AutismKB 2.0

Annotation Detail for PTK2B


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Basic Information Top
Gene Symbol:PTK2B ( CADTK,CAKB,FADK2,FAK2,PKB,PTK,PYK2,RAFTK )
Gene Full Name: PTK2B protein tyrosine kinase 2 beta
Band: 8p21.2
Quick LinksEntrez ID:2185; OMIM: 601212; Uniprot ID:FAK2_HUMAN; ENSEMBL ID: ENSG00000120899; HGNC ID: 9612
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04670Leukocyte transendothelial migration
hsa04912GnRH signaling pathway
hsa04650Natural killer cell mediated cytotoxicity
hsa04020Calcium signaling pathway
hsa04062Chemokine signaling pathway
Pathway IDPathway Name
Interactions of the immunoglobulin superfamily (IgSF) member proteins
Cell junction organization
Pathway IDPathway Name
200038Coregulation of Androgen receptor activity
200187Alpha-synuclein signaling
200189FGF signaling pathway
200004Endothelins
200082IL2-mediated signaling events
200083CXCR4-mediated signaling events
200161Signaling events mediated by VEGFR1 and VEGFR2
200011LPA receptor mediated events
200042Osteopontin-mediated events
200109Integrins in angiogenesis
Pathway IDPathway Name
P00034Integrin signalling pathway
P00031Inflammation mediated by chemokine and cytokine signaling pathway
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1831Prostate cancer
2091Hypertension
2138Osteoporosis
2242Nervous system tumor
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of PTK2B mRNAaffects expression 21346803
C436284 2-cyclopentyl-5-(5-isoquinolylsulfonyl)-6-nitro-1H-benzo(D)imidazole 2-cyclopentyl-5-(5-isoquinolylsulfonyl)-6-nitro-1H-benzo(D)imidazole inhibits the reaction [Acrylamide results in increased phosphorylation of PTK2B protein]decreases reaction|increases phosphorylation 11478917
C436284 2-cyclopentyl-5-(5-isoquinolylsulfonyl)-6-nitro-1H-benzo(D)imidazole 2-cyclopentyl-5-(5-isoquinolylsulfonyl)-6-nitro-1H-benzo(D)imidazole inhibits the reaction [Colchicine results in increased phosphorylation of PTK2B protein]decreases reaction|increases phosphorylation 11478917
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of PTK2B mRNAincreases expression 18648102
C108123 4-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo(3,4-d)pyrimidine 4-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo(3,4-d)pyrimidine inhibits the reaction [Carbachol results in increased phosphorylation of and results in increased activity of PTK2B protein]decreases reaction|increases activity|increases phosphorylation 16877402
C003001 7-ketocholesterol 7-ketocholesterol results in increased phosphorylation of and results in increased activity of PTK2B proteinincreases activity|increases phosphorylation 15955068
D020106 Acrylamide 2-cyclopentyl-5-(5-isoquinolylsulfonyl)-6-nitro-1H-benzo(D)imidazole inhibits the reaction [Acrylamide results in increased phosphorylation of PTK2B protein]decreases reaction|increases phosphorylation 11478917
D020106 Acrylamide Acrylamide results in increased phosphorylation of PTK2B proteinincreases phosphorylation 11478917
C031143 AICA ribonucleotide AICA ribonucleotide results in increased phosphorylation of and results in increased activity of PTK2B proteinincreases activity|increases phosphorylation 11978788
C031143 AICA ribonucleotide PTK2B protein affects the reaction [AICA ribonucleotide results in increased activity of MAPK3 protein]affects reaction|increases activity 11978788
C031143 AICA ribonucleotide PTK2B protein affects the reaction [AICA ribonucleotide results in increased activity of PRKCZ protein]affects reaction|increases activity 11978788
D000643 Ammonium Chloride Ammonium Chloride affects the expression of PTK2B mRNAaffects expression 16483693
D000643 Ammonium Chloride Ammonium Chloride results in decreased expression of PTK2B protein modified formdecreases expression 16483693
D000643 Ammonium Chloride Ammonium Chloride results in increased expression of PTK2B proteinincreases expression 16483693
D000643 Ammonium Chloride Ammonium Chloride results in increased expression of PTK2B protein modified formincreases expression 16483693
D020001 1-Butanol 1-Butanol inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of PTK2B protein]decreases reaction|increases phosphorylation 15705590
D020001 1-Butanol 1-Butanol inhibits the reaction [Potassium Chloride results in increased phosphorylation of PTK2B protein]decreases reaction|increases phosphorylation 18004999
D002118 Calcium Calcium affects the reaction [(N)-methanocarba-2MeSADP results in increased phosphorylation of PTK2B protein]affects reaction|increases phosphorylation 16236484
D002118 Calcium Calcium affects the phosphorylation of and affects the activity of PTK2B proteinaffects activity|affects phosphorylation 16877402
D002217 Carbachol 4-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo(3,4-d)pyrimidine inhibits the reaction [Carbachol results in increased phosphorylation of and results in increased activity of PTK2B protein]decreases reaction|increases activity|increases phosphorylation 16877402
D002217 Carbachol Carbachol results in increased phosphorylation of and results in increased activity of PTK2B proteinincreases activity|increases phosphorylation 16877402
D002217 Carbachol Egtazic Acid inhibits the reaction [Carbachol results in increased phosphorylation of and results in increased activity of PTK2B protein]decreases reaction|increases activity|increases phosphorylation 16877402
D002217 Carbachol PTK2B protein affects the reaction [Carbachol results in increased phosphorylation of and results in increased activity of MAPK1 protein]affects reaction|increases activity|increases phosphorylation 16877402
D002217 Carbachol PTK2B protein affects the reaction [Carbachol results in increased phosphorylation of and results in increased activity of MAPK3 protein]affects reaction|increases activity|increases phosphorylation 16877402
D002217 Carbachol SRC protein affects the reaction [Carbachol results in increased phosphorylation of and results in increased activity of PTK2B protein]affects reaction|increases activity|increases phosphorylation 16877402
D003078 Colchicine 2-cyclopentyl-5-(5-isoquinolylsulfonyl)-6-nitro-1H-benzo(D)imidazole inhibits the reaction [Colchicine results in increased phosphorylation of PTK2B protein]decreases reaction|increases phosphorylation 11478917
D003078 Colchicine Colchicine results in increased phosphorylation of PTK2B proteinincreases phosphorylation 11478917
D003907 Dexamethasone Dexamethasone results in increased expression of PTK2B mRNAincreases expression 12782123
D004317 Doxorubicin PTK2B protein inhibits the reaction [Doxorubicin results in increased phosphorylation of AKT1 protein]decreases reaction|increases phosphorylation 16168102
D004533 Egtazic Acid Egtazic Acid inhibits the reaction [Carbachol results in increased phosphorylation of and results in increased activity of PTK2B protein]decreases reaction|increases activity|increases phosphorylation 16877402
D000431 Ethanol Ethanol results in increased phosphorylation of PTK2B proteinincreases phosphorylation 18182400
D000431 Ethanol sodium arsenite promotes the reaction [Ethanol results in increased phosphorylation of PTK2B protein]increases phosphorylation|increases reaction 18182400
D005419 Flavonoids Flavonoids results in decreased expression of PTK2B mRNAdecreases expression 18035473
C053629 fluoroaluminum fluoroaluminum results in increased phosphorylation of PTK2B proteinincreases phosphorylation 11792571
C010176 halofuginone halofuginone results in increased expression of PTK2B mRNAincreases expression 17180598
D006830 Hydralazine [Hydralazine co-treated with Valproic Acid] results in increased expression of PTK2B mRNAaffects cotreatment|increases expression 17183730
D006861 Hydrogen Peroxide 1-Butanol inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of PTK2B protein]decreases reaction|increases phosphorylation 15705590
D006861 Hydrogen Peroxide Hydrogen Peroxide promotes the reaction [PTK2B protein binds to SRC protein]affects binding|increases reaction 15705590
D006861 Hydrogen Peroxide Hydrogen Peroxide results in increased phosphorylation of PTK2B proteinincreases phosphorylation 15705590
D006861 Hydrogen Peroxide PLD2 protein affects the reaction [Hydrogen Peroxide promotes the reaction [PTK2B protein binds to SRC protein]]affects binding|affects reaction|increases reaction 15705590
D006861 Hydrogen Peroxide PTK2B protein affects the reaction [Hydrogen Peroxide results in increased activity of and results in increased phosphorylation of AKT1 protein]affects reaction|increases activity|increases phosphorylation 15705590
D015759 Ionomycin Ionomycin results in increased phosphorylation of and results in increased activity of PTK2B proteinincreases activity|increases phosphorylation 16877402
C032881 lysophosphatidic acid lysophosphatidic acid results in increased phosphorylation of PTK2B proteinincreases phosphorylation 11792571
D008345 Manganese Manganese results in decreased expression of PTK2B mRNAdecreases expression 17175027
C025340 manganese chloride manganese chloride results in decreased expression of PTK2B mRNAdecreases expression 17175027
C511689 (N)-methanocarba-2MeSADP Calcium affects the reaction [(N)-methanocarba-2MeSADP results in increased phosphorylation of PTK2B protein]affects reaction|increases phosphorylation 16236484
C511689 (N)-methanocarba-2MeSADP IGF1 protein affects the reaction [(N)-methanocarba-2MeSADP results in increased phosphorylation of PTK2B protein]affects reaction|increases phosphorylation 16236484
C511689 (N)-methanocarba-2MeSADP (N)-methanocarba-2MeSADP results in increased phosphorylation of PTK2B proteinincreases phosphorylation 16236484
C511689 (N)-methanocarba-2MeSADP PLD2 protein affects the reaction [(N)-methanocarba-2MeSADP results in increased phosphorylation of PTK2B protein]affects reaction|increases phosphorylation 16236484
D011189 Potassium Chloride 1-Butanol inhibits the reaction [Potassium Chloride results in increased phosphorylation of PTK2B protein]decreases reaction|increases phosphorylation 18004999
D011189 Potassium Chloride CAMK2D protein affects the reaction [Potassium Chloride results in increased phosphorylation of PTK2B protein]affects reaction|increases phosphorylation 18004999
D011189 Potassium Chloride PLD2 protein promotes the reaction [Potassium Chloride results in increased phosphorylation of PTK2B protein]increases phosphorylation|increases reaction 18004999
D011189 Potassium Chloride Potassium Chloride results in increased phosphorylation of PTK2B proteinincreases phosphorylation 18004999
C017947 sodium arsenite sodium arsenite promotes the reaction [Ethanol results in increased phosphorylation of PTK2B protein]increases phosphorylation|increases reaction 18182400
C017947 sodium arsenite sodium arsenite results in increased expression of PTK2B proteinincreases expression 19072884
D013629 Tamoxifen Tamoxifen results in decreased expression of PTK2B mRNAdecreases expression 15590111
D013755 Tetradecanoylphorbol Acetate Tetradecanoylphorbol Acetate results in increased phosphorylation of and results in increased activity of PTK2B proteinincreases activity|increases phosphorylation 16877402
D014212 Tretinoin Tretinoin results in increased expression of PTK2B mRNAincreases expression 16140955
D014635 Valproic Acid [Hydralazine co-treated with Valproic Acid] results in increased expression of PTK2B mRNAaffects cotreatment|increases expression 17183730
D014750 Vincristine Vincristine results in increased phosphorylation of PTK2B proteinincreases phosphorylation 11478917
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.2214745880
MESH:D000014 Abnormalities, Drug-Induced Ethanol 7.6317676605 18926900
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 7.638875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 3.6419490988
MESH:D000138 Acidosis Ammonium Chloride 9.3818287403
MESH:D000138 Acidosis Ethanol 9.3811192467
MESH:D000230 Adenocarcinoma Doxorubicin 4.8117418594
MESH:D000230 Adenocarcinoma Vincristine 4.8119825857
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.563712494
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.3715276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 4.5716712894 17306315
MESH:D000419 Albuminuria Doxorubicin 4.2321441931
MESH:D020268 Alcohol-Induced Disorders, Nervous System Ethanol 4.9915451040 15451039
MESH:D000505 Alopecia Tretinoin 3.3615955085
MESH:D000550 Amblyopia Valproic Acid 4.9017688650
MESH:D000756 Anemia, Sideroblastic Manganese 10.0616910769
MESH:D000756 Anemia, Sideroblastic manganese chloride 10.0616910769
MESH:D000853 Anophthalmos Ethanol 4.5015513904
MESH:D001008 Anxiety Disorders Ethanol 8.1411141031
MESH:D001008 Anxiety Disorders Valproic Acid 8.1417497229
MESH:D001169 Arthritis, Experimental Dexamethasone 6.8617659584
MESH:D001169 Arthritis, Experimental Tretinoin 6.8616412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.1916292516
MESH:D001249 Asthma Tretinoin 2.2416456186
MESH:D001259 Ataxia 1-Butanol 5.287820390
MESH:D050197 Atherosclerosis 7-ketocholesterol 4.7116632123
MESH:D001321 Autistic Disorder Valproic Acid 2.0418177632 18985861 17507914 19232924 17157402 20603192 18396377 18558336 18775368 19460635 18940202 15238991 17688650 18316065 16609825
MESH:D001471 Barrett Esophagus Tretinoin 4.0916935849
MESH:D001528 Behcet Syndrome Colchicine 5.7915870978
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 4.6911289319 1440618
MESH:D001714 Bipolar Disorder Valproic Acid 2.9117594078 20046352
MESH:D001778 Blood Coagulation Disorders Tretinoin 3.3216206674 16197459
MESH:D001848 Bone Diseases, Developmental Valproic Acid 3.198888407
MESH:D019046 Bone Marrow Neoplasms Doxorubicin 4.3714601052
MESH:D001919 Bradycardia Carbachol 5.5812411408
MESH:D001932 Brain Neoplasms Doxorubicin 3.5317150277
MESH:D001943 Breast Neoplasms Acrylamide 1.9918183576 16253758
MESH:D001943 Breast Neoplasms Doxorubicin 1.9916115903 15939500 17369602 16264153 19526202 17426702 17983394 16595493 11325840 16096432 15692762 16322301 15994142 15567936 16826403 15136595 18382427 18695136 15668708 16935488 18234424 18628466 15993339 15634643
MESH:D001943 Breast Neoplasms Tamoxifen 1.9920544844 19244106 11161223 19059307 19115204 18855134 19189212 17242785 19288272 16873071 19221464 20859285 15565566 19289846 18815881 16273361 19487384 19103187 19155303 18425577 20135344 18984771 17049068 16202921 17893378 21138602 17261762 18997820 20390343 18821012 18629630 20005174 19011961 19410462 15668708 20065188 19084267 21152245 19189210 17440819 19142967 19200415 19066611 18351453 16818667
MESH:D001943 Breast Neoplasms Tretinoin 1.9916443354 16166294 16873071
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.2616813970
MESH:D002056 Burns Ethanol 4.3316374292
MESH:D002276 Carcinoid Tumor Doxorubicin 4.4816051944
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.1919066611
MESH:D018236 Carcinoma, Embryonal Tretinoin 4.8316168501
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 13.1816705839
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 13.183581430 7296757
MESH:D006528 Carcinoma, Hepatocellular Doxorubicin 13.1818059187 17876044 16023760 16234567
MESH:D006528 Carcinoma, Hepatocellular Ethanol 13.1815289165 15763234 18788625
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 13.1817306315 15276417 16507464
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 13.1816924424
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 13.181917145
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 10.067296757
MESH:D002292 Carcinoma, Renal Cell Doxorubicin 10.0616201981 1485588
MESH:D002292 Carcinoma, Renal Cell Vincristine 10.0616201981
MESH:D002294 Carcinoma, Squamous Cell Doxorubicin 13.286189445
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 13.2818572023
MESH:D002294 Carcinoma, Squamous Cell Tetradecanoylphorbol Acetate 13.2818922899
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 13.2816096774 16051514
MESH:D002294 Carcinoma, Squamous Cell Vincristine 13.286189445
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.3317572228
MESH:D006332 Cardiomegaly Ethanol 3.2619332462
MESH:D009202 Cardiomyopathies Doxorubicin 3.3217928571 17329180 17519947 15505089 17382496 15811867 16952015 18627295 16612575 17131338 17308081 16731534 17974986 15792986 16278810 17351982 16455267 16651473 15476868 16364871 16242529 16269455 17007740 16109756 17924179
MESH:D002311 Cardiomyopathy, Dilated Doxorubicin 2.8317334414 16243910
MESH:D002318 Cardiovascular Diseases Hydrogen Peroxide 3.2916936243
MESH:D002386 Cataract Tretinoin 2.9017460283
MESH:D002418 Cattle Diseases Acrylamide 5.1212510666
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 9.916135515
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 9.917505956
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 9.9119524636 20056578
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.2616129372
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.5920734317
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 2.9119486331 9022650
MESH:D002822 Choriocarcinoma Tretinoin 4.8316461808
MESH:D002971 Cleft Lip Ethanol 3.4115513904
MESH:D002972 Cleft Palate Ethanol 5.6915513904
MESH:D002972 Cleft Palate Tretinoin 5.699407595
MESH:D003092 Colitis Tretinoin 3.3917035595
MESH:D003110 Colonic Neoplasms Dexamethasone 2.4415824018
MESH:D015179 Colorectal Neoplasms Doxorubicin 2.1418802399 18259882
MESH:D019465 Craniofacial Abnormalities Dexamethasone 5.1417728286
MESH:D019465 Craniofacial Abnormalities Ethanol 5.1410194807 19302082 15451040 15451039 15513904 11198716 11873399
MESH:D019465 Craniofacial Abnormalities Tretinoin 5.149224671 9125849 9211117 9664655 17551590 14991402 10589399 8800419 9142499 16925845
MESH:D019465 Craniofacial Abnormalities Valproic Acid 5.1417688650 16575769 8888407
MESH:D003490 Cyanosis 2,6-dinitrotoluene 3.7018551238
MESH:D003711 Demyelinating Diseases Tamoxifen 4.0419031437
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 6.0118759878 11298694 8970840 11906362 14531868 8156756 2524372 12868966
MESH:D017449 Dermatitis, Allergic Contact Dexamethasone 6.0112438553
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.193621924 2952479
MESH:D003928 Diabetic Nephropathies Tamoxifen 3.2119279558
MESH:D003967 Diarrhea Dexamethasone 3.407237001
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 10.9218551238 21346803
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 10.9218289764 1440618 11289319 6679447 6482804 9328219 9653073 8291058 18648102 16192314 18692083 7440962 9022650
MESH:D056486 Drug-Induced Liver Injury Doxorubicin 10.9217416283
MESH:D056486 Drug-Induced Liver Injury Ethanol 10.9211566570
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 10.9219641884 1733752
MESH:D004362 Drug Toxicity Doxorubicin 3.4318602426
MESH:D004421 Dystonia Valproic Acid 3.751851702
MESH:D004485 Eczema Dexamethasone 4.1512438553
MESH:D004487 Edema Dexamethasone 6.3919703484
MESH:D004487 Edema Tetradecanoylphorbol Acetate 6.398273558 8113982 15177302 7812673 11698051 16716910 9599246
MESH:D004489 Edema, Cardiac Tretinoin 4.1418230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 3.2319031437
MESH:D016889 Endometrial Neoplasms Doxorubicin 11.2617359293
MESH:D016889 Endometrial Neoplasms Tamoxifen 11.2619155303 20544844 17893378 16202921
MESH:D016889 Endometrial Neoplasms Tretinoin 11.2616569247
MESH:D004719 Endomyocardial Fibrosis Doxorubicin 4.8318037988
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 3.843659116 17275665
MESH:D004828 Epilepsies, Partial Valproic Acid 3.593922381 16628512
MESH:D004827 Epilepsy Valproic Acid 2.7720417680 18234410
MESH:D004832 Epilepsy, Absence Valproic Acid 3.326426943 7562514 6254150
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 3.987750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 3.743659116
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 4.333581430
MESH:D004938 Esophageal Neoplasms Ethanol 4.3316704527
MESH:D005124 Eye Abnormalities Tretinoin 3.349664655 16938888
MESH:D005234 Fatty Liver Ethanol 11.5616409862 19236843 18620774
MESH:D005234 Fatty Liver Tamoxifen 11.5614986274 19224547
MESH:D005234 Fatty Liver Valproic Acid 11.5614986274 19224547
MESH:D005235 Fatty Liver, Alcoholic Ethanol 5.3317920746
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.0416709447
MESH:D005310 Fetal Alcohol Syndrome Ethanol 4.9716946407 15513904 10194807 15451040
MESH:D005315 Fetal Diseases Valproic Acid 4.5616575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 3.828888407 18558336
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 4.696705139
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.2014745880
MESH:D018222 Fibromatosis, Aggressive Doxorubicin 10.3519069698
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 10.3519069698
MESH:D005355 Fibrosis Tretinoin 3.2017994277
MESH:D005756 Gastritis Ethanol 4.3615046732
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.3516452187
MESH:D005909 Glioblastoma Doxorubicin 10.7917150277
MESH:D005909 Glioblastoma Manganese 10.7917043766
MESH:D005909 Glioblastoma Tretinoin 10.7917312396
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 3.747505956
MESH:D006258 Head and Neck Neoplasms Doxorubicin 7.1215692506
MESH:D006258 Head and Neck Neoplasms Tretinoin 7.1216096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 4.8316084493
MESH:D006330 Heart Defects, Congenital Tretinoin 2.729664655 14991402
MESH:D006331 Heart Diseases Doxorubicin 3.2617875725 18674790 14766674 16707910 16495754 16144979 16244372 17888722 16879835 12587719 18006777 16330681 16244371
MESH:D006333 Heart Failure Doxorubicin 3.1417481944
MESH:D006394 Hemangiosarcoma Doxorubicin 3.6115692506
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.216705139
MESH:D006548 Hernia, Diaphragmatic Dexamethasone 2.957520565
MESH:D006689 Hodgkin Disease Doxorubicin 10.9118501091 15147373 17606976
MESH:D006689 Hodgkin Disease sodium arsenite 10.9112676792
MESH:D006689 Hodgkin Disease Vincristine 10.9117606976 16135485 16794504 15147373
MESH:D006849 Hydrocephalus Valproic Acid 4.5417688650
MESH:D006930 Hyperalgesia Ethanol 7.1618783367
MESH:D006930 Hyperalgesia Tretinoin 7.1616870215
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.2516778211
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 10.0715034207
MESH:D006965 Hyperplasia halofuginone 10.0711874485
MESH:D006973 Hypertension Dexamethasone 2.8117042910
MESH:D046110 Hypertension, Pregnancy-Induced Hydralazine 4.3116612254
MESH:D007247 Infertility, Female Acrylamide 4.9111020651
MESH:D007248 Infertility, Male Acrylamide 6.5615749267 15355880 12507653 11020651
MESH:D007248 Infertility, Male sodium arsenite 6.5612646999 15346721
MESH:D007249 Inflammation Dexamethasone 10.6211099482 8960868
MESH:D007249 Inflammation Flavonoids 10.6217296493
MESH:D007249 Inflammation Tamoxifen 10.6219457130
MESH:D007249 Inflammation Tetradecanoylphorbol Acetate 10.6215177302 7562506 7812673 11698051 8273558
MESH:D007410 Intestinal Diseases Tretinoin 3.4517994277
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 4.699022650 8074119
MESH:D007569 Jaw Abnormalities Ethanol 9.3615513904
MESH:D007569 Jaw Abnormalities Tretinoin 9.3617551590 15992940
MESH:D007674 Kidney Diseases Doxorubicin 5.6515699352 16775033 15369732
MESH:D007674 Kidney Diseases sodium arsenite 5.6520008137
MESH:D007676 Kidney Failure, Chronic Doxorubicin 9.1616707910
MESH:D007676 Kidney Failure, Chronic Hydrogen Peroxide 9.1616518626
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 10.8916705839
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 10.896582329
MESH:D007680 Kidney Neoplasms Tamoxifen 10.8918625569
MESH:D007683 Kidney Tubular Necrosis, Acute Calcium 4.7116316344
MESH:D007859 Learning Disorders Colchicine 9.2611749816
MESH:D007859 Learning Disorders Ethanol 9.2615451040
MESH:D007938 Leukemia Tretinoin 2.6117143497
MESH:D004915 Leukemia, Erythroblastic, Acute Doxorubicin 4.8316085563
MESH:D007951 Leukemia, Myeloid Tretinoin 3.4116932348 19285840 16482212
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 3.6717596541 16294345 19850784
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 3.6716294345 17596541
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 2.9419642359 17712046 19035177 17294898 17368321 16891316 17217047 19029980 17339181 12679006 17107899 17649720 16140955 19225113 16935935 16823087 17301526 17506722 16331271 17361223 15748426 9834237 16766008 16788101 19075265
MESH:D017880 Limb Deformities, Congenital Ethanol 7.5517676605
MESH:D017880 Limb Deformities, Congenital Tretinoin 7.559224671
MESH:D008064 Lipidoses Tamoxifen 2.9315342952 17567588
MESH:D008103 Liver Cirrhosis Ethanol 6.6615289165
MESH:D008103 Liver Cirrhosis halofuginone 6.6617180598
MESH:D008104 Liver Cirrhosis, Alcoholic Ethanol 4.7718295389
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 2.999327722 15034207
MESH:D008106 Liver Cirrhosis, Experimental Dexamethasone 8.1616718785
MESH:D008106 Liver Cirrhosis, Experimental Doxorubicin 8.1616595196 16439617
MESH:D008106 Liver Cirrhosis, Experimental Ethanol 8.1618166357
MESH:D008106 Liver Cirrhosis, Experimental halofuginone 8.1612175628 11172339 14739098 18458672 16489207
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 8.1618564211
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 8.1618397230 16248980
MESH:D008108 Liver Diseases, Alcoholic Ethanol 4.3317207112 17347304
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 6.727678174
MESH:D008113 Liver Neoplasms sodium arsenite 6.7216712894 15276417
MESH:D008113 Liver Neoplasms Tamoxifen 6.7216684651
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 8.716135515 2876784 2876786
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 8.71598648 1399818 3712494 6587162
MESH:D008114 Liver Neoplasms, Experimental Doxorubicin 8.7117085340 16842330
MESH:D008171 Lung Diseases sodium arsenite 2.9619095001
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 3.9317228818
MESH:D008175 Lung Neoplasms Dexamethasone 7.9915824018 11195469
MESH:D008175 Lung Neoplasms Doxorubicin 7.996189445 17418594
MESH:D008175 Lung Neoplasms sodium arsenite 7.9919931552 17077188 15276417 17306315 16712894
MESH:D008175 Lung Neoplasms Tamoxifen 7.9918625569
MESH:D008175 Lung Neoplasms Tetradecanoylphorbol Acetate 7.9911807781
MESH:D008175 Lung Neoplasms Vincristine 7.996189445 19825857
MESH:D008223 Lymphoma Doxorubicin 3.2316098063
MESH:D008228 Lymphoma, Non-Hodgkin Doxorubicin 3.5317654614
MESH:D016399 Lymphoma, T-Cell Doxorubicin 4.2515621674
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.4419428831
MESH:D008325 Mammary Neoplasms, Experimental Doxorubicin 8.8915458769
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 8.8919196723 14580682 19196722 11731420 16827153
MESH:D008325 Mammary Neoplasms, Experimental Tetradecanoylphorbol Acetate 8.898985016
MESH:D020149 Manganese Poisoning Manganese 11.9219453300 16568477 16551646
MESH:D020149 Manganese Poisoning Tamoxifen 11.9219453300
MESH:D008527 Medulloblastoma Tretinoin 2.6517453147
MESH:D008545 Melanoma marker/mechanism 19718025
MESH:D008545 Melanoma Doxorubicin 6.7716827129
MESH:D008545 Melanoma sodium arsenite 6.7719082730 16487513
MESH:D008545 Melanoma Tamoxifen 6.7719393235 12393984
MESH:D008545 Melanoma Tretinoin 6.7716752155
MESH:D018328 Melanoma, Amelanotic Tamoxifen 10.7915990972
MESH:D018328 Melanoma, Amelanotic Vincristine 10.7915990972
MESH:D008569 Memory Disorders Ethanol 3.8815451040 18411066
MESH:D008591 Meningomyelocele Tretinoin 4.1116940565
MESH:D008654 Mesothelioma Doxorubicin 2.9317638057
MESH:D008881 Migraine Disorders Valproic Acid 2.9618803445 18765137
MESH:D028361 Mitochondrial Diseases Doxorubicin 4.2115792986
MESH:D009069 Movement Disorders Manganese 4.7116551646
MESH:D052016 Mucositis Doxorubicin 4.4617415656
MESH:D009101 Multiple Myeloma Dexamethasone 3.2815867202 15744524 16118317
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 3.748888407
MESH:D009190 Myelodysplastic Syndromes Dexamethasone 11.289809623
MESH:D009190 Myelodysplastic Syndromes Tretinoin 11.2817596541
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 11.2817596541
MESH:D009203 Myocardial Infarction Doxorubicin 5.9819429709 15857846
MESH:D009203 Myocardial Infarction Vincristine 5.9817284715
MESH:D009336 Necrosis 2,6-dinitrotoluene 3.547678174 18551238
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 8.723581430
MESH:D009362 Neoplasm Metastasis Doxorubicin 8.7218259882
MESH:D009362 Neoplasm Metastasis Tamoxifen 8.7219393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.4119410462
MESH:D009369 Neoplasms sodium arsenite 4.5711559025
MESH:D009369 Neoplasms Tretinoin 4.5716594593 16946489
MESH:D009374 Neoplasms, Experimental sodium arsenite 3.3520056578
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 3.6719196722 19189210 19200415
MESH:D009401 Nephrosis Doxorubicin 4.4516899518 16636307
MESH:D009404 Nephrotic Syndrome Doxorubicin 3.7315640375 16889571
MESH:D009410 Nerve Degeneration Acrylamide 8.3312387366 11264303 12387367
MESH:D009410 Nerve Degeneration Manganese 8.3316551646
MESH:D009422 Nervous System Diseases Acrylamide 4.7112507653 12164553
MESH:D009421 Nervous System Malformations Tretinoin 3.479125849
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 15.586679447
MESH:D009436 Neural Tube Defects sodium arsenite 15.5812854658
MESH:D009436 Neural Tube Defects Tretinoin 15.589142499
MESH:D009436 Neural Tube Defects Valproic Acid 15.5816359493 8888407
MESH:D009447 Neuroblastoma Doxorubicin 3.0915555623
MESH:D017599 Neuroectodermal Tumors Vincristine 5.3812837982
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 7.9516049721
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 7.956482804 4026338
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 4.693988306
MESH:D010024 Osteoporosis Calcium 3.5817882678
MESH:D012516 Osteosarcoma Doxorubicin 3.8615930896
MESH:D010051 Ovarian Neoplasms sodium arsenite 4.5217306315 15276417
MESH:D010051 Ovarian Neoplasms Tretinoin 4.5216936753
MESH:D010146 Pain Tretinoin 2.6516870215
MESH:D010190 Pancreatic Neoplasms Ethanol 8.0512384795
MESH:D010190 Pancreatic Neoplasms Tetradecanoylphorbol Acetate 8.0515976015
MESH:D010190 Pancreatic Neoplasms Tretinoin 8.0515976015
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 13.797296757
MESH:D010212 Papilloma Hydrogen Peroxide 13.7912065085
MESH:D010212 Papilloma Tetradecanoylphorbol Acetate 13.7912065085 8330346 18922899 18404319
MESH:D010300 Parkinson Disease Manganese 3.2511181820
MESH:D020734 Parkinsonian Disorders Manganese 4.1916140633
MESH:D010523 Peripheral Nervous System Diseases Acrylamide 4.8011510240
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.146228378
MESH:D003557 Phyllodes Tumor Doxorubicin 4.8317983394
MESH:D010997 Pleural Neoplasms Doxorubicin 4.8317638057
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Dexamethasone 7.5021297632
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Vincristine 7.5021297632
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 3.5120603192
MESH:D011471 Prostatic Neoplasms Doxorubicin 2.7116888761 16868541 16729912 15749863 18437689 15897917
MESH:D011471 Prostatic Neoplasms sodium arsenite 2.7116039940
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.7115067354
MESH:D011507 Proteinuria Tretinoin 3.3116636307
MESH:D019310 Pseudolymphoma Valproic Acid 4.2112752131 11422049
MESH:D011625 Pterygium Tretinoin 4.4716723453
MESH:D051437 Renal Insufficiency Doxorubicin 3.9017922066
MESH:D012128 Respiratory Distress Syndrome, Adult Dexamethasone 3.7211700416 18379247
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.143692021
MESH:D012208 Rhabdomyosarcoma Tretinoin 9.8616116481 16283617
MESH:D012208 Rhabdomyosarcoma Valproic Acid 9.8619155313
MESH:D012509 Sarcoma Doxorubicin 3.7116767912 17710206 17203757 18313854 15625365 15675481
MESH:D012512 Sarcoma, Ewing's Doxorubicin 3.9314601052 16326096
MESH:D012514 Sarcoma, Kaposi Doxorubicin 4.4617846226
MESH:D012559 Schizophrenia Valproic Acid 2.0315737665 19110320
MESH:D012640 Seizures 2,6-dinitrotoluene 8.6218551238
MESH:D012640 Seizures Ethanol 8.629754883
MESH:D012640 Seizures Valproic Acid 8.6214763951 11738929 11044598 15475178 1511512 17978042 16876388 3137016
MESH:D012871 Skin Diseases halofuginone 3.4311874485
MESH:D012878 Skin Neoplasms marker/mechanism 19718025
MESH:D012878 Skin Neoplasms Doxorubicin 16.2815692506
MESH:D012878 Skin Neoplasms Hydrogen Peroxide 16.2812065085
MESH:D012878 Skin Neoplasms sodium arsenite 16.2818572023 19524636
MESH:D012878 Skin Neoplasms Tetradecanoylphorbol Acetate 16.2811807781 8985016 12065085 18404319 8330346
MESH:D012878 Skin Neoplasms Tretinoin 16.2816467112
MESH:D012983 Soft Tissue Neoplasms Doxorubicin 4.2517203757 15625365 16767912
MESH:D013088 Spermatocele Tamoxifen 3.9616709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 3.7119457130
MESH:D016135 Spinal Dysraphism sodium arsenite 8.7212854658
MESH:D016135 Spinal Dysraphism Valproic Acid 8.7219490988
MESH:D013226 Status Epilepticus Valproic Acid 4.2112833885
MESH:D013272 Stomach Diseases Dexamethasone 4.0015472012
MESH:D013274 Stomach Neoplasms Ethanol 2.5318456281
MESH:D013274 Stomach Neoplasms Tretinoin 2.5317261132
MESH:D013276 Stomach Ulcer Dexamethasone 6.6015138204
MESH:D013276 Stomach Ulcer Ethanol 6.6011906479 16755016 17918041 17189318 9211565 9562338
MESH:D013375 Substance Withdrawal Syndrome Ethanol 3.979754883
MESH:D015173 Supratentorial Neoplasms Vincristine 5.5512837982
MESH:D013733 Testicular Diseases Acrylamide 4.9015864552
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 15.186582329 1399818 3712494 6587162 7505956
MESH:D013964 Thyroid Neoplasms 4-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo(3,4-d)pyrimidine 15.1816940797
MESH:D013964 Thyroid Neoplasms Doxorubicin 15.1816010429 17909728
MESH:D013964 Thyroid Neoplasms Tretinoin 15.1816026305 17045167
MESH:D014062 Tongue Neoplasms Tretinoin 3.5116051514
MESH:D014178 Translocation, Genetic Valproic Acid 4.9017262798
MESH:D014376 Tuberculosis Tretinoin 3.0316040207
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.193119515
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 14.3816049721
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 14.388074119
MESH:D001749 Urinary Bladder Neoplasms Doxorubicin 14.3817653716
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 14.3816712894 11723127 17306315 16452187
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 14.3817572228 8653321 16712894
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.328888407
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 3.9910091137
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 8.4811813266
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 8.4816129372
MESH:D014604 Uveal Neoplasms Tretinoin 4.2816752155
MESH:D014605 Uveitis Dexamethasone 4.491336536
MESH:D014652 Vascular Diseases sodium arsenite 4.1017056641
MESH:D018487 Ventricular Dysfunction, Left Doxorubicin 3.9016364871 17678736 17638931 17334414
MESH:D014820 Vitiligo Tretinoin 3.7516761959
MESH:D009396 Wilms Tumor Tretinoin 3.6916287080
MESH:D014947 Wounds and Injuries lysophosphatidic acid 5.0415541073
Pathway ID Pathway Name
KEGG:04020 Calcium signaling pathway
REACT:20676 Cell junction organization
KEGG:04062 Chemokine signaling pathway
KEGG:04912 GnRH signaling pathway
REACT:23853 Interactions of the immunoglobulin superfamily (IgSF) member proteins
KEGG:04670 Leukocyte transendothelial migration
KEGG:04650 Natural killer cell mediated cytotoxicity
REACT:6900 Signaling in Immune system
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA33956
    • No data
    Releated disease ID Related disease Name
    PA444552Hypertension
    Releated drug ID Related drug Name
    PA449092colchicine
    PA449396dopamine
    PA451578tacrolimus
    PA448478l-arginine
    PA450635nitric oxide
    PA449167cyclosporine
    PA151917011valinomycin
    PA448948chloroquine
    PA452347glucocorticoids
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB01097 antagonist Leflunomide Antineoplastic Agents;Antirheumatic Agents;Antiviral Agents;Anti-inflammatory Agents;Enzyme Inhibitors;Immunosuppressive Agents;Antiparasitic Agents;Adjuvants
    DB01645 - Genistein Antineoplastic Agents;Enzyme Inhibitors;Growth Inhibitors;Anticarcinogenic Agents;Protein Kinase Inhibitors;Phytoestrogens
    DB08341 - 4-{[4-{[(1R,2R)-2-(dimethylamino)cyclopentyl]amino}-5-(trifluoromethyl)pyrimidin-2-yl]amino}-N-methylbenzenesulfonamide
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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