AutismKB 2.0

Annotation Detail for FAT1


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Basic Information Top
Gene Symbol:FAT1 ( CDHF7,CDHR8,FAT,ME5,hFat1 )
Gene Full Name: FAT tumor suppressor homolog 1 (Drosophila)
Band: 4q35.2
Quick LinksEntrez ID:2195; OMIM: 600976; Uniprot ID:FAT1_HUMAN; ENSEMBL ID: ENSG00000083857; HGNC ID: 3595
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Pathway IDPathway Name
P00012Cadherin signaling pathway
P00057Wnt signaling pathway
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1739Oral cancer
1976Squamous cell cancer
2045Bipolar disorder
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Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of FAT1 mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of FAT1 mRNAaffects expression 21346803
C035207 4-amino-2,6-dinitrotoluene 4-amino-2,6-dinitrotoluene affects the expression of FAT1 mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of FAT1 mRNAaffects expression 17562736
D000643 Ammonium Chloride Ammonium Chloride affects the expression of FAT1 mRNAaffects expression 16483693
D001280 Atrazine Atrazine results in increased expression of FAT1 mRNAincreases expression 18585445
D004041 Dietary Fats Dietary Fats results in decreased expression of FAT1 mRNAdecreases expression 18042831
D004052 Diethylnitrosamine Diethylnitrosamine results in increased expression of FAT1 mRNAincreases expression 19638242
C041786 palm oil palm oil results in decreased expression of FAT1 mRNAdecreases expression 18042831
D010634 Phenobarbital NR1I3 protein affects the reaction [Phenobarbital results in increased expression of FAT1 mRNA]affects reaction|increases expression 19482888
D010634 Phenobarbital Phenobarbital results in increased expression of FAT1 mRNAincreases expression 19482888
C105686 SU 5402 SU 5402 affects the expression of FAT1 mRNAaffects expression 15298682
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced 4-amino-2,6-dinitrotoluene 9.357525203
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 9.356195326
MESH:D000138 Acidosis Ammonium Chloride 3.7518287403
MESH:D000236 Adenoma Diethylnitrosamine 2.936695378 10737359
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 10.9318056438 17620307 17162532 19061943 16434500 19052882
MESH:D018248 Adenoma, Liver Cell Phenobarbital 10.9317620307
MESH:D000382 Agricultural Workers' Diseases Atrazine 4.4211874814
MESH:D000799 Angioedema Acetaminophen 4.0610982225
MESH:D001161 Arteriosclerosis Dietary Fats 4.0615238619
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001943 Breast Neoplasms Dietary Fats 2.1720435547
MESH:D001943 Breast Neoplasms Diethylnitrosamine 2.1717474063
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 9.0816705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 9.0816705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 9.083084413
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 9.0818665156 19208518 19335982 20214788 18978308 19701751 16779866 16935385 20084675 18788625 20512989 3084413 18971187 16878318 3581430 16569478 17162532 20727157 21159647 19052882 18785209 18210153 20514400 18393292 18056438 19539802 19383236 16328049 17428255 16502159 16807293 19919837 10737359 16288022 19519916 17173139 19107877 17761372 20432363 17138121 19394651 20524982 11831363 19171122 10672840 20007298 16830150 17978847 17055752 18506893 19822196 16698587 16681979 20101231 20935162 19418558 16540662 18691550 18494052
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 9.0817173139 1701930 20007298 20935162 6705139
MESH:D002386 Cataract 4-amino-2,6-dinitrotoluene 7.6814694615
MESH:D002386 Cataract Acetaminophen 7.6810977129
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 7.016135515
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 7.0121159647 17174075 7505956 2727394
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.434080065
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 3.8119052882
MESH:D000013 Congenital Abnormalities 4-amino-2,6-dinitrotoluene 4.2815095906
MESH:D003490 Cyanosis 2,4-dinitrotoluene 11.4918551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 11.4918551238
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 2.2220387270
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 12.4318551238 21346803
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 12.4321346803 18551238
MESH:D056486 Drug-Induced Liver Injury 4-amino-2,6-dinitrotoluene 12.4321346803
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 12.4312153990 17906064 2444490 16177239 12540782 16227642 14550746 18071297 17562736 11461765 19370779 19739265 10774834 10915739 19923254 11287661 16485898 11834606 10663392 16109766 19164858 18713872 16393943 11743745 11529661 16081117 12594235 16781746 19420014 14725611 15619225 12705907 17522070 19085960 12958197 14986274 12392966 11739529 11421492 15968718 19416960
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 12.4319107877
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.3219426721
MESH:D050171 Dyslipidemias Dietary Fats 3.5518367378
MESH:D004421 Dystonia Phenobarbital 4.151851702
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 4.283659116
MESH:D004828 Epilepsies, Partial Phenobarbital 4.093922381 11558140
MESH:D004827 Epilepsy Phenobarbital 2.9520417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.676401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.437750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 4.213659116
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.3316302075
MESH:D005234 Fatty Liver Dietary Fats 8.3219551842 19004024 17967931 18296743
MESH:D005234 Fatty Liver Diethylnitrosamine 8.3221071580 20387270
MESH:D005355 Fibrosis Dietary Fats 3.7018296743
MESH:D005756 Gastritis Acetaminophen 3.8916983495
MESH:D006529 Hepatomegaly Phenobarbital 3.6616109766
MESH:D006930 Hyperalgesia Acetaminophen 2.8116870215
MESH:D006937 Hypercholesterolemia Dietary Fats 3.7321332399
MESH:D006949 Hyperlipidemias Dietary Fats 3.7621332399
MESH:D007248 Infertility, Male Atrazine 3.8012948887
MESH:D007249 Inflammation Dietary Fats 5.3320412841
MESH:D007249 Inflammation Diethylnitrosamine 5.3318785209
MESH:D007333 Insulin Resistance Dietary Fats 3.1918457598 11836018
MESH:D007674 Kidney Diseases Acetaminophen 2.2712587719 15629191
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 7.7616705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 7.7616705839
MESH:D008103 Liver Cirrhosis Dietary Fats 11.4518296743
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 11.4518665156 20032147 18407596 18522880 19638242
MESH:D008103 Liver Cirrhosis Phenobarbital 11.4521047994
MESH:D008107 Liver Diseases Acetaminophen 6.6816611625 16610002 11587558 19460945 12587719 12969438 19784758 19014921
MESH:D008107 Liver Diseases Diethylnitrosamine 6.6817034775
MESH:D008107 Liver Diseases Phenobarbital 6.6819363144
MESH:D017114 Liver Failure, Acute Acetaminophen 3.3716871587 17185352
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 7.747678174
MESH:D008113 Liver Neoplasms Diethylnitrosamine 7.7418978307 18644402 20434301 19294768 20583210 18977376 19090486 18754104 10737359 20101389 19256749 19426721 21167192 18648771 20118626 19690152 19996281 15175105 20405173 19254457 20501860 20137499 21047994 12771043 19073162 16942905 20492335 19427195 21071580 19638242 15885732 19499222 2862719 19812893 2422723 20452335 19255062 21278145 9163691 12112319 19850985 19551842 19642983 19833225
MESH:D008113 Liver Neoplasms Phenobarbital 7.7419812893 19482888 21047994 8742319 15975961 19073162
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 10.366135515 2876784 2876786
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 10.3618775883 2563599 18079962 21159647 18164116 16842330 18253720 19004024 18544905 17942915 19126423 18282651 19009564 18308698 19539802 17174075 16267830 17854601 3124819 19519916 9362446 18093689
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 10.366150874 17172636 18308698 1399818 2563599
MESH:D008175 Lung Neoplasms Diethylnitrosamine 1.7620970405 21163286 20512841 6695378
MESH:D008546 Melanoma, Experimental Acetaminophen 3.7419513568
MESH:D008654 Mesothelioma Atrazine 3.571916698
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.6717484760
MESH:D009336 Necrosis 2,4-dinitrotoluene 11.0018551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 11.007678174 18551238
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.619029167 3581430
MESH:D019636 Neurodegenerative Diseases Acetaminophen 8.5818514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 8.5820387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.3320387270
MESH:D009765 Obesity Dietary Fats 2.3117217161 21332399 11836018 18457598 19632207 18674790 20132043 16723640 20518802
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 15.9416049721 12819281
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 15.9416049721
MESH:D009784 Occupational Diseases 4-amino-2,6-dinitrotoluene 15.9414694615
MESH:D010018 Osteomalacia Phenobarbital 4.5617016548
MESH:D010146 Pain Acetaminophen 2.5016870215
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 5.4116540662
MESH:D010190 Pancreatic Neoplasms Phenobarbital 5.4116965848
MESH:D010300 Parkinson Disease Atrazine 3.3217218051
MESH:D011230 Precancerous Conditions Diethylnitrosamine 9.512563599
MESH:D011230 Precancerous Conditions Phenobarbital 9.512563599
MESH:D019310 Pseudolymphoma Phenobarbital 4.7112752131
MESH:D012135 Respiratory Sounds Atrazine 4.6911874814
MESH:D012640 Seizures 2,4-dinitrotoluene 10.3618551238
MESH:D012640 Seizures 2,6-dinitrotoluene 10.3618551238
MESH:D012640 Seizures Phenobarbital 10.363137016 11442880 16876388 4039156
MESH:D003294 Seizures, Febrile Phenobarbital 5.026407741
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 1.7618456281
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 7.547505956
MESH:D013964 Thyroid Neoplasms Phenobarbital 7.541399818
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 5.1816049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 5.1816049721
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 12.6510091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 12.6510091137
MESH:D014581 Urticaria Acetaminophen 3.1210982225
MESH:D015430 Weight Gain Dietary Fats 3.8616723640
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA164719952
    • No data
    Releated disease ID Related disease Name
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    No data
    Drug Bank Top

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    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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