AutismKB 2.0

Annotation Detail for FABP3


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Basic Information Top
Gene Symbol:FABP3 ( FABP11,H-FABP,MDGI,O-FABP )
Gene Full Name: fatty acid binding protein 3, muscle and heart (mammary-derived growth inhibitor)
Band: 1p35.2
Quick LinksEntrez ID:2170; OMIM: 134651; Uniprot ID:FABPH_HUMAN; ENSEMBL ID: ENSG00000121769; HGNC ID: 3557
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa03320PPAR signaling pathway
No data
No data
No data
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1740Alzheimer's disease
1983Down syndrome
1841Stomach cancer
2066Lung cancer
2075Heart failure
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene results in increased expression of FABP3 mRNAincreases expression 20406850
C040668 2-ethylhexanoic acid 2-ethylhexanoic acid results in increased expression of FABP3 mRNAincreases expression 15647598
C040668 2-ethylhexanoic acid 2-ethylhexanoic acid results in increased expression of FABP3 proteinincreases expression 15647598
D000643 Ammonium Chloride Ammonium Chloride affects the expression of FABP3 mRNAaffects expression 16483693
C015001 arsenite arsenite results in increased expression of FABP3 mRNAincreases expression 18929588
C015001 arsenite TRP53 protein affects the reaction [arsenite results in increased expression of FABP3 mRNA]affects reaction|increases expression 18929588
C006780 bisphenol A bisphenol A affects the expression of FABP3 mRNAaffects expression 18180321
D002251 Carbon Tetrachloride Carbon Tetrachloride results in increased expression of FABP3 mRNAincreases expression 17484886
C074702 chromium hexavalent ion chromium hexavalent ion affects the expression of FABP3affects expression 17022414
D003345 Corticosterone Corticosterone results in decreased expression of FABP3 mRNAdecreases expression 15755911
D004041 Dietary Fats Dietary Fats results in increased expression of FABP3 mRNAincreases expression 16357043
D004051 Diethylhexyl Phthalate Diethylhexyl Phthalate results in increased expression of FABP3 mRNAincreases expression 15647598
D004051 Diethylhexyl Phthalate Diethylhexyl Phthalate results in increased expression of FABP3 proteinincreases expression 15647598
D004317 Doxorubicin [Doxorubicin co-treated with MT2A protein] results in increased expression of FABP3 proteinaffects cotreatment|increases expression 16144979
D004958 Estradiol Estradiol results in increased expression of FABP3 mRNAincreases expression 16192472
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of FABP3 mRNAincreases expression 17606305
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of FABP3 mRNAdecreases expression 17555576
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of FABP3 mRNAaffects cotreatment|increases expression 17942748
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of FABP3 mRNAincreases expression 17555559
D019833 Genistein Genistein results in increased expression of FABP3 mRNAincreases expression 17341692
D008770 Methylnitrosourea Methylnitrosourea results in increased expression of FABP3 mRNAincreases expression 17341692
C016599 mono-(2-ethylhexyl)phthalate mono-(2-ethylhexyl)phthalate results in increased expression of FABP3 mRNAincreases expression 15647598
C016599 mono-(2-ethylhexyl)phthalate mono-(2-ethylhexyl)phthalate results in increased expression of FABP3 proteinincreases expression 15647598
D010126 Ozone Ozone results in decreased expression of FABP3 mRNAdecreases expression 12763052
D010758 Phosphorus Phosphorus results in increased expression of FABP3 mRNAincreases expression 17715259
D010795 Phthalic Acids Phthalic Acids results in decreased expression of FABP3 mRNAdecreases expression 15728792
C006253 pirinixic acid pirinixic acid results in increased expression of FABP3 mRNAincreases expression 20059764
16985257
18301758
15833283
17950772
16357043
C006253 pirinixic acid PPARA protein affects the reaction [pirinixic acid results in increased expression of FABP3 mRNA]affects reaction|increases expression 15833283
C006253 pirinixic acid PPARA protein promotes the reaction [pirinixic acid results in increased expression of FABP3 mRNA]increases expression|increases reaction 17950772
20059764
D012643 Selenium Selenium results in increased expression of FABP3 mRNAincreases expression 18583539
C009277 sodium arsenate sodium arsenate results in decreased expression of FABP3 mRNAdecreases expression 16882884
D013629 Tamoxifen Tamoxifen affects the expression of FABP3 mRNAaffects expression 17555576
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of FABP3 mRNAaffects cotreatment|increases expression 17942748
C052342 topiramate topiramate results in decreased expression of FABP3 mRNAdecreases expression 16979414
D014415 Tunicamycin Tunicamycin results in decreased expression of FABP3 mRNAdecreases expression 17127020
D014810 Vitamin E Vitamin E results in increased expression of FABP3 mRNAincreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.3214745880
MESH:D000014 Abnormalities, Drug-Induced Diethylhexyl Phthalate 7.956734493
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 7.9514514962 15322242 11752688
MESH:D000138 Acidosis Ammonium Chloride 3.3318287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.7117505938
MESH:D055371 Acute Lung Injury pirinixic acid 2.9118653653
MESH:D000230 Adenocarcinoma Doxorubicin 12.9217418594
MESH:D000230 Adenocarcinoma Estradiol 12.9211473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 12.9214692618
MESH:D000230 Adenocarcinoma Genistein 12.9211473722
MESH:D000230 Adenocarcinoma Methylnitrosourea 12.9215688392 15113128
MESH:D018248 Adenoma, Liver Cell pirinixic acid 9.1416434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 9.1416835633
MESH:D000419 Albuminuria Doxorubicin 4.3221441931
MESH:D000437 Alcoholism topiramate 4.8519331489 17925516 18552399
MESH:D000544 Alzheimer Disease Ozone 2.3915513908
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.7511748828
MESH:D001161 Arteriosclerosis Dietary Fats 9.1615238619
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 9.1611256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.5315885639
MESH:D001172 Arthritis, Rheumatoid Ozone 2.5115570426
MESH:D001249 Asthma Ozone 2.5717854713 16373670
MESH:D001289 Attention Deficit Disorder with Hyperactivity Phthalic Acids 4.2120106747
MESH:D001778 Blood Coagulation Disorders pirinixic acid 8.0919483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 8.0912125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.5615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.6215746008
MESH:D019046 Bone Marrow Neoplasms Doxorubicin 4.4714601052
MESH:D001862 Bone Resorption bisphenol A 3.6611985600
MESH:D001932 Brain Neoplasms Doxorubicin 3.6117150277
MESH:D001943 Breast Neoplasms bisphenol A 4.5517123778
MESH:D001943 Breast Neoplasms Dietary Fats 4.5520435547
MESH:D001943 Breast Neoplasms Doxorubicin 4.5515567936 15939500 16115903 18695136 16826403 16264153 16322301 18628466 15634643 16096432 15136595 18234424 15668708 19526202 11325840 15692762 17426702 15993339 16935488 16595493 15994142 17983394 18382427 17369602
MESH:D001943 Breast Neoplasms Estradiol 4.5517289903 16675129 12948864 17018787 14630087 19861407 17261762 18497071
MESH:D001943 Breast Neoplasms Genistein 4.5516873071 17200150 16541309
MESH:D001943 Breast Neoplasms Methylnitrosourea 4.5516253758 11306469 14633655
MESH:D001943 Breast Neoplasms Tamoxifen 4.5519289846 17893378 19200415 19011961 19103187 19189212 19244106 19142967 18821012 16202921 19066611 18815881 18984771 20135344 20005174 19221464 20390343 16273361 20065188 18629630 20859285 11161223 16873071 19059307 18997820 18855134 16818667 19084267 17440819 18351453 18425577 19115204 21152245 19155303 17261762 17242785 15565566 19189210 20544844 17049068 19288272 19410462 21138602 19487384 15668708
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 4.5520435547
MESH:D016535 Bronchial Hyperreactivity Ozone 3.5016777450 18315731 17626835 19059883 18417511 14754758 15516495
MESH:D002100 Cachexia Ozone 4.5116183385
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.2316111702
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 9.1910355542 18705752 3786805 15673190 16124888 15721981 16192424 16227642 16097048 15700767 16050911 16011737
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 9.1916050911
MESH:D002276 Carcinoid Tumor Doxorubicin 4.5816051944
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.6216835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.2819066611
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 10.8916705839
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 10.8918788625
MESH:D006528 Carcinoma, Hepatocellular Doxorubicin 10.8917876044 18059187 16234567 16023760
MESH:D006528 Carcinoma, Hepatocellular Estradiol 10.8916924424
MESH:D006528 Carcinoma, Hepatocellular Genistein 10.8916924424
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 10.8916924424
MESH:D002278 Carcinoma in Situ bisphenol A 4.7617123778
MESH:D002292 Carcinoma, Renal Cell Doxorubicin 3.0516201981 1485588
MESH:D002294 Carcinoma, Squamous Cell Doxorubicin 2.576189445
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.4217572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.2418670907 18850075 16120746
MESH:D009202 Cardiomyopathies Doxorubicin 3.3816242529 17308081 17974986 15476868 16455267 17351982 17928571 16612575 16952015 17131338 17924179 17519947 16278810 16269455 17007740 16651473 16109756 16364871 15811867 18627295 15792986 16731534 15505089 17329180 17382496
MESH:D002311 Cardiomyopathy, Dilated Doxorubicin 2.8717334414 16243910
MESH:D002318 Cardiovascular Diseases Genistein 3.1516332659
MESH:D002386 Cataract Methylnitrosourea 3.8612484553
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 10.416135515
MESH:D002471 Cell Transformation, Neoplastic Estradiol 10.4118566989
MESH:D002471 Cell Transformation, Neoplastic Methylnitrosourea 10.412727394 7505956
MESH:D002659 Child Development Disorders, Pervasive topiramate 4.0115650499
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 2.9716835633
MESH:D002779 Cholestasis Ethinyl Estradiol 7.1917333356 15861022 11677210 16919318 17110522 16105132 17681005
MESH:D002779 Cholestasis pirinixic acid 7.1919176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.0115668235 15340226 16354765 8697196 12621046
MESH:D003092 Colitis Selenium 3.5617936198
MESH:D003110 Colonic Neoplasms arsenite 3.8315037631
MESH:D003110 Colonic Neoplasms Genistein 3.8317182828
MESH:D015179 Colorectal Neoplasms Doxorubicin 2.1418802399 18259882
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.8717141729 14669216
MESH:D019465 Craniofacial Abnormalities sodium arsenate 3.7410525206
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 3.7420055451 10048152 15322242
MESH:D019465 Craniofacial Abnormalities Vitamin E 3.7419769572
MESH:D003490 Cyanosis 2,6-dinitrotoluene 3.7918551238
MESH:D003711 Demyelinating Diseases Tamoxifen 4.1419031437
MESH:D003876 Dermatitis, Atopic Diethylhexyl Phthalate 6.6316882537
MESH:D003876 Dermatitis, Atopic pirinixic acid 6.6318249437
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 6.9616647724
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 6.9617107852
MESH:D003924 Diabetes Mellitus, Type 2 topiramate 6.9616979414
MESH:D003928 Diabetic Nephropathies Estradiol 8.2019279558
MESH:D003928 Diabetic Nephropathies Tamoxifen 8.2019279558
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 14.3618551238 21346803
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 14.367440962 16227642 19336974 19085960 3786805 15968718 7120509 16177239 7179309 17522070 3732212 6884620 15027814 4309450 10092053 21278145 15998439 10915739 11566570 9327722 6623471 2869522
MESH:D056486 Drug-Induced Liver Injury Doxorubicin 14.3617416283
MESH:D056486 Drug-Induced Liver Injury Selenium 14.3615131321
MESH:D056486 Drug-Induced Liver Injury sodium arsenate 14.3618186108
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 14.3620420201
MESH:D004362 Drug Toxicity Doxorubicin 7.5618602426
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 7.5611462148
MESH:D050171 Dyslipidemias Dietary Fats 3.2918367378
MESH:C538011 Eales disease Vitamin E 4.479068938
MESH:D004487 Edema pirinixic acid 5.8712083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 5.8711000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.6718230668 15322242 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 8.2212538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 8.2219031437
MESH:D004714 Endometrial Hyperplasia Genistein 4.3616402032
MESH:D016889 Endometrial Neoplasms Doxorubicin 16.5917359293
MESH:D016889 Endometrial Neoplasms Estradiol 16.5918566989 11473722 19148513
MESH:D016889 Endometrial Neoplasms Genistein 16.5911473722
MESH:D016889 Endometrial Neoplasms Tamoxifen 16.5917893378 20544844 16202921 19155303
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.829294722 10568697
MESH:D004719 Endomyocardial Fibrosis Doxorubicin 4.9318037988
MESH:D004827 Epilepsy topiramate 4.2119148780
MESH:D004833 Epilepsy, Temporal Lobe topiramate 6.0416499746
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.8411564622
MESH:D005234 Fatty Liver arsenite 28.0518296743
MESH:D005234 Fatty Liver Carbon Tetrachloride 28.0517595544 16045604 16239168 12631006 12795759 15959796 61145 19224547
MESH:D005234 Fatty Liver Dietary Fats 28.0517967931 19551842 18296743 19004024
MESH:D005234 Fatty Liver Ethinyl Estradiol 28.0515345470
MESH:D005234 Fatty Liver pirinixic acid 28.0520131406 19236843
MESH:D005234 Fatty Liver Tamoxifen 28.0519224547 14986274
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.1016709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.2311858732
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.3014745880
MESH:D018222 Fibromatosis, Aggressive Doxorubicin 10.6819069698
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 10.6819069698
MESH:D005354 Fibrosarcoma Methylnitrosourea 5.0011555667
MESH:D005355 Fibrosis arsenite 19.3318296743
MESH:D005355 Fibrosis Carbon Tetrachloride 19.3318705752
MESH:D005355 Fibrosis Dietary Fats 19.3318296743
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 19.3320067830
MESH:D005909 Glioblastoma Doxorubicin 6.8517150277
MESH:D005909 Glioblastoma Genistein 6.8516598420
MESH:D005910 Glioma Methylnitrosourea 3.479825942
MESH:D018149 Glucose Intolerance sodium arsenate 4.8719446573
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.3610696789
MESH:D006258 Head and Neck Neoplasms Doxorubicin 3.3815692506
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.1710048152 11294989
MESH:D006330 Heart Defects, Congenital Vitamin E 6.1716080930
MESH:D006331 Heart Diseases Doxorubicin 3.3317875725 16244371 16244372 17888722 16495754 16330681 18674790 12587719 18006777 16144979 16879835 16707910 14766674
MESH:D006333 Heart Failure Doxorubicin 11.0017481944
MESH:D006333 Heart Failure pirinixic acid 11.0020558911
MESH:D006333 Heart Failure Selenium 11.0017162251
MESH:D006394 Hemangiosarcoma Doxorubicin 3.7015692506
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.1311000095
MESH:D006505 Hepatitis Carbon Tetrachloride 3.3819110552 19900420
MESH:D006529 Hepatomegaly pirinixic acid 7.5218467677 16221962 19176532 19772884
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 7.5215340226 12621046 16120746
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.6216863852 16490937
MESH:D006558 Herpes Genitalis Estradiol 4.8015709030
MESH:D006689 Hodgkin Disease Doxorubicin 3.2218501091 17606976 15147373
MESH:D019584 Hot Flashes Estradiol 9.2817088409
MESH:D019584 Hot Flashes Vitamin E 9.2814716179
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.8116959395 15340226 18606429 8697196 16354765
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.3016899240
MESH:D006937 Hypercholesterolemia Dietary Fats 3.3921332399
MESH:D006943 Hyperglycemia pirinixic acid 2.9920558911
MESH:D006949 Hyperlipidemias Dietary Fats 3.4021332399
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.8218670907 18850075
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.8615338365
MESH:D007021 Hypospadias Ethinyl Estradiol 3.5816569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.2512013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 6.4417937319
MESH:D007248 Infertility, Male Methylnitrosourea 6.447193160
MESH:D007249 Inflammation Dietary Fats 7.5920412841
MESH:D007249 Inflammation Tamoxifen 7.5919457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 7.5912878042 12200463
MESH:D007251 Influenza, Human Selenium 10.1916624496
MESH:D007251 Influenza, Human Vitamin E 10.1916624496
MESH:D007333 Insulin Resistance bisphenol A 16.4316393666
MESH:D007333 Insulin Resistance Dietary Fats 16.4318457598 11836018
MESH:D007333 Insulin Resistance Estradiol 16.4316627594 16393666
MESH:D007333 Insulin Resistance pirinixic acid 16.4316306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.1316580747
MESH:D007674 Kidney Diseases Doxorubicin 9.4015699352 15369732 16775033
MESH:D007674 Kidney Diseases Estradiol 9.4015618244
MESH:D007674 Kidney Diseases Vitamin E 9.4012488133
MESH:D007676 Kidney Failure, Chronic Doxorubicin 9.3016707910
MESH:D007676 Kidney Failure, Chronic Selenium 9.3016518626
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 11.3416705839
MESH:D007680 Kidney Neoplasms Estradiol 11.3415610895
MESH:D007680 Kidney Neoplasms Tamoxifen 11.3418625569
MESH:D007938 Leukemia Genistein 2.9117468513 18980019
MESH:D004915 Leukemia, Erythroblastic, Acute Doxorubicin 4.9316085563
MESH:D017880 Limb Deformities, Congenital Methylnitrosourea 4.0415526292
MESH:D008064 Lipidoses Tamoxifen 2.9915342952 17567588
MESH:D008103 Liver Cirrhosis arsenite 10.3718296743
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 10.3716239168 16943688 11903743 11408273 21278145 16221502 17334410 17174718 17157831
MESH:D008103 Liver Cirrhosis Dietary Fats 10.3718296743
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 12.7317557913 15925388 16027843 17481882 18395914 18006644 18156304 15338365 18412020 14620537 15876570 12389079 17640975 17761835 12667390 14748882 17525996 17698563 17714472 15818738 18251166 17708605 12546737 17805973 18376398 14512876 18429990 15370692 12445421 12666154 12898905 17823541 18418968 15730626 18166357 18472094 15052691 14716496 17922224 16136751 12609069 18472332 12741479 18277467 16638106 12649538 17565644 18210741 16033810 16015684 12958196 12445418 18420326 15931870 18187930 16248980 12586293 12632514 17900296 15673190 17944888 17869086 17631135 18054572 15057751 18339082 16116963 12632512 16011737 14724832 16097048 18279442 17721639 11481614 10355542 16192424 15996030 18395095 18317297 14716833 18481824 17766677 15123356 15959796 15362042 13678700 15893842 18263696 15650968 17976157 18205269 18705752 20821823
MESH:D008106 Liver Cirrhosis, Experimental Doxorubicin 12.7316439617 16595196
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 12.7314716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Genistein 12.7317823541
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 12.7315474484
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 12.7318564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 12.7312878042
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 12.7316169303
MESH:D008107 Liver Diseases Carbon Tetrachloride 2.0316964402 15830285 16246199 15720792 17285989
MESH:D017093 Liver Failure Carbon Tetrachloride 3.9415123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.4914706259 16899240
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 16.857678174
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 16.8519294768
MESH:D008113 Liver Neoplasms Diethylhexyl Phthalate 16.8511940454
MESH:D008113 Liver Neoplasms pirinixic acid 16.8520007298 16377806 15890375
MESH:D008113 Liver Neoplasms Tamoxifen 16.8516684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 16.8516984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 12.962876784 2876786 6135515
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 12.9612014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Doxorubicin 12.9617085340 16842330
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 12.9612151625
MESH:D038061 Lower Extremity Deformities, Congenital Methylnitrosourea 5.2416080182
MESH:D008171 Lung Diseases chromium hexavalent ion 11.6916775837
MESH:D008171 Lung Diseases Ozone 11.6919066396 8266340
MESH:D008171 Lung Diseases Vitamin E 11.6916863852
MESH:D055370 Lung Injury Ozone 3.6320417186
MESH:D008175 Lung Neoplasms arsenite 12.4816809336
MESH:D008175 Lung Neoplasms chromium hexavalent ion 12.4816876463 16570259
MESH:D008175 Lung Neoplasms Doxorubicin 12.4817418594 6189445
MESH:D008175 Lung Neoplasms Methylnitrosourea 12.4818062963
MESH:D008175 Lung Neoplasms Ozone 12.487614698 8597069
MESH:D008175 Lung Neoplasms Tamoxifen 12.4818625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 12.4819555203 11884234
MESH:D008175 Lung Neoplasms Vitamin E 12.4811062179
MESH:D008223 Lymphoma Doxorubicin 7.4116098063
MESH:D008223 Lymphoma Methylnitrosourea 7.4111418001 16257854
MESH:D016393 Lymphoma, B-Cell Methylnitrosourea 4.5614633661
MESH:D008228 Lymphoma, Non-Hodgkin Doxorubicin 3.6117654614
MESH:D016399 Lymphoma, T-Cell Doxorubicin 4.3415621674
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.5319428831
MESH:D008325 Mammary Neoplasms, Experimental Corticosterone 26.2912807724
MESH:D008325 Mammary Neoplasms, Experimental Doxorubicin 26.2915458769
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 26.2911807958 17203775 16891317 11408345
MESH:D008325 Mammary Neoplasms, Experimental Genistein 26.2914578162 12929590
MESH:D008325 Mammary Neoplasms, Experimental Methylnitrosourea 26.2915113128 19196723 16619500 10838139 15313902 10767621 11807958 16827153 11751437 15688392 14999141 12931682 16944150 14633655 16051031 17131329 17020996
MESH:D008325 Mammary Neoplasms, Experimental Selenium 26.2915318939
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 26.2919196722 19196723 14580682 16827153 11731420
MESH:D020149 Manganese Poisoning Estradiol 11.8719453300
MESH:D020149 Manganese Poisoning Tamoxifen 11.8719453300
MESH:D008545 Melanoma Doxorubicin 3.2816827129
MESH:D008545 Melanoma Tamoxifen 3.2812393984 19393235
MESH:D018328 Melanoma, Amelanotic Tamoxifen 3.9515990972
MESH:D008654 Mesothelioma Doxorubicin 5.9917638057
MESH:D008654 Mesothelioma Selenium 5.9915107826
MESH:D008679 Metaplasia Ozone 4.8710496685
MESH:D008881 Migraine Disorders topiramate 4.4216942474 18759728 18803445 18765137
MESH:D028361 Mitochondrial Diseases Doxorubicin 4.2915792986
MESH:D052016 Mucositis Doxorubicin 4.5617415656
MESH:D009135 Muscular Diseases pirinixic acid 3.2816239165
MESH:D009139 Musculoskeletal Abnormalities sodium arsenate 4.6518186108
MESH:D009203 Myocardial Infarction Doxorubicin 8.9315857846 19429709
MESH:D009203 Myocardial Infarction Genistein 8.9317141266
MESH:D009203 Myocardial Infarction pirinixic acid 8.9319151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.8412213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 13.1716810080
MESH:D015428 Myocardial Reperfusion Injury Genistein 13.1717141266
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 13.1716411023
MESH:D009336 Necrosis 2,6-dinitrotoluene 3.637678174 18551238
MESH:D009362 Neoplasm Metastasis Doxorubicin 5.5718259882
MESH:D009362 Neoplasm Metastasis Tamoxifen 5.5719393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.4419410462
MESH:D009369 Neoplasms Methylnitrosourea 4.8715533788
MESH:D009369 Neoplasms pirinixic acid 4.8717405874
MESH:D009374 Neoplasms, Experimental Methylnitrosourea 4.2512696579
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 3.7719200415 19196722 19189210
MESH:D009389 Neovascularization, Pathologic arsenite 9.3915738583
MESH:D009389 Neovascularization, Pathologic Estradiol 9.3917289903
MESH:D009401 Nephrosis Doxorubicin 4.5416636307 16899518
MESH:D009404 Nephrotic Syndrome Doxorubicin 3.8116889571 15640375
MESH:D009421 Nervous System Malformations bisphenol A 21.6416427766 11399458
MESH:D009421 Nervous System Malformations Estradiol 21.6411399458 16427766
MESH:D009421 Nervous System Malformations Genistein 21.6416427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 21.6414600291
MESH:D009436 Neural Tube Defects sodium arsenate 3.8110525206 18186108 19446573 11749123
MESH:D009442 Neurilemmoma Methylnitrosourea 5.2611555667
MESH:D009447 Neuroblastoma Doxorubicin 3.1515555623
MESH:D009669 Nose Neoplasms chromium hexavalent ion 4.8916876463
MESH:D009765 Obesity Dietary Fats 4.2417217161 18674790 21332399 19632207 16723640 20518802 11836018 20132043 18457598
MESH:D009765 Obesity pirinixic acid 4.2420558911
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 3.2316049721
MESH:D010024 Osteoporosis Genistein 3.1119401787
MESH:D015663 Osteoporosis, Postmenopausal Genistein 3.8716169203
MESH:D012516 Osteosarcoma Doxorubicin 3.9315930896
MESH:D010049 Ovarian Diseases bisphenol A 4.7611985600
MESH:D010051 Ovarian Neoplasms Estradiol 4.6619401270
MESH:D010051 Ovarian Neoplasms Genistein 4.6619005980
MESH:D010190 Pancreatic Neoplasms Methylnitrosourea 3.2816965848
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.4711578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.0212520081
MESH:D010538 Peritonitis Ozone 3.9116369182
MESH:D003557 Phyllodes Tumor Doxorubicin 4.9317983394
MESH:D010954 Plasmacytoma Selenium 4.6615087411
MESH:D010997 Pleural Neoplasms Doxorubicin 4.9317638057
MESH:D011014 Pneumonia Ozone 4.1718007984 18929643 18381685
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.3418163543
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 8.7510548101
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 8.7511222880 11896295 11118676 11399792
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 9.8720887781
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 9.8720887781
MESH:D011471 Prostatic Neoplasms bisphenol A 2.0716740699
MESH:D011471 Prostatic Neoplasms Doxorubicin 2.0716888761 15897917 15749863 16729912 16868541 18437689
MESH:D011471 Prostatic Neoplasms Estradiol 2.0716740699
MESH:D011471 Prostatic Neoplasms Genistein 2.0715256057 15378649 16925846
MESH:D011471 Prostatic Neoplasms Methylnitrosourea 2.0715682402 12376480
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.0715067354
MESH:D011471 Prostatic Neoplasms Vitamin E 2.0715084515
MESH:D011537 Pruritus Ethinyl Estradiol 3.0916919318 15861022
MESH:D011629 Puberty, Precocious bisphenol A 4.5610548101
MESH:D051437 Renal Insufficiency Doxorubicin 4.0017922066
MESH:D015427 Reperfusion Injury pirinixic acid 2.2819058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.6218990726
MESH:D012162 Retinal Degeneration Methylnitrosourea 4.2418155124 18172121
MESH:D012175 Retinoblastoma Methylnitrosourea 5.2611555667
MESH:D012509 Sarcoma Doxorubicin 3.7915625365 16767912 17203757 17710206 18313854 15675481
MESH:D012512 Sarcoma, Ewing's Doxorubicin 4.0214601052 16326096
MESH:D012514 Sarcoma, Kaposi Doxorubicin 4.5617846226
MESH:D012640 Seizures 2,6-dinitrotoluene 5.9518551238
MESH:D012640 Seizures topiramate 5.9516499746
MESH:D012871 Skin Diseases Vitamin E 2.3818709164
MESH:D012878 Skin Neoplasms Doxorubicin 5.3315692506
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.3316192470
MESH:D012983 Soft Tissue Neoplasms Doxorubicin 4.3415625365 17203757 16767912
MESH:D013088 Spermatocele Ethinyl Estradiol 10.7916709447
MESH:D013088 Spermatocele Tamoxifen 10.7916709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 3.8119457130
MESH:D013274 Stomach Neoplasms Methylnitrosourea 2.6918593901 16257854 15930296
MESH:D020521 Stroke Vitamin E 3.3416517955
MESH:D019966 Substance-Related Disorders bisphenol A 3.7616684133 16045194
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.4111994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.9615669648
MESH:D013953 Thymus Neoplasms Methylnitrosourea 5.0011418001
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.6712697716
MESH:D013964 Thyroid Neoplasms Doxorubicin 7.0717909728 16010429
MESH:D013964 Thyroid Neoplasms Methylnitrosourea 7.073078959 7505956
MESH:D013978 Tibial Fractures Estradiol 4.4519048282
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 7.8316049721
MESH:D001749 Urinary Bladder Neoplasms Doxorubicin 7.8317653716
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 7.8316712894 17572228 8653321
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.0910091137
MESH:D014591 Uterine Diseases bisphenol A 4.7814652134
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.0814692618
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.3612125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.3314671159 15869587
MESH:D018487 Ventricular Dysfunction, Left Doxorubicin 4.0017334414 17638931 17678736 16364871
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.0215886252
MESH:D015430 Weight Gain Dietary Fats 3.5516723640
Pathway ID Pathway Name
KEGG:03320 PPAR signaling pathway
Pharmacogenomics Knowledge Base Top
Drug Bank Top
No data
No data
No data
Drugbank ID Action Drug Name Description
DB03193 - Borage Oil Pharmaceutical Aids
DB03796 - Palmitic Acid Enzyme Inhibitors
DB04224 - Oleic Acid

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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