AutismKB 2.0

Annotation Detail for EZH2


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Basic Information Top
Gene Symbol:EZH2 ( ENX-1,ENX1,EZH1,KMT6,KMT6A,MGC9169 )
Gene Full Name: enhancer of zeste homolog 2 (Drosophila)
Band: 7q36.1
Quick LinksEntrez ID:2146; OMIM: 601573; Uniprot ID:EZH2_HUMAN; ENSEMBL ID: ENSG00000106462; HGNC ID: 3527
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen results in decreased expression of EZH2 mRNAdecreases expression 17942131
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of EZH2 proteinaffects expression 20106945
C430898 AGN 194204 AGN 194204 results in decreased expression of EZH2 mRNAdecreases expression 16339527
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of EZH2 mRNAdecreases expression 17942131
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of EZH2 mRNAdecreases expression 20382639
C005961 bis(tri-n-butyltin)oxide bis(tri-n-butyltin)oxide results in decreased expression of EZH2 mRNAdecreases expression 17942131
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in decreased expression of EZH2 mRNAdecreases expression 15336504
D002251 Carbon Tetrachloride Carbon Tetrachloride results in increased expression of EZH2 mRNAincreases expression 17484886
D002330 Carmustine Carmustine results in decreased expression of EZH2 mRNAdecreases expression 15980968
D003010 Clorgyline Clorgyline results in decreased expression of EZH2 mRNAdecreases expression 19691856
D003345 Corticosterone Corticosterone results in decreased expression of EZH2 mRNAdecreases expression 15755911
D016572 Cyclosporine Cyclosporine results in increased expression of EZH2 mRNAincreases expression 20106945
D016572 Cyclosporine Cyclosporine results in decreased expression of EZH2 mRNAdecreases expression 17942131
D004052 Diethylnitrosamine Diethylnitrosamine results in increased expression of EZH2 mRNAincreases expression 17854601
D004052 Diethylnitrosamine RB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of EZH2 mRNA]decreases reaction|increases expression 17854601
D004317 Doxorubicin EZH2 protein affects the susceptibility to Doxorubicinaffects response to substance 16217747
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of EZH2 mRNAaffects cotreatment|increases expression 17942748
C030667 methylazoxymethanol methylazoxymethanol results in increased expression of EZH2 mRNAincreases expression 17107856
D011374 Progesterone Progesterone results in increased expression of EZH2 mRNAincreases expression 18070364
D013629 Tamoxifen [EZH2 protein results in decreased expression of ESR1 protein] which results in decreased susceptibility to Tamoxifendecreases expression|decreases response to substance 20306127
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of EZH2 mRNAaffects cotreatment|increases expression 17942748
D019772 Topotecan EZH2 protein affects the susceptibility to Topotecanaffects response to substance 16217747
C496197 trans-10,cis-12-conjugated linoleic acid trans-10,cis-12-conjugated linoleic acid results in decreased expression of EZH2 mRNAdecreases expression 17951470
D014212 Tretinoin Tretinoin results in increased expression of EZH2 mRNAincreases expression 17198874
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.4214745880
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.7211752688 14514962 15322242
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.8117505938
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 6.8720127859 20464547
MESH:D000230 Adenocarcinoma Doxorubicin 6.8717418594
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 6.8714692618
MESH:D000236 Adenoma Benzo(a)pyrene 6.386695378
MESH:D000236 Adenoma Diethylnitrosamine 6.3810737359 6695378
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 9.6217162532 19061943 16434500 17620307 18056438 19052882
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 9.6216835633
MESH:D000419 Albuminuria Doxorubicin 4.4221441931
MESH:D000505 Alopecia Tretinoin 3.5115955085
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.8311748828
MESH:D000799 Angioedema Acetaminophen 3.7110982225
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.9419183758
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.3311256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 6.9415885639
MESH:D001169 Arthritis, Experimental Tretinoin 6.9416412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.2316292516
MESH:D001249 Asthma Tretinoin 2.3116456186
MESH:D001321 Autistic Disorder Acetaminophen 1.4318445737
MESH:D001471 Barrett Esophagus Tretinoin 4.2716935849
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 8.5412125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 8.5416206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.6615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.6815746008
MESH:D019046 Bone Marrow Neoplasms Doxorubicin 4.5714601052
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.2117868700
MESH:D001930 Brain Injuries Progesterone 4.1315665606 15845082 15380490
MESH:D001932 Brain Neoplasms Carmustine 8.7416187019
MESH:D001932 Brain Neoplasms Doxorubicin 8.7417150277
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 3.6917474063 20146248
MESH:D001943 Breast Neoplasms Diethylnitrosamine 3.6917474063
MESH:D001943 Breast Neoplasms Doxorubicin 3.6918628466 15634643 16264153 11325840 15939500 16322301 15136595 18382427 18695136 15668708 16096432 16595493 18234424 15993339 19526202 16115903 16826403 15567936 17426702 17983394 17369602 16935488 15692762 15994142
MESH:D001943 Breast Neoplasms Progesterone 3.6917614352 15562024 16175315
MESH:D001943 Breast Neoplasms Tamoxifen 3.6916273361 20390343 18855134 19244106 17242785 18984771 19011961 20005174 19115204 21152245 18629630 17261762 19221464 19103187 19142967 19200415 18815881 17440819 19059307 18997820 19155303 18821012 17893378 20065188 16202921 20859285 19084267 19289846 11161223 16818667 20135344 19066611 19189210 18425577 18351453 16873071 19189212 21138602 15565566 19288272 20544844 17049068 19410462 15668708 19487384
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 3.6920435547
MESH:D001943 Breast Neoplasms Tretinoin 3.6916443354 16166294 16873071
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.4616813970
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.6515721981 16011737 16227642 16050911 18705752 16124888 15673190 16097048 15700767 10355542 3786805 16192424
MESH:D002276 Carcinoid Tumor Doxorubicin 4.6816051944
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.6916835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.3819066611
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.0316168501
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 13.773084413
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 13.7712907637 12619106 21507988
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 13.7718788625
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 13.773581430 17761372 18691550 19208518 18506893 19919837 21159647 16502159 16830150 17055752 11831363 18393292 19335982 10672840 19383236 17138121 20101231 16328049 16681979 16569478 16779866 19052882 20524982 20214788 16807293 16935385 17428255 19171122 20007298 16288022 20935162 17173139 19822196 18210153 16698587 17978847 20432363 19539802 19394651 3084413 18056438 20512989 18785209 18665156 19107877 20727157 16540662 18788625 19701751 19418558 19519916 20514400 20084675 18971187 17162532 10737359 18978308 16878318 18494052
MESH:D006528 Carcinoma, Hepatocellular Doxorubicin 13.7718059187 16023760 16234567 17876044
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 13.7716924424
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 13.771917145
MESH:D002292 Carcinoma, Renal Cell Doxorubicin 3.1016201981 1485588
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 7.3220419170
MESH:D002294 Carcinoma, Squamous Cell Doxorubicin 7.326189445
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 7.3216096774 16051514
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.5017572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3018670907 16120746 18850075
MESH:D009202 Cardiomyopathies Doxorubicin 3.4416455267 15476868 17928571 17351982 16242529 17308081 16952015 17519947 16278810 16651473 17974986 16731534 17924179 18627295 17007740 16364871 15505089 17329180 17382496 16612575 15792986 17131338 16109756 16269455 15811867
MESH:D002311 Cardiomyopathy, Dilated Doxorubicin 2.9016243910 17334414
MESH:D002386 Cataract Acetaminophen 6.9710977129
MESH:D002386 Cataract Tretinoin 6.9717460283
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 10.6320889678
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 10.6312371664
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 10.6317174075 21159647 7505956 2727394
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.4616129372
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 8.9519052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 8.9516835633
MESH:D002779 Cholestasis Cyclosporine 7.4519486331
MESH:D002779 Cholestasis Ethinyl Estradiol 7.4516105132 17333356 16919318 11677210 15861022 17110522 17681005
MESH:D002822 Choriocarcinoma Tretinoin 5.0316461808
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.5816354765 15340226 15668235 8697196 12621046
MESH:D002972 Cleft Palate Tretinoin 5.589407595
MESH:D003092 Colitis Tretinoin 3.5717035595
MESH:D015179 Colorectal Neoplasms Doxorubicin 2.1418802399 18259882
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.9517141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.4120055451 10048152 15322242
MESH:D019465 Craniofacial Abnormalities Tretinoin 2.419142499 14991402 9211117 9125849 8800419 9664655 9224671 17551590 10589399 16925845
MESH:D003711 Demyelinating Diseases Tamoxifen 4.2319031437
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 4.1120387270
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.1117107852
MESH:D003928 Diabetic Nephropathies Tamoxifen 3.3619279558
MESH:D003929 Diabetic Neuropathies Progesterone 4.3617187935
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 11.592444490 11529661 11421492 18713872 11287661 12392966 19923254 16393943 19085960 19370779 17522070 15619225 10915739 17562736 16781746 12594235 16177239 19164858 19739265 10663392 17906064 16485898 16081117 12153990 14986274 10774834 12705907 19420014 14725611 14550746 12958197 11461765 16227642 18071297 16109766 11739529 15968718 11743745 11834606 12540782 19416960
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 11.5916177239 19336974 2869522 3786805 6884620 7440962 21278145 7120509 15968718 7179309 17522070 11566570 10915739 15027814 9327722 3732212 4309450 6623471 16227642 15998439 10092053 19085960
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 11.5919107877
MESH:D056486 Drug-Induced Liver Injury Doxorubicin 11.5917416283
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 11.5920420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.9719426721
MESH:D004362 Drug Toxicity Doxorubicin 7.7918602426
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 7.7911462148
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.2611000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 11.5116714409 15322242 18230668
MESH:D004489 Edema, Cardiac Tretinoin 11.5118230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 14.5812538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 14.5817692515
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 14.5819031437
MESH:D016889 Endometrial Neoplasms Doxorubicin 12.0017359293
MESH:D016889 Endometrial Neoplasms Tamoxifen 12.0019155303 20544844 17893378 16202921
MESH:D016889 Endometrial Neoplasms Tretinoin 12.0016569247
MESH:D004715 Endometriosis Progesterone 8.5416134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 8.5410568697 9294722
MESH:D004719 Endomyocardial Fibrosis Doxorubicin 5.0318037988
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 4.9916302075
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.2420426865
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.2416530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 8.5111564622
MESH:D005124 Eye Abnormalities Tretinoin 8.519664655 16938888
MESH:D005234 Fatty Liver Carbon Tetrachloride 23.3616045604 61145 16239168 12631006 17595544 12795759 15959796 19224547
MESH:D005234 Fatty Liver Cyclosporine 23.3619224547
MESH:D005234 Fatty Liver Diethylnitrosamine 23.3621071580 20387270
MESH:D005234 Fatty Liver Ethinyl Estradiol 23.3615345470
MESH:D005234 Fatty Liver Tamoxifen 23.3619224547 14986274
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.1616709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.3311858732
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.4014745880
MESH:D018222 Fibromatosis, Aggressive Doxorubicin 11.0019069698
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 11.0019069698
MESH:D005355 Fibrosis Carbon Tetrachloride 20.0618705752
MESH:D005355 Fibrosis Cyclosporine 20.0612639820 12168785
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 20.0620067830
MESH:D005355 Fibrosis Tretinoin 20.0617994277
MESH:D005756 Gastritis Acetaminophen 3.5516983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.098708960
MESH:D005909 Glioblastoma Carmustine 11.5316187019
MESH:D005909 Glioblastoma Doxorubicin 11.5317150277
MESH:D005909 Glioblastoma Tretinoin 11.5317312396
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.4710696789
MESH:D006258 Head and Neck Neoplasms Doxorubicin 7.5515692506
MESH:D006258 Head and Neck Neoplasms Tretinoin 7.5516096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.0316084493
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 10.6920471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 10.6911294989 10048152
MESH:D006330 Heart Defects, Congenital Tretinoin 10.699664655 14991402
MESH:D006331 Heart Diseases Doxorubicin 3.3916879835 12587719 17875725 16244371 14766674 17888722 16707910 16144979 18006777 16330681 16495754 18674790 16244372
MESH:D006333 Heart Failure Doxorubicin 3.2617481944
MESH:D006394 Hemangiosarcoma Doxorubicin 3.7815692506
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.2915720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.2111000095
MESH:D006505 Hepatitis Carbon Tetrachloride 3.4719110552 19900420
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 2.7612621046 15340226 16120746
MESH:D006689 Hodgkin Disease Doxorubicin 3.3015147373 17606976 18501091
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.9218606429 15340226 16354765 8697196 16959395
MESH:D006930 Hyperalgesia Acetaminophen 7.2816870215
MESH:D006930 Hyperalgesia Tretinoin 7.2816870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.4016899240
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.4416778211
MESH:D006973 Hypertension Cyclosporine 4.7810903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 4.7818670907 18850075
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.9615338365
MESH:D007021 Hypospadias Ethinyl Estradiol 3.6816569931 16945680
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.2715869954
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.3412013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.4017937319
MESH:D007249 Inflammation Diethylnitrosamine 11.3918785209
MESH:D007249 Inflammation Progesterone 11.3915869954
MESH:D007249 Inflammation Tamoxifen 11.3919457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 11.3912878042 12200463
MESH:D007410 Intestinal Diseases Tretinoin 3.6417994277
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 9.5316580747
MESH:D007569 Jaw Abnormalities Tretinoin 9.5315992940 17551590
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.3115604871
MESH:D007674 Kidney Diseases Acetaminophen 9.6012587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 9.608314463 10903974 18776723
MESH:D007674 Kidney Diseases Doxorubicin 9.6016775033 15699352 15369732
MESH:D007676 Kidney Failure, Chronic Doxorubicin 4.0316707910
MESH:D007680 Kidney Neoplasms Cyclosporine 6.9412371664
MESH:D007680 Kidney Neoplasms Tamoxifen 6.9418625569
MESH:D007938 Leukemia Tretinoin 2.7117143497
MESH:D004915 Leukemia, Erythroblastic, Acute Doxorubicin 5.0316085563
MESH:D007951 Leukemia, Myeloid Tretinoin 3.5819285840 16482212 16932348
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.0619850784 16294345 17596541
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.0716935935 19035177 15748426 17368321 17301526 17649720 16766008 9834237 16331271 19075265 17217047 19642359 16140955 17712046 17294898 17339181 12679006 16891316 17361223 16788101 19029980 17107899 16823087 17506722 19225113
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.219224671
MESH:D008064 Lipidoses Tamoxifen 3.0617567588 15342952
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 6.3716943688 17334410 11408273 11903743 17174718 21278145 16221502 17157831 16239168
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 6.3718665156 19638242 20032147 18522880 18407596
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 6.5616136751 17631135 16015684 14716833 12445418 18166357 17708605 18481824 17869086 18395095 18210741 13678700 14512876 20821823 15370692 12741479 12666154 12609069 12649538 12958196 17823541 16097048 14716496 17944888 18277467 15052691 15925388 15996030 16248980 17900296 18472094 18205269 18006644 15893842 14620537 12586293 12389079 18420326 17698563 12632512 15730626 17721639 15673190 15123356 14748882 18263696 17761835 17976157 15818738 16033810 15338365 15057751 12632514 16011737 18054572 16116963 16638106 18317297 18472332 18705752 17481882 15959796 17805973 18187930 18156304 15931870 17557913 15650968 15876570 15362042 18395914 11481614 18412020 14724832 18418968 18279442 12546737 10355542 18376398 17922224 18429990 16192424 12898905 17565644 16027843 18339082 12445421 17766677 12667390 17525996 17714472 18251166 17640975
MESH:D008106 Liver Cirrhosis, Experimental Doxorubicin 6.5616595196 16439617
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 6.5618564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 6.5612878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 6.5618397230 16248980
MESH:D008107 Liver Diseases Acetaminophen 6.2712969438 12587719 19784758 16610002 19460945 11587558 16611625 19014921
MESH:D008107 Liver Diseases Carbon Tetrachloride 6.2716964402 15830285 16246199 17285989 15720792
MESH:D008107 Liver Diseases Diethylnitrosamine 6.2717034775
MESH:D017093 Liver Failure Carbon Tetrachloride 4.0315123358
MESH:D017114 Liver Failure, Acute Acetaminophen 9.0216871587 17185352
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 9.0216899240 14706259
MESH:D008113 Liver Neoplasms Aflatoxin B1 17.342125692 15890375 9163691 18177683
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 17.3421137059 20195826
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 17.3419294768
MESH:D008113 Liver Neoplasms Diethylnitrosamine 17.3420583210 19812893 19996281 21278145 19642983 19254457 19638242 20101389 19255062 20452335 21071580 18648771 19833225 12112319 19427195 18977376 21047994 18754104 18978307 12771043 20492335 20137499 19256749 18644402 16942905 19426721 15885732 19690152 10737359 15175105 2862719 19850985 20118626 19551842 20405173 19294768 9163691 2422723 19073162 20434301 21167192 19090486 19499222 20501860
MESH:D008113 Liver Neoplasms Tamoxifen 17.3416684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 17.3416984957
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 17.788603461
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 17.7815583823 12014681
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 17.7818544905 18253720 18079962 9362446 18775883 18164116 19539802 18093689 16267830 21159647 17854601 19004024 19009564 17174075 2563599 17942915 3124819 18282651 16842330 19519916 18308698 19126423
MESH:D008114 Liver Neoplasms, Experimental Doxorubicin 17.7816842330 17085340
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 17.7812151625
MESH:D008175 Lung Neoplasms Aflatoxin B1 8.3414755239
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 8.346695378 20464547 18520028 17053015 20064080 18816296 20135361 18569708 20869020
MESH:D008175 Lung Neoplasms Diethylnitrosamine 8.3420970405 20512841 6695378 21163286
MESH:D008175 Lung Neoplasms Doxorubicin 8.3417418594 6189445
MESH:D008175 Lung Neoplasms Tamoxifen 8.3418625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 8.3411884234 19555203
MESH:D008223 Lymphoma Doxorubicin 3.3716098063
MESH:D016403 Lymphoma, Large B-Cell, Diffuse marker/mechanism 20081860
MESH:D008228 Lymphoma, Non-Hodgkin Doxorubicin 3.6817654614
MESH:D016399 Lymphoma, T-Cell Doxorubicin 4.4415621674
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.6319428831
MESH:D008325 Mammary Neoplasms, Experimental Corticosterone 13.6512807724
MESH:D008325 Mammary Neoplasms, Experimental Doxorubicin 13.6515458769
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 13.6517203775 11408345
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 13.6519196722 11731420 16827153 14580682 19196723
MESH:D020149 Manganese Poisoning Tamoxifen 4.4219453300
MESH:D008527 Medulloblastoma Tretinoin 2.7317453147
MESH:D008545 Melanoma Carmustine 7.1512393984
MESH:D008545 Melanoma Doxorubicin 7.1516827129
MESH:D008545 Melanoma Tamoxifen 7.1519393235 12393984
MESH:D008545 Melanoma Tretinoin 7.1516752155
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.0515990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.4419513568
MESH:D008591 Meningomyelocele Tretinoin 4.2916940565
MESH:D008654 Mesothelioma Doxorubicin 3.0117638057
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.6616801185
MESH:D028361 Mitochondrial Diseases Doxorubicin 4.3815792986
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.0916381670
MESH:D052016 Mucositis Doxorubicin 4.6617415656
MESH:D054437 Myelodysplastic-Myeloproliferative Diseases marker/mechanism 20601953
MESH:D009190 Myelodysplastic Syndromes marker/mechanism 20601954
MESH:D009190 Myelodysplastic Syndromes Tretinoin 3.0117596541
MESH:D009203 Myocardial Infarction Doxorubicin 2.9015857846 19429709
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.9112213967
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 9.223581430 9029167
MESH:D009362 Neoplasm Metastasis Doxorubicin 9.2218259882
MESH:D009362 Neoplasm Metastasis Tamoxifen 9.2219393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.4719410462
MESH:D009369 Neoplasms Benzo(a)pyrene 4.7811141357
MESH:D009369 Neoplasms Tretinoin 4.7816946489 16594593
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 3.8719200415 19196722 19189210
MESH:D009401 Nephrosis Doxorubicin 4.6416636307 16899518
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.3117954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 8.9219348381 18481113
MESH:D009404 Nephrotic Syndrome Doxorubicin 8.9216889571 15640375
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 9.0914600291
MESH:D009421 Nervous System Malformations Tretinoin 9.099125849
MESH:D009436 Neural Tube Defects Tretinoin 2.979142499
MESH:D009447 Neuroblastoma Doxorubicin 7.0715555623
MESH:D009447 Neuroblastoma Topotecan 7.0715176712
MESH:D019636 Neurodegenerative Diseases Acetaminophen 7.8218514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 7.8220387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 4.9920387270
MESH:D012516 Osteosarcoma Doxorubicin 4.0115930896
MESH:D010051 Ovarian Neoplasms Progesterone 4.7816525653 17393432
MESH:D010051 Ovarian Neoplasms Tretinoin 4.7816936753
MESH:D010146 Pain Acetaminophen 6.2316870215
MESH:D010146 Pain Tretinoin 6.2316870215
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 5.0916540662
MESH:D010190 Pancreatic Neoplasms Tretinoin 5.0915976015
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.5611578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.1212520081
MESH:D003557 Phyllodes Tumor Doxorubicin 5.0317983394
MESH:D010997 Pleural Neoplasms Doxorubicin 5.0317638057
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.4318163543
MESH:D011230 Precancerous Conditions Cyclosporine 8.5712371664
MESH:D011230 Precancerous Conditions Diethylnitrosamine 8.572563599
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.0611222880 11118676 11399792 11896295
MESH:D055728 Primary Myelofibrosis marker/mechanism 20601953
MESH:D011471 Prostatic Neoplasms marker/mechanism 17173048
MESH:D011471 Prostatic Neoplasms AGN 194204 1.9016000583
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 1.9017292933
MESH:D011471 Prostatic Neoplasms Clorgyline 1.9019691856
MESH:D011471 Prostatic Neoplasms Doxorubicin 1.9016888761 16729912 16868541 15897917 15749863 18437689
MESH:D011471 Prostatic Neoplasms Tamoxifen 1.9015067354
MESH:D011507 Proteinuria Tretinoin 3.4816636307
MESH:D011537 Pruritus Ethinyl Estradiol 3.1815861022 16919318
MESH:D011565 Psoriasis Cyclosporine 2.1816882103
MESH:D011625 Pterygium Tretinoin 4.6616723453
MESH:D051437 Renal Insufficiency Doxorubicin 4.0917922066
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.7118990726
MESH:D012208 Rhabdomyosarcoma Tretinoin 3.9816283617 16116481
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.8118045962
MESH:D012509 Sarcoma Doxorubicin 3.8715625365 18313854 16767912 17710206 15675481 17203757
MESH:D012512 Sarcoma, Ewing's Doxorubicin 4.1114601052 16326096
MESH:D012514 Sarcoma, Kaposi Doxorubicin 4.6617846226
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 17.2710029692 19755658
MESH:D012878 Skin Neoplasms Doxorubicin 17.2715692506
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 17.278532709
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 17.2716192470
MESH:D012878 Skin Neoplasms Tretinoin 17.2716467112
MESH:D012983 Soft Tissue Neoplasms Doxorubicin 4.4415625365 17203757 16767912
MESH:D013088 Spermatocele Ethinyl Estradiol 11.1316709447
MESH:D013088 Spermatocele Tamoxifen 11.1316709447
MESH:D013119 Spinal Cord Injuries Progesterone 10.4316503802 15862959
MESH:D013119 Spinal Cord Injuries Tamoxifen 10.4319457130
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 3.2620155912 2093021
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 3.2618456281
MESH:D013274 Stomach Neoplasms Tretinoin 3.2617261132
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.5011994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.0415669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.7712697716
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 11.437505956
MESH:D013964 Thyroid Neoplasms Doxorubicin 11.4316010429 17909728
MESH:D013964 Thyroid Neoplasms Tretinoin 11.4317045167 16026305
MESH:D014062 Tongue Neoplasms Tretinoin 3.6716051514
MESH:D014376 Tuberculosis Tretinoin 3.1516040207
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 8.0417053015
MESH:D001749 Urinary Bladder Neoplasms Doxorubicin 8.0417653716
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 8.0416712894 17572228 8653321
MESH:D014581 Urticaria Acetaminophen 2.8510982225
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 3.5616129372
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.1714692618
MESH:D014604 Uveal Neoplasms Tretinoin 4.4816752155
MESH:D014605 Uveitis Cyclosporine 3.851336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.4712125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.4214671159 15869587
MESH:D018487 Ventricular Dysfunction, Left Doxorubicin 4.0917678736 17638931 17334414 16364871
MESH:D014820 Vitiligo Tretinoin 3.9316761959
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.1215886252
MESH:D009396 Wilms Tumor Tretinoin 3.8516287080
MESH:D014985 Xerophthalmia Cyclosporine 4.3117120751
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA27939
    • Releated gene ID Related gene Name
    PA164722518MIR16-1
    PA164722519MIR16-2
    PA164722600MIR217
    PA164722618MIR26A1
    PA164722619MIR26A2
    PA164722741MIR495
    PA134898266MIRN128A
    PA164722334MIR101-1
    PA164722335MIR101-2
    Releated disease ID Related disease Name
    PA443560Breast Neoplasms
    PA445425Prostatic Neoplasms
    No data
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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