AutismKB 2.0

Annotation Detail for F11


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Basic Information Top
Gene Symbol:F11 ( FXI,MGC141891 )
Gene Full Name: coagulation factor XI
Band: 4q35.2
Quick LinksEntrez ID:2160; OMIM: 264900; Uniprot ID:FA11_HUMAN; ENSEMBL ID: ENSG00000088926; HGNC ID: 3529
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04610Complement and coagulation cascades
Pathway IDPathway Name
Hemostasis
No data
No data
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1706Thrombophilia
1858Hemorrhagic disorder
1918Atherosclerosis
Desease Name
CARDIOVASCULAR
Heterozygous factor XI deficiency
hypertension, pregnancy induced
No data
Desease Name
Factor XI deficiency, autosomal recessive
Factor XI deficiency, autosomal dominant
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of F11 proteinaffects expression 20106945
D003913 Dextroamphetamine Dextroamphetamine results in increased expression of F11 mRNAincreases expression 12558987
D002122 Calcium Chloride [F11 protein co-treated with Calcium Chloride] results in increased activity of F9 proteinaffects cotreatment|increases activity 6604052
D016572 Cyclosporine Cyclosporine results in decreased expression of F11 mRNAdecreases expression 20106945
D004958 Estradiol Estradiol results in decreased expression of F11 mRNAdecreases expression 20106945
D007460 Iodoacetamide Iodoacetamide results in increased cleavage of F11 proteinincreases cleavage 6604052
D007616 Kaolin Kaolin results in decreased activity of F11 proteindecreases activity 6604052
C023036 perfluorooctanoic acid perfluorooctanoic acid results in decreased expression of F11 mRNAdecreases expression 18467677
C023036 perfluorooctanoic acid PPARA protein promotes the reaction [perfluorooctanoic acid results in decreased expression of F11 mRNA]decreases expression|increases reaction 18467677
D010634 Phenobarbital Phenobarbital affects the expression of F11 mRNAaffects expression 19136022
C006253 pirinixic acid pirinixic acid affects the expression of F11 mRNAaffects expression 19136022
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of F11 mRNAaffects binding|decreases expression|increases activity 19710929
C006253 pirinixic acid pirinixic acid results in decreased expression of F11 mRNAdecreases expression 18467677
17950772
18445702
C006253 pirinixic acid PPARA protein promotes the reaction [pirinixic acid results in decreased expression of F11 mRNA]decreases expression|increases reaction 18467677
17950772
D020849 Raloxifene Raloxifene results in increased activity of F11 proteinincreases activity 16359964
C040190 S 2366 F11 protein alternative form affects the metabolism of S 2366affects metabolic processing 6604052
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of F11 mRNAincreases expression 11489354
20106945
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 8.696195326
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 8.6915322242 14514962 11752688
MESH:D055371 Acute Lung Injury pirinixic acid 3.2018653653
MESH:D000230 Adenocarcinoma Estradiol 2.1111473722
MESH:D018248 Adenoma, Liver Cell Phenobarbital 18.0017620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 18.0016434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 18.0016835633
MESH:D000419 Albuminuria Raloxifene 4.6917308373 17451421
MESH:D000544 Alzheimer Disease Raloxifene 2.5515800139
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.0211748828
MESH:D001169 Arthritis, Experimental Kaolin 6.0317392412
MESH:D001778 Blood Coagulation Disorders pirinixic acid 9.0419483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 9.0412125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.9215340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8115746008
MESH:D001930 Brain Injuries Raloxifene 4.5816580743
MESH:D001943 Breast Neoplasms Estradiol 1.8717289903 17261762 12948864 19861407 17018787 14630087 18497071 16675129
MESH:D001943 Breast Neoplasms Raloxifene 1.8715775269 17952589 15758505 17242785 17440819 17261762 17893378 17049068 16912660 16837676 15572757 17595753
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.8720435547
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.5816111702
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.8616835633
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 4.6712907637 21507988 12619106
MESH:D006528 Carcinoma, Hepatocellular Estradiol 4.6716924424
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 4.6717173139 1701930 20007298 20935162 6705139
MESH:D002295 Carcinoma, Transitional Cell Raloxifene 4.1517572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4118850075 18670907 16120746
MESH:D002318 Cardiovascular Diseases Raloxifene 3.5015775269
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 6.7612371664
MESH:D002471 Cell Transformation, Neoplastic Estradiol 6.7618566989
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.364080065
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.2316835633
MESH:D002779 Cholestasis Cyclosporine 7.9619486331
MESH:D002779 Cholestasis pirinixic acid 7.9619176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1315340226 8697196 12621046 16354765 15668235
MESH:D003072 Cognition Disorders Raloxifene 4.7215800139
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1314669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2615322242 20055451 10048152
MESH:D003865 Depressive Disorder, Major Raloxifene 4.2317474826
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4618249437
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6817107852
MESH:D003928 Diabetic Nephropathies Estradiol 9.2519279558
MESH:D003928 Diabetic Nephropathies Raloxifene 9.2515920148 17451421 17308373
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 1.5520420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8211462148
MESH:D004421 Dystonia Phenobarbital 4.091851702
MESH:D004487 Edema perfluorooctanoic acid 17.1617259670 12083418
MESH:D004487 Edema pirinixic acid 17.1612083418
MESH:D004487 Edema Raloxifene 17.1615860553
MESH:D004487 Edema Tetrachlorodibenzodioxin 17.1612711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.0415322242 16714409 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Raloxifene 4.0915845917
MESH:D016889 Endometrial Neoplasms Estradiol 3.0311473722 19148513 18566989
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.1010568697 9294722
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 4.213659116
MESH:D004828 Epilepsies, Partial Phenobarbital 4.003922381 11558140
MESH:D004827 Epilepsy Phenobarbital 2.9320417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.616401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.367750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 4.143659116
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0711564622
MESH:D005173 Factor XI Deficiency marker/mechanism
MESH:D005234 Fatty Liver Cyclosporine 13.5919224547
MESH:D005234 Fatty Liver pirinixic acid 13.5919236843 20131406
MESH:D005234 Fatty Liver Raloxifene 13.5917473493
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.5611858732
MESH:D005355 Fibrosis Cyclosporine 8.8312168785 12639820
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 8.8320067830
MESH:D005756 Gastritis Iodoacetamide 6.4215046732
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.348708960
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.7310696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.3710048152 11294989
MESH:D006331 Heart Diseases Raloxifene 3.5911110106
MESH:D006333 Heart Failure pirinixic acid 2.5820558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.5415720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.4211000095
MESH:D006529 Hepatomegaly perfluorooctanoic acid 21.623609246
MESH:D006529 Hepatomegaly Phenobarbital 21.6216109766
MESH:D006529 Hepatomegaly pirinixic acid 21.6218467677 19176532 19772884 16221962
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 21.6212621046 16120746 15340226
MESH:D006558 Herpes Genitalis Estradiol 5.1715709030
MESH:D019584 Hot Flashes Estradiol 3.8917088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.188697196 16959395 15340226 18606429 16354765
MESH:D006930 Hyperalgesia perfluorooctanoic acid 3.9212083418
MESH:D006943 Hyperglycemia pirinixic acid 3.2620558911
MESH:D006973 Hypertension Cyclosporine 8.7510903974
MESH:D006973 Hypertension Raloxifene 8.7517577099 15787275
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 8.7518850075 18670907
MESH:D007249 Inflammation perfluorooctanoic acid 5.2812083418
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.2812878042 12200463
MESH:D007333 Insulin Resistance Estradiol 7.3716627594 16393666
MESH:D007333 Insulin Resistance pirinixic acid 7.3716306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.4216580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.5815604871
MESH:D007674 Kidney Diseases Cyclosporine 6.088314463 10903974 18776723
MESH:D007674 Kidney Diseases Estradiol 6.0815618244
MESH:D007680 Kidney Neoplasms Cyclosporine 7.5012371664
MESH:D007680 Kidney Neoplasms Estradiol 7.5015610895
MESH:D007889 Leiomyoma Raloxifene 4.5816973256
MESH:D007984 Leydig Cell Tumor perfluorooctanoic acid 5.358812269
MESH:D008103 Liver Cirrhosis Phenobarbital 2.9421047994
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 3.4214716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.4215474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.4212878042
MESH:D008107 Liver Diseases Phenobarbital 2.1919363144
MESH:D008113 Liver Neoplasms Aflatoxin B1 14.5618177683 2125692 15890375 9163691
MESH:D008113 Liver Neoplasms perfluorooctanoic acid 14.5618709148 14757943
MESH:D008113 Liver Neoplasms Phenobarbital 14.5619812893 8742319 15975961 19482888 19073162 21047994
MESH:D008113 Liver Neoplasms pirinixic acid 14.5620007298 15890375 16377806
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 14.5616984957
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 10.118603461
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 10.116150874 1399818 2563599 17172636 18308698
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 10.1112151625
MESH:D008175 Lung Neoplasms Aflatoxin B1 2.3214755239
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.3219555203 11884234
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 2.6111807958 11408345 17203775 16891317
MESH:D020149 Manganese Poisoning Estradiol 4.6219453300
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.9216801185
MESH:D018200 Mixed Tumor, Mullerian Raloxifene 5.6915863610
MESH:D009041 Motion Sickness Dextroamphetamine 5.651613127
MESH:D009101 Multiple Myeloma Raloxifene 3.4916497877
MESH:D009135 Muscular Diseases pirinixic acid 3.6116239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.1719151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.0812213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 8.4616810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 8.4616411023
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.5917484760
MESH:D009232 Myxoma Raloxifene 5.6916343187
MESH:D009369 Neoplasms pirinixic acid 1.9817405874
MESH:D009389 Neovascularization, Pathologic Estradiol 3.8517289903
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.5817954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.3618481113 19348381
MESH:D009421 Nervous System Malformations Estradiol 9.7816427766 11399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 9.7814600291
MESH:D052556 Niemann-Pick Disease, Type C perfluorooctanoic acid 5.069802331
MESH:D009765 Obesity pirinixic acid 1.8320558911
MESH:D010018 Osteomalacia Phenobarbital 4.4817016548
MESH:D010024 Osteoporosis Raloxifene 3.4417882678 15775268 19059307
MESH:D015663 Osteoporosis, Postmenopausal Raloxifene 4.3115758505 15579764 17893378 17823083
MESH:D010051 Ovarian Neoplasms Estradiol 2.2419401270
MESH:D010190 Pancreatic Neoplasms Phenobarbital 2.5216965848
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.3812520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.6518163543
MESH:D011230 Precancerous Conditions Cyclosporine 9.2112371664
MESH:D011230 Precancerous Conditions Phenobarbital 9.212563599
MESH:D011297 Prenatal Exposure Delayed Effects perfluorooctanoic acid 10.0717132714
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 10.0711896295 11118676 11399792 11222880
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.9720887781
MESH:D011471 Prostatic Neoplasms Estradiol 3.3216740699
MESH:D011471 Prostatic Neoplasms Raloxifene 3.3216536755 15731164 16220300
MESH:D019310 Pseudolymphoma Phenobarbital 4.6312752131
MESH:D011565 Psoriasis Cyclosporine 2.2516882103
MESH:D011693 Purpura Raloxifene 5.6915770314
MESH:D015427 Reperfusion Injury pirinixic acid 2.4219058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.9318990726
MESH:D012640 Seizures Phenobarbital 2.7411442880 3137016 16876388 4039156
MESH:D003294 Seizures, Febrile Phenobarbital 4.946407741
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.0816192470
MESH:D020521 Stroke Raloxifene 3.8916837676
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.0412697716
MESH:D013964 Thyroid Neoplasms Phenobarbital 3.111399818
MESH:D013978 Tibial Fractures Estradiol 14.1719048282
MESH:D013978 Tibial Fractures Raloxifene 14.1719048282
MESH:D001749 Urinary Bladder Neoplasms Raloxifene 2.8417572228
MESH:D014605 Uveitis Cyclosporine 4.121336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.7312125929
MESH:D054556 Venous Thromboembolism Raloxifene 5.3416837676
MESH:D014846 Vulvar Neoplasms Raloxifene 5.6916343187
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.3815886252
MESH:D014985 Xerophthalmia Cyclosporine 4.5817120751
Pathway ID Pathway Name
KEGG:04610 Complement and coagulation cascades
REACT:604 Hemostasis
Pharmacogenomics Knowledge Base Top
Drug Bank Top
Drugbank ID Action Drug Name Description
DB00100 ligand Coagulation Factor IX Coagulants;Thrombotic Agents
DB07022 - 3-HYDROXYPROPYL 3-[({7-[AMINO(IMINO)METHYL]-1-NAPHTHYL}AMINO)CARBONYL]BENZENESULFONATE
DB07023 - (1R)-2-{[AMINO(IMINO)METHYL]AMINO}-1-{4-[(4R)-4-(HYDROXYMETHYL)-1,3,2-DIOXABOROLAN-2-YL]PHENYL}ETHYL NICOTINATE
DB07071 - (R)-1-(4-(4-(HYDROXYMETHYL)-1,3,2-DIOXABOROLAN-2-YL)PHENETHYL)GUANIDINE
DB07074 - 6-CARBAMIMIDOYL-4-(3-HYDROXY-2-METHYL-BENZOYLAMINO)-NAPHTHALENE-2-CARBOXYLIC ACID METHYL ESTER
DB07077 - (R)-1-(4-(4-(HYDROXYMETHYL)-1,3,2-DIOXABOROLAN-2-YL)PHENYL)GUANIDINE
DB07212 - N-(7-CARBAMIMIDOYL-NAPHTHALEN-1-YL)-3-HYDROXY-2-METHYL-BENZAMIDE
DB07299 - 4-METHYL-PENTANOIC ACID {1-[4-GUANIDINO-1-(THIAZOLE-2-CARBONYL)-BUTYLCARBAMOYL]-2-METHYL-PROPYL}-AMIDE
DB07887 - (R)-1-(4-(4-(HYDROXYMETHYL)-1,3,2-DIOXABOROLAN-2-YL)BENZYL)GUANIDINE
No data
No data
No data

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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