AutismKB 2.0

Annotation Detail for F8


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Basic Information Top
Gene Symbol:F8 ( AHF,DXS1253E,F8B,F8C,FVIII,HEMA )
Gene Full Name: coagulation factor VIII, procoagulant component
Band: Xq28
Quick LinksEntrez ID:2157; OMIM: 306700; Uniprot ID:FA8_HUMAN; ENSEMBL ID: ENSG00000185010; HGNC ID: 3546
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04610Complement and coagulation cascades
Pathway IDPathway Name
Hemostasis
No data
Pathway IDPathway Name
P00011Blood coagulation
Pathway IDPathway Name
500302Intrinsic Pathway
Related Diseases/Disorders Top
Desease IDDesease Name
Circulatory system diseases
Hematologic diseases
H00219Hemophilia
Desease IDDesease Name
1706Thrombophilia
1713Hemophilia
1724Vascular disease
1819Malignant childhood tumor
1858Hemorrhagic disorder
1918Atherosclerosis
1944Breast cancer
1954Stroke
2009Sarcoma
2051Leukemia
2120Rabies
2162Capillaries disease
2233Cirrhosis
Desease Name
HEMATOLOGICAL
retinal artery occlusion
Venous Thrombosis
CARDIOVASCULAR
hemophilia
Brain Infarction
Stroke
Myocardial Infarction
VISION
thrombosis, deep vein
coronary heart disease
thromboembolism, venous
cerebrovascular disease
factor VIII and factor IX genes
No data
Desease Name
Hemophilia A
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of F8 mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of F8 mRNAaffects expression 21346803
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of F8 mRNAincreases expression 18648102
D000535 Aluminum Aluminum affects the folding of F8 proteinaffects folding 15349964
D000535 Aluminum [Aluminum promotes the reaction [F8 protein binds to F8 protein]] which results in decreased activity of F8 proteinaffects binding|decreases activity|increases reaction 15349964
D044966 Anti-Retroviral Agents Anti-Retroviral Agents results in decreased expression of F8 proteindecreases expression 19929230
D002118 Calcium Calcium results in increased activity of [F8 protein alternative form binds to F8 protein alternative form]affects binding|increases activity 11513607
D002118 Calcium [Copper co-treated with Calcium] results in increased activity of [F8 protein alternative form binds to F8 protein alternative form]affects binding|affects cotreatment|increases activity 11513607
D003300 Copper [Copper co-treated with Calcium] results in increased activity of [F8 protein alternative form binds to F8 protein alternative form]affects binding|affects cotreatment|increases activity 11513607
D003300 Copper Copper promotes the reaction [F8 protein alternative form binds to F8 protein alternative form]affects binding|increases reaction 11513607
D016572 Cyclosporine Cyclosporine results in decreased expression of F8 mRNAdecreases expression 20106945
D004997 Ethinyl Estradiol [Ethinyl Estradiol co-treated with Gestodene] affects the activity of F8 proteinaffects activity|affects cotreatment 11720199
D004997 Ethinyl Estradiol [Ethinyl Estradiol co-treated with Gestodene] results in increased expression of F8 proteinaffects cotreatment|increases expression 12618251
D004997 Ethinyl Estradiol [Ethinyl Estradiol co-treated with Levonorgestrel] results in increased expression of F8 proteinaffects cotreatment|increases expression 12618251
D004997 Ethinyl Estradiol [Ethinyl Estradiol co-treated with norgestimate] results in increased expression of F8 proteinaffects cotreatment|increases expression 12618251
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of F8 mRNAincreases expression 17555576
17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of F8 mRNAaffects cotreatment|increases expression 17942748
C442659 ethinyl estradiol-desogestrel combination ethinyl estradiol-desogestrel combination results in increased expression of F8 proteinincreases expression 12618251
D005472 Fluorouracil F8 mRNA results in increased susceptibility to [Leucovorin co-treated with Fluorouracil co-treated with irinotecan]affects cotreatment|increases response to substance 17327601
D002955 Leucovorin F8 mRNA results in increased susceptibility to [Leucovorin co-treated with Fluorouracil co-treated with irinotecan]affects cotreatment|increases response to substance 17327601
D005839 Gentamicins Gentamicins results in increased expression of F8 proteinincreases expression 16051741
C033273 Gestodene [Ethinyl Estradiol co-treated with Gestodene] affects the activity of F8 proteinaffects activity|affects cotreatment 11720199
C033273 Gestodene [Ethinyl Estradiol co-treated with Gestodene] results in increased expression of F8 proteinaffects cotreatment|increases expression 12618251
C051890 irinotecan F8 mRNA results in increased susceptibility to [Leucovorin co-treated with Fluorouracil co-treated with irinotecan]affects cotreatment|increases response to substance 17327601
C017576 norgestimate [Ethinyl Estradiol co-treated with norgestimate] results in increased expression of F8 proteinaffects cotreatment|increases expression 12618251
D016912 Levonorgestrel [Ethinyl Estradiol co-treated with Levonorgestrel] results in increased expression of F8 proteinaffects cotreatment|increases expression 12618251
D010634 Phenobarbital NR1I3 protein affects the reaction [Phenobarbital results in decreased expression of F8 mRNA]affects reaction|decreases expression 19482888
D010634 Phenobarbital Phenobarbital results in decreased expression of F8 mRNAdecreases expression 19482888
D020849 Raloxifene Raloxifene results in increased activity of F8 proteinincreases activity 16359964
D020849 Raloxifene Raloxifene results in increased expression of F8 proteinincreases expression 15850603
D013629 Tamoxifen Tamoxifen results in increased expression of F8 proteinincreases expression 15850603
D013629 Tamoxifen Tamoxifen affects the expression of F8 mRNAaffects expression 17555576
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of F8 mRNAaffects cotreatment|increases expression 17942748
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.4414745880
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 7.936195326
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 7.9311752688 14514962 15322242
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 11.9717505938
MESH:D000152 Acne Vulgaris norgestimate 11.9717505938
MESH:D058186 Acute Kidney Injury Gentamicins 4.4411274264
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.2514692618
MESH:D000230 Adenocarcinoma Fluorouracil 4.2517638652
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.693712494
MESH:D018248 Adenoma, Liver Cell Phenobarbital 9.7217620307
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 9.7216835633
MESH:D000419 Albuminuria Raloxifene 4.4917308373 17451421
MESH:D000544 Alzheimer Disease Aluminum 6.8417662457 10721010
MESH:D000544 Alzheimer Disease Copper 6.8417119284 16886094 16325427 16410023 16866297 16962711
MESH:D000544 Alzheimer Disease Raloxifene 6.8415800139
MESH:D000690 Amyotrophic Lateral Sclerosis Copper 4.2310694572
MESH:D000740 Anemia Fluorouracil 8.3515504547 17963324 16511603
MESH:D000740 Anemia Tetrachlorodibenzodioxin 8.3511748828
MESH:D018798 Anemia, Iron-Deficiency Copper 4.7816614410
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.3611256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.6015885639
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 4.911440618 11289319
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 2.9412125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.6915340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.6915746008
MESH:D001930 Brain Injuries Raloxifene 4.3716580743
MESH:D001932 Brain Neoplasms Copper 4.4617079463
MESH:D001943 Breast Neoplasms Copper 2.3215986119 17079463
MESH:D001943 Breast Neoplasms Fluorouracil 2.3215136595 16110121 19217205 16595493 18608205 16557594 18357371
MESH:D001943 Breast Neoplasms Raloxifene 2.3216837676 17952589 16912660 17049068 15572757 17242785 17595753 17893378 17261762 15758505 17440819 15775269
MESH:D001943 Breast Neoplasms Tamoxifen 2.3219200415 19011961 21138602 19189212 19289846 18855134 20065188 17893378 21152245 18629630 20005174 18815881 17049068 15565566 20390343 19189210 18984771 18351453 19487384 20135344 17440819 19288272 17242785 20544844 19244106 20859285 16818667 15668708 17261762 19084267 16873071 19221464 18425577 11161223 18821012 19115204 18997820 19155303 19066611 19142967 19410462 16273361 19059307 19103187 16202921
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.3220435547
MESH:D002276 Carcinoid Tumor Fluorouracil 4.5616051944
MESH:D002277 Carcinoma Fluorouracil 7.8917121937
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 7.8916835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.4019066611
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 11.1616705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 11.1616705839
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 11.163581430 7296757
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 11.1617971768 18930000 17088986 16332177 16799960 17045692
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 11.1617173139 20935162 6705139 20007298 1701930
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 11.1616924424
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 6.337296757
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 6.3318695887
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 2.4616280240 18986760 17066447 16757204
MESH:D002295 Carcinoma, Transitional Cell Raloxifene 9.1717572228
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 9.1717572228
MESH:D006332 Cardiomegaly Copper 6.8617327471
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 6.8618850075 16120746 18670907
MESH:D002318 Cardiovascular Diseases Raloxifene 3.3715775269
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 10.706135515
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 10.707505956
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 10.7012371664
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.144080065
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.0716835633
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 18.6419486331 9022650
MESH:D002779 Cholestasis Cyclosporine 18.6419486331
MESH:D002779 Cholestasis Ethinyl Estradiol 18.6417681005 11677210 16105132 15861022 16919318 17110522 17333356
MESH:D002779 Cholestasis Levonorgestrel 18.6415861022
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.0615668235 15340226 12621046 8697196 16354765
MESH:D003072 Cognition Disorders Raloxifene 4.5115800139
MESH:D003110 Colonic Neoplasms Fluorouracil 3.9017169374 18772588 15001691 17018589 16510598 17287894 17725105 17016597 17172411 16340194
MESH:D003110 Colonic Neoplasms irinotecan 3.9017725105 17287894
MESH:D015179 Colorectal Neoplasms Fluorouracil 3.6818949393 16303861 18288408 16524972 14970324 18383874 17094418 16331619 17695437 17401013 18802399 20501625 15289873 15148649 17594712 16282729 16391804 18509181 18448328 17454858 17255274 17016601
MESH:D015179 Colorectal Neoplasms irinotecan 3.6818259882 18509181 16391804 17454858 15273666 16303861 17159606
MESH:D015179 Colorectal Neoplasms Leucovorin 3.6817401013 17255274 16303861 17594712 17454858 20501625
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.9617141729 14669216
MESH:D019465 Craniofacial Abnormalities Leucovorin 3.0516925845
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 3.0510048152 20055451 15322242
MESH:D003490 Cyanosis 2,4-dinitrotoluene 10.5318551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 10.5318551238
MESH:D007644 Darier Disease Fluorouracil 4.6816733453
MESH:D003711 Demyelinating Diseases Tamoxifen 4.2519031437
MESH:D003865 Depressive Disorder, Major Raloxifene 4.0717474826
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 2.7012868966 2524372 11906362 14531868 8156756 8970840 18759878 11298694
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.392952479 3621924
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6417107852
MESH:D003928 Diabetic Nephropathies Raloxifene 8.7217451421 17308373 15920148
MESH:D003928 Diabetic Nephropathies Tamoxifen 8.7219279558
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 8.6918551238 21346803
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 8.6918551238 21346803
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 8.6918692083 7440962 11289319 9653073 18289764 1440618 6482804 9328219 18648102 9022650 8291058 6679447 16192314
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 8.6920420201
MESH:D004362 Drug Toxicity Gentamicins 8.1215033597 11033412
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 8.1211462148
MESH:D004421 Dystonia Phenobarbital 3.901851702
MESH:D004487 Edema Raloxifene 6.5215860553
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.5212711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.8015322242 16714409 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 14.7312538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Raloxifene 14.7315845917
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 14.7319031437
MESH:D016889 Endometrial Neoplasms Tamoxifen 2.9719155303 16202921 20544844 17893378
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.9210568697 9294722
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 4.003659116
MESH:D004828 Epilepsies, Partial Phenobarbital 3.773922381 11558140
MESH:D004827 Epilepsy Phenobarbital 2.8320417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.456401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.147750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 3.913659116
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 4.433581430
MESH:D004938 Esophageal Neoplasms Fluorouracil 4.4316481741 15173087 16785472 16337965 17638652
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.9311564622
MESH:D005234 Fatty Liver Cyclosporine 17.9419224547
MESH:D005234 Fatty Liver Ethinyl Estradiol 17.9415345470
MESH:D005234 Fatty Liver Raloxifene 17.9417473493
MESH:D005234 Fatty Liver Tamoxifen 17.9414986274 19224547
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.1716709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.3511858732
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 4.916705139
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.4214745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.0719069698
MESH:D005355 Fibrosis Cyclosporine 8.1212639820 12168785
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 8.1220067830
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.118708960
MESH:D005910 Glioma Fluorouracil 2.8316145905
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 3.937505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.4910696789
MESH:D006258 Head and Neck Neoplasms Fluorouracil 3.3118337622 15162350 15102660
MESH:D034381 Hearing Loss Gentamicins 4.7919130971 18024279 17868369 15968427
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.2710048152 11294989
MESH:D006331 Heart Diseases Raloxifene 3.4611110106
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.3115720958
MESH:D006467 Hemophilia A marker/mechanism 11918545 16051741
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.2311000095
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.416705139
MESH:D006521 Hepatitis, Chronic Copper 5.1717338147
MESH:D006527 Hepatolenticular Degeneration Copper 5.0616607473 17182432 17276780 17109627 19888908
MESH:D006529 Hepatomegaly Phenobarbital 8.0816109766
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 8.0815340226 12621046 16120746
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.9418606429 8697196 16354765 15340226 16959395
MESH:D053565 Hypercalciuria Gentamicins 5.6017652376
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 3.8315034207
MESH:D006973 Hypertension Cyclosporine 8.3410903974
MESH:D006973 Hypertension Raloxifene 8.3417577099 15787275
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 8.3418850075 18670907
MESH:D007021 Hypospadias Ethinyl Estradiol 3.7016569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.3612013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.4117937319
MESH:D007249 Inflammation Aluminum 8.1516052892
MESH:D007249 Inflammation Tamoxifen 8.1519457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 8.1512200463 12878042
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 4.918074119 9022650
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.2316580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.3415604871
MESH:D007673 Kidney Cortex Necrosis Gentamicins 5.6218842672
MESH:D007674 Kidney Diseases Cyclosporine 6.1810903974 18776723 8314463
MESH:D007674 Kidney Diseases Gentamicins 6.1818289764 17934191 19349640
MESH:D007676 Kidney Failure, Chronic Copper 4.8016518626
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 27.9216705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 27.9216705839
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 27.926582329
MESH:D007680 Kidney Neoplasms Cyclosporine 27.9212371664
MESH:D007680 Kidney Neoplasms Fluorouracil 27.9216985049
MESH:D007680 Kidney Neoplasms Tamoxifen 27.9218625569
MESH:D007683 Kidney Tubular Necrosis, Acute Calcium 11.7516316344
MESH:D007683 Kidney Tubular Necrosis, Acute Gentamicins 11.7511231351
MESH:D007859 Learning Disorders Copper 4.6817134702
MESH:D007889 Leiomyoma Raloxifene 4.3916973256
MESH:D016773 Leishmaniasis, Cutaneous Gentamicins 4.3710219319
MESH:D008064 Lipidoses Tamoxifen 3.0815342952 17567588
MESH:D008103 Liver Cirrhosis Phenobarbital 2.8321047994
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.139327722 15034207
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 2.2518564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.2512878042
MESH:D008107 Liver Diseases Phenobarbital 2.1519363144
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 17.467678174
MESH:D008113 Liver Neoplasms Copper 17.4620302851
MESH:D008113 Liver Neoplasms Fluorouracil 17.4617045692 15113037 18383874 16603448
MESH:D008113 Liver Neoplasms Phenobarbital 17.4619812893 19073162 8742319 19482888 15975961 21047994
MESH:D008113 Liver Neoplasms Tamoxifen 17.4616684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 17.4616984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 13.542876784 2876786 6135515
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 13.541399818 6587162 598648 3712494
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 13.541399818 18308698 17172636 2563599 6150874
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 13.5412151625
MESH:D008171 Lung Diseases Aluminum 4.5716052892
MESH:D008175 Lung Neoplasms Fluorouracil 3.3315246190
MESH:D008175 Lung Neoplasms Tamoxifen 3.3318625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.3311884234 19555203
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 4.6815086387
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.6519428831
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 2.5511731420 16827153 14580682 19196722 19196723
MESH:D020149 Manganese Poisoning Tamoxifen 4.4419453300
MESH:D008545 Melanoma Tamoxifen 1.8719393235 12393984
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.0715990972
MESH:D007706 Menkes Kinky Hair Syndrome Copper 5.7717109627 17268249
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.6816801185
MESH:D018200 Mixed Tumor, Mullerian Raloxifene 5.4515863610
MESH:D009062 Mouth Neoplasms Fluorouracil 3.5518986760 16757204
MESH:D052016 Mucositis irinotecan 4.9017159606
MESH:D009101 Multiple Myeloma Raloxifene 3.3616497877
MESH:D020528 Multiple Sclerosis, Chronic Progressive Aluminum 6.2717086897
MESH:D020529 Multiple Sclerosis, Relapsing-Remitting Aluminum 6.2717086897
MESH:D009137 Muscular Dystrophy, Animal Gentamicins 6.1718694830
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.9312213967
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.3717484760
MESH:D009232 Myxoma Raloxifene 5.4516343187
MESH:D009336 Necrosis 2,4-dinitrotoluene 9.9818551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 9.987678174 18551238
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 9.293581430
MESH:D009362 Neoplasm Metastasis irinotecan 9.2918259882
MESH:D009362 Neoplasm Metastasis Tamoxifen 9.2919393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.4819410462
MESH:D009369 Neoplasms Fluorouracil 2.5616928823 18600527 18239605
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 3.8919189210 19196722 19200415
MESH:D009389 Neovascularization, Pathologic Copper 4.8417308104
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.3417954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.1918481113 19348381
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.1114600291
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 2.846679447
MESH:D009447 Neuroblastoma irinotecan 3.428761367
MESH:D017599 Neuroectodermal Tumors irinotecan 4.628761367
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.3616436463
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 14.5016049721 12819281
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 14.5016049721
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 14.506482804 4026338
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 4.913988306
MESH:D010018 Osteomalacia Phenobarbital 4.2617016548
MESH:D010024 Osteoporosis Calcium 11.8017882678
MESH:D010024 Osteoporosis Levonorgestrel 11.8012665316
MESH:D010024 Osteoporosis Raloxifene 11.8017882678 15775268 19059307
MESH:D015663 Osteoporosis, Postmenopausal Raloxifene 4.1217823083 15579764 15758505 17893378
MESH:D010190 Pancreatic Neoplasms Fluorouracil 5.2216929163 19003803 16500647 15113037
MESH:D010190 Pancreatic Neoplasms Phenobarbital 5.2216965848
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.5811578682
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.387296757
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.1412520081
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.366228378
MESH:D011085 Polycystic Ovary Syndrome ethinyl estradiol-desogestrel combination 5.5017105841
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.4518163543
MESH:D011230 Precancerous Conditions Cyclosporine 8.6512371664
MESH:D011230 Precancerous Conditions Phenobarbital 8.652563599
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.0811222880 11896295 11399792 11118676
MESH:D011471 Prostatic Neoplasms Copper 2.1717308104 17079463
MESH:D011471 Prostatic Neoplasms Fluorouracil 2.1719082440 18626508
MESH:D011471 Prostatic Neoplasms Raloxifene 2.1716536755 15731164 16220300
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.1715067354
MESH:D011507 Proteinuria Gentamicins 4.6215033597
MESH:D011537 Pruritus Ethinyl Estradiol 9.6416919318 15861022
MESH:D011537 Pruritus Levonorgestrel 9.6415861022
MESH:D019310 Pseudolymphoma Phenobarbital 4.3912752131
MESH:D011565 Psoriasis Cyclosporine 2.1916882103
MESH:D011693 Purpura Raloxifene 5.4515770314
MESH:D012004 Rectal Neoplasms Fluorouracil 3.9218722050 18286688 15538739 16160472
MESH:D051437 Renal Insufficiency Gentamicins 4.8817132701 15728788
MESH:D015427 Reperfusion Injury Leucovorin 4.5417295595
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.7318990726
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.293692021
MESH:D012173 Retinitis Gentamicins 6.1718644591
MESH:D012559 Schizophrenia Copper 3.0716842975
MESH:D012640 Seizures 2,4-dinitrotoluene 9.3718551238
MESH:D012640 Seizures 2,6-dinitrotoluene 9.3718551238
MESH:D012640 Seizures Phenobarbital 9.373137016 16876388 4039156 11442880
MESH:D003294 Seizures, Febrile Phenobarbital 4.716407741
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 1.9916192470
MESH:D013088 Spermatocele Ethinyl Estradiol 11.2116709447
MESH:D013088 Spermatocele Tamoxifen 11.2116709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 3.9319457130
MESH:D013274 Stomach Neoplasms Fluorouracil 2.6919084572 16424979 18567086 18396642 19015929 17522103 17498489 17172411 16951190 15786421
MESH:D013274 Stomach Neoplasms irinotecan 2.6915723263
MESH:D020521 Stroke Raloxifene 3.7316837676
MESH:D019851 Thrombophilia Ethinyl Estradiol 17.8711994571
MESH:D019851 Thrombophilia ethinyl estradiol-desogestrel combination 17.8711994571
MESH:D019851 Thrombophilia Gestodene 17.8711994571
MESH:D013927 Thrombosis Ethinyl Estradiol 9.2315669648
MESH:D013927 Thrombosis Gestodene 9.2315669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.8012697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 6.867505956 3712494 1399818 6582329 6587162
MESH:D013964 Thyroid Neoplasms Phenobarbital 6.861399818
MESH:D013978 Tibial Fractures Raloxifene 5.1019048282
MESH:D014062 Tongue Neoplasms Fluorouracil 3.8916280240
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 15.3516049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 15.3516049721
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 15.358074119
MESH:D001749 Urinary Bladder Neoplasms Raloxifene 15.3517572228
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 15.3516712894 8653321 17572228
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 11.6310091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 11.6310091137
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 3.7816803524
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.1914692618
MESH:D014605 Uveitis Cyclosporine 3.881336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.4912125929
MESH:D054556 Venous Thromboembolism Raloxifene 5.1016837676
MESH:D020246 Venous Thrombosis marker/mechanism 16875063
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 17.3514671159 15869587
MESH:D020246 Venous Thrombosis ethinyl estradiol-desogestrel combination 17.3515869587
MESH:D020246 Venous Thrombosis Levonorgestrel 17.3515869587
MESH:D015837 Vestibular Diseases Gentamicins 5.4118776599
MESH:D014846 Vulvar Neoplasms Raloxifene 5.4516343187
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.1415886252
MESH:D014985 Xerophthalmia Cyclosporine 4.3417120751
Pathway ID Pathway Name
KEGG:04610 Complement and coagulation cascades
REACT:604 Hemostasis
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA27952
    • No data
    Releated disease ID Related disease Name
    PA446974Choroidal Neovascularization
    Releated drug ID Related drug Name
    PA451871verteporfin
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00055 multitarget Drotrecogin alfa Antisepsis Agents
    DB00100 cofactor Coagulation Factor IX Coagulants;Thrombotic Agents
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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