Annotation Detail for FANCE
Basic Information Top
| Gene Symbol: | FANCE ( FACE,FAE ) |
|---|---|
| Gene Full Name: | Fanconi anemia, complementation group E |
| Band: | 6p21.31 |
| Quick Links | Entrez ID:2178; OMIM: 600901; Uniprot ID:FANCE_HUMAN; ENSEMBL ID: ENSG00000112039; HGNC ID: 3586 |
| Relate to Another Database: | SFARIGene; denovo-db |
| No data |
| No data |
| Pathway ID | Pathway Name |
|---|---|
| DNA Repair |
| Pathway ID | Pathway Name |
|---|---|
| 200174 | BARD1 signaling events |
| No data |
| Pathway ID | Pathway Name |
|---|---|
| 500068 | Fanconi Anemia pathway |
| Chemical ID | Chemical Name | Interaction | Interaction Action | Publication |
|---|---|---|---|---|
| D016572 | Cyclosporine | Cyclosporine results in increased expression of FANCE mRNA | increases expression | 20106945 |
| D012402 | Rotenone | Rotenone results in increased expression of FANCE mRNA | increases expression | 18191903 |
| Disease ID | Disease Name | Direct Evidence | Inference Chemical Name | Inference Score | Publication |
|---|---|---|---|---|---|
| MESH:D002471 | Cell Transformation, Neoplastic | Cyclosporine | 2.85 | 12371664 | |
| MESH:D002779 | Cholestasis | Cyclosporine | 3.28 | 19486331 | |
| MESH:D005199 | Fanconi Anemia | marker/mechanism | |||
| MESH:D005234 | Fatty Liver | Cyclosporine | 3.40 | 19224547 | |
| MESH:D005355 | Fibrosis | Cyclosporine | 3.90 | 12639820 12168785 | |
| MESH:D005885 | Gingival Hyperplasia | Cyclosporine | 5.11 | 8708960 | |
| MESH:D006457 | Hemoglobinuria, Paroxysmal | Cyclosporine | 5.31 | 15720958 | |
| MESH:D006973 | Hypertension | Cyclosporine | 2.24 | 10903974 | |
| MESH:D007638 | Keratoconjunctivitis Sicca | Cyclosporine | 5.51 | 15604871 | |
| MESH:D007674 | Kidney Diseases | Cyclosporine | 2.58 | 8314463 10903974 18776723 | |
| MESH:D007680 | Kidney Neoplasms | Cyclosporine | 3.17 | 12371664 | |
| MESH:D008664 | Metal Metabolism, Inborn Errors | Cyclosporine | 5.86 | 16801185 | |
| MESH:D009402 | Nephrosis, Lipoid | Cyclosporine | 5.51 | 17954296 | |
| MESH:D009404 | Nephrotic Syndrome | Cyclosporine | 3.75 | 18481113 19348381 | |
| MESH:D009410 | Nerve Degeneration | Rotenone | 4.26 | 17356569 15790535 18619942 | |
| MESH:D010300 | Parkinson Disease | Rotenone | 3.11 | 16412576 19114014 18619942 11445065 15451049 11535288 16140633 19232380 18191903 | |
| MESH:D020734 | Parkinsonian Disorders | Rotenone | 4.58 | 18197244 15574749 15795934 15927086 | |
| MESH:D011230 | Precancerous Conditions | Cyclosporine | 3.69 | 12371664 | |
| MESH:D011565 | Psoriasis | Cyclosporine | 2.35 | 16882103 | |
| MESH:D014605 | Uveitis | Cyclosporine | 5.05 | 1336536 | |
| MESH:D014985 | Xerophthalmia | Cyclosporine | 5.51 | 17120751 |
| Pathway ID | Pathway Name |
|---|---|
| REACT:216 | DNA Repair |
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