AutismKB 2.0

Annotation Detail for ALDH3A1


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Basic Information Top
Gene Symbol:ALDH3A1 ( ALDH3,ALDHIII,MGC10406 )
Gene Full Name: aldehyde dehydrogenase 3 family, member A1
Band: 17p11.2
Quick LinksEntrez ID:218; OMIM: 100660; Uniprot ID:AL3A1_HUMAN; ENSEMBL ID: ENSG00000108602; HGNC ID: 405
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Pathway IDPathway Name
PWY-2501fatty acid alpha-oxidation
Pathway IDPathway Name
hsa00360Phenylalanine metabolism
hsa00010Glycolysis / Gluconeogenesis
hsa00980Metabolism of xenobiotics by cytochrome P450
hsa00982Drug metabolism - cytochrome P450
hsa00350Tyrosine metabolism
hsa01100Metabolic pathways
hsa00340Histidine metabolism
No data
No data
Pathway IDPathway Name
P043725-Hydroxytryptamine degredation
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1848Embryoma
2066Lung cancer
Desease Name
PSYCH
schizophrenia
METABOLIC
Posttransplantation diabetes mellitus (PTDM)
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C548651 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of ALDH3A1 mRNAincreases expression 19933214
C010914 2,4-diaminotoluene 2,4-diaminotoluene results in increased expression of ALDH3A1 mRNAincreases expression 20713471
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of ALDH3A1 mRNAaffects expression 21346803
C051750 2-hexenal ALDH3A1 protein affects the metabolism of 2-hexenalaffects metabolic processing 11306050
C051750 2-hexenal ALDH3A1 protein results in decreased susceptibility to 2-hexenaldecreases response to substance 11306050
C013166 2-nonenal ALDH3A1 protein affects the metabolism of 2-nonenalaffects metabolic processing 11306050
C013166 2-nonenal ALDH3A1 protein results in decreased susceptibility to 2-nonenaldecreases response to substance 11306050
C057348 2-octenal ALDH3A1 protein affects the metabolism of 2-octenalaffects metabolic processing 11306050
C057348 2-octenal ALDH3A1 protein results in decreased susceptibility to 2-octenaldecreases response to substance 11306050
C027576 4-hydroxy-2-nonenal ALDH3A1 protein affects the susceptibility to 4-hydroxy-2-nonenalaffects response to substance 15905174
C027576 4-hydroxy-2-nonenal ALDH3A1 protein results in decreased susceptibility to 4-hydroxy-2-nonenaldecreases response to substance 11306050
C027576 4-hydroxy-2-nonenal ALDH3A1 protein affects the metabolism of 4-hydroxy-2-nonenalaffects metabolic processing 11018474
D000082 Acetaminophen Acetaminophen affects the expression of ALDH3A1 mRNAaffects expression 17562736
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of ALDH3A1 proteinaffects expression 20106945
C006446 aldophosphamide [ALDH3A1 protein co-treated with NADP] results in increased oxidation of aldophosphamideaffects cotreatment|increases oxidation 10856427
C006446 aldophosphamide [ALDH3A1 protein co-treated with NAD] results in increased oxidation of aldophosphamideaffects cotreatment|increases oxidation 10856427
D000643 Ammonium Chloride Ammonium Chloride affects the expression of ALDH3A1 mRNAaffects expression 16483693
C015001 arsenite [arsenite co-treated with Benzo(a)pyrene] results in increased expression of ALDH3A1 mRNAaffects cotreatment|increases expression 15894712
C015001 arsenite arsenite results in increased expression of ALDH3A1 mRNAincreases expression 15894712
D001374 Azacitidine [Azacitidine co-treated with Butyrates] inhibits the reaction [Chromium inhibits the reaction [Benzo(a)pyrene results in increased expression of ALDH3A1 mRNA]]affects cotreatment|decreases reaction|increases expression 17682057
D001374 Azacitidine Azacitidine inhibits the reaction [Chromium inhibits the reaction [Benzo(a)pyrene results in increased expression of ALDH3A1 mRNA]]decreases reaction|increases expression 17682057
C032175 benzaldehyde [ALDH3A1 protein co-treated with NADP] results in increased oxidation of benzaldehydeaffects cotreatment|increases oxidation 10856427
C032175 benzaldehyde [ALDH3A1 protein co-treated with NAD] results in increased oxidation of benzaldehydeaffects cotreatment|increases oxidation 10856427
D019324 beta-Naphthoflavone [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of ALDH3A1 mRNAaffects cotreatment|increases expression 18164116
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of ALDH3A1 mRNAincreases expression 20106945
D001564 Benzo(a)pyrene [arsenite co-treated with Benzo(a)pyrene] results in increased expression of ALDH3A1 mRNAaffects cotreatment|increases expression 15894712
D001564 Benzo(a)pyrene [Azacitidine co-treated with Butyrates] inhibits the reaction [Chromium inhibits the reaction [Benzo(a)pyrene results in increased expression of ALDH3A1 mRNA]]affects cotreatment|decreases reaction|increases expression 17682057
D001564 Benzo(a)pyrene Azacitidine inhibits the reaction [Chromium inhibits the reaction [Benzo(a)pyrene results in increased expression of ALDH3A1 mRNA]]decreases reaction|increases expression 17682057
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of ALDH3A1 mRNAincreases expression 15894712
17682057
20713471
D001564 Benzo(a)pyrene Butyrates inhibits the reaction [Chromium inhibits the reaction [Benzo(a)pyrene results in increased expression of ALDH3A1 mRNA]]decreases reaction|increases expression 17682057
D001564 Benzo(a)pyrene Chromium inhibits the reaction [Benzo(a)pyrene results in increased expression of ALDH3A1 mRNA]decreases reaction|increases expression 17682057
C006780 bisphenol A bisphenol A affects the expression of ALDH3A1 mRNAaffects expression 20170705
D002087 Butyrates [Azacitidine co-treated with Butyrates] inhibits the reaction [Chromium inhibits the reaction [Benzo(a)pyrene results in increased expression of ALDH3A1 mRNA]]affects cotreatment|decreases reaction|increases expression 17682057
D002087 Butyrates Butyrates inhibits the reaction [Chromium inhibits the reaction [Benzo(a)pyrene results in increased expression of ALDH3A1 mRNA]]decreases reaction|increases expression 17682057
D020111 Chlorodiphenyl (54% Chlorine) Chlorodiphenyl (54% Chlorine) results in increased expression of ALDH3A1 mRNAincreases expression 18178546
D002857 Chromium [Azacitidine co-treated with Butyrates] inhibits the reaction [Chromium inhibits the reaction [Benzo(a)pyrene results in increased expression of ALDH3A1 mRNA]]affects cotreatment|decreases reaction|increases expression 17682057
D002857 Chromium Azacitidine inhibits the reaction [Chromium inhibits the reaction [Benzo(a)pyrene results in increased expression of ALDH3A1 mRNA]]decreases reaction|increases expression 17682057
D002857 Chromium Butyrates inhibits the reaction [Chromium inhibits the reaction [Benzo(a)pyrene results in increased expression of ALDH3A1 mRNA]]decreases reaction|increases expression 17682057
D002857 Chromium Chromium inhibits the reaction [Benzo(a)pyrene results in increased expression of ALDH3A1 mRNA]decreases reaction|increases expression 17682057
D009243 NAD [ALDH3A1 protein co-treated with NAD] results in increased oxidation of aldophosphamideaffects cotreatment|increases oxidation 10856427
D009243 NAD [ALDH3A1 protein co-treated with NAD] results in increased oxidation of benzaldehydeaffects cotreatment|increases oxidation 10856427
D009249 NADP [ALDH3A1 protein co-treated with NADP] results in increased oxidation of aldophosphamideaffects cotreatment|increases oxidation 10856427
D009249 NADP [ALDH3A1 protein co-treated with NADP] results in increased oxidation of benzaldehydeaffects cotreatment|increases oxidation 10856427
D003520 Cyclophosphamide ALDH3A1 protein affects the susceptibility to Cyclophosphamideaffects response to substance 18854779
D016572 Cyclosporine Cyclosporine results in decreased expression of ALDH3A1 mRNAdecreases expression 20106945
D016190 Carboplatin ALDH3A1 protein affects the susceptibility to Carboplatinaffects response to substance 18854779
D004041 Dietary Fats Dietary Fats results in increased expression of ALDH3A1 mRNAincreases expression 18042831
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of ALDH3A1 mRNAaffects cotreatment|increases expression 18164116
D004052 Diethylnitrosamine Diethylnitrosamine results in increased expression of ALDH3A1 mRNAincreases expression 19638242
D004221 Disulfiram ALDH3A1 protein results in increased metabolism of Disulfiramincreases metabolic processing 18591790
D004050 Ditiocarb ALDH3A1 protein results in increased chemical synthesis of Ditiocarbincreases chemical synthesis 18591790
D004958 Estradiol [Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of ALDH3A1 mRNAaffects cotreatment|increases expression 19619570
D004958 Estradiol Estradiol results in increased expression of ALDH3A1 mRNAincreases expression 19619570
D004958 Estradiol Estradiol promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of ALDH3A1 mRNA]increases expression|increases reaction 18691609
D000431 Ethanol [Ethanol co-treated with Zinc Sulfate] results in increased activity of ALDH3A1 proteinaffects cotreatment|increases activity 15920153
D000431 Ethanol Ethanol results in increased activity of ALDH3A1 proteinincreases activity 15920153
D005047 Etoposide ALDH3A1 protein affects the susceptibility to Etoposideaffects response to substance 15905174
D015073 2-Acetylaminofluorene TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in increased expression of ALDH3A1 mRNA]affects reaction|increases expression 17317680
D008748 Methylcholanthrene Methylcholanthrene results in increased expression of ALDH3A1 mRNAincreases expression 20713471
D020366 Methylmethacrylate Methylmethacrylate results in increased expression of ALDH3A1 mRNAincreases expression 16916219
D016685 Mitomycin ALDH3A1 protein affects the susceptibility to Mitomycinaffects response to substance 15905174
C010463 n-hexanal ALDH3A1 protein affects the metabolism of n-hexanalaffects metabolic processing 11306050
C010463 n-hexanal ALDH3A1 protein results in decreased susceptibility to n-hexanaldecreases response to substance 11306050
C014707 nitrosobenzylmethylamine nitrosobenzylmethylamine results in decreased expression of ALDH3A1 mRNAdecreases expression 17616710
D009853 Omeprazole Omeprazole results in increased expression of ALDH3A1 mRNAincreases expression 12040753
C041786 palm oil palm oil results in increased expression of ALDH3A1 mRNAincreases expression 18042831
C011272 perfosfamide ALDH3A1 protein results in decreased susceptibility to perfosfamidedecreases response to substance 16614850
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of ALDH3A1 mRNAaffects binding|increases activity|increases expression 19710929
D011374 Progesterone Progesterone results in decreased expression of ALDH3A1 mRNAdecreases expression 18037150
D012172 Retinaldehyde Retinaldehyde results in increased activity of ALDH3A1 proteinincreases activity 17126819
D013749 Tetrachlorodibenzodioxin [Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of ALDH3A1 mRNAaffects cotreatment|increases expression 19619570
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of ALDH3A1 mRNAincreases expression 17517823
19619570
20106945
12377990
15345368
D013749 Tetrachlorodibenzodioxin Estradiol promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of ALDH3A1 mRNA]increases expression|increases reaction 18691609
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of ALDH3A1 mRNAincreases expression 18691609
19933214
10677587
15667827
16120747
16467188
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of ALDH3A1increases expression 15993909
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of ALDH3A1 mRNAincreases expression 18178546
18796159
16054898
16497791
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of ALDH3A1 proteinincreases expression 16497791
16548065
D013852 Thiotepa ALDH3A1 protein affects the susceptibility to Thiotepaaffects response to substance 18854779
D014212 Tretinoin Tretinoin results in decreased activity of ALDH3A1 proteindecreases activity 16614850
D014212 Tretinoin Tretinoin results in decreased expression of ALDH3A1 proteindecreases expression 16614850
D014212 Tretinoin Tretinoin results in decreased expression of and results in decreased activity of ALDH3A1 proteindecreases activity|decreases expression 15470086
D014752 Vinyl Chloride Vinyl Chloride results in increased activity of ALDH3A1 proteinincreases activity 15211785
D002762 Cholecalciferol Cholecalciferol results in increased expression of ALDH3A1 mRNAincreases expression 17170073
D019287 Zinc Sulfate [Ethanol co-treated with Zinc Sulfate] results in increased activity of ALDH3A1 proteinaffects cotreatment|increases activity 15920153
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Disulfiram 11.4117676605
MESH:D000014 Abnormalities, Drug-Induced Ethanol 11.4117676605 18926900
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 11.4111752688 14514962 15322242
MESH:D000138 Acidosis Ammonium Chloride 14.8018287403
MESH:D000138 Acidosis Ethanol 14.8011192467
MESH:D000138 Acidosis Zinc Sulfate 14.807265320
MESH:D000163 Acquired Immunodeficiency Syndrome Disulfiram 5.049207937
MESH:D055371 Acute Lung Injury pirinixic acid 2.6318653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 3.7420127859 20464547
MESH:D000230 Adenocarcinoma Estradiol 3.7411473722
MESH:D000236 Adenoma 2-Acetylaminofluorene 17.5910737359
MESH:D000236 Adenoma Benzo(a)pyrene 17.596695378
MESH:D000236 Adenoma beta-Naphthoflavone 17.5919389873
MESH:D000236 Adenoma Diethylnitrosamine 17.5910737359 6695378
MESH:D000236 Adenoma Methylcholanthrene 17.5910545420 6695378
MESH:D002759 Adenoma, Bile Duct 2-Acetylaminofluorene 5.476705139
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 14.2319052882 17620307 19061943 18056438 17162532 16434500
MESH:D018248 Adenoma, Liver Cell pirinixic acid 14.2316434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 14.2316835633
MESH:D020268 Alcohol-Induced Disorders, Nervous System Ethanol 4.7815451039 15451040
MESH:D000437 Alcoholism Disulfiram 4.5610841824 17079463 18968458
MESH:D000505 Alopecia Tretinoin 3.1915955085
MESH:D000690 Amyotrophic Lateral Sclerosis 4-hydroxy-2-nonenal 3.7610965797
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.4911748828
MESH:D000799 Angioedema Acetaminophen 3.3110982225
MESH:D000853 Anophthalmos Ethanol 4.3015513904
MESH:D000860 Anoxia Zinc Sulfate 4.497265320
MESH:D001008 Anxiety Disorders Ethanol 3.5811141031
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.5619183758
MESH:D001161 Arteriosclerosis Cyclophosphamide 8.6215014928
MESH:D001161 Arteriosclerosis Dietary Fats 8.6215238619
MESH:D001169 Arthritis, Experimental Tretinoin 2.7416412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.1216292516
MESH:D001249 Asthma Tretinoin 2.1716456186
MESH:D050197 Atherosclerosis Methylcholanthrene 3.1311922910
MESH:D001321 Autistic Disorder Acetaminophen 1.4918445737
MESH:D001327 Autoimmune Diseases Cholecalciferol 4.5216142846
MESH:D001471 Barrett Esophagus Tretinoin 3.9016935849
MESH:D001661 Biliary Tract Neoplasms Vinyl Chloride 6.3311024202
MESH:D001778 Blood Coagulation Disorders Omeprazole 18.1019483382
MESH:D001778 Blood Coagulation Disorders pirinixic acid 18.1019483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 18.1012125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 18.1016206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.2515340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.4115746008
MESH:D019046 Bone Marrow Neoplasms Etoposide 4.6214601052
MESH:D001862 Bone Resorption bisphenol A 3.3911985600
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 4.8017868700
MESH:D001930 Brain Injuries Progesterone 3.7415845082 15665606 15380490
MESH:D001932 Brain Neoplasms Vinyl Chloride 4.7212562636
MESH:D001943 Breast Neoplasms 2,4-diaminotoluene 11.5311921183
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 11.5317474063 20146248
MESH:D001943 Breast Neoplasms bisphenol A 11.5317123778
MESH:D001943 Breast Neoplasms Chromium 11.5315986119
MESH:D001943 Breast Neoplasms Cyclophosphamide 11.5311325840 17020986 18323546 15136595 18234424 16978400 17388661 15093573 12006526
MESH:D001943 Breast Neoplasms Dietary Fats 11.5320435547
MESH:D001943 Breast Neoplasms Diethylnitrosamine 11.5317474063
MESH:D001943 Breast Neoplasms Disulfiram 11.5317026967
MESH:D001943 Breast Neoplasms Estradiol 11.5317289903 16675129 17261762 18497071 19861407 17018787 12948864 14630087
MESH:D001943 Breast Neoplasms Etoposide 11.5316322251
MESH:D001943 Breast Neoplasms Methylcholanthrene 11.5317474063
MESH:D001943 Breast Neoplasms Progesterone 11.5315562024 16175315 17614352
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 11.5320435547
MESH:D001943 Breast Neoplasms Tretinoin 11.5316166294 16443354 16873071
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.0616813970
MESH:D002056 Burns Ethanol 4.1416374292
MESH:D002177 Candidiasis Disulfiram 5.3315325261
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 3.9316111702
MESH:D002277 Carcinoma Disulfiram 11.7217026967
MESH:D002277 Carcinoma Methylcholanthrene 11.7210545420
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 11.7216835633
MESH:D018236 Carcinoma, Embryonal Tretinoin 4.6216168501
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 20.5016705839
MESH:D006528 Carcinoma, Hepatocellular 2-Acetylaminofluorene 20.503581430 17761372 10737359 3084413 6705139
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 20.503084413
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 20.5012907637 12619106 21507988
MESH:D006528 Carcinoma, Hepatocellular Cyclophosphamide 20.5019701751
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 20.5016681979 18978308 18056438 19519916 20512989 11831363 18788625 16807293 19383236 20935162 19107877 18785209 16569478 20524982 19418558 17428255 16878318 16830150 20514400 16540662 17162532 19394651 18971187 16698587 17761372 20084675 18665156 17138121 20214788 19335982 17055752 19701751 16935385 18506893 10737359 19822196 19919837 18210153 20101231 19539802 10672840 3581430 20432363 21159647 18494052 20007298 20727157 16288022 16328049 17173139 18393292 19171122 19208518 16779866 16502159 17978847 18691550 19052882 3084413
MESH:D006528 Carcinoma, Hepatocellular Estradiol 20.5016924424
MESH:D006528 Carcinoma, Hepatocellular Ethanol 20.5018788625 15763234 15289165
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 20.501917145
MESH:D006528 Carcinoma, Hepatocellular Vinyl Chloride 20.5012958735 15289165 12828392 10699891
MESH:D002278 Carcinoma in Situ bisphenol A 4.4617123778
MESH:D018827 Carcinoma, Lewis Lung Cyclophosphamide 4.3616152834
MESH:D002289 Carcinoma, Non-Small-Cell Lung Carboplatin 5.7616685392
MESH:D002289 Carcinoma, Non-Small-Cell Lung Disulfiram 5.7617026967
MESH:D002292 Carcinoma, Renal Cell Cyclophosphamide 3.2716201981
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 3.9620419170
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 3.9616051514 16096774
MESH:D006332 Cardiomegaly Ethanol 5.8019332462
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 5.8016120746 18670907 18850075
MESH:D002386 Cataract Acetaminophen 10.5910977129
MESH:D002386 Cataract Disulfiram 10.5915003327 17936468
MESH:D002386 Cataract Tretinoin 10.5917460283
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 12.9712371664
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 12.972727394 7505956 21159647 17174075
MESH:D002471 Cell Transformation, Neoplastic Estradiol 12.9718566989
MESH:D002471 Cell Transformation, Neoplastic Methylcholanthrene 12.9716192471
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.0616129372
MESH:D002637 Chest Pain Omeprazole 4.5715447763
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 7.8419052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 7.8416835633
MESH:D002779 Cholestasis Cyclosporine 6.4419486331
MESH:D002779 Cholestasis pirinixic acid 6.4419176532
MESH:D002822 Choriocarcinoma Tretinoin 4.6216461808
MESH:D002971 Cleft Lip Ethanol 3.2915513904
MESH:D002972 Cleft Palate Ethanol 8.4015513904
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 8.408697196 16354765 15340226 12621046 15668235
MESH:D002972 Cleft Palate Tretinoin 8.409407595
MESH:D019970 Cocaine-Related Disorders Disulfiram 5.2219462300
MESH:D003092 Colitis Tretinoin 3.1917035595
MESH:D003110 Colonic Neoplasms arsenite 3.8715037631
MESH:D003110 Colonic Neoplasms Butyrates 3.8715936596
MESH:D015179 Colorectal Neoplasms Azacitidine 2.7219934284
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.6114669216 17141729
MESH:D019465 Craniofacial Abnormalities Ethanol 3.4015513904 15451039 15451040 19302082 11198716 10194807 11873399
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 3.4015322242 20055451 10048152
MESH:D019465 Craniofacial Abnormalities Tretinoin 3.409142499 14991402 16925845 17551590 8800419 9125849 9211117 9664655 9224671 10589399
MESH:D003490 Cyanosis 2,4-dinitrotoluene 3.5018551238
MESH:D003556 Cystitis Cyclophosphamide 4.4515276878 11948286 12913760 10700343 18433785 18372110 10498854 16989017 18093676 16413132 15643279 12388444 16614059 18483878 17979934 12161096 18710439 18295254 17010015 16651033
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.1618249437
MESH:D009783 Dermatitis, Occupational Vinyl Chloride 5.1810870345
MESH:D003921 Diabetes Mellitus, Experimental Cyclophosphamide 3.6411751995 15331540 10990075
MESH:D003922 Diabetes Mellitus, Type 1 Cyclophosphamide 3.0418772604
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 3.6920387270
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 3.6917107852
MESH:D003928 Diabetic Nephropathies Estradiol 2.9719279558
MESH:D003929 Diabetic Neuropathies Progesterone 3.9817187935
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 15.7721346803 18551238
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 15.7716081117 11739529 10915739 14550746 19739265 18713872 11287661 12392966 17522070 19370779 16109766 12153990 11421492 11461765 15968718 14725611 17906064 16485898 14986274 18071297 10774834 12540782 19923254 11529661 16227642 11743745 12958197 17562736 2444490 19416960 19420014 16781746 12594235 16393943 19085960 10663392 11834606 12705907 16177239 19164858 15619225
MESH:D056486 Drug-Induced Liver Injury Chlorodiphenyl (54% Chlorine) 15.7717851650
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 15.7719107877
MESH:D056486 Drug-Induced Liver Injury Ethanol 15.7711566570
MESH:D056486 Drug-Induced Liver Injury NAD 15.7711461765
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 15.7720420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.5619426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.3611462148
MESH:D004381 Duodenal Ulcer Omeprazole 3.8321218061 17151854 16613094 15991576
MESH:D050171 Dyslipidemias Dietary Fats 3.0718367378
MESH:D004487 Edema pirinixic acid 5.0112083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 5.0111000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 10.1518230668 16714409 15322242
MESH:D004489 Edema, Cardiac Tretinoin 10.1518230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 3.2817692515
MESH:D016889 Endometrial Neoplasms Estradiol 6.2219148513 18566989 11473722
MESH:D016889 Endometrial Neoplasms Tretinoin 6.2216569247
MESH:D004715 Endometriosis Progesterone 7.4116134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 7.4110568697 9294722
MESH:D004802 Eosinophilia Cyclophosphamide 3.7111006010
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 4.5816302075
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 6.3916530937
MESH:D004938 Esophageal Neoplasms Ethanol 6.3916704527
MESH:D004938 Esophageal Neoplasms nitrosobenzylmethylamine 6.3916510608 15150132 16704527 16805852 15878914 15623463 15264214 15547733 15547721
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 7.5011564622
MESH:D005124 Eye Abnormalities Tretinoin 7.5016938888 9664655
MESH:D005234 Fatty Liver arsenite 29.7518296743
MESH:D005234 Fatty Liver Cyclosporine 29.7519224547
MESH:D005234 Fatty Liver Dietary Fats 29.7517967931 19004024 18296743 19551842
MESH:D005234 Fatty Liver Diethylnitrosamine 29.7521071580 20387270
MESH:D005234 Fatty Liver Ethanol 29.7519236843 18620774 16409862
MESH:D005234 Fatty Liver pirinixic acid 29.7519236843 20131406
MESH:D005234 Fatty Liver Vinyl Chloride 29.7512197357
MESH:D005235 Fatty Liver, Alcoholic Ethanol 5.1317920746
MESH:D005310 Fetal Alcohol Syndrome Ethanol 4.7716946407 15513904 10194807 15451040
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 2.9411858732
MESH:D005354 Fibrosarcoma Methylcholanthrene 4.4114633661 10962813
MESH:D005355 Fibrosis arsenite 22.3018296743
MESH:D005355 Fibrosis Cyclosporine 22.3012639820 12168785
MESH:D005355 Fibrosis Dietary Fats 22.3018296743
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 22.3020067830
MESH:D005355 Fibrosis Tretinoin 22.3017994277
MESH:D005756 Gastritis Acetaminophen 9.3416983495
MESH:D005756 Gastritis Ethanol 9.3415046732
MESH:D005885 Gingival Hyperplasia Cyclosporine 3.698708960
MESH:D005909 Glioblastoma Tretinoin 2.6517312396
MESH:D018316 Gliosarcoma Cyclophosphamide 4.9811389073
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.0510696789
MESH:D006086 Graft vs Host Disease Cyclophosphamide 4.5211014644 16376943 15172196
MESH:D006258 Head and Neck Neoplasms Tretinoin 2.8216096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 4.6216084493
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 9.3420471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 9.3410048152 11294989
MESH:D006330 Heart Defects, Congenital Tretinoin 9.349664655 14991402
MESH:D006333 Heart Failure pirinixic acid 2.2020558911
MESH:D006390 Hemangioendothelioma 2-Acetylaminofluorene 11.306705139
MESH:D006390 Hemangioendothelioma Vinyl Chloride 11.3015380572
MESH:D006393 Hemangiopericytoma Vinyl Chloride 6.3310964802
MESH:D006394 Hemangiosarcoma 2-Acetylaminofluorene 8.346705139
MESH:D006394 Hemangiosarcoma Vinyl Chloride 8.3415989139 12211074 12958735 11217710 12828392 12762079 15999577
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 3.8915720958
MESH:D006467 Hemophilia A Cyclophosphamide 4.7711918545
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 2.8611000095
MESH:D006504 Hepatic Veno-Occlusive Disease Cyclophosphamide 4.9914986274
MESH:D006527 Hepatolenticular Degeneration Zinc Sulfate 4.4817063115
MESH:D006529 Hepatomegaly pirinixic acid 6.5619772884 18467677 19176532 16221962
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 6.5616120746 15340226 12621046
MESH:D006558 Herpes Genitalis Estradiol 4.4915709030
MESH:D006561 Herpes Simplex Etoposide 4.0410809021
MESH:D006689 Hodgkin Disease Cyclophosphamide 6.4217606976 16135485
MESH:D006689 Hodgkin Disease Etoposide 6.4218180244 16200630 16135485 17606976 15147373
MESH:D019584 Hot Flashes Estradiol 3.2217088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.5115340226 18606429 8697196 16959395 16354765
MESH:D006930 Hyperalgesia Acetaminophen 10.6416870215
MESH:D006930 Hyperalgesia Ethanol 10.6418783367
MESH:D006930 Hyperalgesia Tretinoin 10.6416870215
MESH:D006937 Hypercholesterolemia Dietary Fats 3.1221332399
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.0516778211
MESH:D006943 Hyperglycemia pirinixic acid 2.7320558911
MESH:D006949 Hyperlipidemias Dietary Fats 3.1321332399
MESH:D006973 Hypertension Cyclosporine 4.1910903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 4.1918670907 18850075
MESH:D007022 Hypotension Zinc Sulfate 3.997265320
MESH:D007154 Immune System Diseases Cyclophosphamide 4.7916076520
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 3.8915869954
MESH:D007248 Infertility, Male Cyclophosphamide 3.2716517039 7193160
MESH:D007249 Inflammation Dietary Fats 9.5020412841
MESH:D007249 Inflammation Diethylnitrosamine 9.5018785209
MESH:D007249 Inflammation Progesterone 9.5015869954
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 9.5012878042 12200463
MESH:D007333 Insulin Resistance bisphenol A 14.6916393666
MESH:D007333 Insulin Resistance Dietary Fats 14.6918457598 11836018
MESH:D007333 Insulin Resistance Estradiol 14.6916393666 16627594
MESH:D007333 Insulin Resistance pirinixic acid 14.6916306350
MESH:D007410 Intestinal Diseases Tretinoin 3.2617994277
MESH:D007569 Jaw Abnormalities Ethanol 14.4415513904
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 14.4416580747
MESH:D007569 Jaw Abnormalities Tretinoin 14.4417551590 15992940
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 3.9015604871
MESH:D007674 Kidney Diseases Acetaminophen 11.8112587719 15629191
MESH:D007674 Kidney Diseases Chromium 11.8117934191
MESH:D007674 Kidney Diseases Cyclosporine 11.8110903974 8314463 18776723
MESH:D007674 Kidney Diseases Estradiol 11.8115618244
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 14.3016705839
MESH:D007680 Kidney Neoplasms Cyclosporine 14.3012371664
MESH:D007680 Kidney Neoplasms Estradiol 14.3015610895
MESH:D007680 Kidney Neoplasms Vinyl Chloride 14.3012562636
MESH:D007859 Learning Disorders Ethanol 3.7015451040
MESH:D016773 Leishmaniasis, Cutaneous Omeprazole 7.4419248655
MESH:D016773 Leishmaniasis, Cutaneous Zinc Sulfate 7.4415237267
MESH:D007938 Leukemia Azacitidine 9.0119148494
MESH:D007938 Leukemia Cyclophosphamide 9.0110602166
MESH:D007938 Leukemia Tretinoin 9.0117143497
MESH:D015451 Leukemia, Lymphocytic, Chronic, B-Cell Cyclophosphamide 6.2918587576 17658394 17296974 18172266 17008537 17802794
MESH:D015451 Leukemia, Lymphocytic, Chronic, B-Cell Disulfiram 6.2917026967
MESH:D007945 Leukemia, Lymphoid Thiotepa 5.7510069464
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive Cyclophosphamide 7.9410373061
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive Thiotepa 7.9410373061
MESH:D007951 Leukemia, Myeloid Azacitidine 13.5919077051
MESH:D007951 Leukemia, Myeloid Thiotepa 13.5910069464
MESH:D007951 Leukemia, Myeloid Tretinoin 13.5916932348 19285840 16482212
MESH:D015470 Leukemia, Myeloid, Acute Azacitidine 3.7918720364 17596541
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 3.7916294345 19850784 17596541
MESH:D054429 Leukemia, Myelomonocytic, Juvenile Azacitidine 4.7019299654
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 2.8017301526 19075265 17649720 17107899 17361223 16788101 17294898 17712046 17506722 19642359 16823087 17339181 12679006 15748426 19029980 16766008 19225113 9834237 16935935 17368321 16891316 16331271 16140955 17217047 19035177
MESH:D007970 Leukopenia Cyclophosphamide 4.4410052129 11830472
MESH:D017880 Limb Deformities, Congenital Disulfiram 11.6417676605
MESH:D017880 Limb Deformities, Congenital Ethanol 11.6417676605
MESH:D017880 Limb Deformities, Congenital Tretinoin 11.649224671
MESH:D008103 Liver Cirrhosis arsenite 17.4718296743
MESH:D008103 Liver Cirrhosis Dietary Fats 17.4718296743
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 17.4718522880 19638242 18407596 18665156 20032147
MESH:D008103 Liver Cirrhosis Ethanol 17.4715289165
MESH:D008103 Liver Cirrhosis Vinyl Chloride 17.4715289165 11679801 12499459 12958735 15354062
MESH:D008104 Liver Cirrhosis, Alcoholic Ethanol 4.5718295389
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 7.6214716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Ethanol 7.6218166357
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 7.6215474484
MESH:D008106 Liver Cirrhosis, Experimental Retinaldehyde 7.6216248980
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 7.6212878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 7.6218397230 16248980
MESH:D008107 Liver Diseases Acetaminophen 5.7319014921 16611625 11587558 12969438 12587719 19784758 19460945 16610002
MESH:D008107 Liver Diseases Diethylnitrosamine 5.7317034775
MESH:D008107 Liver Diseases Vinyl Chloride 5.7316270392 15211785
MESH:D008108 Liver Diseases, Alcoholic Ethanol 4.1417207112 17347304
MESH:D017114 Liver Failure, Acute Acetaminophen 2.7817185352 16871587
MESH:D008113 Liver Neoplasms 2-Acetylaminofluorene 25.5618001218 16273603 10672840 14678523 10737359 11376686
MESH:D008113 Liver Neoplasms Aflatoxin B1 25.5615890375 18177683 2125692 9163691
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 25.5620195826 21137059
MESH:D008113 Liver Neoplasms beta-Naphthoflavone 25.5621295105 19389873
MESH:D008113 Liver Neoplasms Diethylnitrosamine 25.5620583210 18978307 2862719 19551842 10737359 15885732 20492335 15175105 20405173 20434301 19256749 18977376 21071580 18648771 21167192 19090486 19642983 19294768 21047994 2422723 9163691 20118626 19255062 20101389 19996281 19812893 18644402 20452335 19426721 19254457 19499222 19850985 19427195 20501860 21278145 19690152 19073162 12771043 20137499 19833225 12112319 18754104 19638242 16942905
MESH:D008113 Liver Neoplasms Mitomycin 25.5615113037
MESH:D008113 Liver Neoplasms pirinixic acid 25.5620007298 16377806 15890375
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 25.5616984957
MESH:D008113 Liver Neoplasms Vinyl Chloride 25.5610629081 12762079 12211074 11024202 10964802 11679801 15999577
MESH:D008114 Liver Neoplasms, Experimental 2-Acetylaminofluorene 22.986150874 534488 1399818
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 22.988603461
MESH:D008114 Liver Neoplasms, Experimental beta-Naphthoflavone 22.9818164116
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 22.9817174075 19126423 21159647 18093689 17854601 18775883 16267830 9362446 19004024 16842330 18079962 18164116 19009564 18253720 19539802 18308698 2563599 3124819 18544905 19519916 17942915 18282651
MESH:D008114 Liver Neoplasms, Experimental Methylcholanthrene 22.98598648 1399818
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 22.9812151625
MESH:D008114 Liver Neoplasms, Experimental Vinyl Chloride 22.9812562636
MESH:D008175 Lung Neoplasms 2-Acetylaminofluorene 13.6711376686
MESH:D008175 Lung Neoplasms Aflatoxin B1 13.6714755239
MESH:D008175 Lung Neoplasms arsenite 13.6716809336
MESH:D008175 Lung Neoplasms Azacitidine 13.6721224363
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 13.6720464547 20869020 17053015 18816296 18520028 6695378 18569708 20064080 20135361
MESH:D008175 Lung Neoplasms Diethylnitrosamine 13.6720970405 6695378 20512841 21163286
MESH:D008175 Lung Neoplasms Methylcholanthrene 13.6715390079 10545420 16337739 20512841 20970405 7750092 16271038 1399818 17909032 6695378 9230183 21163286 11893704
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 13.6711884234 19555203
MESH:D008175 Lung Neoplasms Vinyl Chloride 13.6712958735 12562636
MESH:D008223 Lymphoma Cyclophosphamide 10.7212854902
MESH:D008223 Lymphoma Etoposide 10.7212556972 12854902
MESH:D008223 Lymphoma Thiotepa 10.7210069464
MESH:D016393 Lymphoma, B-Cell Cyclophosphamide 4.1116675587
MESH:D008228 Lymphoma, Non-Hodgkin Cyclophosphamide 3.7411911406
MESH:D015674 Mammary Neoplasms, Animal Vinyl Chloride 5.0012562636
MESH:D008325 Mammary Neoplasms, Experimental 2,4-diaminotoluene 8.0611921183
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 8.0611408345 17203775 16891317 11807958
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 8.0611408345 17203775
MESH:D020149 Manganese Poisoning Estradiol 3.9419453300
MESH:D008527 Medulloblastoma Tretinoin 2.5517453147
MESH:D008545 Melanoma Carboplatin 4.7916225601 16342250 11712820 12040289
MESH:D008545 Melanoma Disulfiram 4.7915367699
MESH:D008545 Melanoma Tretinoin 4.7916752155
MESH:D008546 Melanoma, Experimental Acetaminophen 9.1219513568
MESH:D008546 Melanoma, Experimental Cyclophosphamide 9.1216388313
MESH:D008569 Memory Disorders Ethanol 3.6918411066 15451040
MESH:D008591 Meningomyelocele Tretinoin 3.9116940565
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.2516801185
MESH:D009006 Monosomy Azacitidine 5.5419299654
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 2.7816381670
MESH:D009101 Multiple Myeloma Azacitidine 3.5918443271 19549372
MESH:D009135 Muscular Diseases pirinixic acid 2.9916239165
MESH:D009190 Myelodysplastic Syndromes Azacitidine 6.6418720364 17596541 19805378 17611569
MESH:D009190 Myelodysplastic Syndromes Tretinoin 6.6417596541
MESH:D009203 Myocardial Infarction pirinixic acid 1.9119151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.6012213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 6.8916810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 6.8916411023
MESH:D009336 Necrosis 2,4-dinitrotoluene 3.3318551238
MESH:D009361 Neoplasm Invasiveness Disulfiram 4.8118047805
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 5.483581430 9029167
MESH:D009362 Neoplasm Metastasis Disulfiram 5.4815367699
MESH:D009369 Neoplasms 2-hexenal 27.2610626223
MESH:D009369 Neoplasms Benzo(a)pyrene 27.2611141357
MESH:D009369 Neoplasms Carboplatin 27.2617925555 18854779
MESH:D009369 Neoplasms Cyclophosphamide 27.2618854779
MESH:D009369 Neoplasms Disulfiram 27.2617079463
MESH:D009369 Neoplasms pirinixic acid 27.2617405874
MESH:D009369 Neoplasms Thiotepa 27.2618854779
MESH:D009369 Neoplasms Tretinoin 27.2616594593 16946489
MESH:D009369 Neoplasms Vinyl Chloride 27.2611911487
MESH:D009389 Neovascularization, Pathologic arsenite 14.1115738583
MESH:D009389 Neovascularization, Pathologic Disulfiram 14.1115367699
MESH:D009389 Neovascularization, Pathologic Estradiol 14.1117289903
MESH:D009402 Nephrosis, Lipoid Cyclosporine 3.9017954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 2.8419348381 18481113
MESH:D009421 Nervous System Malformations bisphenol A 19.3311399458 16427766
MESH:D009421 Nervous System Malformations Estradiol 19.3311399458 16427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 19.3314600291
MESH:D009421 Nervous System Malformations Tretinoin 19.339125849
MESH:D009436 Neural Tube Defects Tretinoin 2.709142499
MESH:D009447 Neuroblastoma Cyclophosphamide 6.788761367 15176712 16115947
MESH:D009447 Neuroblastoma Thiotepa 6.788761367
MESH:D019636 Neurodegenerative Diseases Acetaminophen 6.7518514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 6.7520387270
MESH:D017599 Neuroectodermal Tumors Carboplatin 16.3612837982
MESH:D017599 Neuroectodermal Tumors Cyclophosphamide 16.368761367 12837982
MESH:D017599 Neuroectodermal Tumors Thiotepa 16.3612837982 8761367
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 4.5820387270
MESH:D020258 Neurotoxicity Syndromes Disulfiram 4.2811005259
MESH:D009503 Neutropenia Cyclophosphamide 3.848291058
MESH:D009765 Obesity Dietary Fats 3.9018674790 20518802 20132043 19632207 17217161 21332399 11836018 16723640 18457598
MESH:D009765 Obesity pirinixic acid 3.9020558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 8.0416049721 12819281
MESH:D009784 Occupational Diseases Vinyl Chloride 8.0412061072
MESH:D009845 Oligospermia Cyclophosphamide 4.1916517039
MESH:D012516 Osteosarcoma Disulfiram 4.7518047805
MESH:D010049 Ovarian Diseases bisphenol A 4.4611985600
MESH:D010051 Ovarian Neoplasms Disulfiram 9.7317026967
MESH:D010051 Ovarian Neoplasms Estradiol 9.7319401270
MESH:D010051 Ovarian Neoplasms Progesterone 9.7317393432 16525653
MESH:D010051 Ovarian Neoplasms Tretinoin 9.7316936753
MESH:D010146 Pain Acetaminophen 8.8216870215
MESH:D010146 Pain Cyclophosphamide 8.8212161096 18093676
MESH:D010146 Pain Tretinoin 8.8216870215
MESH:D010190 Pancreatic Neoplasms Cyclophosphamide 17.6611332152
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 17.6616540662
MESH:D010190 Pancreatic Neoplasms Ethanol 17.6612384795
MESH:D010190 Pancreatic Neoplasms Etoposide 17.6619003803
MESH:D010190 Pancreatic Neoplasms Mitomycin 17.6615113037
MESH:D010190 Pancreatic Neoplasms Tretinoin 17.6615976015
MESH:D010300 Parkinson Disease Ditiocarb 4.1011445065
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.7112520081
MESH:D010787 Photosensitivity Disorders 4-hydroxy-2-nonenal 4.9611550810
MESH:D017285 Polymyositis Vinyl Chloride 6.3311642524
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.0618163543
MESH:D011230 Precancerous Conditions Cyclosporine 7.4612371664
MESH:D011230 Precancerous Conditions Diethylnitrosamine 7.462563599
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Cyclophosphamide 3.4921297632
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 7.7610548101
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 7.7611896295 11118676 11399792 11222880
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 8.9820887781
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 8.9820887781
MESH:D011471 Prostatic Neoplasms Azacitidine 2.2918324645
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.2917292933
MESH:D011471 Prostatic Neoplasms bisphenol A 2.2916740699
MESH:D011471 Prostatic Neoplasms Cholecalciferol 2.2917024972
MESH:D011471 Prostatic Neoplasms Cyclophosphamide 2.2917136230
MESH:D011471 Prostatic Neoplasms Disulfiram 2.2919789329
MESH:D011471 Prostatic Neoplasms Estradiol 2.2916740699
MESH:D011471 Prostatic Neoplasms Etoposide 2.2917172428
MESH:D011507 Proteinuria Tretinoin 3.1216636307
MESH:D011565 Psoriasis Cyclosporine 2.0216882103
MESH:D011625 Pterygium Tretinoin 4.2616723453
MESH:D011629 Puberty, Precocious bisphenol A 4.2610548101
MESH:D011658 Pulmonary Fibrosis Cyclophosphamide 3.0616636934
MESH:D011928 Raynaud Disease Vinyl Chloride 5.6116977343
MESH:D015427 Reperfusion Injury pirinixic acid 2.1119058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.3318990726
MESH:D012208 Rhabdomyosarcoma Tretinoin 3.6116283617 16116481
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.6518045962
MESH:D012509 Sarcoma Vinyl Chloride 4.8912828392
MESH:D012512 Sarcoma, Ewing's Etoposide 4.2014601052
MESH:D012595 Scleroderma, Systemic Cyclophosphamide 10.1116636934
MESH:D012595 Scleroderma, Systemic Vinyl Chloride 10.1114979077
MESH:D012640 Seizures 2,4-dinitrotoluene 4.8918551238
MESH:D012640 Seizures Ethanol 4.899754883
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 7.7910029692 19755658
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 7.7916192470
MESH:D012878 Skin Neoplasms Tretinoin 7.7916467112
OMIM:102530 SPERMATOGENIC FAILURE 6 Cyclophosphamide 4.9816517039
MESH:D013119 Spinal Cord Injuries Progesterone 3.7515862959 16503802
MESH:D013272 Stomach Diseases Omeprazole 4.0918545984
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 7.3720155912 2093021
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 7.3718456281
MESH:D013274 Stomach Neoplasms Ethanol 7.3718456281
MESH:D013274 Stomach Neoplasms nitrosobenzylmethylamine 7.3717575124 12958204
MESH:D013274 Stomach Neoplasms Tretinoin 7.3717261132
MESH:D013274 Stomach Neoplasms Vinyl Chloride 7.3712562636
MESH:D013276 Stomach Ulcer Ethanol 6.1117918041 9211565 11906479 17189318 16755016 9562338
MESH:D013276 Stomach Ulcer Omeprazole 6.1110750652 18237397 15991576 16755016 11906479 17977527
MESH:D019966 Substance-Related Disorders bisphenol A 3.4616045194 16684133
MESH:D013375 Substance Withdrawal Syndrome Ethanol 3.809754883
MESH:D015173 Supratentorial Neoplasms Carboplatin 17.5212837982
MESH:D015173 Supratentorial Neoplasms Cyclophosphamide 17.5212837982
MESH:D015173 Supratentorial Neoplasms Thiotepa 17.5212837982
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.3612697716
MESH:D013964 Thyroid Neoplasms Butyrates 9.7617967635
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 9.767505956
MESH:D013964 Thyroid Neoplasms Tretinoin 9.7617045167 16026305
MESH:D013978 Tibial Fractures Estradiol 4.1519048282
MESH:D014062 Tongue Neoplasms Tretinoin 3.3316051514
MESH:D014376 Tuberculosis Tretinoin 2.8816040207
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 10.0416049721
MESH:D001749 Urinary Bladder Neoplasms 2-Acetylaminofluorene 10.0415867355 1399818 15289314
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 10.0417053015
MESH:D001749 Urinary Bladder Neoplasms Cyclophosphamide 10.0414692829
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 3.7910091137
MESH:D014581 Urticaria Acetaminophen 2.5010982225
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 3.2216129372
MESH:D014591 Uterine Diseases bisphenol A 4.4714652134
MESH:D014604 Uveal Neoplasms Tretinoin 4.0716752155
MESH:D014605 Uveitis Cyclosporine 3.451336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.0512125929
MESH:D014820 Vitiligo Tretinoin 3.5616761959
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.7115886252
MESH:D015430 Weight Gain Dietary Fats 3.2916723640
MESH:D009396 Wilms Tumor Tretinoin 3.5216287080
MESH:D014985 Xerophthalmia Cyclosporine 3.9017120751
Pathway ID Pathway Name
KEGG:00410 beta-Alanine metabolism
KEGG:00982 Drug metabolism - cytochrome P450
KEGG:00010 Glycolysis / Gluconeogenesis
KEGG:00340 Histidine metabolism
KEGG:01100 Metabolic pathways
KEGG:00980 Metabolism of xenobiotics by cytochrome P450
KEGG:00360 Phenylalanine metabolism
KEGG:00350 Tyrosine metabolism
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA24697
    • Releated gene ID Related gene Name
    PA24697ALDH3A1
    Releated disease ID Related disease Name
    PA443833Cystitis
    Releated drug ID Related drug Name
    PA448803carboplatin
    PA451668thiotepa
    PA449165cyclophosphamide
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00157 - NADH Dietary supplement;Micronutrient
    DB01907 - Nicotinamide-Adenine-Dinucleotide
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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