AutismKB 2.0

Annotation Detail for FASN


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Basic Information Top
Gene Symbol:FASN ( FAS,MGC14367,MGC15706,OA-519,SDR27X1 )
Gene Full Name: fatty acid synthase
Band: 17q25.3
Quick LinksEntrez ID:2194; OMIM: 600212; Uniprot ID:FAS_HUMAN; ENSEMBL ID: ENSG00000169710; HGNC ID: 3594
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Pathway IDPathway Name
PWY-5994palmitate biosynthesis I (animals)
PWY-5966fatty acid biosynthesis initiation II
Pathway IDPathway Name
hsa04910Insulin signaling pathway
hsa01100Metabolic pathways
hsa00061Fatty acid biosynthesis
Pathway IDPathway Name
Metabolism of vitamins and cofactors
Metabolism of lipids and lipoproteins
Integration of energy metabolism
No data
No data
Pathway IDPathway Name
500597Vitamin B5 (pantothenate) metabolism
500801Fatty Acyl-CoA Biosynthesis
500721ChREBP activates metabolic gene expression
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1856Obesity
1934Cancer
2135Osteitis deformans
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C049325 1,2-dithiol-3-thione 1,2-dithiol-3-thione results in decreased expression of FASN mRNAdecreases expression 15302862
C014024 2,4,5,2',4',5'-hexachlorobiphenyl 2,4,5,2',4',5'-hexachlorobiphenyl results in decreased expression of FASN mRNAdecreases expression 20005886
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of FASN mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene results in decreased expression of FASN mRNAdecreases expression 20406850
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of FASN mRNAaffects expression 21346803
C406734 4-methylene-2-octyl-5-oxofuran-3-carboxylic acid 4-methylene-2-octyl-5-oxofuran-3-carboxylic acid binds to and results in decreased activity of FASN proteinaffects binding|decreases activity 17847090
C406734 4-methylene-2-octyl-5-oxofuran-3-carboxylic acid 4-methylene-2-octyl-5-oxofuran-3-carboxylic acid results in decreased activity of FASN proteindecreases activity 15707987
14736702
C406734 4-methylene-2-octyl-5-oxofuran-3-carboxylic acid 4-methylene-2-octyl-5-oxofuran-3-carboxylic acid results in decreased expression of FASN mRNAdecreases expression 15707987
C406734 4-methylene-2-octyl-5-oxofuran-3-carboxylic acid 4-methylene-2-octyl-5-oxofuran-3-carboxylic acid results in decreased activity of FASN proteindecreases activity 17283163
C016583 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of FASN proteinincreases expression 18413838
C002202 4-oxoretinoic acid 4-oxoretinoic acid results in increased expression of FASN mRNAincreases expression 15982314
D000082 Acetaminophen Acetaminophen affects the expression of FASN mRNAaffects expression 17562736
D000082 Acetaminophen Acetaminophen results in decreased expression of FASN mRNAdecreases expression 17522070
15084756
C103303 alitretinoin alitretinoin results in decreased expression of FASN mRNAdecreases expression 15982314
D013196 Dihydrotestosterone Dihydrotestosterone results in increased expression of FASN mRNAincreases expression 16990341
C004984 apocarotenal apocarotenal results in decreased expression of FASN mRNAdecreases expression 17034753
D001554 Benzene Benzene results in decreased expression of FASN mRNAdecreases expression 15878777
C013894 beta-conglycinin protein, Glycine max beta-conglycinin protein, Glycine max results in decreased activity of FASN proteindecreases activity 20148945
C013894 beta-conglycinin protein, Glycine max beta-conglycinin protein, Glycine max binds to and results in decreased activity of FASN proteinaffects binding|decreases activity 20148945
C095105 bexarotene bexarotene results in increased expression of FASN mRNAincreases expression 16648578
D001629 Bezafibrate Bezafibrate results in increased expression of FASN mRNAincreases expression 17118139
C006780 bisphenol A bisphenol A results in increased expression of FASN mRNAincreases expression 20019905
D002251 Carbon Tetrachloride Carbon Tetrachloride results in decreased expression of FASN mRNAdecreases expression 17522070
16239168
19224547
D002569 Cerulenin Cerulenin results in decreased activity of FASN proteindecreases activity 12798352
D002569 Cerulenin [Cerulenin results in decreased activity of FASN protein] which results in decreased abundance of Phosphorylcholinedecreases abundance|decreases activity 18723500
D002569 Cerulenin Cerulenin results in decreased activity of FASN proteindecreases activity 15707987
D002569 Cerulenin Cerulenin results in decreased expression of FASN mRNAdecreases expression 15707987
D002569 Cerulenin Cerulenin results in decreased activity of FASN proteindecreases activity 20805790
17283163
20372807
D002994 Clofibrate Clofibrate results in decreased expression of FASN mRNAdecreases expression 17522070
19224547
D003024 Clozapine Clozapine results in increased expression of FASN mRNAincreases expression 16027736
17052361
D003314 Corn Oil Corn Oil affects the expression of FASN mRNAaffects expression 16360708
C030123 coumarin coumarin affects the expression of FASN mRNAaffects expression 16963487
D003513 Cycloheximide Cycloheximide inhibits the reaction [Calcitriol results in decreased expression of FASN mRNA]decreases expression|decreases reaction 12798352
D016572 Cyclosporine Cyclosporine results in decreased expression of FASN mRNAdecreases expression 20106945
D016572 Cyclosporine Cyclosporine results in decreased expression of FASN mRNAdecreases expression 19224547
D018119 Stavudine [Stavudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of FASN mRNAaffects cotreatment|increases expression 11741158
D018119 Stavudine [Stavudine co-treated with Lamivudine] results in increased expression of FASN mRNAaffects cotreatment|increases expression 11741158
D018119 Stavudine Stavudine results in decreased expression of FASN proteindecreases expression 15722030
D003907 Dexamethasone Dexamethasone results in increased expression of FASN mRNAincreases expression 17522070
D019259 Lamivudine [Stavudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of FASN mRNAaffects cotreatment|increases expression 11741158
D019259 Lamivudine [Stavudine co-treated with Lamivudine] results in increased expression of FASN mRNAaffects cotreatment|increases expression 11741158
D019259 Lamivudine [Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of FASN mRNAaffects cotreatment|increases expression 11741158
D019259 Lamivudine [Zidovudine co-treated with Lamivudine] results in increased expression of FASN mRNAaffects cotreatment|increases expression 11741158
D004041 Dietary Fats [Fructose co-treated with Dietary Fats co-treated with TO-901317] results in increased expression of FASN mRNAaffects cotreatment|increases expression 19509184
D004041 Dietary Fats Dietary Fats results in decreased expression of FASN mRNAdecreases expression 18042831
18457598
D004041 Dietary Fats Dietary Fats results in increased expression of FASN mRNAincreases expression 18292748
21332399
17932310
D004041 Dietary Fats PPARGC1B protein promotes the reaction [Dietary Fats results in increased expression of FASN mRNA]increases expression|increases reaction 17932310
D004041 Dietary Fats Dietary Fats analog results in decreased expression of FASN mRNAdecreases expression 12669817
D002117 Calcitriol Calcitriol results in decreased expression of FASN mRNAdecreases expression 12798352
D002117 Calcitriol Cycloheximide inhibits the reaction [Calcitriol results in decreased expression of FASN mRNA]decreases expression|decreases reaction 12798352
D004317 Doxorubicin Doxorubicin results in increased expression of FASN mRNAincreases expression 17089011
D004317 Doxorubicin FASN protein inhibits the reaction [Doxorubicin results in increased cleavage of PARP1 protein]decreases reaction|increases cleavage 18281512
D004317 Doxorubicin FASN protein results in decreased susceptibility to Doxorubicindecreases response to substance 18281512
D004317 Doxorubicin orlistat inhibits the reaction [FASN protein results in decreased susceptibility to Doxorubicin]decreases reaction|decreases response to substance 18281512
C045651 epigallocatechin gallate epigallocatechin gallate results in decreased expression of FASN mRNAdecreases expression 16988119
D004918 Erythromycin Estolate Erythromycin Estolate results in decreased expression of FASN mRNAdecreases expression 17522070
D004958 Estradiol Estradiol results in decreased expression of FASN mRNAdecreases expression 20106945
D000431 Ethanol Ethanol inhibits the reaction [Fish Oils results in decreased expression of FASN mRNA]decreases expression|decreases reaction 18620774
D000431 Ethanol Ethanol inhibits the reaction [pirinixic acid results in decreased expression of FASN mRNA]decreases expression|decreases reaction 18620774
D000431 Ethanol Ethanol results in increased expression of FASN mRNAincreases expression 18620774
D000431 Ethanol [Fish Oils co-treated with Ethanol] results in increased expression of FASN mRNAaffects cotreatment|increases expression 17347304
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of FASN mRNAaffects cotreatment|decreases expression 17942748
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of FASN mRNAaffects expression 16079270
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of FASN mRNAdecreases expression 15953391
17108234
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of FASN mRNAincreases expression 16174780
D005047 Etoposide Etoposide results in increased expression of FASN mRNAincreases expression 17089011
D005227 Fatty Acids FASN protein results in increased chemical synthesis of Fatty Acidsincreases chemical synthesis 18723500
D005227 Fatty Acids [orlistat results in decreased activity of FASN protein] which results in decreased abundance of Fatty Acidsdecreases abundance|decreases activity 18723500
D005227 Fatty Acids [orlistat results in decreased activity of FASN protein] which results in decreased chemical synthesis of Fatty Acidsdecreases activity|decreases chemical synthesis 17012255
D005230 Fatty Acids, Nonesterified [orlistat results in decreased activity of FASN protein] which affects the abundance of Fatty Acids, Nonesterifiedaffects abundance|decreases activity 21213365
D011345 Fenofibrate Fenofibrate results in increased expression of FASN mRNAincreases expression 17118139
D005395 Fish Oils Ethanol inhibits the reaction [Fish Oils results in decreased expression of FASN mRNA]decreases expression|decreases reaction 18620774
D005395 Fish Oils Fish Oils results in decreased expression of FASN mRNAdecreases expression 18620774
D005395 Fish Oils [Fish Oils co-treated with Ethanol] results in increased expression of FASN mRNAaffects cotreatment|increases expression 17347304
D005395 Fish Oils Fish Oils results in decreased expression of FASN mRNAdecreases expression 15654130
D005632 Fructose [Fructose co-treated with Dietary Fats co-treated with TO-901317] results in increased expression of FASN mRNAaffects cotreatment|increases expression 19509184
D005632 Fructose Fructose results in increased expression of FASN mRNAincreases expression 15066988
D005632 Fructose SCD1 gene mutant form inhibits the reaction [Fructose results in increased expression of FASN mRNA]decreases reaction|increases expression 15066988
D005632 Fructose Triolein inhibits the reaction [SCD1 gene mutant form inhibits the reaction [Fructose results in increased expression of FASN mRNA]]decreases reaction|increases expression 15066988
D005632 Fructose Triolein promotes the reaction [Fructose results in increased expression of FASN mRNA]increases expression|increases reaction 15066988
D005632 Fructose Fructose results in increased activity of FASN proteinincreases activity 9566986
8759368
D005632 Fructose Fructose results in increased expression of FASN mRNAincreases expression 19193814
18346472
12065722
19196556
19053045
9566986
8759368
D005632 Fructose rosiglitazone inhibits the reaction [Fructose results in increased expression of FASN mRNA]decreases reaction|increases expression 19196556
D005632 Fructose Tea inhibits the reaction [Fructose results in increased expression of FASN mRNA]decreases reaction|increases expression 19193814
C070081 fulvestrant fulvestrant inhibits the reaction [Norethynodrel results in increased activity of FASN protein]decreases reaction|increases activity 15870863
D005947 Glucose Glucose results in increased expression of FASN mRNAincreases expression 15066988
D006220 Haloperidol Haloperidol results in increased expression of FASN mRNAincreases expression 16027736
D007052 Ibuprofen Ibuprofen affects the expression of FASN proteinaffects expression 18351690
D007052 Ibuprofen Ibuprofen results in decreased expression of FASN mRNAdecreases expression 18351690
D019469 Indinavir Indinavir results in increased expression of FASN mRNAincreases expression 11741158
D019469 Indinavir [Stavudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of FASN mRNAaffects cotreatment|increases expression 11741158
D019469 Indinavir [Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of FASN mRNAaffects cotreatment|increases expression 11741158
C054164 lipstatin lipstatin analog binds to FASN proteinaffects binding 20577697
C445068 methyl 2-cyano-3,12-dioxoolean-1,9-dien-28-oate methyl 2-cyano-3,12-dioxoolean-1,9-dien-28-oate results in decreased expression of FASN mRNAdecreases expression 20372807
D008767 Methylmercury Compounds Methylmercury Compounds results in decreased expression of FASN mRNAdecreases expression 16966085
D008769 Methylnitronitrosoguanidine Methylnitronitrosoguanidine results in increased expression of FASN mRNAincreases expression 12634122
D008770 Methylnitrosourea Methylnitrosourea results in increased expression of FASN mRNAincreases expression 16525678
D015741 Metribolone Metribolone promotes the reaction [NDRG1 protein binds to FASN protein]affects binding|increases reaction 17220478
D015741 Metribolone Metribolone results in increased expression of FASN proteinincreases expression 17152098
D015735 Mifepristone Mifepristone inhibits the reaction [Norethynodrel results in increased activity of FASN protein]decreases reaction|increases activity 15870863
D008942 Mitoxantrone FASN protein results in decreased susceptibility to Mitoxantronedecreases response to substance 18281512
D008942 Mitoxantrone orlistat inhibits the reaction [FASN protein results in decreased susceptibility to Mitoxantrone]decreases reaction|decreases response to substance 18281512
D009270 Naloxone Naloxone results in decreased expression of FASN mRNAdecreases expression 17522070
C029938 nickel sulfate nickel sulfate results in increased expression of FASN mRNAincreases expression 16780908
C029938 nickel sulfate nickel sulfate results in decreased expression of FASN mRNAdecreases expression 16100012
C002741 N-nitrosomorpholine N-nitrosomorpholine results in increased expression of FASN mRNAincreases expression 15543204
C002741 N-nitrosomorpholine N-nitrosomorpholine results in increased expression of FASN proteinincreases expression 15543204
D009640 Norethindrone Norethindrone results in increased activity of FASN proteinincreases activity 15870863
D009641 Norethynodrel fulvestrant inhibits the reaction [Norethynodrel results in increased activity of FASN protein]decreases reaction|increases activity 15870863
D009641 Norethynodrel Mifepristone inhibits the reaction [Norethynodrel results in increased activity of FASN protein]decreases reaction|increases activity 15870863
D009641 Norethynodrel Norethynodrel results in increased activity of and results in increased expression of FASN proteinincreases activity|increases expression 15870863
C055122 orlistat orlistat analog binds to FASN proteinaffects binding 20577697
C055122 orlistat orlistat analog results in decreased activity of FASN proteindecreases activity 18710210
C055122 orlistat orlistat binds to and results in decreased activity of FASN proteinaffects binding|decreases activity 17847090
17618296
20148945
C055122 orlistat orlistat inhibits the reaction [FASN protein results in decreased susceptibility to Doxorubicin]decreases reaction|decreases response to substance 18281512
C055122 orlistat orlistat inhibits the reaction [FASN protein results in decreased susceptibility to Mitoxantrone]decreases reaction|decreases response to substance 18281512
C055122 orlistat orlistat results in decreased activity of FASN proteindecreases activity 18723500
18710210
17012255
C055122 orlistat [orlistat results in decreased activity of FASN protein] which results in decreased abundance of Fatty Acidsdecreases abundance|decreases activity 18723500
C055122 orlistat [orlistat results in decreased activity of FASN protein] which results in decreased abundance of Phosphatidylcholinesdecreases abundance|decreases activity 18723500
C055122 orlistat [orlistat results in decreased activity of FASN protein] which results in decreased abundance of Phosphorylcholinedecreases abundance|decreases activity 18723500
C055122 orlistat [orlistat results in decreased activity of FASN protein] which results in decreased chemical synthesis of Fatty Acidsdecreases activity|decreases chemical synthesis 17012255
C055122 orlistat orlistat inhibits the reaction [FASN protein results in increased chemical synthesis of Palmitic Acid]decreases reaction|increases chemical synthesis 21213365
C055122 orlistat orlistat results in decreased activity of FASN proteindecreases activity 21213365
C055122 orlistat [orlistat results in decreased activity of FASN protein] which affects the abundance of Fatty Acids, Nonesterifiedaffects abundance|decreases activity 21213365
C055122 orlistat orlistat results in decreased activity of FASN proteindecreases activity 17283163
20372807
20805790
18770866
16986934
18796435
D010126 Ozone Ozone results in decreased expression of FASN mRNAdecreases expression 16716893
D010168 Palmitates Palmitates binds to FASN proteinaffects binding 17847090
D010168 Palmitates FASN protein results in increased chemical synthesis of Palmitatesincreases chemical synthesis 17283163
D019308 Palmitic Acid orlistat inhibits the reaction [FASN protein results in increased chemical synthesis of Palmitic Acid]decreases reaction|increases chemical synthesis 21213365
D019308 Palmitic Acid FASN protein results in increased chemical synthesis of Palmitic Acidincreases chemical synthesis 21213365
18281512
20805790
C041786 palm oil palm oil results in decreased expression of FASN mRNAdecreases expression 18042831
D010713 Phosphatidylcholines [orlistat results in decreased activity of FASN protein] which results in decreased abundance of Phosphatidylcholinesdecreases abundance|decreases activity 18723500
D010767 Phosphorylcholine [Cerulenin results in decreased activity of FASN protein] which results in decreased abundance of Phosphorylcholinedecreases abundance|decreases activity 18723500
D010767 Phosphorylcholine [orlistat results in decreased activity of FASN protein] which results in decreased abundance of Phosphorylcholinedecreases abundance|decreases activity 18723500
C006253 pirinixic acid Ethanol inhibits the reaction [pirinixic acid results in decreased expression of FASN mRNA]decreases expression|decreases reaction 18620774
C006253 pirinixic acid pirinixic acid results in decreased expression of FASN mRNAdecreases expression 18620774
C006253 pirinixic acid pirinixic acid results in increased expression of FASN mRNAincreases expression 18301758
20059764
17118139
15375163
15302862
15777286
C006253 pirinixic acid PPARA protein affects the reaction [pirinixic acid results in increased expression of FASN mRNA]affects reaction|increases expression 15777286
C006253 pirinixic acid PPARA protein promotes the reaction [pirinixic acid results in increased expression of FASN mRNA]increases expression|increases reaction 20059764
C006253 pirinixic acid [[[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased localization of and results in decreased activity of SREBF1 protein] which results in decreased expression of FASN mRNA] which results in decreased abundance of Triglyceridesaffects binding|decreases abundance|decreases activity|decreases expression|decreases localization|increases activity 19248225
D011794 Quercetin Quercetin results in decreased expression of FASN mRNAdecreases expression 19729006
D011794 Quercetin Quercetin results in decreased activity of FASN proteindecreases activity 17032037
D011794 Quercetin Quercetin results in decreased expression of FASN mRNAdecreases expression 17032037
C059514 resveratrol resveratrol inhibits the reaction [INS1 protein results in increased expression of FASN mRNA]decreases reaction|increases expression 16626303
C059514 resveratrol resveratrol results in decreased expression of FASN mRNAdecreases expression 16626303
D015474 Isotretinoin Isotretinoin results in decreased expression of FASN mRNAdecreases expression 15982314
C089730 rosiglitazone rosiglitazone inhibits the reaction [Fructose results in increased expression of FASN mRNA]decreases reaction|increases expression 19196556
D012402 Rotenone Rotenone results in decreased expression of FASN mRNAdecreases expression 19693701
19013527
D012643 Selenium Selenium results in increased expression of FASN mRNAincreases expression 19244175
D012643 Selenium Selenium results in increased expression of FASN mRNAincreases expression 19022953
D012822 Silicon Dioxide Silicon Dioxide results in increased activity of FASN proteinincreases activity 1647683
D013311 Streptozocin GHRL protein promotes the reaction [Streptozocin results in decreased expression of FASN mRNA]decreases expression|increases reaction 20219977
D013311 Streptozocin INS protein inhibits the reaction [Streptozocin results in decreased expression of FASN mRNA]decreases expression|decreases reaction 20219977
D013311 Streptozocin Streptozocin results in decreased expression of FASN mRNAdecreases expression 20219977
D014284 Triiodothyronine Triiodothyronine results in increased expression of FASN mRNAincreases expression 15953391
D013629 Tamoxifen Tamoxifen results in decreased expression of FASN mRNAdecreases expression 19224547
D013662 Tea Tea inhibits the reaction [Fructose results in increased expression of FASN mRNA]decreases reaction|increases expression 19193814
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of FASN mRNAaffects cotreatment|decreases expression 17942748
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of FASN mRNAdecreases expression 16960034
20005886
15800033
18295293
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of FASN mRNAdecreases expression 16054898
16960034
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of FASN proteindecreases expression 16548065
D013752 Tetracycline Tetracycline results in decreased expression of FASN mRNAdecreases expression 19224547
17522070
C423915 TO-901317 TO-901317 results in increased expression of FASN mRNAincreases expression 15548517
C423915 TO-901317 [Fructose co-treated with Dietary Fats co-treated with TO-901317] results in increased expression of FASN mRNAaffects cotreatment|increases expression 19509184
C423915 TO-901317 TO-901317 results in increased expression of FASN mRNAincreases expression 15302862
C496197 trans-10,cis-12-conjugated linoleic acid trans-10,cis-12-conjugated linoleic acid results in decreased expression of FASN mRNAdecreases expression 16988111
C496197 trans-10,cis-12-conjugated linoleic acid trans-10,cis-12-conjugated linoleic acid results in increased expression of FASN mRNAincreases expression 17217560
D014212 Tretinoin Tretinoin metabolite results in increased expression of FASN mRNAincreases expression 15982314
D014212 Tretinoin Tretinoin results in decreased expression of FASN mRNAdecreases expression 15982314
D014260 Triclosan Triclosan results in decreased activity of FASN proteindecreases activity 15707987
D014260 Triclosan Triclosan results in decreased expression of FASN mRNAdecreases expression 15707987
D014260 Triclosan Triclosan results in decreased activity of FASN proteindecreases activity 15358634
D014280 Triglycerides [[[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased localization of and results in decreased activity of SREBF1 protein] which results in decreased expression of FASN mRNA] which results in decreased abundance of Triglyceridesaffects binding|decreases abundance|decreases activity|decreases expression|decreases localization|increases activity 19248225
D014280 Triglycerides [[[troglitazone binds to and results in increased activity of PPARG protein] which results in decreased localization of and results in decreased activity of SREBF1 protein] which results in decreased expression of FASN mRNA] which results in decreased abundance of Triglyceridesaffects binding|decreases abundance|decreases activity|decreases expression|decreases localization|increases activity 19248225
D014304 Triolein Triolein inhibits the reaction [SCD1 gene mutant form inhibits the reaction [Fructose results in increased expression of FASN mRNA]]decreases reaction|increases expression 15066988
D014304 Triolein Triolein promotes the reaction [Fructose results in increased expression of FASN mRNA]increases expression|increases reaction 15066988
C057693 troglitazone [[[troglitazone binds to and results in increased activity of PPARG protein] which results in decreased localization of and results in decreased activity of SREBF1 protein] which results in decreased expression of FASN mRNA] which results in decreased abundance of Triglyceridesaffects binding|decreases abundance|decreases activity|decreases expression|decreases localization|increases activity 19248225
D014520 Urethane Urethane results in increased expression of FASN proteinincreases expression 18413838
C054478 valilactone valilactone results in decreased activity of FASN proteindecreases activity 18710210
C054478 valilactone valilactone results in decreased activity of FASN proteindecreases activity 16986934
D014635 Valproic Acid Valproic Acid results in increased expression of FASN mRNAincreases expression 15345369
D014635 Valproic Acid Valproic Acid results in decreased expression of FASN mRNAdecreases expression 19224547
D015215 Zidovudine Zidovudine affects the expression of FASN mRNAaffects expression 20032539
D015215 Zidovudine [Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of FASN mRNAaffects cotreatment|increases expression 11741158
D015215 Zidovudine [Zidovudine co-treated with Lamivudine] results in increased expression of FASN mRNAaffects cotreatment|increases expression 11741158
D015215 Zidovudine Zidovudine results in decreased expression of FASN proteindecreases expression 15722030
D015032 Zinc Zinc affects the activity of FASN proteinaffects activity 17181878
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 3.7114745880
MESH:D000014 Abnormalities, Drug-Induced Ethanol 13.7218926900 17676605
MESH:D000014 Abnormalities, Drug-Induced Isotretinoin 13.7218769834
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 13.7214514962 15322242 11752688
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 13.728875741
MESH:D000015 Abnormalities, Multiple Isotretinoin 7.9218769834
MESH:D000015 Abnormalities, Multiple Valproic Acid 7.9219490988
MESH:D000138 Acidosis Ethanol 3.6711192467
MESH:D017486 Acneiform Eruptions Isotretinoin 5.4416232082
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 9.2117505938
MESH:D000152 Acne Vulgaris Isotretinoin 9.2116185265 18769834
MESH:D000163 Acquired Immunodeficiency Syndrome Zidovudine 4.029612607
MESH:D000169 Acrodermatitis Zinc 4.5717190629 17202136 16889938
MESH:D058186 Acute Kidney Injury Ibuprofen 6.596375363
MESH:D058186 Acute Kidney Injury resveratrol 6.5916538975
MESH:D055371 Acute Lung Injury nickel sulfate 6.6012718980 19131640 16100012 11954676
MESH:D055371 Acute Lung Injury pirinixic acid 6.6018653653
MESH:D000230 Adenocarcinoma Doxorubicin 13.1017418594
MESH:D000230 Adenocarcinoma Estradiol 13.1011473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 13.1014692618
MESH:D000230 Adenocarcinoma Ibuprofen 13.1010697514
MESH:D000230 Adenocarcinoma Methylnitrosourea 13.1015113128 15688392
MESH:D000230 Adenocarcinoma Urethane 13.1018316556
MESH:D002282 Adenocarcinoma, Bronchiolo-Alveolar Urethane 4.8715814487
MESH:D000236 Adenoma 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone 8.3316176798
MESH:D000236 Adenoma resveratrol 8.3315688382
MESH:D000236 Adenoma Urethane 8.3317093202 16926031 11497255 10822126 10530776 6695378 17195641
MESH:D018248 Adenoma, Liver Cell pirinixic acid 7.1716434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 7.1716835633
MESH:D000380 Agranulocytosis Clozapine 4.2514617031 16160616 12649775
MESH:D000419 Albuminuria Doxorubicin 3.7521441931
MESH:D020268 Alcohol-Induced Disorders, Nervous System Ethanol 4.4815451039 15451040
MESH:D000505 Alopecia Tretinoin 2.9315955085
MESH:D000544 Alzheimer Disease Ibuprofen 9.5118351690
MESH:D000544 Alzheimer Disease Ozone 9.5115513908
MESH:D000544 Alzheimer Disease resveratrol 9.5116162502 16183991
MESH:D000544 Alzheimer Disease rosiglitazone 9.5119621015
MESH:D000544 Alzheimer Disease Zinc 9.5116580781 17119284 16410023 16325427
MESH:D000550 Amblyopia Valproic Acid 4.3917688650
MESH:D000707 Anaphylaxis Ibuprofen 4.449532969
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.2211748828
MESH:D000741 Anemia, Aplastic Benzene 3.7017661222 14761424 11369114
MESH:D000743 Anemia, Hemolytic Quercetin 3.4917084956
MESH:D000755 Anemia, Sickle Cell Zinc 4.1116916123
MESH:D000799 Angioedema Acetaminophen 3.0010982225
MESH:D000853 Anophthalmos Ethanol 4.0115513904
MESH:D001008 Anxiety Disorders Ethanol 6.7211141031
MESH:D001008 Anxiety Disorders Valproic Acid 6.7217497229
MESH:D001161 Arteriosclerosis Dietary Fats 7.2415238619
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 7.2411256880
MESH:D001169 Arthritis, Experimental Dexamethasone 12.8317659584
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 12.8315885639
MESH:D001169 Arthritis, Experimental resveratrol 12.8317115116
MESH:D001169 Arthritis, Experimental Tretinoin 12.8316412693
MESH:D001172 Arthritis, Rheumatoid Ozone 3.7115570426
MESH:D001172 Arthritis, Rheumatoid Tretinoin 3.7116292516
MESH:D001249 Asthma epigallocatechin gallate 8.4316516891
MESH:D001249 Asthma Ozone 8.4316373670 17854713
MESH:D001249 Asthma Tretinoin 8.4316456186
MESH:D001249 Asthma Zinc 8.4317085522
MESH:D001260 Ataxia Telangiectasia Quercetin 4.1515336622
MESH:D050197 Atherosclerosis resveratrol 2.7417967414 16873680
MESH:D001284 Atrophy fulvestrant 4.0611514358
MESH:D001321 Autistic Disorder Acetaminophen 2.0018445737
MESH:D001321 Autistic Disorder Haloperidol 2.0019368416 18080171
MESH:D001321 Autistic Disorder Valproic Acid 2.0018985861 15238991 18177632 17507914 16609825 18316065 18558336 20603192 18940202 18396377 18775368 17157402 19232924 19460635 17688650
MESH:D001327 Autoimmune Diseases epigallocatechin gallate 8.4019761891
MESH:D001327 Autoimmune Diseases Quercetin 8.4019761891
MESH:D001471 Barrett Esophagus Tretinoin 3.6116935849
MESH:D001714 Bipolar Disorder Valproic Acid 2.5817594078 20046352
MESH:D001778 Blood Coagulation Disorders Clofibrate 15.8519483382
MESH:D001778 Blood Coagulation Disorders pirinixic acid 15.8519483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 15.8512125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 15.8516206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 2.9515340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 6.0515746008
MESH:D001848 Bone Diseases, Developmental Valproic Acid 6.058888407
MESH:D001855 Bone Marrow Diseases Benzene 4.3916183116
MESH:D019046 Bone Marrow Neoplasms Doxorubicin 9.3714601052
MESH:D019046 Bone Marrow Neoplasms Etoposide 9.3714601052
MESH:D001862 Bone Resorption bisphenol A 3.1211985600
MESH:D001930 Brain Injuries Zinc 3.8817109824
MESH:D002545 Brain Ischemia Ibuprofen 7.8015837124
MESH:D002545 Brain Ischemia resveratrol 7.8017600658
MESH:D001932 Brain Neoplasms Doxorubicin 3.0917150277
MESH:D001943 Breast Neoplasms marker/mechanism 17089011 18281512
MESH:D001943 Breast Neoplasms 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone 14.5220146248
MESH:D001943 Breast Neoplasms alitretinoin 14.5216344269
MESH:D001943 Breast Neoplasms Benzene 14.5211921183 17162533
MESH:D001943 Breast Neoplasms bexarotene 14.5216344269 16818667
MESH:D001943 Breast Neoplasms bisphenol A 14.5217123778
MESH:D001943 Breast Neoplasms Calcitriol 14.5211237771
MESH:D001943 Breast Neoplasms Dietary Fats 14.5220435547
MESH:D001943 Breast Neoplasms Doxorubicin 14.5217426702 15136595 16826403 18695136 17369602 19526202 15634643 15939500 18382427 16264153 15993339 16096432 15994142 18628466 15567936 17983394 16595493 16935488 11325840 15668708 16322301 18234424 16115903 15692762
MESH:D001943 Breast Neoplasms Estradiol 14.5217261762 14630087 19861407 18497071 17289903 16675129 12948864 17018787
MESH:D001943 Breast Neoplasms Etoposide 14.5216322251
MESH:D001943 Breast Neoplasms fulvestrant 14.5218984771
MESH:D001943 Breast Neoplasms Methylnitrosourea 14.5214633655 16253758 11306469
MESH:D001943 Breast Neoplasms Quercetin 14.5218628248
MESH:D001943 Breast Neoplasms resveratrol 14.5217651959 16393696 17534123
MESH:D001943 Breast Neoplasms Tamoxifen 14.5219200415 15668708 21152245 18821012 19115204 19011961 17440819 19221464 16873071 18629630 20005174 18351453 19487384 18855134 21138602 18815881 17049068 18997820 20859285 19084267 19059307 19142967 17242785 16818667 18425577 19189212 19289846 20065188 19288272 11161223 19410462 16202921 17261762 20544844 19103187 19244106 20390343 19155303 16273361 17893378 18984771 20135344 19189210 19066611 15565566
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 14.5220435547
MESH:D001943 Breast Neoplasms Tretinoin 14.5216166294 16443354 16873071
MESH:D016535 Bronchial Hyperreactivity Ozone 3.0017626835 18417511 16777450 15516495 19059883 18315731 14754758
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 3.7616813970
MESH:D019121 Burkholderia Infections orlistat 5.8017874328
MESH:D002056 Burns Ethanol 3.8416374292
MESH:D002100 Cachexia Ibuprofen 9.8315141370
MESH:D002100 Cachexia Ozone 9.8316183385
MESH:D002105 Cadmium Poisoning Quercetin 4.7016962696
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 3.6416111702
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 2.9816124888 15721981 16011737 15673190 10355542 15700767 18705752 16227642 16097048 16192424 16050911 3786805
MESH:D002276 Carcinoid Tumor Doxorubicin 9.9016051944
MESH:D002276 Carcinoid Tumor Streptozocin 9.9016051944
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.1316835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 3.6919066611
MESH:D018236 Carcinoma, Embryonal Tretinoin 4.3116168501
MESH:D006528 Carcinoma, Hepatocellular marker/mechanism 15543204
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 23.5216705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 23.5216705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 23.523084413
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 23.5218788625
MESH:D006528 Carcinoma, Hepatocellular Doxorubicin 23.5217876044 18059187 16023760 16234567
MESH:D006528 Carcinoma, Hepatocellular Estradiol 23.5216924424
MESH:D006528 Carcinoma, Hepatocellular Ethanol 23.5218788625 15763234 15289165
MESH:D006528 Carcinoma, Hepatocellular N-nitrosomorpholine 23.521917145 8364915 15010824 9466558 9029167 2885971 16935385 19335982 15543204 11509945 10629087 9311599 1701930 19383236 1967229
MESH:D006528 Carcinoma, Hepatocellular Quercetin 23.5212508355 19519916
MESH:D006528 Carcinoma, Hepatocellular resveratrol 23.5216227395 19321006
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 23.5216924424
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 23.521917145
MESH:D002278 Carcinoma in Situ bisphenol A 4.1617123778
MESH:D018827 Carcinoma, Lewis Lung resveratrol 3.7716675471
MESH:D002289 Carcinoma, Non-Small-Cell Lung bexarotene 2.8716247446
MESH:D021441 Carcinoma, Pancreatic Ductal Quercetin 4.1417234771
MESH:D002292 Carcinoma, Renal Cell Doxorubicin 5.721485588 16201981
MESH:D002292 Carcinoma, Renal Cell N-nitrosomorpholine 5.727921415 1429202
MESH:D002294 Carcinoma, Squamous Cell Calcitriol 13.6411237771
MESH:D002294 Carcinoma, Squamous Cell Doxorubicin 13.646189445
MESH:D002294 Carcinoma, Squamous Cell Isotretinoin 13.6411237771
MESH:D002294 Carcinoma, Squamous Cell resveratrol 13.6416227395
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 13.6416051514 16096774
MESH:D002294 Carcinoma, Squamous Cell Zinc 13.6416543248
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 2.8817572228
MESH:D006332 Cardiomegaly Ethanol 8.3719332462
MESH:D006332 Cardiomegaly Quercetin 8.3719794523
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 8.3718670907 16120746 18850075
MESH:D009202 Cardiomyopathies Doxorubicin 2.9416455267 15505089 15792986 16364871 17007740 16109756 15811867 15476868 16278810 16731534 16242529 16651473 16612575 17131338 17382496 17519947 16952015 17308081 17928571 18627295 17351982 17329180 17924179 16269455 17974986
MESH:D002311 Cardiomyopathy, Dilated Doxorubicin 2.5817334414 16243910
MESH:D002318 Cardiovascular Diseases resveratrol 5.5915458977
MESH:D002318 Cardiovascular Diseases Zinc 5.5916936243
MESH:D002375 Catalepsy Haloperidol 4.0915215559 1977408
MESH:D002386 Cataract Acetaminophen 9.2010977129
MESH:D002386 Cataract Methylnitrosourea 9.2012484553
MESH:D002386 Cataract Tretinoin 9.2017460283
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 18.426135515
MESH:D002471 Cell Transformation, Neoplastic Clofibrate 18.421399818
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 18.4212371664
MESH:D002471 Cell Transformation, Neoplastic Estradiol 18.4218566989
MESH:D002471 Cell Transformation, Neoplastic Methylnitronitrosoguanidine 18.422727394
MESH:D002471 Cell Transformation, Neoplastic Methylnitrosourea 18.422727394 7505956
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 3.7616129372
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.3320734317
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 2.4516835633
MESH:D002779 Cholestasis Cyclosporine 9.5819486331
MESH:D002779 Cholestasis Ethinyl Estradiol 9.5817681005 17110522 16919318 11677210 16105132 17333356 15861022
MESH:D002779 Cholestasis pirinixic acid 9.5819176532
MESH:D002822 Choriocarcinoma Tretinoin 4.3116461808
MESH:D002916 Chylothorax orlistat 5.8017003701
MESH:D002971 Cleft Lip Ethanol 3.0815513904
MESH:D002972 Cleft Palate Ethanol 10.5215513904
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 10.5212621046 16354765 15668235 8697196 15340226
MESH:D002972 Cleft Palate Tretinoin 10.529407595
MESH:D002972 Cleft Palate Urethane 10.5212810352
MESH:D003072 Cognition Disorders Clozapine 4.1617123785
MESH:D003092 Colitis resveratrol 11.4016474422
MESH:D003092 Colitis Selenium 11.4017936198
MESH:D003092 Colitis Tretinoin 11.4017035595
MESH:D003110 Colonic Neoplasms Dexamethasone 4.5415824018
MESH:D003110 Colonic Neoplasms Quercetin 4.5419056647 11134977 17148506 17191121 19440933 16640504 15741050
MESH:D003110 Colonic Neoplasms resveratrol 4.5416338953
MESH:D015179 Colorectal Neoplasms Doxorubicin 2.8818802399 18259882
MESH:D015179 Colorectal Neoplasms Quercetin 2.8818095365 18852136
MESH:D015179 Colorectal Neoplasms resveratrol 2.8816550006
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 7.1717141729 14669216
MESH:D000013 Congenital Abnormalities Triclosan 7.1719283420
MESH:D003327 Coronary Disease Fructose 6.8118504504
MESH:D003327 Coronary Disease resveratrol 6.8116507316
MESH:D019465 Craniofacial Abnormalities Benzene 11.4015643154
MESH:D019465 Craniofacial Abnormalities Dexamethasone 11.4017728286
MESH:D019465 Craniofacial Abnormalities Ethanol 11.4011198716 15451039 15513904 19302082 15451040 10194807 11873399
MESH:D019465 Craniofacial Abnormalities Isotretinoin 11.4018769834 9879862
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 11.4015322242 10048152 20055451
MESH:D019465 Craniofacial Abnormalities Tretinoin 11.4017551590 9224671 10589399 9211117 8800419 9664655 9142499 16925845 9125849 14991402
MESH:D019465 Craniofacial Abnormalities Valproic Acid 11.4016575769 8888407 17688650
MESH:D019465 Craniofacial Abnormalities Zinc 11.4019302082
MESH:D003490 Cyanosis 2,4-dinitrotoluene 8.2118551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 8.2118551238
MESH:D016757 Death, Sudden, Cardiac Haloperidol 4.0720210726
MESH:D003704 Dementia Haloperidol 7.9511575062
MESH:D003704 Dementia Methylmercury Compounds 7.9516140633
MESH:D003711 Demyelinating Diseases Tamoxifen 3.5519031437
MESH:D003872 Dermatitis Benzene 3.9615902427
MESH:D017449 Dermatitis, Allergic Contact Dexamethasone 4.8012438553
MESH:D017449 Dermatitis, Allergic Contact nickel sulfate 4.8011298694 16823706 16780908
MESH:D003876 Dermatitis, Atopic pirinixic acid 1.9718249437
MESH:D048909 Diabetes Complications orlistat 5.0019207292
MESH:D003920 Diabetes Mellitus rosiglitazone 11.5217446233
MESH:D003920 Diabetes Mellitus Streptozocin 11.5216285004
MESH:D003920 Diabetes Mellitus Zinc 11.5216479319
MESH:D003921 Diabetes Mellitus, Experimental Fructose 14.2318603373
MESH:D003921 Diabetes Mellitus, Experimental Quercetin 14.2319496084
MESH:D003921 Diabetes Mellitus, Experimental resveratrol 14.2316873680
MESH:D003921 Diabetes Mellitus, Experimental Streptozocin 14.2318603373 12083368 12644472 17442507 7637645 15298345 12446591 11055810 15862027 11260395 19496084 19586609 16286809 17874149 19960420 8740154 19298542 1374869 6379147 12093613 16684804 15831366 2177838 18715473
MESH:D003922 Diabetes Mellitus, Type 1 Streptozocin 3.3118603373
MESH:D003924 Diabetes Mellitus, Type 2 Clozapine 19.5316402076
MESH:D003924 Diabetes Mellitus, Type 2 coumarin 19.5319647726
MESH:D003924 Diabetes Mellitus, Type 2 epigallocatechin gallate 19.5316988119
MESH:D003924 Diabetes Mellitus, Type 2 Fructose 19.5318603373
MESH:D003924 Diabetes Mellitus, Type 2 rosiglitazone 19.5312642470
MESH:D003924 Diabetes Mellitus, Type 2 Streptozocin 19.5319586609 19647726
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 19.5317107852
MESH:D003924 Diabetes Mellitus, Type 2 troglitazone 19.5316023994
MESH:D003925 Diabetic Angiopathies troglitazone 4.8312601628
MESH:D058065 Diabetic Cardiomyopathies Streptozocin 4.9016025228
MESH:D003928 Diabetic Nephropathies Estradiol 15.6319279558
MESH:D003928 Diabetic Nephropathies resveratrol 15.6316286809
MESH:D003928 Diabetic Nephropathies Streptozocin 15.6319682444 19960420
MESH:D003928 Diabetic Nephropathies Tamoxifen 15.6319279558
MESH:D003930 Diabetic Retinopathy Streptozocin 4.6317662242
MESH:D003967 Diarrhea Dexamethasone 6.047237001
MESH:D003967 Diarrhea orlistat 6.0420002075
MESH:D006970 Disorders of Excessive Somnolence Clozapine 4.7115331141
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 31.5918551238 21346803
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 31.5918551238 21346803
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 31.5918713872 17522070 14725611 11421492 16781746 14986274 10663392 19164858 12540782 10915739 15619225 15968718 12153990 17906064 11739529 12705907 11743745 19085960 10774834 11461765 19923254 19420014 14550746 16177239 2444490 19416960 16485898 16109766 17562736 11834606 11529661 12958197 19370779 16227642 16393943 16081117 12392966 18071297 11287661 19739265 12594235
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 31.596884620 7179309 15998439 9327722 3786805 16227642 10092053 4309450 6623471 10915739 3732212 2869522 7120509 15027814 19336974 21278145 11566570 17522070 19085960 7440962 16177239 15968718
MESH:D056486 Drug-Induced Liver Injury Doxorubicin 31.5917416283
MESH:D056486 Drug-Induced Liver Injury Erythromycin Estolate 31.5914998559 17522070
MESH:D056486 Drug-Induced Liver Injury Ethanol 31.5911566570
MESH:D056486 Drug-Induced Liver Injury Selenium 31.5915131321
MESH:D056486 Drug-Induced Liver Injury Tea 31.5919370779
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 31.5920420201
MESH:D056486 Drug-Induced Liver Injury Tetracycline 31.5917522070
MESH:D056486 Drug-Induced Liver Injury troglitazone 31.5914986274
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 31.591733752 19641884
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.2619426721
MESH:D004362 Drug Toxicity Doxorubicin 18.9018602426
MESH:D004362 Drug Toxicity Lamivudine 18.9015040536
MESH:D004362 Drug Toxicity Stavudine 18.9015040536
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 18.9011462148
MESH:D004362 Drug Toxicity Zidovudine 18.9015040536
MESH:D004374 Ductus Arteriosus, Patent Ibuprofen 4.7918446180 16133044 18450898
MESH:D050171 Dyslipidemias Clofibrate 15.4916707586
MESH:D050171 Dyslipidemias Clozapine 15.4916402076
MESH:D050171 Dyslipidemias Dietary Fats 15.4918367378
MESH:D050171 Dyslipidemias Fenofibrate 15.4916707586
MESH:D004421 Dystonia Valproic Acid 3.281851702
MESH:D004485 Eczema Dexamethasone 3.6712438553
MESH:D004487 Edema Dexamethasone 13.8819703484
MESH:D004487 Edema pirinixic acid 13.8812083418
MESH:D004487 Edema resveratrol 13.888985016
MESH:D004487 Edema rosiglitazone 13.8812083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 13.8811000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 9.1518230668 16714409 15322242
MESH:D004489 Edema, Cardiac Tretinoin 9.1518230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Calcitriol 15.5315138306
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 15.5312538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental resveratrol 15.5317872969
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 15.5319031437
MESH:D016889 Endometrial Neoplasms Doxorubicin 17.0617359293
MESH:D016889 Endometrial Neoplasms Estradiol 17.0611473722 18566989 19148513
MESH:D016889 Endometrial Neoplasms Fenofibrate 17.0616569247
MESH:D016889 Endometrial Neoplasms Tamoxifen 17.0620544844 16202921 19155303 17893378
MESH:D016889 Endometrial Neoplasms Tretinoin 17.0616569247
MESH:D004715 Endometriosis Ibuprofen 11.2215652904
MESH:D004715 Endometriosis Mifepristone 11.2216134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 11.229294722 10568697
MESH:D004719 Endomyocardial Fibrosis Doxorubicin 4.3118037988
MESH:D019446 Endotoxemia Ibuprofen 4.1511545620
MESH:D020345 Enterocolitis, Necrotizing resveratrol 4.0417923197
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 3.3517275665 3659116
MESH:D004828 Epilepsies, Partial Valproic Acid 3.083922381 16628512
MESH:D004827 Epilepsy Valproic Acid 2.4520417680 18234410
MESH:D004832 Epilepsy, Absence Naloxone 7.126254150
MESH:D004832 Epilepsy, Absence Valproic Acid 7.126254150 6426943 7562514
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 3.497750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 3.243659116
MESH:D004938 Esophageal Neoplasms Ethanol 3.9116704527
MESH:D004938 Esophageal Neoplasms Zinc 3.9116543248
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 6.6511564622
MESH:D005124 Eye Abnormalities Tretinoin 6.6516938888 9664655
MESH:D005234 Fatty Liver 4-methylene-2-octyl-5-oxofuran-3-carboxylic acid 72.7714736702
MESH:D005234 Fatty Liver Carbon Tetrachloride 72.7719224547 12795759 61145 12631006 17595544 15959796 16239168 16045604
MESH:D005234 Fatty Liver Clofibrate 72.7719224547
MESH:D005234 Fatty Liver Cyclosporine 72.7719224547
MESH:D005234 Fatty Liver Dietary Fats 72.7717967931 19551842 18296743 19004024
MESH:D005234 Fatty Liver Ethanol 72.7718620774 16409862 19236843
MESH:D005234 Fatty Liver Ethinyl Estradiol 72.7715345470
MESH:D005234 Fatty Liver Fish Oils 72.7718620774
MESH:D005234 Fatty Liver Fructose 72.7718395287 19196556 18641190
MESH:D005234 Fatty Liver pirinixic acid 72.7719236843 20131406
MESH:D005234 Fatty Liver rosiglitazone 72.7719196556
MESH:D005234 Fatty Liver Stavudine 72.7718299183
MESH:D005234 Fatty Liver Tamoxifen 72.7719224547 14986274
MESH:D005234 Fatty Liver Tetracycline 72.7719224547 16917069
MESH:D005234 Fatty Liver Valproic Acid 72.7714986274 19224547
MESH:D005234 Fatty Liver Zidovudine 72.7718299183
MESH:D005235 Fatty Liver, Alcoholic Ethanol 4.8217920746
MESH:D052776 Female Urogenital Diseases Tamoxifen 2.6716709447
MESH:D005310 Fetal Alcohol Syndrome Ethanol 4.4715513904 16946407 15451040 10194807
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 2.6511858732
MESH:D005315 Fetal Diseases Valproic Acid 4.0416575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 3.348888407 18558336
MESH:D005334 Fever Ibuprofen 3.8616997862
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 3.7014745880
MESH:D018222 Fibromatosis, Aggressive Doxorubicin 8.7019069698
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 8.7019069698
MESH:D005354 Fibrosarcoma Methylnitrosourea 4.4111555667
MESH:D005355 Fibrosis Carbon Tetrachloride 29.2918705752
MESH:D005355 Fibrosis Cyclosporine 29.2912639820 12168785
MESH:D005355 Fibrosis Dietary Fats 29.2918296743
MESH:D005355 Fibrosis Fructose 29.2918504504
MESH:D005355 Fibrosis Quercetin 29.2919474275
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 29.2920067830
MESH:D005355 Fibrosis Tretinoin 29.2917994277
MESH:D005414 Flatulence orlistat 5.8020002075
MESH:D005756 Gastritis Acetaminophen 14.2216983495
MESH:D005756 Gastritis Ethanol 14.2215046732
MESH:D005756 Gastritis Zinc 14.2217241300
MESH:D005885 Gingival Hyperplasia Cyclosporine 3.398708960
MESH:D005909 Glioblastoma Doxorubicin 8.5017150277
MESH:D005909 Glioblastoma Quercetin 8.5019804834
MESH:D005909 Glioblastoma Tretinoin 8.5017312396
MESH:D005910 Glioma Methylnitrosourea 5.049825942
MESH:D005910 Glioma Quercetin 5.0417643826
MESH:D018149 Glucose Intolerance Fructose 4.5519165636
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 3.7510696789
MESH:D006130 Growth Disorders Zinc 3.3717217573
MESH:D006258 Head and Neck Neoplasms Doxorubicin 5.8215692506
MESH:D006258 Head and Neck Neoplasms Tretinoin 5.8216096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 4.3116084493
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 4.8310048152 11294989
MESH:D006330 Heart Defects, Congenital Tretinoin 4.8314991402 9664655
MESH:D006331 Heart Diseases Doxorubicin 13.1316244372 12587719 16879835 16144979 16330681 16707910 14766674 18674790 17875725 17888722 18006777 16244371 16495754
MESH:D006331 Heart Diseases Mitoxantrone 13.1316019553
MESH:D006331 Heart Diseases Streptozocin 13.1312093613
MESH:D006331 Heart Diseases Urethane 13.1316046796
MESH:D006333 Heart Failure Doxorubicin 12.1917481944
MESH:D006333 Heart Failure pirinixic acid 12.1920558911
MESH:D006333 Heart Failure Selenium 12.1917162251
MESH:D006333 Heart Failure Zinc 12.1917162251
MESH:D006335 Heart Injuries Zinc 4.9317074742
MESH:D016481 Helicobacter Infections Zinc 3.7617241300
MESH:D006394 Hemangiosarcoma Doxorubicin 3.1615692506
MESH:D006402 Hematologic Diseases Benzene 8.5216183116
MESH:D006402 Hematologic Diseases Zidovudine 8.5212579204
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 3.5915720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 2.5811000095
MESH:D006505 Hepatitis Carbon Tetrachloride 2.8219900420 19110552
MESH:D006509 Hepatitis B Lamivudine 4.3417703166
MESH:D019694 Hepatitis B, Chronic Lamivudine 4.3415274664 16476009 12044531 15631357 15309715
MESH:D006527 Hepatolenticular Degeneration Zinc 3.8817276780
MESH:D006529 Hepatomegaly pirinixic acid 5.6119176532 16221962 19772884 18467677
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 5.6116120746 15340226 12621046
MESH:D006548 Hernia, Diaphragmatic Dexamethasone 2.717520565
MESH:D006558 Herpes Genitalis Estradiol 4.1915709030
MESH:D006561 Herpes Simplex Etoposide 7.3710809021
MESH:D006561 Herpes Simplex resveratrol 7.3716876885
MESH:D015658 HIV Infections Indinavir 11.3111141242 11363243 15388451
MESH:D015658 HIV Infections Lamivudine 11.3111141242 20032539 9296927 17530837
MESH:D015658 HIV Infections Stavudine 11.3111141242
MESH:D015658 HIV Infections Zidovudine 11.3111141242 20032539 11363243 11698656 17358032
MESH:D006689 Hodgkin Disease Doxorubicin 5.4215147373 18501091 17606976
MESH:D006689 Hodgkin Disease Etoposide 5.4218180244 16200630 16135485 15147373 17606976
MESH:D019584 Hot Flashes Estradiol 2.9217088409
MESH:D006849 Hydrocephalus Valproic Acid 4.0417688650
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.2016354765 16959395 15340226 18606429 8697196
MESH:D006930 Hyperalgesia Acetaminophen 13.1416870215
MESH:D006930 Hyperalgesia Ethanol 13.1418783367
MESH:D006930 Hyperalgesia rosiglitazone 13.1412083418
MESH:D006930 Hyperalgesia Tretinoin 13.1416870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 3.7016899240
MESH:D006937 Hypercholesterolemia Dietary Fats 6.7321332399
MESH:D006937 Hypercholesterolemia resveratrol 6.7317188708
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 3.7616778211
MESH:D006943 Hyperglycemia pirinixic acid 6.8120558911
MESH:D006943 Hyperglycemia Quercetin 6.8111834736 18262572
MESH:D006946 Hyperinsulinism Fructose 4.1918563319 14757778 18360027 19008412 15752949
MESH:D006948 Hyperkinesis Clozapine 4.0816046005
MESH:D006949 Hyperlipidemias Dietary Fats 20.7621332399
MESH:D006949 Hyperlipidemias Fish Oils 20.7615752949
MESH:D006949 Hyperlipidemias Fructose 20.7615752949
MESH:D006949 Hyperlipidemias orlistat 20.7621332399
MESH:D006949 Hyperlipidemias resveratrol 20.7616873680
MESH:D006968 Hypersensitivity, Delayed Corn Oil 9.9011484837
MESH:D006968 Hypersensitivity, Delayed Fish Oils 9.9011484837
MESH:D006973 Hypertension Benzene 15.2817940673
MESH:D006973 Hypertension Cyclosporine 15.2810903974
MESH:D006973 Hypertension Dexamethasone 15.2817042910
MESH:D006973 Hypertension Fructose 15.2819008412 14633139 14568997 16843071 14573337
MESH:D006973 Hypertension Quercetin 15.2818356687
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 15.2818850075 18670907
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.2815338365
MESH:D015228 Hypertriglyceridemia Fructose 8.9319342510 19799862
MESH:D015228 Hypertriglyceridemia Triglycerides 8.9316979400 16238453
MESH:D006984 Hypertrophy Ibuprofen 4.2216672835
MESH:D017379 Hypertrophy, Left Ventricular resveratrol 3.5717488730
MESH:D007021 Hypospadias Ethinyl Estradiol 3.0016945680 16569931
MESH:D007235 Infant, Premature, Diseases Ibuprofen 4.9916133044
MESH:D020244 Infarction, Middle Cerebral Artery resveratrol 3.8417600658
MESH:D007247 Infertility, Female Ethinyl Estradiol 2.6912013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 11.2417937319
MESH:D007248 Infertility, Male fulvestrant 11.2411514358
MESH:D007248 Infertility, Male Methylnitrosourea 11.247193160
MESH:D007248 Infertility, Male Triclosan 11.2420821571
MESH:D007249 Inflammation Dexamethasone 19.7011099482 8960868
MESH:D007249 Inflammation Dietary Fats 19.7020412841
MESH:D007249 Inflammation Ibuprofen 19.703291741
MESH:D007249 Inflammation resveratrol 19.7016366677
MESH:D007249 Inflammation rosiglitazone 19.7012083418
MESH:D007249 Inflammation Tamoxifen 19.7019457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 19.7012200463 12878042
MESH:D007249 Inflammation Triclosan 19.709584910 20507366
MESH:D007251 Influenza, Human Quercetin 13.8216624496
MESH:D007251 Influenza, Human resveratrol 13.8216624496
MESH:D007251 Influenza, Human Selenium 13.8216624496
MESH:D007333 Insulin Resistance bisphenol A 30.4716393666
MESH:D007333 Insulin Resistance Dietary Fats 30.4718457598 11836018
MESH:D007333 Insulin Resistance Estradiol 30.4716393666 16627594
MESH:D007333 Insulin Resistance Fructose 30.4714633139 19342510 19586609 14757778 14573337 17133782 19008412 19799862 18981581 18057795 18563319
MESH:D007333 Insulin Resistance orlistat 30.4717201808
MESH:D007333 Insulin Resistance Palmitates 30.4717471172
MESH:D007333 Insulin Resistance pirinixic acid 30.4716306350
MESH:D007333 Insulin Resistance rosiglitazone 30.4716306350
MESH:D007410 Intestinal Diseases Tretinoin 2.9717994277
MESH:D007511 Ischemia Zinc 3.8316584753
MESH:D007569 Jaw Abnormalities Ethanol 12.8415513904
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 12.8416580747
MESH:D007569 Jaw Abnormalities Tretinoin 12.8415992940 17551590
MESH:D007627 Keloid Quercetin 4.1417086741
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 3.6015604871
MESH:D017492 Keratosis, Seborrheic alitretinoin 4.8116144296
MESH:D007674 Kidney Diseases Acetaminophen 20.5215629191 12587719
MESH:D007674 Kidney Diseases Cyclosporine 20.528314463 10903974 18776723
MESH:D007674 Kidney Diseases Doxorubicin 20.5215699352 15369732 16775033
MESH:D007674 Kidney Diseases Estradiol 20.5215618244
MESH:D007674 Kidney Diseases Quercetin 20.5216962696
MESH:D007674 Kidney Diseases Streptozocin 20.5212093613
MESH:D007674 Kidney Diseases Zinc 20.5216960431
MESH:C531755 Kidney disorder involving deposition of calcium and oxalate or phosphate in the renal tubules orlistat 5.8017185156
MESH:D007676 Kidney Failure, Chronic Doxorubicin 12.4316707910
MESH:D007676 Kidney Failure, Chronic Selenium 12.4316518626
MESH:D007676 Kidney Failure, Chronic Zinc 12.4316518626
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 20.1916705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 20.1916705839
MESH:D007680 Kidney Neoplasms Cyclosporine 20.1912371664
MESH:D007680 Kidney Neoplasms Estradiol 20.1915610895
MESH:D007680 Kidney Neoplasms Tamoxifen 20.1918625569
MESH:D007680 Kidney Neoplasms Zidovudine 20.1912579204
MESH:D007859 Learning Disorders Ethanol 3.4115451040
MESH:D007938 Leukemia Benzene 7.7114694614 17119257 15935818 18335105
MESH:D007938 Leukemia Quercetin 7.7117468513
MESH:D007938 Leukemia Tretinoin 7.7117143497
MESH:D004915 Leukemia, Erythroblastic, Acute Doxorubicin 11.4316085563
MESH:D004915 Leukemia, Erythroblastic, Acute troglitazone 11.4316085563
MESH:D015451 Leukemia, Lymphocytic, Chronic, B-Cell Mitoxantrone 3.3618172266
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Zidovudine 3.6620370541
MESH:D007951 Leukemia, Myeloid Benzene 7.1917506065
MESH:D007951 Leukemia, Myeloid Tretinoin 7.1916482212 19285840 16932348
MESH:D015470 Leukemia, Myeloid, Acute Benzene 4.8019478238
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 4.8016294345 17596541 19850784
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 4.8016294345 17596541
MESH:D015473 Leukemia, Promyelocytic, Acute resveratrol 5.7816087638
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 5.7816331271 17368321 9834237 17506722 17107899 16140955 19035177 19029980 17361223 17217047 16788101 19225113 16823087 12679006 15748426 16935935 17339181 17649720 19075265 17301526 16766008 16891316 17294898 17712046 19642359
MESH:D017880 Limb Deformities, Congenital Ethanol 10.1317676605
MESH:D017880 Limb Deformities, Congenital Methylnitrosourea 10.1315526292
MESH:D017880 Limb Deformities, Congenital Tretinoin 10.139224671
MESH:D008064 Lipidoses Clozapine 5.9717567588
MESH:D008064 Lipidoses Tamoxifen 5.9717567588 15342952
MESH:D008080 Liposarcoma therapeutic 20372807
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 11.4916943688 17157831 11903743 16221502 11408273 17174718 21278145 16239168 17334410
MESH:D008103 Liver Cirrhosis Dietary Fats 11.4918296743
MESH:D008103 Liver Cirrhosis Ethanol 11.4915289165
MESH:D008103 Liver Cirrhosis orlistat 11.4917404856
MESH:D008104 Liver Cirrhosis, Alcoholic Ethanol 4.2718295389
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 23.8117823541 17640975 14512876 12741479 15370692 18418968 12546737 12586293 12445418 15650968 16015684 12445421 15931870 17631135 18395914 16192424 17714472 15959796 18054572 18339082 15818738 18187930 18472332 18705752 17557913 12667390 17698563 15996030 12389079 16097048 18006644 17766677 14620537 15052691 15925388 18472094 18412020 15057751 12898905 16116963 17869086 18481824 18376398 18317297 18251166 12632512 14716496 18263696 16638106 20821823 17922224 15876570 12666154 14748882 12632514 16011737 13678700 17900296 18210741 17481882 18205269 18156304 18279442 15893842 10355542 11481614 17761835 15362042 15338365 16027843 17805973 18166357 17708605 18429990 17721639 18277467 15730626 18395095 16248980 18420326 15673190 15123356 16136751 12609069 12649538 12958196 17976157 14716833 17565644 16033810 17944888 17525996 14724832
MESH:D008106 Liver Cirrhosis, Experimental Dexamethasone 23.8116718785
MESH:D008106 Liver Cirrhosis, Experimental Doxorubicin 23.8116595196 16439617
MESH:D008106 Liver Cirrhosis, Experimental epigallocatechin gallate 23.8117481882
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 23.8114716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Ethanol 23.8118166357
MESH:D008106 Liver Cirrhosis, Experimental Fenofibrate 23.8115474484
MESH:D008106 Liver Cirrhosis, Experimental Phosphatidylcholines 23.8116169303
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 23.8115474484
MESH:D008106 Liver Cirrhosis, Experimental Quercetin 23.8112741479
MESH:D008106 Liver Cirrhosis, Experimental rosiglitazone 23.8117347453 15980055
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 23.8118564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 23.8112878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 23.8118397230 16248980
MESH:D008107 Liver Diseases Acetaminophen 2.9212969438 16611625 19014921 11587558 19784758 16610002 19460945 12587719
MESH:D008107 Liver Diseases Carbon Tetrachloride 2.9217285989 16964402 15720792 16246199 15830285
MESH:D008108 Liver Diseases, Alcoholic Ethanol 3.8417347304 17207112
MESH:D017093 Liver Failure Carbon Tetrachloride 9.1615123358
MESH:D017093 Liver Failure Stavudine 9.1618299183
MESH:D017114 Liver Failure, Acute Acetaminophen 6.9717185352 16871587
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 6.9716899240 14706259
MESH:D008113 Liver Neoplasms 2,4,5,2',4',5'-hexachlorobiphenyl 28.7916835634 18644402
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 28.797678174
MESH:D008113 Liver Neoplasms 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone 28.7915890375
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 28.7919294768
MESH:D008113 Liver Neoplasms Fenofibrate 28.7918978307
MESH:D008113 Liver Neoplasms pirinixic acid 28.7916377806 20007298 15890375
MESH:D008113 Liver Neoplasms Quercetin 28.7918980244
MESH:D008113 Liver Neoplasms resveratrol 28.7919321006 19812893 20405173 19073162
MESH:D008113 Liver Neoplasms Tamoxifen 28.7916684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 28.7916984957
MESH:D008113 Liver Neoplasms Urethane 28.7917559639 16391232 17093202
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 19.492876786 6135515 2876784
MESH:D008114 Liver Neoplasms, Experimental Benzene 19.4912562636
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 19.4915583823 12014681
MESH:D008114 Liver Neoplasms, Experimental Doxorubicin 19.4916842330 17085340
MESH:D008114 Liver Neoplasms, Experimental Fenofibrate 19.4918775883 18253720
MESH:D008114 Liver Neoplasms, Experimental Quercetin 19.4919519916
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 19.4912151625
MESH:D038061 Lower Extremity Deformities, Congenital Methylnitrosourea 4.6516080182
MESH:D008171 Lung Diseases Ozone 2.7819066396 8266340
MESH:D017563 Lung Diseases, Interstitial Benzene 8.6014698565
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 8.6017228818
MESH:D055370 Lung Injury Ozone 3.0620417186
MESH:D008175 Lung Neoplasms 4-methylene-2-octyl-5-oxofuran-3-carboxylic acid 28.5918413838
MESH:D008175 Lung Neoplasms 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone 28.5912438228 14755239 16061637 19931552 18813816 18508827 9255578 15893417 15172992 17139156 16401635
MESH:D008175 Lung Neoplasms alitretinoin 28.5916413115
MESH:D008175 Lung Neoplasms Benzene 28.5912562636
MESH:D008175 Lung Neoplasms bexarotene 28.5917849452
MESH:D008175 Lung Neoplasms Dexamethasone 28.5915824018 11195469
MESH:D008175 Lung Neoplasms Doxorubicin 28.5917418594 6189445
MESH:D008175 Lung Neoplasms Isotretinoin 28.5915899809
MESH:D008175 Lung Neoplasms methyl 2-cyano-3,12-dioxoolean-1,9-dien-28-oate 28.5917363558
MESH:D008175 Lung Neoplasms Methylnitrosourea 28.5918062963
MESH:D008175 Lung Neoplasms Ozone 28.597614698 8597069
MESH:D008175 Lung Neoplasms Quercetin 28.5916280456
MESH:D008175 Lung Neoplasms Tamoxifen 28.5918625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 28.5919555203 11884234
MESH:D008175 Lung Neoplasms Urethane 28.5911992545 16337739 10997738 7750092 11807781 10530776 16204055 17195641 12765245 11307925 16289808 16391232 12466968 11246140 17255336 11074608 11893704 11062179 15166089 12117781 12957351 16926031 11544531 15136453 6695378 11497255 10822126 16788158 15902970 17093202 10779650 16007126 11323394 11552296 14587096
MESH:D008175 Lung Neoplasms Zidovudine 28.5918800350
MESH:D008180 Lupus Erythematosus, Systemic Silicon Dioxide 4.1816373255
MESH:D008207 Lymphatic Metastasis orlistat 5.0920805790 18770866
MESH:D008223 Lymphoma Benzene 12.7817584886 17119257
MESH:D008223 Lymphoma Doxorubicin 12.7816098063
MESH:D008223 Lymphoma Etoposide 12.7812854902 12556972
MESH:D008223 Lymphoma Methylnitrosourea 12.7811418001 16257854
MESH:D016393 Lymphoma, B-Cell Methylnitrosourea 7.9814633661
MESH:D016393 Lymphoma, B-Cell resveratrol 7.9817088997
MESH:D008228 Lymphoma, Non-Hodgkin Doxorubicin 6.5617654614
MESH:D008228 Lymphoma, Non-Hodgkin resveratrol 6.5614749477
MESH:D016399 Lymphoma, T-Cell Doxorubicin 3.7615621674
MESH:D016410 Lymphoma, T-Cell, Cutaneous bexarotene 4.3411161223
MESH:D015674 Mammary Neoplasms, Animal Benzene 12.0812562636
MESH:D015674 Mammary Neoplasms, Animal resveratrol 12.0815688416
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 12.0819428831
MESH:D008325 Mammary Neoplasms, Experimental Benzene 39.4211921183
MESH:D008325 Mammary Neoplasms, Experimental bexarotene 39.4219196723 19196722 15591091
MESH:D008325 Mammary Neoplasms, Experimental Doxorubicin 39.4215458769
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 39.4211807958 16891317 17203775 11408345
MESH:D008325 Mammary Neoplasms, Experimental Ibuprofen 39.4210697514
MESH:D008325 Mammary Neoplasms, Experimental Methylnitrosourea 39.4214999141 11807958 10838139 10767621 17131329 15113128 12931682 15313902 16619500 11751437 17020996 15688392 19196723 14633655 16944150 16051031 16827153
MESH:D008325 Mammary Neoplasms, Experimental resveratrol 39.428985016 11606380
MESH:D008325 Mammary Neoplasms, Experimental rosiglitazone 39.4216827153
MESH:D008325 Mammary Neoplasms, Experimental Selenium 39.4215318939
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 39.4214580682 19196722 11731420 19196723 16827153
MESH:D008325 Mammary Neoplasms, Experimental Triclosan 39.4215358634
MESH:D008325 Mammary Neoplasms, Experimental Zinc 39.4212773700
MESH:D020149 Manganese Poisoning Estradiol 9.8519453300
MESH:D020149 Manganese Poisoning Tamoxifen 9.8519453300
MESH:D008527 Medulloblastoma Tretinoin 2.3817453147
MESH:D008545 Melanoma marker/mechanism 18770866 20805790 21213365
MESH:D008545 Melanoma Cerulenin 16.8520805790
MESH:D008545 Melanoma Doxorubicin 16.8516827129
MESH:D008545 Melanoma epigallocatechin gallate 16.8511746506 17992120
MESH:D008545 Melanoma Glucose 16.8514993021
MESH:D008545 Melanoma Isotretinoin 16.8517237267
MESH:D008545 Melanoma orlistat 16.8520805790 18770866
MESH:D008545 Melanoma resveratrol 16.8517992120
MESH:D008545 Melanoma Tamoxifen 16.8519393235 12393984
MESH:D008545 Melanoma Tretinoin 16.8516752155
MESH:D018328 Melanoma, Amelanotic Tamoxifen 3.3615990972
MESH:D008546 Melanoma, Experimental Acetaminophen 2.7619513568
MESH:D008569 Memory Disorders Ethanol 7.4218411066 15451040
MESH:D008569 Memory Disorders Methylmercury Compounds 7.4218436314
MESH:D008591 Meningomyelocele Tretinoin 3.6116940565
MESH:D001523 Mental Disorders Clozapine 5.6916856516
MESH:D001523 Mental Disorders Haloperidol 5.6916856516
MESH:D008654 Mesothelioma Doxorubicin 4.8817638057
MESH:D008654 Mesothelioma Selenium 4.8815107826
MESH:D008659 Metabolic Diseases resveratrol 3.6217112576
MESH:D024821 Metabolic Syndrome X Clozapine 12.0919142101
MESH:D024821 Metabolic Syndrome X Fructose 12.0917261469 18497449 17098227 16815490 19165636
MESH:D024821 Metabolic Syndrome X rosiglitazone 12.0917261469
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 3.9416801185
MESH:D008679 Metaplasia Ozone 4.2610496685
MESH:D048629 Micronuclei, Chromosome-Defective Zidovudine 4.9917358032
MESH:D053842 Microsatellite Instability Methylnitronitrosoguanidine 5.0617671175
MESH:D008881 Migraine Disorders Valproic Acid 2.5718765137 18803445
MESH:D028361 Mitochondrial Diseases Doxorubicin 3.7415792986
MESH:D009069 Movement Disorders Methylmercury Compounds 4.5518436314
MESH:D052016 Mucositis Doxorubicin 3.9617415656
MESH:D009101 Multiple Myeloma Benzene 8.6217119195
MESH:D009101 Multiple Myeloma Dexamethasone 8.6215867202 16118317 15744524
MESH:D009101 Multiple Myeloma resveratrol 8.6216267019 16490592 17935668 17164350 14749477 17049120
MESH:D009134 Muscular Atrophy, Spinal epigallocatechin gallate 9.8817962980
MESH:D009134 Muscular Atrophy, Spinal resveratrol 9.8817962980
MESH:D009135 Muscular Diseases Bezafibrate 13.2716239165
MESH:D009135 Muscular Diseases orlistat 13.2718430571
MESH:D009135 Muscular Diseases pirinixic acid 13.2716239165
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 3.278888407
MESH:D009164 Mycobacterium Infections Indinavir 8.7921442799
MESH:D009164 Mycobacterium Infections orlistat 8.7921442799
MESH:D009190 Myelodysplastic Syndromes Dexamethasone 9.209809623
MESH:D009190 Myelodysplastic Syndromes Tretinoin 9.2017596541
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 9.2017596541
MESH:D009203 Myocardial Infarction Doxorubicin 9.9715857846 19429709
MESH:D009203 Myocardial Infarction pirinixic acid 9.9719151258
MESH:D009203 Myocardial Infarction Quercetin 9.9719595682
MESH:D009203 Myocardial Infarction resveratrol 9.9717188708 17125593 16525036 16456233 16317513 17015251
MESH:D017202 Myocardial Ischemia resveratrol 6.7417125593 17015251
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 6.7412213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 10.3316810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 10.3316411023
MESH:D015428 Myocardial Reperfusion Injury Quercetin 10.3319207477
MESH:D009205 Myocarditis resveratrol 3.9317322642
MESH:D009336 Necrosis 2,4-dinitrotoluene 7.6118551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 7.617678174 18551238
MESH:D009362 Neoplasm Metastasis Doxorubicin 4.4718259882
MESH:D009362 Neoplasm Metastasis Tamoxifen 4.4719393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.1719410462
MESH:D009369 Neoplasms 2,4,5,2',4',5'-hexachlorobiphenyl 26.648820588
MESH:D009369 Neoplasms alitretinoin 26.6416946489
MESH:D009369 Neoplasms Methylnitrosourea 26.6415533788
MESH:D009369 Neoplasms Mitoxantrone 26.6416640825
MESH:D009369 Neoplasms orlistat 26.6418710210
MESH:D009369 Neoplasms pirinixic acid 26.6417405874
MESH:D009369 Neoplasms Quercetin 26.6415185748
MESH:D009369 Neoplasms Tretinoin 26.6416594593 16946489
MESH:D009369 Neoplasms Urethane 26.6415625555
MESH:D009369 Neoplasms valilactone 26.6418710210
MESH:D009374 Neoplasms, Experimental Methylnitrosourea 15.3512696579
MESH:D009374 Neoplasms, Experimental orlistat 15.3519381703
MESH:D009374 Neoplasms, Experimental resveratrol 15.358985016
MESH:D009374 Neoplasms, Experimental Urethane 15.3515582191
MESH:D009376 Neoplasms, Hormone-Dependent bexarotene 8.1519196722
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 8.1519189210 19196722 19200415
MESH:D009389 Neovascularization, Pathologic Estradiol 7.7617289903
MESH:D009389 Neovascularization, Pathologic orlistat 7.7617012255
MESH:D009395 Nephritis, Interstitial Ibuprofen 8.246375363
MESH:D009395 Nephritis, Interstitial Tetracycline 8.249884423
MESH:D009401 Nephrosis Doxorubicin 3.9616899518 16636307
MESH:D009402 Nephrosis, Lipoid Cyclosporine 3.6017954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 6.9218481113 19348381
MESH:D009404 Nephrotic Syndrome Doxorubicin 6.9216889571 15640375
MESH:D009410 Nerve Degeneration Ibuprofen 6.6710961664
MESH:D009410 Nerve Degeneration Rotenone 6.6715790535 18619942 17356569
MESH:D009421 Nervous System Malformations bisphenol A 17.0116427766 11399458
MESH:D009421 Nervous System Malformations Estradiol 17.0116427766 11399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 17.0114600291
MESH:D009421 Nervous System Malformations Tretinoin 17.019125849
MESH:D009436 Neural Tube Defects Benzene 8.7715643154
MESH:D009436 Neural Tube Defects Tretinoin 8.779142499
MESH:D009436 Neural Tube Defects Valproic Acid 8.7716359493 8888407
MESH:D009442 Neurilemmoma Methylnitrosourea 4.6611555667
MESH:D009447 Neuroblastoma Doxorubicin 5.6815555623
MESH:D009447 Neuroblastoma Isotretinoin 5.6817368321
MESH:D019636 Neurodegenerative Diseases Acetaminophen 6.0418514411
MESH:D019636 Neurodegenerative Diseases resveratrol 6.0417652729
MESH:D020078 Neurogenic Inflammation Quercetin 8.1417929310
MESH:D020078 Neurogenic Inflammation resveratrol 8.1417929310
MESH:D052556 Niemann-Pick Disease, Type C Clofibrate 4.139802331
MESH:C541083 Non-alcoholic Fatty Liver Disease orlistat 4.8017404856
MESH:D009765 Obesity 4-methylene-2-octyl-5-oxofuran-3-carboxylic acid 13.9014736702
MESH:D009765 Obesity Clozapine 13.9019142110 18515891
MESH:D009765 Obesity Dietary Fats 13.9017217161 18674790 20132043 16723640 21332399 18457598 20518802 11836018 19632207
MESH:D009765 Obesity Fructose 13.9018585860 17707055
MESH:D009765 Obesity orlistat 13.9018773755 20599501 20065556 20518802 16938137 21438711 19046740 20002075 19461584 20540997 21442799 19207292
MESH:D009765 Obesity pirinixic acid 13.9020558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 10.9412819281 16049721
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 10.9416049721
MESH:D009784 Occupational Diseases Benzene 10.9417178637 15727169 17479406 15935809 17119257 16737584 15576619 15913788 15612468
MESH:D010003 Osteoarthritis Ibuprofen 3.577009135
MESH:D015663 Osteoporosis, Postmenopausal Quercetin 7.6519495926
MESH:D015663 Osteoporosis, Postmenopausal resveratrol 7.6517513867
MESH:D012516 Osteosarcoma Doxorubicin 3.4315930896
MESH:D010049 Ovarian Diseases bisphenol A 4.1611985600
MESH:D010051 Ovarian Neoplasms Benzene 14.2012562636
MESH:D010051 Ovarian Neoplasms Estradiol 14.2019401270
MESH:D010051 Ovarian Neoplasms Mifepristone 14.2016525653
MESH:D010051 Ovarian Neoplasms Quercetin 14.2019005980
MESH:D010051 Ovarian Neoplasms Tretinoin 14.2016936753
MESH:D010051 Ovarian Neoplasms Urethane 14.2016391232
MESH:D010146 Pain Acetaminophen 7.3816870215
MESH:D010146 Pain Ibuprofen 7.383291741
MESH:D010146 Pain Tretinoin 7.3816870215
MESH:D010149 Pain, Postoperative Ibuprofen 4.3116678543
MESH:D010190 Pancreatic Neoplasms 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone 18.8212384795
MESH:D010190 Pancreatic Neoplasms Ethanol 18.8212384795
MESH:D010190 Pancreatic Neoplasms Etoposide 18.8219003803
MESH:D010190 Pancreatic Neoplasms Ibuprofen 18.8212384795
MESH:D010190 Pancreatic Neoplasms Methylnitrosourea 18.8216965848
MESH:D010190 Pancreatic Neoplasms Quercetin 18.8216965848
MESH:D010190 Pancreatic Neoplasms Tretinoin 18.8215976015
MESH:D010195 Pancreatitis Fatty Acids, Nonesterified 7.1218983441
MESH:D010195 Pancreatitis orlistat 7.1220065556 16938137
MESH:D016584 Panic Disorder Ethinyl Estradiol 2.9111578682
MESH:D010300 Parkinson Disease Rotenone 2.6111535288 16140633 11445065 16412576 19114014 18619942 15451049 18191903 19232380
MESH:D020734 Parkinsonian Disorders Rotenone 3.3515795934 15574749 15927086 18197244
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.4012520081
MESH:D010391 Pemphigoid, Bullous Tetracycline 4.5911026799
MESH:D010538 Peritonitis Ozone 3.3316369182
MESH:D003557 Phyllodes Tumor Doxorubicin 4.3117983394
MESH:D010911 Pituitary Neoplasms Urethane 4.6016391232
MESH:D010954 Plasmacytoma Selenium 4.0515087411
MESH:D010997 Pleural Neoplasms Doxorubicin 4.3117638057
MESH:D011014 Pneumonia Ozone 3.5718929643 18381685 18007984
MESH:D011085 Polycystic Ovary Syndrome orlistat 4.5417201808
MESH:D017499 Porokeratosis alitretinoin 5.1616144296
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 2.7718163543
MESH:D011230 Precancerous Conditions Corn Oil 11.3914668109
MESH:D011230 Precancerous Conditions Cyclosporine 11.3912371664
MESH:D011230 Precancerous Conditions Quercetin 11.3919056647
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Dexamethasone 3.0121297632
MESH:D011225 Pre-Eclampsia Zinc 3.5117114810
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 27.3410548101
MESH:D011297 Prenatal Exposure Delayed Effects Isotretinoin 27.3418769834
MESH:D011297 Prenatal Exposure Delayed Effects Methylmercury Compounds 27.3418436314
MESH:D011297 Prenatal Exposure Delayed Effects resveratrol 27.3416679765
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 27.3411896295 11399792 11118676 11222880
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 27.3420603192
MESH:D017096 Prion Diseases Tetracycline 4.5810903871
MESH:D011470 Prostatic Hyperplasia Calcitriol 3.9515572423
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 8.0520887781
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 8.0520887781
MESH:D011471 Prostatic Neoplasms bisphenol A 3.4216740699
MESH:D011471 Prostatic Neoplasms Calcitriol 3.4216289102 18247401 16644109 15754350 12479363
MESH:D011471 Prostatic Neoplasms Doxorubicin 3.4216888761 18437689 15749863 15897917 16868541 16729912
MESH:D011471 Prostatic Neoplasms Estradiol 3.4216740699
MESH:D011471 Prostatic Neoplasms Etoposide 3.4217172428
MESH:D011471 Prostatic Neoplasms Ibuprofen 3.4217409433
MESH:D011471 Prostatic Neoplasms Methylnitrosourea 3.4215682402 12376480
MESH:D011471 Prostatic Neoplasms Quercetin 3.4214715546 17292933
MESH:D011471 Prostatic Neoplasms resveratrol 3.4217804756 16731767 17636462 15767336 17675339 17718901
MESH:D011471 Prostatic Neoplasms Tamoxifen 3.4215067354
MESH:D011471 Prostatic Neoplasms Zinc 3.4212429649 16606632 16517595 16700911
MESH:D011507 Proteinuria Ibuprofen 6.966375363
MESH:D011507 Proteinuria Tretinoin 6.9616636307
MESH:D011537 Pruritus Ethinyl Estradiol 7.3015861022 16919318
MESH:D011537 Pruritus Naloxone 7.3015861022
MESH:D019310 Pseudolymphoma Valproic Acid 3.7011422049 12752131
MESH:D011565 Psoriasis Cyclosporine 1.8616882103
MESH:D011595 Psychomotor Agitation Haloperidol 4.1511575062
MESH:D011596 Psychomotor Disorders Isotretinoin 5.0918769834
MESH:D011618 Psychotic Disorders Clozapine 7.0315331141
MESH:D011618 Psychotic Disorders Haloperidol 7.0311575062
MESH:D011625 Pterygium Tretinoin 3.9616723453
MESH:D011629 Puberty, Precocious bisphenol A 3.9610548101
MESH:D011658 Pulmonary Fibrosis Silicon Dioxide 5.4917365031 12193738 14975940
MESH:D011658 Pulmonary Fibrosis troglitazone 5.4918162602
MESH:D012035 Refsum Disease orlistat 5.2420871815
MESH:D051437 Renal Insufficiency Doxorubicin 3.4217922066
MESH:D051436 Renal Insufficiency, Chronic resveratrol 4.7416325855
MESH:D015427 Reperfusion Injury pirinixic acid 4.9419058328
MESH:D015427 Reperfusion Injury resveratrol 4.9416317513 16314181 15827377 17058453 17520802
MESH:D012128 Respiratory Distress Syndrome, Adult Dexamethasone 3.2611700416 18379247
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.0418990726
MESH:D012162 Retinal Degeneration Methylnitrosourea 7.2118172121 18155124
MESH:D012162 Retinal Degeneration Zinc 7.2116584753
MESH:D012175 Retinoblastoma Methylnitrosourea 4.6611555667
MESH:D012206 Rhabdomyolysis Lamivudine 4.719296927
MESH:D012208 Rhabdomyosarcoma Tretinoin 8.3016283617 16116481
MESH:D012208 Rhabdomyosarcoma Valproic Acid 8.3019155313
MESH:D012509 Sarcoma Doxorubicin 3.2618313854 15625365 15675481 16767912 17710206 17203757
MESH:D012512 Sarcoma, Ewing's Doxorubicin 7.9414601052 16326096
MESH:D012512 Sarcoma, Ewing's Etoposide 7.9414601052
MESH:D012514 Sarcoma, Kaposi Doxorubicin 3.9617846226
MESH:D012554 Schistosomiasis japonica Quercetin 4.7016862918
MESH:D012559 Schizophrenia Clozapine 4.5211151749 20452607 17123785 20521326 19369910 20107430 16141801 18855531 20521320 17726453 18806925 11763009 20580759 17667964 20168265
MESH:D012559 Schizophrenia Haloperidol 4.521830565 19369910 18513383 20107430
MESH:D012559 Schizophrenia Valproic Acid 4.5215737665 19110320
MESH:D012640 Seizures 2,4-dinitrotoluene 9.1218551238
MESH:D012640 Seizures 2,6-dinitrotoluene 9.1218551238
MESH:D012640 Seizures Ethanol 9.129754883
MESH:D012640 Seizures Valproic Acid 9.1215475178 17978042 11738929 3137016 16876388 11044598 1511512 14763951
MESH:D012829 Silicosis Silicon Dioxide 6.3618666137
MESH:D012878 Skin Neoplasms Doxorubicin 16.3315692506
MESH:D012878 Skin Neoplasms Glucose 16.3314993021
MESH:D012878 Skin Neoplasms resveratrol 16.338985016 15837718
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 16.3316192470
MESH:D012878 Skin Neoplasms Tretinoin 16.3316467112
MESH:D012878 Skin Neoplasms Urethane 16.3311807781
MESH:D012983 Soft Tissue Neoplasms Doxorubicin 3.7617203757 16767912 15625365
MESH:D013088 Spermatocele Ethinyl Estradiol 8.7716709447
MESH:D013088 Spermatocele Tamoxifen 8.7716709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 3.2219457130
MESH:D016135 Spinal Dysraphism Valproic Acid 3.1119490988
MESH:D013226 Status Epilepticus Valproic Acid 3.7012833885
MESH:D013272 Stomach Diseases Dexamethasone 3.5015472012
MESH:D013274 Stomach Neoplasms Benzene 8.1312562636
MESH:D013274 Stomach Neoplasms Ethanol 8.1318456281
MESH:D013274 Stomach Neoplasms Methylnitrosourea 8.1316257854 18593901 15930296
MESH:D013274 Stomach Neoplasms orlistat 8.1319381703
MESH:D013274 Stomach Neoplasms Tretinoin 8.1317261132
MESH:D013274 Stomach Neoplasms troglitazone 8.1315930296
MESH:D013274 Stomach Neoplasms Zidovudine 8.1317696246
MESH:D013276 Stomach Ulcer Dexamethasone 5.1315138204
MESH:D013276 Stomach Ulcer Ethanol 5.1317189318 11906479 9562338 16755016 9211565 17918041
OMIM:601367 STROKE, ISCHEMIC resveratrol 3.7416321402
MESH:D019966 Substance-Related Disorders bisphenol A 3.1716684133 16045194
MESH:D013375 Substance Withdrawal Syndrome Ethanol 3.529754883
MESH:D017180 Tachycardia, Ventricular Haloperidol 3.9220210726
MESH:D019851 Thrombophilia Ethinyl Estradiol 2.8511994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.4415669648
MESH:D013953 Thymus Neoplasms Benzene 9.4810850423
MESH:D013953 Thymus Neoplasms Methylnitrosourea 9.4811418001
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 9.7112697716
MESH:D013959 Thyroid Diseases Triclosan 9.7119910387
MESH:D013964 Thyroid Neoplasms Doxorubicin 8.3316010429 17909728
MESH:D013964 Thyroid Neoplasms Methylnitrosourea 8.337505956 3078959
MESH:D013964 Thyroid Neoplasms Tretinoin 8.3317045167 16026305
MESH:D013978 Tibial Fractures Estradiol 3.8419048282
MESH:D014062 Tongue Neoplasms resveratrol 12.4016227395
MESH:D014062 Tongue Neoplasms Tretinoin 12.4016051514
MESH:D014062 Tongue Neoplasms Zinc 12.4016543248
MESH:D014178 Translocation, Genetic Valproic Acid 4.3917262798
MESH:D014376 Tuberculosis Tretinoin 2.6516040207
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 3.693119515
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 11.3516049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 11.3516049721
MESH:D001749 Urinary Bladder Neoplasms Doxorubicin 11.3517653716
MESH:D001749 Urinary Bladder Neoplasms Quercetin 11.3516720314
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 11.358653321 16712894 17572228
MESH:D014564 Urogenital Abnormalities Valproic Acid 3.838888407
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 9.2510091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 9.2510091137
MESH:D014581 Urticaria Acetaminophen 2.2210982225
MESH:D002583 Uterine Cervical Neoplasms resveratrol 7.1017473185
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 7.1016129372
MESH:D014591 Uterine Diseases bisphenol A 4.1614652134
MESH:D014594 Uterine Neoplasms Benzene 11.5712562636
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 11.5714692618
MESH:D014594 Uterine Neoplasms resveratrol 11.5717044934
MESH:D014604 Uveal Neoplasms Tretinoin 3.7716752155
MESH:D014605 Uveitis Cyclosporine 8.981336536
MESH:D014605 Uveitis Dexamethasone 8.981336536
MESH:D014625 Vaginal Neoplasms Zidovudine 3.9512579204
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 3.7512125929
MESH:D019043 Vascular Neoplasms Urethane 5.0710620525
MESH:D020301 Vasospasm, Intracranial Ibuprofen 4.3719057314
MESH:D014689 Venous Insufficiency coumarin 4.9312708602
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 2.7915869587 14671159
MESH:D018487 Ventricular Dysfunction, Left Doxorubicin 7.6716364871 17638931 17334414 17678736
MESH:D018487 Ventricular Dysfunction, Left resveratrol 7.6717488730
MESH:D014820 Vitiligo Tretinoin 3.2716761959
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.4015886252
MESH:D015430 Weight Gain Clozapine 7.4420564506 20521320 16141801 20107430 16402076 17502770
MESH:D015430 Weight Gain Dietary Fats 7.4416723640
MESH:D015431 Weight Loss Clozapine 4.2517933447
MESH:D009396 Wilms Tumor Tretinoin 3.2516287080
MESH:D014985 Xerophthalmia Cyclosporine 3.6017120751
Pathway ID Pathway Name
KEGG:00061 Fatty acid biosynthesis
KEGG:04910 Insulin signaling pathway
REACT:1505 Integration of energy metabolism
KEGG:01100 Metabolic pathways
REACT:22258 Metabolism of lipids and lipoproteins
REACT:11193 Metabolism of vitamins and cofactors
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA28006
    • No data
    Releated disease ID Related disease Name
    PA447216Schizophrenia
    Releated drug ID Related drug Name
    PA449061clozapine
    PA449841haloperidol
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB01034 antagonist Cerulenin Antibiotics, Antifungal;Fatty Acid Synthesis Inhibitors
    DB01083 antagonist Orlistat Enzyme Inhibitors;Anti-Obesity Agents
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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