AutismKB 2.0

Annotation Detail for ACSL4


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:ACSL4 ( ACS4,FACL4,LACS4,MRX63,MRX68 )
Gene Full Name: acyl-CoA synthetase long-chain family member 4
Band: Xq23
Quick LinksEntrez ID:2182; OMIM: 300157; Uniprot ID:ACSL4_HUMAN; ENSEMBL ID: ENSG00000068366; HGNC ID: 3571
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Pathway IDPathway Name
PWY-6000gamma-linolenate biosynthesis II (animals)
PWY-5972stearate biosynthesis I (animals)
FAO-PWYfatty acid beta-oxidation I
PWY-5143fatty acid activation
Pathway IDPathway Name
hsa04920Adipocytokine signaling pathway
hsa03320PPAR signaling pathway
hsa01100Metabolic pathways
hsa04146Peroxisome
hsa00071Fatty acid metabolism
Pathway IDPathway Name
Metabolism of lipids and lipoproteins
No data
No data
Pathway IDPathway Name
500802Synthesis of very long-chain fatty acyl-CoAs
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1848Embryoma
1982Myopathy
2001Mental retardation
2022Liver cancer
2053Colon cancer
Desease Name
PSYCH
schizoaffective disorder
dermal erythema
depressive disorder, major
alcohol abuse
schizophrenia
No data
Desease Name
Mental retardation, X-linked nonspecific, 63
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of ACSL4 mRNAaffects expression 21346803
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of ACSL4 mRNAincreases expression 18648102
D000082 Acetaminophen Acetaminophen affects the expression of ACSL4 mRNAaffects expression 17562736
D000643 Ammonium Chloride Ammonium Chloride affects the expression of ACSL4 mRNAaffects expression 16483693
D001629 Bezafibrate Bezafibrate results in increased expression of ACSL4 mRNAincreases expression 17118139
D002251 Carbon Tetrachloride Carbon Tetrachloride results in decreased expression of ACSL4 mRNAdecreases expression 17484886
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of ACSL4 mRNAaffects expression 16239168
D003907 Dexamethasone [Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of ACSL4 mRNAaffects cotreatment|increases expression 16054899
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of ACSL4 mRNAincreases expression 17108234
D011345 Fenofibrate Fenofibrate results in increased expression of ACSL4 mRNAincreases expression 17118139
D005978 Glutathione Glutathione deficiency results in increased expression of ACSL4 mRNAincreases expression 15345336
D015056 1-Methyl-3-isobutylxanthine [Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of ACSL4 mRNAaffects cotreatment|increases expression 16054899
C406082 monomethylarsonous acid monomethylarsonous acid results in decreased expression of ACSL4 mRNAdecreases expression 20024957
C023036 perfluorooctanoic acid perfluorooctanoic acid results in increased expression of ACSL4 mRNAincreases expression 18467677
17681415
C023036 perfluorooctanoic acid PPARA protein promotes the reaction [perfluorooctanoic acid results in increased expression of ACSL4 mRNA]increases expression|increases reaction 18467677
D010634 Phenobarbital NR1I3 protein affects the reaction [Phenobarbital results in increased expression of ACSL4 mRNA]affects reaction|increases expression 19482888
D010634 Phenobarbital Phenobarbital results in decreased expression of ACSL4 mRNAdecreases expression 19363144
D010634 Phenobarbital Phenobarbital results in increased expression of ACSL4 mRNAincreases expression 19482888
D010795 Phthalic Acids Phthalic Acids results in decreased expression of ACSL4 mRNAdecreases expression 15728792
C006253 pirinixic acid pirinixic acid results in increased expression of ACSL4 mRNAincreases expression 18467677
18301758
17950772
17118139
C006253 pirinixic acid PPARA protein promotes the reaction [pirinixic acid results in increased expression of ACSL4 mRNA]increases expression|increases reaction 18467677
17950772
C089730 rosiglitazone [Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of ACSL4 mRNAaffects cotreatment|increases expression 16054899
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin binds to AHR protein] which results in decreased expression of ACSL4 mRNAaffects binding|decreases expression 16214954
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of ACSL4 mRNAdecreases expression 18796159
C052342 topiramate topiramate results in decreased expression of ACSL4 mRNAdecreases expression 16979414
D002762 Cholecalciferol Cholecalciferol results in increased expression of ACSL4 mRNAincreases expression 16508948
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 8.016195326
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 8.0115322242 14514962 11752688
MESH:D000138 Acidosis Ammonium Chloride 3.4718287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.8617505938
MESH:D055371 Acute Lung Injury pirinixic acid 3.0318653653
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.7914692618
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.703712494
MESH:D018248 Adenoma, Liver Cell Phenobarbital 16.8017620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 16.8016434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 16.8016835633
MESH:D000437 Alcoholism topiramate 4.9618552399 17925516 19331489
MESH:D000544 Alzheimer Disease rosiglitazone 2.8319621015
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.8711748828
MESH:D000799 Angioedema Acetaminophen 3.7610982225
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.3811256880
MESH:D001169 Arthritis, Experimental marker/mechanism 18988084
MESH:D001169 Arthritis, Experimental Dexamethasone 7.1917659584
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 7.1915885639
MESH:D001289 Attention Deficit Disorder with Hyperactivity Phthalic Acids 4.3020106747
MESH:D001321 Autistic Disorder Acetaminophen 2.2218445737
MESH:D001321 Autistic Disorder Glutathione 2.2219267885 16917939 19056591 18929414
MESH:D001327 Autoimmune Diseases Cholecalciferol 4.9416142846
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 4.9411289319 1440618
MESH:D001778 Blood Coagulation Disorders pirinixic acid 8.4919483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 8.4912125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.7115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.7115746008
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.7320435547
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.6918705752 15673190 16124888 3786805 16192424 10355542 16097048 15721981 16011737 16227642 16050911 15700767
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.7316835633
MESH:D006528 Carcinoma, Hepatocellular marker/mechanism 19363144
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 8.7116705839
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 8.717296757 3581430
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 8.713084413
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 8.7118788625
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 8.7120007298 17173139 1701930 6705139 20935162
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.637296757
MESH:D002294 Carcinoma, Squamous Cell Glutathione 3.3517015178
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3216120746 18850075 18670907
MESH:D002386 Cataract Acetaminophen 2.5310977129
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 6.887505956
MESH:D002471 Cell Transformation, Neoplastic monomethylarsonous acid 6.8819716837
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.164080065
MESH:D002659 Child Development Disorders, Pervasive topiramate 4.0615650499
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.0816835633
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 12.999022650 19486331
MESH:D002779 Cholestasis Ethinyl Estradiol 12.9915861022 16919318 17110522 11677210 17333356 16105132 17681005
MESH:D002779 Cholestasis pirinixic acid 12.9919176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.078697196 12621046 16354765 15340226 15668235
MESH:D003110 Colonic Neoplasms Dexamethasone 2.4815824018
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.9817141729 14669216
MESH:D019465 Craniofacial Abnormalities Dexamethasone 2.5917728286
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.5915322242 20055451 10048152
MESH:D003490 Cyanosis 2,4-dinitrotoluene 3.9318551238
MESH:D003550 Cystic Fibrosis Glutathione 4.4119747007
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 6.7618759878 11298694 8156756 11906362 12868966 14531868 8970840 2524372
MESH:D017449 Dermatitis, Allergic Contact Dexamethasone 6.7612438553
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.3818249437
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.413621924 2952479
MESH:D003920 Diabetes Mellitus rosiglitazone 4.2217446233
MESH:D003924 Diabetes Mellitus, Type 2 rosiglitazone 7.2412642470
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 7.2417107852
MESH:D003924 Diabetes Mellitus, Type 2 topiramate 7.2416979414
MESH:D003967 Diarrhea Dexamethasone 3.617237001
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 11.7221346803 18551238
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 11.726679447 9022650 7440962 16192314 11289319 9328219 18648102 1440618 6482804 8291058 18692083 9653073 18289764
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 11.7216227642 16109766 14725611 16177239 11834606 15968718 11421492 10774834 17522070 12594235 12958197 17562736 12705907 16393943 11287661 19085960 14986274 16081117 18071297 2444490 10915739 19923254 17906064 15619225 16781746 19420014 19416960 19164858 12540782 12392966 18713872 16485898 19739265 19370779 11461765 11739529 11743745 14550746 10663392 11529661 12153990
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 11.727179309 9327722 10092053 3732212 2869522 11566570 6884620 4309450 15027814 17522070 16177239 15998439 19085960 7120509 15968718 3786805 21278145 19336974 7440962 6623471 16227642 10915739
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 11.7220420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.0219426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.6911462148
MESH:D050171 Dyslipidemias Fenofibrate 4.3616707586
MESH:D004421 Dystonia Phenobarbital 3.921851702
MESH:D004485 Eczema Dexamethasone 4.3712438553
MESH:D004487 Edema Dexamethasone 20.8019703484
MESH:D004487 Edema perfluorooctanoic acid 20.8012083418 17259670
MESH:D004487 Edema pirinixic acid 20.8012083418
MESH:D004487 Edema rosiglitazone 20.8012083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 20.8011000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.8216714409 15322242 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.1012538720
MESH:D016889 Endometrial Neoplasms Fenofibrate 4.0316569247
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.9410568697 9294722
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 4.023659116
MESH:D004828 Epilepsies, Partial Phenobarbital 3.793922381 11558140
MESH:D004827 Epilepsy Phenobarbital 7.0320417680
MESH:D004827 Epilepsy topiramate 7.0319148780
MESH:D004832 Epilepsy, Absence Phenobarbital 3.466401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.167750514
MESH:D004833 Epilepsy, Temporal Lobe topiramate 6.1916499746
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 3.933659116
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 2.093581430
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.9511564622
MESH:D005234 Fatty Liver Carbon Tetrachloride 18.1117595544 12631006 15959796 16239168 12795759 16045604 19224547 61145
MESH:D005234 Fatty Liver Ethinyl Estradiol 18.1115345470
MESH:D005234 Fatty Liver pirinixic acid 18.1119236843 20131406
MESH:D005234 Fatty Liver rosiglitazone 18.1119196556
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.3711858732
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 4.946705139
MESH:D005355 Fibrosis Carbon Tetrachloride 8.3118705752
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 8.3120067830
MESH:D005756 Gastritis Acetaminophen 3.5916983495
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 3.957505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.5110696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.2811294989 10048152
MESH:D006333 Heart Failure pirinixic acid 2.4820558911
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.2511000095
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 8.946705139
MESH:D006505 Hepatitis Carbon Tetrachloride 8.9419900420 19110552
MESH:D006529 Hepatomegaly perfluorooctanoic acid 19.993609246
MESH:D006529 Hepatomegaly Phenobarbital 19.9916109766
MESH:D006529 Hepatomegaly pirinixic acid 19.9918467677 19772884 16221962 19176532
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 19.9915340226 16120746 12621046
MESH:D006548 Hernia, Diaphragmatic Dexamethasone 3.047520565
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.9615340226 18606429 8697196 16354765 16959395
MESH:D006930 Hyperalgesia Acetaminophen 12.7716870215
MESH:D006930 Hyperalgesia perfluorooctanoic acid 12.7712083418
MESH:D006930 Hyperalgesia rosiglitazone 12.7712083418
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.4516899240
MESH:D006943 Hyperglycemia pirinixic acid 3.1020558911
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 3.8515034207
MESH:D006973 Hypertension Dexamethasone 5.1417042910
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.1418670907 18850075
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.0015338365
MESH:D007021 Hypospadias Ethinyl Estradiol 3.7216569931 16945680
MESH:D007077 Ileal Diseases 1-Methyl-3-isobutylxanthine 5.3618306037
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.3812013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.4317937319
MESH:D007249 Inflammation Dexamethasone 11.6611099482 8960868
MESH:D007249 Inflammation perfluorooctanoic acid 11.6612083418
MESH:D007249 Inflammation rosiglitazone 11.6612083418
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 11.6612878042 12200463
MESH:D007333 Insulin Resistance pirinixic acid 7.3116306350
MESH:D007333 Insulin Resistance rosiglitazone 7.3116306350
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 4.949022650 8074119
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.2516580747
MESH:D007579 Jejunal Diseases 1-Methyl-3-isobutylxanthine 5.3618306037
MESH:D007674 Kidney Diseases Acetaminophen 2.1512587719 15629191
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 7.1116705839
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 7.116582329
MESH:D007984 Leydig Cell Tumor perfluorooctanoic acid 5.148812269
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 6.4716943688 17334410 11408273 17174718 16221502 11903743 16239168 17157831 21278145
MESH:D008103 Liver Cirrhosis Phenobarbital 6.4721047994
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.149327722 15034207
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 8.6117565644 18205269 14724832 18395095 15370692 12609069 11481614 13678700 16248980 16097048 14748882 17900296 14620537 16033810 17481882 18339082 15925388 15052691 18472094 15362042 18412020 12741479 15650968 16027843 17922224 18279442 14716496 17721639 17869086 10355542 18054572 18429990 18395914 15996030 12666154 14716833 15338365 18263696 12445418 15959796 17805973 12586293 18317297 17976157 16116963 16011737 16638106 15123356 20821823 18420326 18481824 18156304 12649538 12632512 18166357 12667390 12389079 15730626 16015684 17761835 18472332 18187930 18705752 17640975 15057751 12546737 18006644 17631135 14512876 12958196 17698563 12445421 17823541 18251166 18277467 17525996 16136751 15876570 15893842 12632514 15931870 18376398 17944888 17708605 18210741 17714472 12898905 17557913 18418968 17766677 15673190 16192424 15818738
MESH:D008106 Liver Cirrhosis, Experimental Dexamethasone 8.6116718785
MESH:D008106 Liver Cirrhosis, Experimental Fenofibrate 8.6115474484
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 8.6115474484
MESH:D008106 Liver Cirrhosis, Experimental rosiglitazone 8.6117347453 15980055
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 8.6112878042
MESH:D008107 Liver Diseases Acetaminophen 6.3516610002 16611625 19014921 11587558 12587719 19784758 19460945 12969438
MESH:D008107 Liver Diseases Carbon Tetrachloride 6.3516246199 15830285 17285989 16964402 15720792
MESH:D008107 Liver Diseases Phenobarbital 6.3519363144
MESH:D017093 Liver Failure Carbon Tetrachloride 4.0815123358
MESH:D017114 Liver Failure, Acute Acetaminophen 9.1417185352 16871587
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 9.1416899240 14706259
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 17.5619294768
MESH:D008113 Liver Neoplasms Fenofibrate 17.5618978307
MESH:D008113 Liver Neoplasms perfluorooctanoic acid 17.5614757943 18709148
MESH:D008113 Liver Neoplasms Phenobarbital 17.5615975961 8742319 19073162 21047994 19812893 19482888
MESH:D008113 Liver Neoplasms pirinixic acid 17.5616377806 15890375 20007298
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 17.5616984957
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 18.073712494 1399818 6587162 598648
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 18.0715583823 12014681
MESH:D008114 Liver Neoplasms, Experimental Fenofibrate 18.0718253720 18775883
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 18.071399818 17172636 2563599 6150874 18308698
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 18.0712151625
MESH:D008175 Lung Neoplasms Dexamethasone 2.4115824018 11195469
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.4111884234 19555203
MESH:D008325 Mammary Neoplasms, Experimental rosiglitazone 3.3416827153
MESH:D008546 Melanoma, Experimental Acetaminophen 3.4819513568
MESH:D038901 Mental Retardation, X-Linked marker/mechanism
MESH:D024821 Metabolic Syndrome X rosiglitazone 4.3017261469
MESH:D008881 Migraine Disorders topiramate 4.5118765137 16942474 18759728 18803445
MESH:D009101 Multiple Myeloma Dexamethasone 3.4415867202 15744524 16118317
MESH:D009135 Muscular Diseases Bezafibrate 10.4416239165
MESH:D009135 Muscular Diseases pirinixic acid 10.4416239165
MESH:D009190 Myelodysplastic Syndromes Dexamethasone 3.499809623
MESH:D009203 Myocardial Infarction pirinixic acid 2.1119151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.9512213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 2.8816411023
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.3917484760
MESH:D009336 Necrosis 2,4-dinitrotoluene 3.7718551238
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.433581430
MESH:D009369 Neoplasms pirinixic acid 1.9117405874
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.1314600291
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 2.866679447
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.8018514411
MESH:D052556 Niemann-Pick Disease, Type C perfluorooctanoic acid 4.879802331
MESH:D009765 Obesity pirinixic acid 1.7920558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 8.6216049721 12819281
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 8.626482804 4026338
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 4.943988306
MESH:D010018 Osteomalacia Phenobarbital 4.2817016548
MESH:D010146 Pain Acetaminophen 2.3216870215
MESH:D010190 Pancreatic Neoplasms Phenobarbital 2.4616965848
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.6011578682
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.407296757
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.1712520081
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.396228378
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.4718163543
MESH:D011230 Precancerous Conditions Phenobarbital 3.552563599
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Dexamethasone 3.4921297632
MESH:D011297 Prenatal Exposure Delayed Effects perfluorooctanoic acid 9.3917132714
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 9.3911118676 11896295 11222880 11399792
MESH:D011471 Prostatic Neoplasms marker/mechanism 17013881
MESH:D011471 Prostatic Neoplasms Cholecalciferol 4.2517024972
MESH:D011537 Pruritus Ethinyl Estradiol 3.2315861022 16919318
MESH:D019310 Pseudolymphoma Phenobarbital 4.4112752131
MESH:D015427 Reperfusion Injury pirinixic acid 2.3419058328
MESH:D012128 Respiratory Distress Syndrome, Adult Dexamethasone 3.9318379247 11700416
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.7518990726
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.313692021
MESH:D012640 Seizures 2,4-dinitrotoluene 9.6718551238
MESH:D012640 Seizures Phenobarbital 9.6716876388 11442880 4039156 3137016
MESH:D012640 Seizures topiramate 9.6716499746
MESH:D003294 Seizures, Febrile Phenobarbital 4.746407741
MESH:D012871 Skin Diseases monomethylarsonous acid 3.3517431481
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.0016192470
MESH:D013088 Spermatocele Ethinyl Estradiol 3.8616709447
MESH:D013272 Stomach Diseases Dexamethasone 4.2415472012
MESH:D013276 Stomach Ulcer Dexamethasone 3.4115138204
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.5411994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.0715669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.8212697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 6.921399818 6582329 6587162 3712494 7505956
MESH:D013964 Thyroid Neoplasms Phenobarbital 6.921399818
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 8.2316049721
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 8.238074119
MESH:D001749 Urinary Bladder Neoplasms monomethylarsonous acid 8.2320375083
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.2310091137
MESH:D014581 Urticaria Acetaminophen 2.8910982225
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.2114692618
MESH:D014605 Uveitis Dexamethasone 4.741336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.5112125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.4615869587 14671159
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.1715886252
Pathway ID Pathway Name
KEGG:04920 Adipocytokine signaling pathway
KEGG:00071 Fatty acid metabolism
KEGG:01100 Metabolic pathways
REACT:22258 Metabolism of lipids and lipoproteins
KEGG:04146 Peroxisome
KEGG:03320 PPAR signaling pathway
Pharmacogenomics Knowledge Base Top
Drug Bank Top
Drugbank ID Action Drug Name Description
DB00159 potentiator Icosapent Dietary supplement;Micronutrient
DB00197 antagonist Troglitazone Antineoplastic Agents;Hypoglycemic Agents;Vasodilator Agents;Platelet Aggregation Inhibitors;Fibrinolytic Agents
DB00412 inhibitor Avandaryl Hypoglycemic Agents;Vasodilator Agents;Fibrinolytic Agents;Thazolidinediones
No data
No data
No data

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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