186
MESH:D001471 Barrett Esophagus Tretinoin 4.5616935849
MESH:D001768 Blister Mustard Gas 5.3519167455
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 9.4112125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 9.4116206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.0115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8515746008
MESH:D001919 Bradycardia Phenylephrine 4.7415306635
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9720435547
MESH:D001943 Breast Neoplasms Tretinoin 1.9716873071 16443354 16166294
MESH:D001989 Bronchiolitis Obliterans Mustard Gas 5.3515286001
MESH:D029481 Bronchitis, Chronic Mustard Gas 5.1910378619 17687719
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.7816813970
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 4.1116050911
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9116835633
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.3816168501
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 1.901917145
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 2.3216051514 16096774
MESH:D006332 Cardiomegaly Phenylephrine 7.1211754973 17287366 17124262 16170337 15728586 11179087
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 7.1218670907 18850075 16120746
MESH:D002386 Cataract Tretinoin 3.1717460283
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 2.6212371664
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.7816129372
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.2916835633
MESH:D002779 Cholestasis Cyclosporine 8.1219486331
MESH:D002779 Cholestasis Ethinyl Estradiol 8.1216105132 11677210 17681005 15861022 16919318 17110522 17333356
MESH:D002822 Choriocarcinoma Tretinoin 5.3816461808
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.9412621046 15340226 15668235 8697196 16354765
MESH:D002972 Cleft Palate Tretinoin 5.949407595
MESH:D003092 Colitis Selenium 10.0917936198
MESH:D003092 Colitis Tretinoin 10.0917035595
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1817141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 3.8415322242 10048152 20055451
MESH:D019465 Craniofacial Abnormalities Tretinoin 3.849142499 17551590 9211117 10589399 8800419 16925845 9664655 14991402 9224671 9125849
MESH:D019465 Craniofacial Abnormalities Vitamin E 3.8419769572
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6917107852
MESH:D056486 Drug-Induced Liver Injury Selenium 3.8915131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 3.8920420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8611462148
MESH:C538011 Eales disease Vitamin E 4.929068938
MESH:D004487 Edema Mustard Gas 7.3111402378 11428631 11428647 9260866
MESH:D004487 Edema Tetrachlorodibenzodioxin 7.3111000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 12.6818230668 15322242 16714409
MESH:D004489 Edema, Cardiac Tretinoin 12.6818230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.3512538720
MESH:D016889 Endometrial Neoplasms Tretinoin 3.1916569247
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.159294722 10568697
MESH:D004890 Erythema Mustard Gas 5.359357497
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 9.1811564622
MESH:D005124 Eye Abnormalities Tretinoin 9.189664655 16938888
MESH:D005234 Fatty Liver Cyclosporine 8.0519224547
MESH:D005234 Fatty Liver Ethinyl Estradiol 8.0515345470
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.6311858732
MESH:D005355 Fibrosis Cyclosporine 15.7812639820 12168785
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 15.7820067830
MESH:D005355 Fibrosis Tretinoin 15.7817994277
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.418708960
MESH:D005909 Glioblastoma Tretinoin 3.0917312396
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.8110696789
MESH:D006258 Head and Neck Neoplasms Tretinoin 3.2716096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.3816084493
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 11.5310048152 11294989
MESH:D006330 Heart Defects, Congenital Tretinoin 11.5314991402 9664655
MESH:D006330 Heart Defects, Congenital Vitamin E 11.5316080930
MESH:D006333 Heart Failure Selenium 3.1517162251
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.6215720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.4811000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.0715340226 16120746 12621046
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.7416490937 16863852
MESH:D019584 Hot Flashes Vitamin E 4.1914716179
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.2616959395 8697196 18606429 15340226 16354765
MESH:D006930 Hyperalgesia Tretinoin 3.3216870215
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.7416778211
MESH:D006973 Hypertension Cyclosporine 8.8910903974
MESH:D006973 Hypertension Phenylephrine 8.8912717712 8949925
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 8.8918670907 18850075
MESH:D006984 Hypertrophy Phenylephrine 4.6912791704 18502941
MESH:D007021 Hypospadias Ethinyl Estradiol 3.9816569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.6112013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.5717937319
MESH:D007249 Inflammation Flavonoids 8.7617296493
MESH:D007249 Inflammation Mustard Gas 8.7611428647 9260866 9357497 11428620 17524151 11402378 8975870 11428631 16001271
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 8.7612878042 12200463
MESH:D007251 Influenza, Human Selenium 11.7016624496
MESH:D007251 Influenza, Human Vitamin E 11.7016624496
MESH:D007410 Intestinal Diseases Tretinoin 3.9417994277
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 10.4016580747
MESH:D007569 Jaw Abnormalities Tretinoin 10.4015992940 17551590
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.6615604871
MESH:D007674 Kidney Diseases Cyclosporine 6.2718776723 10903974 8314463
MESH:D007674 Kidney Diseases Vitamin E 6.2712488133
MESH:D007676 Kidney Failure, Chronic Selenium 4.0216518626
MESH:D007680 Kidney Neoplasms Cyclosporine 2.8512371664
MESH:D007938 Leukemia Tretinoin 2.8317143497
MESH:D007951 Leukemia, Myeloid Tretinoin 3.8416482212 16932348 19285840
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.1017596541 16294345 19850784
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.2417217047 16766008 17301526 15748426 19029980 9834237 16140955 17712046 17506722 16331271 12679006 17368321 16823087 19225113 17649720 17339181 17107899 16935935 16891316 19035177 19075265 16788101 17361223 17294898 19642359
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.419224671
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.5512878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 3.5518397230 16248980
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 3.5516169303
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 1.7616984957
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 2.1912151625
MESH:D008171 Lung Diseases Mustard Gas 7.8518161513 18702808
MESH:D008171 Lung Diseases Vitamin E 7.8516863852
MESH:D008175 Lung Neoplasms Mustard Gas 3.528781369 3148597
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.5211884234 19555203
MESH:D008175 Lung Neoplasms Vitamin E 3.5211062179
MESH:D008325 Mammary Neoplasms, Experimental Selenium 2.8515318939
MESH:D008527 Medulloblastoma Tretinoin 2.8317453147
MESH:D008545 Melanoma Tretinoin 1.9616752155
MESH:D008591 Meningomyelocele Tretinoin 4.6016940565
MESH:D008654 Mesothelioma Selenium 2.8415107826
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.0116801185
MESH:D009190 Myelodysplastic Syndromes Tretinoin 3.1517596541
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1312213967
MESH:D009369 Neoplasms Tretinoin 2.4716946489 16594593
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.6617954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.4118481113 19348381
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 10.0614600291
MESH:D009421 Nervous System Malformations Tretinoin 10.069125849
MESH:D009436 Neural Tube Defects Tretinoin 3.149142499
MESH:D009503 Neutropenia Mustard Gas 4.127688884 16761898
MESH:D010051 Ovarian Neoplasms Tretinoin 2.3816936753
MESH:D010146 Pain Tretinoin 3.0216870215
MESH:D010190 Pancreatic Neoplasms Tretinoin 2.5015976015
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.8411578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.4712520081
MESH:D010954 Plasmacytoma Selenium 5.1115087411
MESH:D011041 Poisoning Mustard Gas 3.9415727166
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.7218163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.3512371664
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.3811222880 11118676 11399792 11896295
MESH:D011471 Prostatic Neoplasms Vitamin E 3.2815084515
MESH:D011507 Proteinuria Tretinoin 3.7516636307
MESH:D011537 Pruritus Ethinyl Estradiol 10.1815861022 16919318
MESH:D011537 Pruritus Mustard Gas 10.1818058305
MESH:D011565 Psoriasis Cyclosporine 2.2716882103
MESH:D011625 Pterygium Tretinoin 4.9916723453
MESH:D011658 Pulmonary Fibrosis Mustard Gas 2.9717266442 17894541 10334151 17720292 17620002
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.0018990726
MESH:D012208 Rhabdomyosarcoma Tretinoin 4.2516283617 16116481
MESH:D012852 Sinusitis Phenylephrine 4.907327846
MESH:D012871 Skin Diseases Mustard Gas 5.1312880345 16961503 15451306
MESH:D012871 Skin Diseases Vitamin E 5.1318709164
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.7616192470
MESH:D012878 Skin Neoplasms Tretinoin 5.7616467112
MESH:D013088 Spermatocele Ethinyl Estradiol 4.1616709447
MESH:D013274 Stomach Neoplasms Tretinoin 1.8017261132
MESH:D020521 Stroke Vitamin E 3.6316517955
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.7711994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.2815669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.1212697716
MESH:D013964 Thyroid Neoplasms Tretinoin 3.1316026305 17045167
MESH:D014062 Tongue Neoplasms Tretinoin 3.9216051514
MESH:D014376 Tuberculosis Tretinoin 3.3116040207
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 3.8116129372
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.4614692618
MESH:D014604 Uveal Neoplasms Tretinoin 4.8316752155
MESH:D014605 Uveitis Cyclosporine 4.201336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.8112125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.6814671159 15869587
MESH:D014820 Vitiligo Tretinoin 4.2216761959
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.4715886252
MESH:D009396 Wilms Tumor Tretinoin 4.0916287080
MESH:D014985 Xerophthalmia Cyclosporine 4.6617120751
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA27932
    • No data
    Releated disease ID Related disease Name
    PA446714Neoplasm, Residual
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    No data
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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