AutismKB 2.0

Annotation Detail for F13B


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Basic Information Top
Gene Symbol:F13B ( FXIIIB )
Gene Full Name: coagulation factor XIII, B polypeptide
Band: 1q31.3
Quick LinksEntrez ID:2165; OMIM: 134580; Uniprot ID:F13B_HUMAN; ENSEMBL ID: ENSG00000143278; HGNC ID: 3534
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04610Complement and coagulation cascades
Pathway IDPathway Name
Hemostasis
No data
Pathway IDPathway Name
P00011Blood coagulation
Pathway IDPathway Name
500303Common Pathway
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1954Stroke
No data
No data
Desease Name
Factor XIIIB deficiency
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of F13B mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of F13B mRNAaffects expression 17562736
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of F13B proteinaffects expression 20106945
D001104 Arbutin Arbutin results in decreased expression of F13B mRNAdecreases expression 17103032
D002994 Clofibrate PPARA protein affects the reaction [Clofibrate results in decreased expression of F13B mRNA]affects reaction|decreases expression 17585979
D016572 Cyclosporine Cyclosporine results in decreased expression of F13B mRNAdecreases expression 20106945
D002117 Calcitriol Calcitriol results in increased expression of F13B mRNAincreases expression 16002434
D004958 Estradiol Estradiol results in decreased expression of F13B mRNAdecreases expression 20106945
C017947 sodium arsenite sodium arsenite affects the expression of F13B mRNAaffects expression 20451245
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of F13B mRNAdecreases expression 15703262
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of F13B mRNAincreases expression 16267337
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.0811752688 15322242 14514962
MESH:D000230 Adenocarcinoma Estradiol 2.1311473722
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.6116835633
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.9615276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 5.1716712894 17306315
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.1111748828
MESH:D000799 Angioedema Acetaminophen 4.1110982225
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001778 Blood Coagulation Disorders Clofibrate 9.7519483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 9.7512125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.0615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8715746008
MESH:D001943 Breast Neoplasms Calcitriol 1.8611237771
MESH:D001943 Breast Neoplasms Estradiol 1.8619861407 14630087 17289903 16675129 17261762 12948864 17018787 18497071
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.8620435547
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.7016111702
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9316835633
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 9.1316705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 9.133084413
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 9.1312907637 12619106 21507988
MESH:D006528 Carcinoma, Hepatocellular Estradiol 9.1316924424
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 9.1315276417 17306315 16507464
MESH:D002294 Carcinoma, Squamous Cell Calcitriol 4.9611237771
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 4.9618572023
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4518670907 18850075 16120746
MESH:D002386 Cataract Acetaminophen 2.6710977129
MESH:D002471 Cell Transformation, Neoplastic Clofibrate 17.031399818
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 17.0312371664
MESH:D002471 Cell Transformation, Neoplastic Estradiol 17.0318566989
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 17.0319524636 20056578
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.3116835633
MESH:D002779 Cholestasis Cyclosporine 3.0419486331
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1615668235 12621046 8697196 16354765 15340226
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.2117141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2615322242 20055451 10048152
MESH:D003490 Cyanosis 2,4-dinitrotoluene 4.2318551238
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7017107852
MESH:D003928 Diabetic Nephropathies Estradiol 3.5619279558
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 6.3818551238 21346803
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.3811743745 11461765 11529661 17906064 14725611 10915739 16781746 19085960 12705907 16109766 11739529 16177239 12540782 17522070 10663392 19416960 18713872 11287661 14550746 18071297 2444490 11834606 10774834 19739265 19164858 15968718 19370779 12594235 17562736 19420014 15619225 14986274 16485898 16227642 19923254 11421492 12392966 12958197 16393943 16081117 12153990
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 6.3820420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.3619426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8911462148
MESH:D050171 Dyslipidemias Clofibrate 4.1916707586
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.5511000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.1718230668 15322242 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Calcitriol 4.1315138306
MESH:D016889 Endometrial Neoplasms Estradiol 3.0918566989 11473722 19148513
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.189294722 10568697
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1411564622
MESH:D005177 Factor XIII Deficiency marker/mechanism
MESH:D005234 Fatty Liver Clofibrate 8.5419224547
MESH:D005234 Fatty Liver Cyclosporine 8.5419224547
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.6711858732
MESH:D005355 Fibrosis Cyclosporine 9.2112168785 12639820
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 9.2120067830
MESH:D005756 Gastritis Acetaminophen 3.9416983495
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.9216452187
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.468708960
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.8610696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4111294989 10048152
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.6615720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.5111000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.1112621046 15340226 16120746
MESH:D006558 Herpes Genitalis Estradiol 5.3015709030
MESH:D006689 Hodgkin Disease sodium arsenite 3.3012676792
MESH:D019584 Hot Flashes Estradiol 4.0217088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.3115340226 16959395 16354765 18606429 8697196
MESH:D006930 Hyperalgesia Acetaminophen 2.8416870215
MESH:D006973 Hypertension Cyclosporine 5.1410903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.1418850075 18670907
MESH:D007248 Infertility, Male sodium arsenite 3.1012646999 15346721
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.9312878042 12200463
MESH:D007333 Insulin Resistance Estradiol 3.0716627594 16393666
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.5116580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.7115604871
MESH:D007674 Kidney Diseases Acetaminophen 15.1915629191 12587719
MESH:D007674 Kidney Diseases Cyclosporine 15.1910903974 8314463 18776723
MESH:D007674 Kidney Diseases Estradiol 15.1915618244
MESH:D007674 Kidney Diseases sodium arsenite 15.1920008137
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 13.2216705839
MESH:D007680 Kidney Neoplasms Cyclosporine 13.2212371664
MESH:D007680 Kidney Neoplasms Estradiol 13.2215610895
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 2.3014659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.3012878042
MESH:D008107 Liver Diseases Acetaminophen 1.6612969438 11587558 19014921 16610002 19784758 12587719 19460945 16611625
MESH:D017114 Liver Failure, Acute Acetaminophen 3.4017185352 16871587
MESH:D008113 Liver Neoplasms Aflatoxin B1 7.769163691 18177683 2125692 15890375
MESH:D008113 Liver Neoplasms sodium arsenite 7.7615276417 16712894
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 7.7616984957
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 6.158603461
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 6.1512151625
MESH:D008171 Lung Diseases sodium arsenite 3.2819095001
MESH:D008175 Lung Neoplasms Aflatoxin B1 3.5014755239
MESH:D008175 Lung Neoplasms sodium arsenite 3.5017306315 15276417 17077188 19931552 16712894
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.5019555203 11884234
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 2.6611807958 16891317 17203775 11408345
MESH:D020149 Manganese Poisoning Estradiol 4.7519453300
MESH:D008545 Melanoma sodium arsenite 2.0519082730 16487513
MESH:D008546 Melanoma, Experimental Acetaminophen 3.7819513568
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.0516801185
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1612213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 3.4116810080
MESH:D009336 Necrosis 2,4-dinitrotoluene 4.0918551238
MESH:D009369 Neoplasms sodium arsenite 2.5711559025
MESH:D009374 Neoplasms, Experimental sodium arsenite 3.8820056578
MESH:D009389 Neovascularization, Pathologic Estradiol 3.9717289903
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.7117954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.4419348381 18481113
MESH:D009421 Nervous System Malformations Estradiol 10.1411399458 16427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 10.1414600291
MESH:D009436 Neural Tube Defects sodium arsenite 3.2512854658
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.0118514411
MESH:D052556 Niemann-Pick Disease, Type C Clofibrate 5.159802331
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 3.5916049721 12819281
MESH:D010051 Ovarian Neoplasms Estradiol 4.9919401270
MESH:D010051 Ovarian Neoplasms sodium arsenite 4.9917306315 15276417
MESH:D010146 Pain Acetaminophen 2.5316870215
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.5112520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.7618163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.3712371664
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.4311399792 11222880 11896295 11118676
MESH:D011470 Prostatic Hyperplasia Calcitriol 5.0215572423
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 4.0620887781
MESH:D011471 Prostatic Neoplasms Calcitriol 2.5716289102 12479363 16644109 18247401 15754350
MESH:D011471 Prostatic Neoplasms Estradiol 2.5716740699
MESH:D011471 Prostatic Neoplasms sodium arsenite 2.5716039940
MESH:D011565 Psoriasis Cyclosporine 2.2816882103
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.0418990726
MESH:D012640 Seizures 2,4-dinitrotoluene 2.6418551238
MESH:D012878 Skin Neoplasms sodium arsenite 5.8418572023 19524636
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.8416192470
MESH:D016135 Spinal Dysraphism sodium arsenite 3.9312854658
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.1712697716
MESH:D013978 Tibial Fractures Estradiol 4.9519048282
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 5.2916049721
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 5.2911723127 16712894 16452187 17306315
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.5510091137
MESH:D014581 Urticaria Acetaminophen 3.1610982225
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 3.9311813266
MESH:D014605 Uveitis Cyclosporine 4.251336536
MESH:D014652 Vascular Diseases sodium arsenite 4.6617056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.8612125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.5115886252
MESH:D014985 Xerophthalmia Cyclosporine 4.7117120751
Pathway ID Pathway Name
KEGG:04610 Complement and coagulation cascades
REACT:604 Hemostasis
Pharmacogenomics Knowledge Base Top
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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