AutismKB 2.0

Annotation Detail for FAT2


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:FAT2 ( CDHF8,CDHR9,HFAT2,MEGF1 )
Gene Full Name: FAT tumor suppressor homolog 2 (Drosophila)
Band: 5q33.1
Quick LinksEntrez ID:2196; OMIM: 604269; Uniprot ID:FAT2_HUMAN; ENSEMBL ID: ENSG00000086570; HGNC ID: 3596
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
No data
No data
No data
Pathway IDPathway Name
P00012Cadherin signaling pathway
P00057Wnt signaling pathway
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000643 Ammonium Chloride Ammonium Chloride affects the expression of FAT2 mRNAaffects expression 16483693
C014707 nitrosobenzylmethylamine nitrosobenzylmethylamine results in decreased expression of FAT2 mRNAdecreases expression 17616710
C023036 perfluorooctanoic acid perfluorooctanoic acid results in increased expression of FAT2 mRNAincreases expression 16221955
D011374 Progesterone Progesterone results in decreased expression of FAT2 mRNAdecreases expression 18037150
D018038 Sodium Selenite Sodium Selenite results in decreased expression of FAT2 mRNAdecreases expression 18175754
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 4.1018287403
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.9517868700
MESH:D001930 Brain Injuries Progesterone 4.7415665606 15845082 15380490
MESH:D001943 Breast Neoplasms Progesterone 2.4116175315 15562024 17614352
MESH:D019457 Chromosome Breakage Sodium Selenite 5.2415894690
MESH:D003920 Diabetes Mellitus Sodium Selenite 4.1016285004
MESH:D003929 Diabetic Neuropathies Progesterone 4.9817187935
MESH:D056486 Drug-Induced Liver Injury Sodium Selenite 2.3615131321
MESH:D004487 Edema perfluorooctanoic acid 3.9517259670 12083418
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 4.2217692515
MESH:D004715 Endometriosis Progesterone 4.1116134523
MESH:D004938 Esophageal Neoplasms nitrosobenzylmethylamine 2.8415623463 15878914 16704527 15547733 15150132 16510608 15547721 16805852 15264214
MESH:D006529 Hepatomegaly perfluorooctanoic acid 4.583609246
MESH:D006930 Hyperalgesia perfluorooctanoic acid 4.1412083418
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.8915869954
MESH:D007249 Inflammation perfluorooctanoic acid 5.9612083418
MESH:D007249 Inflammation Progesterone 5.9615869954
MESH:D007333 Insulin Resistance Sodium Selenite 3.4914714311
MESH:D007984 Leydig Cell Tumor perfluorooctanoic acid 5.778812269
MESH:D008113 Liver Neoplasms perfluorooctanoic acid 3.0218709148 14757943
MESH:D016393 Lymphoma, B-Cell Sodium Selenite 4.4614737004
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 3.0711408345 17203775
MESH:D052556 Niemann-Pick Disease, Type C perfluorooctanoic acid 5.449802331
MESH:D010051 Ovarian Neoplasms Progesterone 2.6117393432 16525653
MESH:D011297 Prenatal Exposure Delayed Effects perfluorooctanoic acid 4.9317132714
MESH:D011471 Prostatic Neoplasms Sodium Selenite 3.3418760546
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.9518045962
MESH:D013119 Spinal Cord Injuries Progesterone 4.8215862959 16503802
MESH:D013274 Stomach Neoplasms nitrosobenzylmethylamine 2.3317575124 12958204
No data
Pharmacogenomics Knowledge Base Top
Drug Bank Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved