AutismKB 2.0

Annotation Detail for F12


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Basic Information Top
Gene Symbol:F12 ( HAE3,HAEX,HAF )
Gene Full Name: coagulation factor XII (Hageman factor)
Band: 5q35.3
Quick LinksEntrez ID:2161; OMIM: 610619; Uniprot ID:FA12_HUMAN; ENSEMBL ID: ENSG00000131187; HGNC ID: 3530
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Pathway IDPathway Name
hsa04610Complement and coagulation cascades
Related Diseases/Disorders Top
Desease IDDesease Name
1858Hemorrhagic disorder
1918Atherosclerosis
1943Adenocarcinoma
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of F12 mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of F12 mRNAaffects expression 21346803
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of F12 proteinaffects expression 20106945
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of F12 mRNAincreases expression 20064835
D003513 Cycloheximide Cycloheximide inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of F12 mRNA]decreases expression|decreases reaction 11007951
D016572 Cyclosporine Cyclosporine results in decreased expression of F12 mRNAdecreases expression 20106945
D004610 Ellagic Acid ALB protein promotes the reaction [Ellagic Acid results in increased activity of F12 protein]increases activity|increases reaction 6343536
D004610 Ellagic Acid Ellagic Acid results in increased activity of F12 proteinincreases activity 6343536
D005472 Fluorouracil F12 protein affects the susceptibility to Fluorouracilaffects response to substance 15352031
D005472 Fluorouracil Fluorouracil results in decreased expression of F12 proteindecreases expression 15352031
D006830 Hydralazine [Hydralazine co-treated with Valproic Acid] results in increased expression of F12 mRNAaffects cotreatment|increases expression 17183730
D007529 Isoflavones Isoflavones affects the expression of F12 mRNAaffects expression 16365062
D007616 Kaolin Kaolin results in increased activity of F12 proteinincreases activity 6343536
D008727 Methotrexate F12 protein affects the susceptibility to Methotrexateaffects response to substance 16217747
D020849 Raloxifene Raloxifene results in increased activity of F12 proteinincreases activity 16359964
D013433 Sulfoglycosphingolipids ALB protein promotes the reaction [Sulfoglycosphingolipids results in increased activity of F12 protein]increases activity|increases reaction 6343536
D013433 Sulfoglycosphingolipids Sulfoglycosphingolipids results in increased activity of F12 proteinincreases activity 6343536
D013433 Sulfoglycosphingolipids Sulfoglycosphingolipids results in increased cleavage of F12 proteinincreases cleavage 6343536
D013749 Tetrachlorodibenzodioxin Cycloheximide inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of F12 mRNA]decreases expression|decreases reaction 11007951
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of F12 mRNAdecreases expression 11007951
D014635 Valproic Acid [Hydralazine co-treated with Valproic Acid] results in increased expression of F12 mRNAaffects cotreatment|increases expression 17183730
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA161
  • Releated disease ID Related disease Name
    PA443523Blood Coagulation Disorders
    PA445850Thrombosis
    Drug Bank Top

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    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018