AutismKB 2.0

Annotation Detail for FBLN1


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Basic Information Top
Gene Symbol:FBLN1 ( FBLN,FIBL1 )
Gene Full Name: fibulin 1
Band: 22q13.31
Quick LinksEntrez ID:2192; OMIM: 135820; Uniprot ID:FBLN1_HUMAN; ENSEMBL ID: ENSG00000077942; HGNC ID: 3600
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1858Hemorrhagic disorder
1864Fibroid tumor
1944Breast cancer
2053Colon cancer
2178Retinal disease
No data
No data
Desease Name
Synpolydactyly, 3/3'4, associated with metacarpal and metatarsal synostoses
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene results in decreased expression of FBLN1 mRNAdecreases expression 20406850
C075773 4-phenylbutyric acid 4-phenylbutyric acid results in increased expression of FBLN1 mRNAincreases expression 14583596
D000082 Acetaminophen Acetaminophen affects the expression of FBLN1 mRNAaffects expression 17562736
D015124 8-Bromo Cyclic Adenosine Monophosphate 8-Bromo Cyclic Adenosine Monophosphate results in increased expression of FBLN1 mRNAincreases expression 15774544
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in decreased expression of FBLN1 mRNAdecreases expression 15336504
D004052 Diethylnitrosamine Diethylnitrosamine results in increased expression of FBLN1 mRNAincreases expression 17854601
D004052 Diethylnitrosamine RB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of FBLN1 mRNA]decreases reaction|increases expression 17854601
D004317 Doxorubicin Doxorubicin affects the expression of FBLN1 mRNAaffects expression 15205334
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of FBLN1 mRNAincreases expression 17606305
D005472 Fluorouracil Fluorouracil affects the expression of FBLN1 mRNAaffects expression 15205334
D005472 Fluorouracil Fluorouracil results in increased expression of FBLN1 mRNAincreases expression 17039268
D017258 Medroxyprogesterone Acetate Medroxyprogesterone Acetate results in increased expression of FBLN1 mRNAincreases expression 15774544
D017258 Medroxyprogesterone Acetate Medroxyprogesterone Acetate results in increased expression of FBLN1 proteinincreases expression 15774544
D017258 Medroxyprogesterone Acetate Mifepristone inhibits the reaction [Medroxyprogesterone Acetate results in increased expression of FBLN1 mRNA]decreases reaction|increases expression 15774544
D015735 Mifepristone Mifepristone inhibits the reaction [Medroxyprogesterone Acetate results in increased expression of FBLN1 mRNA]decreases reaction|increases expression 15774544
D015735 Mifepristone Mifepristone results in decreased expression of FBLN1 mRNAdecreases expression 17584828
D010634 Phenobarbital NR1I3 protein affects the reaction [Phenobarbital results in increased expression of FBLN1 mRNA]affects reaction|increases expression 19482888
D010634 Phenobarbital Phenobarbital results in increased expression of FBLN1 mRNAincreases expression 19482888
C006253 pirinixic acid pirinixic acid results in decreased expression of FBLN1 mRNAdecreases expression 17426115
D011374 Progesterone Progesterone results in increased expression of FBLN1 mRNAincreases expression 15774544
D012643 Selenium Selenium results in increased expression of FBLN1 mRNAincreases expression 19244175
C017947 sodium arsenite sodium arsenite results in decreased expression of FBLN1 mRNAdecreases expression 18812580
D014212 Tretinoin Tretinoin results in increased expression of FBLN1 mRNAincreases expression 16604517
D014810 Vitamin E Vitamin E results in increased expression of FBLN1 mRNAincreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 3.416195326
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.9117505938
MESH:D055371 Acute Lung Injury pirinixic acid 3.0818653653
MESH:D000230 Adenocarcinoma Doxorubicin 7.0617418594
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 7.0614692618
MESH:D000230 Adenocarcinoma Fluorouracil 7.0617638652
MESH:D000236 Adenoma Diethylnitrosamine 2.8210737359 6695378
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 17.1616434500 19061943 17162532 17620307 18056438 19052882
MESH:D018248 Adenoma, Liver Cell Phenobarbital 17.1617620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 17.1616434500
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.6715276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 4.8716712894 17306315
MESH:D000419 Albuminuria Doxorubicin 4.5021441931
MESH:D000505 Alopecia Tretinoin 3.5815955085
MESH:D000740 Anemia Fluorouracil 3.6716511603 15504547 17963324
MESH:D000799 Angioedema Acetaminophen 3.8110982225
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.4211256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 7.1115885639
MESH:D001169 Arthritis, Experimental Tretinoin 7.1116412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.2516292516
MESH:D001249 Asthma Tretinoin 2.3316456186
MESH:D001321 Autistic Disorder Acetaminophen 1.4218445737
MESH:D001471 Barrett Esophagus Tretinoin 4.3616935849
MESH:D001778 Blood Coagulation Disorders pirinixic acid 8.8419483382
MESH:D001778 Blood Coagulation Disorders Tretinoin 8.8416197459 16206674
MESH:D019046 Bone Marrow Neoplasms Doxorubicin 4.6714601052
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.3117868700
MESH:D001930 Brain Injuries Progesterone 4.2215665606 15380490 15845082
MESH:D001932 Brain Neoplasms Doxorubicin 3.7717150277
MESH:D001943 Breast Neoplasms Diethylnitrosamine 2.3417474063
MESH:D001943 Breast Neoplasms Doxorubicin 2.3415136595 17426702 18628466 16826403 16264153 15993339 15939500 16595493 18695136 16322301 16096432 18234424 19526202 15994142 15692762 15567936 17983394 16115903 15634643 15668708 11325840 16935488 18382427 17369602
MESH:D001943 Breast Neoplasms Fluorouracil 2.3418357371 16557594 15136595 16595493 19217205 18608205 16110121
MESH:D001943 Breast Neoplasms Progesterone 2.3417614352 15562024 16175315
MESH:D001943 Breast Neoplasms Tretinoin 2.3416443354 16873071 16166294
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.5516813970
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 3.8916050911
MESH:D002276 Carcinoid Tumor Doxorubicin 12.2616051944
MESH:D002276 Carcinoid Tumor Fluorouracil 12.2616051944
MESH:D002277 Carcinoma Fluorouracil 3.5317121937
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.1316168501
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 16.8416705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 16.843084413
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 16.8417162532 16878318 16830150 19418558 19335982 20727157 19383236 20514400 20524982 18788625 21159647 10737359 20432363 20512989 16698587 18971187 19519916 18665156 20084675 17138121 19701751 16288022 19107877 17761372 16807293 19208518 18691550 19919837 18056438 16328049 18506893 16502159 20101231 19539802 19822196 17055752 16779866 18393292 16540662 10672840 11831363 16569478 20007298 19052882 16681979 17978847 17428255 20214788 18785209 16935385 18494052 18210153 3581430 19171122 19394651 17173139 18978308 3084413 20935162
MESH:D006528 Carcinoma, Hepatocellular Doxorubicin 16.8418059187 16234567 16023760 17876044
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 16.8418930000 16332177 17088986 17971768 16799960 17045692
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 16.846705139 1701930 20935162 17173139 20007298
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 16.8416507464 17306315 15276417
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 16.841917145
MESH:D002292 Carcinoma, Renal Cell Doxorubicin 6.6116201981 1485588
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 6.6118695887
MESH:D002294 Carcinoma, Squamous Cell Doxorubicin 10.726189445
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 10.7216280240 16757204 17066447 18986760
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 10.7218572023
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 10.7216096774 16051514
MESH:D009202 Cardiomyopathies Doxorubicin 3.5016364871 16455267 17329180 16242529 17351982 17928571 16612575 16952015 16651473 16278810 17131338 17974986 17308081 17924179 17519947 17007740 15476868 16109756 18627295 15505089 16731534 17382496 16269455 15811867 15792986
MESH:D002311 Cardiomyopathy, Dilated Doxorubicin 2.9316243910 17334414
MESH:D002386 Cataract Acetaminophen 7.1410977129
MESH:D002386 Cataract Tretinoin 7.1417460283
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 11.046135515
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 11.047505956 17174075 21159647 2727394
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 11.0420056578 19524636
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.214080065
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.5516129372
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 3.6519052882
MESH:D002779 Cholestasis Ethinyl Estradiol 7.6317681005 17333356 16105132 15861022 16919318 11677210 17110522
MESH:D002779 Cholestasis pirinixic acid 7.6319176532
MESH:D002822 Choriocarcinoma Tretinoin 5.1316461808
MESH:D002972 Cleft Palate Tretinoin 2.659407595
MESH:D003092 Colitis Selenium 9.3717936198
MESH:D003092 Colitis Tretinoin 9.3717035595
MESH:D003110 Colonic Neoplasms Fluorouracil 2.2316340194 15001691 17172411 16510598 18772588 17725105 17287894 17016597 17169374 17018589
MESH:D015179 Colorectal Neoplasms Doxorubicin 2.6418259882 18802399
MESH:D015179 Colorectal Neoplasms Fluorouracil 2.6414970324 16331619 18288408 16282729 17255274 16303861 15289873 16524972 18949393 17454858 17094418 18509181 17594712 17401013 18448328 18383874 15148649 17695437 16391804 18802399 17016601 20501625
MESH:D019465 Craniofacial Abnormalities Tretinoin 2.689224671 9664655 9142499 9125849 14991402 17551590 9211117 10589399 8800419 16925845
MESH:D019465 Craniofacial Abnormalities Vitamin E 2.6819769572
MESH:D003490 Cyanosis 2,6-dinitrotoluene 3.9818551238
MESH:D007644 Darier Disease Fluorouracil 4.7616733453
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4018249437
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 2.1820387270
MESH:D003929 Diabetic Neuropathies Progesterone 4.4517187935
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 11.8921346803 18551238
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 11.8911529661 19923254 12392966 2444490 16393943 17906064 18713872 17522070 19370779 10915739 19420014 16081117 17562736 11421492 10663392 19085960 16485898 14725611 19164858 16781746 12594235 12705907 12153990 11287661 10774834 12958197 15619225 16109766 19416960 16227642 11461765 15968718 14550746 19739265 11739529 16177239 12540782 11834606 11743745 14986274 18071297
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 11.8919107877
MESH:D056486 Drug-Induced Liver Injury Doxorubicin 11.8917416283
MESH:D056486 Drug-Induced Liver Injury Selenium 11.8915131321
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.0719426721
MESH:D004362 Drug Toxicity Doxorubicin 3.6418602426
MESH:D004421 Dystonia Phenobarbital 3.961851702
MESH:C538011 Eales disease Vitamin E 4.689068938
MESH:D004487 Edema pirinixic acid 2.4412083418
MESH:D004489 Edema, Cardiac Tretinoin 4.4418230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 8.9012538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 8.9017692515
MESH:D016889 Endometrial Neoplasms Doxorubicin 7.4917359293
MESH:D016889 Endometrial Neoplasms Tretinoin 7.4916569247
MESH:D004715 Endometriosis Mifepristone 9.2916134523
MESH:D004715 Endometriosis Progesterone 9.2916134523
MESH:D004719 Endomyocardial Fibrosis Doxorubicin 5.1318037988
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 4.073659116
MESH:D004828 Epilepsies, Partial Phenobarbital 3.843922381 11558140
MESH:D004827 Epilepsy Phenobarbital 2.8720417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.506401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.217750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 3.983659116
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.0916302075
MESH:D004938 Esophageal Neoplasms Fluorouracil 2.4416481741 16337965 16785472 17638652 15173087
MESH:D005124 Eye Abnormalities Tretinoin 3.549664655 16938888
MESH:D005234 Fatty Liver Diethylnitrosamine 12.8120387270 21071580
MESH:D005234 Fatty Liver Ethinyl Estradiol 12.8115345470
MESH:D005234 Fatty Liver pirinixic acid 12.8120131406 19236843
MESH:D018222 Fibromatosis, Aggressive Doxorubicin 4.5519069698
MESH:D005355 Fibrosis Tretinoin 3.4717994277
MESH:D005756 Gastritis Acetaminophen 3.6516983495
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.6416452187
MESH:D005909 Glioblastoma Doxorubicin 7.1517150277
MESH:D005909 Glioblastoma Tretinoin 7.1517312396
MESH:D005910 Glioma Fluorouracil 2.8516145905
MESH:D006258 Head and Neck Neoplasms Doxorubicin 12.8115692506
MESH:D006258 Head and Neck Neoplasms Fluorouracil 12.8115162350 18337622 15102660
MESH:D006258 Head and Neck Neoplasms Tretinoin 12.8116096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.1316084493
MESH:D006330 Heart Defects, Congenital Tretinoin 6.709664655 14991402
MESH:D006330 Heart Defects, Congenital Vitamin E 6.7016080930
MESH:D006331 Heart Diseases Doxorubicin 3.4514766674 12587719 18006777 16244371 17875725 17888722 16707910 16144979 16879835 16330681 16244372 18674790 16495754
MESH:D006333 Heart Failure Doxorubicin 11.6517481944
MESH:D006333 Heart Failure pirinixic acid 11.6520558911
MESH:D006333 Heart Failure Selenium 11.6517162251
MESH:D006394 Hemangiosarcoma Doxorubicin 3.8615692506
MESH:D006529 Hepatomegaly Phenobarbital 8.3516109766
MESH:D006529 Hepatomegaly pirinixic acid 8.3519772884 16221962 19176532 18467677
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.6916490937 16863852
MESH:D006689 Hodgkin Disease Doxorubicin 7.3518501091 15147373 17606976
MESH:D006689 Hodgkin Disease sodium arsenite 7.3512676792
MESH:D019584 Hot Flashes Vitamin E 3.9414716179
MESH:D006930 Hyperalgesia Acetaminophen 7.5016870215
MESH:D006930 Hyperalgesia Tretinoin 7.5016870215
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.5316778211
MESH:D006943 Hyperglycemia pirinixic acid 3.1420558911
MESH:D007021 Hypospadias Ethinyl Estradiol 3.7716945680 16569931
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.3615869954
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.4212013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 6.5417937319
MESH:D007248 Infertility, Male sodium arsenite 6.5412646999 15346721
MESH:D007249 Inflammation Diethylnitrosamine 5.0918785209
MESH:D007249 Inflammation Progesterone 5.0915869954
MESH:D007251 Influenza, Human Selenium 10.8616624496
MESH:D007251 Influenza, Human Vitamin E 10.8616624496
MESH:D007333 Insulin Resistance pirinixic acid 2.6016306350
MESH:D007410 Intestinal Diseases Tretinoin 3.7317994277
MESH:D007569 Jaw Abnormalities Tretinoin 3.8617551590 15992940
MESH:D007674 Kidney Diseases Acetaminophen 14.2515629191 12587719
MESH:D007674 Kidney Diseases Doxorubicin 14.2515369732 16775033 15699352
MESH:D007674 Kidney Diseases sodium arsenite 14.2520008137
MESH:D007674 Kidney Diseases Vitamin E 14.2512488133
MESH:D007676 Kidney Failure, Chronic Doxorubicin 9.8516707910
MESH:D007676 Kidney Failure, Chronic Selenium 9.8516518626
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 7.3616705839
MESH:D007680 Kidney Neoplasms Fluorouracil 7.3616985049
MESH:D007938 Leukemia Tretinoin 2.7517143497
MESH:D004915 Leukemia, Erythroblastic, Acute Doxorubicin 5.1316085563
MESH:D007951 Leukemia, Myeloid Tretinoin 3.6616932348 16482212 19285840
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.0719850784 16294345 17596541
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.1216331271 17107899 16935935 16891316 15748426 16788101 17301526 19075265 16766008 19035177 17217047 17649720 16140955 17712046 17506722 19642359 19225113 17339181 19029980 17368321 12679006 9834237 16823087 17294898 17361223
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.279224671
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 6.5620032147 19638242 18407596 18665156 18522880
MESH:D008103 Liver Cirrhosis Phenobarbital 6.5621047994
MESH:D008106 Liver Cirrhosis, Experimental Doxorubicin 4.9316439617 16595196
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 4.9315474484
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 4.9318397230 16248980
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 4.9316169303
MESH:D008107 Liver Diseases Acetaminophen 6.4219460945 12587719 12969438 16610002 16611625 11587558 19784758 19014921
MESH:D008107 Liver Diseases Diethylnitrosamine 6.4217034775
MESH:D008107 Liver Diseases Phenobarbital 6.4219363144
MESH:D017114 Liver Failure, Acute Acetaminophen 3.2016871587 17185352
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 17.787678174
MESH:D008113 Liver Neoplasms Diethylnitrosamine 17.7819833225 19812893 20118626 12112319 15885732 19254457 19256749 20137499 18978307 19426721 20583210 21278145 19996281 20101389 9163691 12771043 19642983 20452335 19499222 18648771 10737359 18754104 19255062 18977376 19638242 19690152 2862719 18644402 21047994 15175105 20501860 19294768 16942905 19850985 20405173 19551842 19073162 19090486 19427195 20434301 21071580 2422723 21167192 20492335
MESH:D008113 Liver Neoplasms Fluorouracil 17.7816603448 15113037 17045692 18383874
MESH:D008113 Liver Neoplasms Phenobarbital 17.788742319 19073162 19812893 19482888 15975961 21047994
MESH:D008113 Liver Neoplasms pirinixic acid 17.7820007298 16377806 15890375
MESH:D008113 Liver Neoplasms sodium arsenite 17.7816712894 15276417
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 13.932876786 2876784 6135515
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 13.9318308698 18544905 17174075 18079962 18093689 18775883 18253720 17854601 9362446 2563599 19004024 19539802 16842330 16267830 17942915 19009564 19519916 21159647 18282651 19126423 3124819 18164116
MESH:D008114 Liver Neoplasms, Experimental Doxorubicin 13.9316842330 17085340
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 13.9317172636 2563599 1399818 18308698 6150874
MESH:D008171 Lung Diseases sodium arsenite 7.3419095001
MESH:D008171 Lung Diseases Vitamin E 7.3416863852
MESH:D008175 Lung Neoplasms Diethylnitrosamine 6.5520512841 20970405 6695378 21163286
MESH:D008175 Lung Neoplasms Doxorubicin 6.5517418594 6189445
MESH:D008175 Lung Neoplasms Fluorouracil 6.5515246190
MESH:D008175 Lung Neoplasms sodium arsenite 6.5519931552 17077188 15276417 16712894 17306315
MESH:D008175 Lung Neoplasms Vitamin E 6.5511062179
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 4.7615086387
MESH:D008223 Lymphoma Doxorubicin 3.4316098063
MESH:D008228 Lymphoma, Non-Hodgkin Doxorubicin 3.7517654614
MESH:D016399 Lymphoma, T-Cell Doxorubicin 4.5315621674
MESH:D008325 Mammary Neoplasms, Experimental Doxorubicin 9.8915458769
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 9.8917203775 11408345
MESH:D008325 Mammary Neoplasms, Experimental Selenium 9.8915318939
MESH:D008527 Medulloblastoma Tretinoin 2.7717453147
MESH:D008545 Melanoma Doxorubicin 5.1116827129
MESH:D008545 Melanoma sodium arsenite 5.1116487513 19082730
MESH:D008545 Melanoma Tretinoin 5.1116752155
MESH:D008546 Melanoma, Experimental Acetaminophen 3.5319513568
MESH:D008591 Meningomyelocele Tretinoin 4.3916940565
MESH:D008654 Mesothelioma Doxorubicin 6.2317638057
MESH:D008654 Mesothelioma Selenium 6.2315107826
MESH:D028361 Mitochondrial Diseases Doxorubicin 4.4615792986
MESH:D009062 Mouth Neoplasms Fluorouracil 3.6016757204 18986760
MESH:D052016 Mucositis Doxorubicin 4.7517415656
MESH:D009135 Muscular Diseases pirinixic acid 3.4716239165
MESH:D009190 Myelodysplastic Syndromes Tretinoin 3.0517596541
MESH:D009203 Myocardial Infarction Doxorubicin 5.6519429709 15857846
MESH:D009203 Myocardial Infarction pirinixic acid 5.6519151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 2.9116411023
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.4417484760
MESH:D009336 Necrosis 2,6-dinitrotoluene 3.8318551238 7678174
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 5.829029167 3581430
MESH:D009362 Neoplasm Metastasis Doxorubicin 5.8218259882
MESH:D009369 Neoplasms 4-phenylbutyric acid 15.5319116145
MESH:D009369 Neoplasms Fluorouracil 15.5318600527 16928823 18239605
MESH:D009369 Neoplasms pirinixic acid 15.5317405874
MESH:D009369 Neoplasms sodium arsenite 15.5311559025
MESH:D009369 Neoplasms Tretinoin 15.5316594593 16946489
MESH:D009374 Neoplasms, Experimental sodium arsenite 3.6320056578
MESH:D009401 Nephrosis Doxorubicin 4.7316636307 16899518
MESH:D009404 Nephrotic Syndrome Doxorubicin 3.9616889571 15640375
MESH:D009421 Nervous System Malformations Tretinoin 3.749125849
MESH:D009436 Neural Tube Defects sodium arsenite 7.2112854658
MESH:D009436 Neural Tube Defects Tretinoin 7.219142499
MESH:D009447 Neuroblastoma Doxorubicin 3.2415555623
MESH:D019636 Neurodegenerative Diseases Acetaminophen 8.0618514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 8.0620387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.0920387270
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.4116436463
MESH:D009765 Obesity pirinixic acid 1.8020558911
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 3.3916049721
MESH:D010018 Osteomalacia Phenobarbital 4.3317016548
MESH:D012516 Osteosarcoma Doxorubicin 4.0815930896
MESH:D010051 Ovarian Neoplasms Medroxyprogesterone Acetate 14.8817393432
MESH:D010051 Ovarian Neoplasms Mifepristone 14.8816525653
MESH:D010051 Ovarian Neoplasms Progesterone 14.8817393432 16525653
MESH:D010051 Ovarian Neoplasms sodium arsenite 14.8817306315 15276417
MESH:D010051 Ovarian Neoplasms Tretinoin 14.8816936753
MESH:D010146 Pain Acetaminophen 6.4616870215
MESH:D010146 Pain Tretinoin 6.4616870215
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 12.2116540662
MESH:D010190 Pancreatic Neoplasms Fluorouracil 12.2119003803 16929163 16500647 15113037
MESH:D010190 Pancreatic Neoplasms Phenobarbital 12.2116965848
MESH:D010190 Pancreatic Neoplasms Tretinoin 12.2115976015
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.6511578682
MESH:D003557 Phyllodes Tumor Doxorubicin 5.1317983394
MESH:D010954 Plasmacytoma Selenium 4.8615087411
MESH:D010997 Pleural Neoplasms Doxorubicin 5.1317638057
MESH:D011230 Precancerous Conditions Diethylnitrosamine 8.962563599
MESH:D011230 Precancerous Conditions Phenobarbital 8.962563599
MESH:D011471 Prostatic Neoplasms marker/mechanism 17929269
MESH:D011471 Prostatic Neoplasms Doxorubicin 2.1116729912 16888761 18437689 16868541 15897917 15749863
MESH:D011471 Prostatic Neoplasms Fluorouracil 2.1119082440 18626508
MESH:D011471 Prostatic Neoplasms sodium arsenite 2.1116039940
MESH:D011471 Prostatic Neoplasms Vitamin E 2.1115084515
MESH:D011507 Proteinuria Tretinoin 3.5616636307
MESH:D011537 Pruritus Ethinyl Estradiol 3.2815861022 16919318
MESH:D019310 Pseudolymphoma Phenobarbital 4.4712752131
MESH:D011625 Pterygium Tretinoin 4.7616723453
MESH:D012004 Rectal Neoplasms Fluorouracil 3.9718722050 15538739 18286688 16160472
MESH:D051437 Renal Insufficiency Doxorubicin 4.1817922066
MESH:D015427 Reperfusion Injury pirinixic acid 2.3619058328
MESH:D012208 Rhabdomyosarcoma Tretinoin 4.0616283617 16116481
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.8418045962
MESH:D012509 Sarcoma Doxorubicin 3.9515625365 17710206 16767912 18313854 17203757 15675481
MESH:D012512 Sarcoma, Ewing's Doxorubicin 4.2014601052 16326096
MESH:D012514 Sarcoma, Kaposi Doxorubicin 4.7517846226
MESH:D012640 Seizures 2,6-dinitrotoluene 5.8218551238
MESH:D012640 Seizures Phenobarbital 5.823137016 11442880 16876388 4039156
MESH:D003294 Seizures, Febrile Phenobarbital 4.796407741
MESH:D012871 Skin Diseases Vitamin E 2.4318709164
MESH:D012878 Skin Neoplasms Doxorubicin 13.4415692506
MESH:D012878 Skin Neoplasms sodium arsenite 13.4419524636 18572023
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 13.448532709
MESH:D012878 Skin Neoplasms Tretinoin 13.4416467112
MESH:D012983 Soft Tissue Neoplasms Doxorubicin 4.5315625365 17203757 16767912
MESH:D013088 Spermatocele Ethinyl Estradiol 3.9116709447
MESH:D013119 Spinal Cord Injuries Progesterone 4.2415862959 16503802
MESH:D016135 Spinal Dysraphism sodium arsenite 3.7612854658
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 3.3618456281
MESH:D013274 Stomach Neoplasms Fluorouracil 3.3618567086 18396642 17172411 17522103 16424979 17498489 19084572 16951190 19015929 15786421
MESH:D013274 Stomach Neoplasms Tretinoin 3.3617261132
MESH:D020521 Stroke Vitamin E 3.4816517955
OMIM:608180 SYNPOLYDACTYLY 2 marker/mechanism
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.5811994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.1115669648
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 16.847505956
MESH:D013964 Thyroid Neoplasms Doxorubicin 16.8417909728 16010429
MESH:D013964 Thyroid Neoplasms Phenobarbital 16.841399818
MESH:D013964 Thyroid Neoplasms Tretinoin 16.8416026305 17045167
MESH:D014062 Tongue Neoplasms Fluorouracil 9.7016280240
MESH:D014062 Tongue Neoplasms Tretinoin 9.7016051514
MESH:D014376 Tuberculosis Tretinoin 3.2016040207
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 8.2716049721
MESH:D001749 Urinary Bladder Neoplasms Doxorubicin 8.2717653716
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 8.2716712894 11723127 17306315 16452187
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.2810091137
MESH:D014581 Urticaria Acetaminophen 2.9410982225
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 15.6316803524
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 15.6311813266
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 15.6316129372
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.2614692618
MESH:D014604 Uveal Neoplasms Tretinoin 4.5816752155
MESH:D014652 Vascular Diseases sodium arsenite 4.3917056641
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.5015869587 14671159
MESH:D018487 Ventricular Dysfunction, Left Doxorubicin 4.1817638931 17678736 16364871 17334414
MESH:D014820 Vitiligo Tretinoin 4.0216761959
MESH:D009396 Wilms Tumor Tretinoin 3.9316287080
No data
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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