AutismKB 2.0

Annotation Detail for UNC5B


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Basic Information Top
Gene Symbol:UNC5B ( UNC5H2,p53RDL1 )
Gene Full Name: unc-5 homolog B (C. elegans)
Band: 10q22.1
Quick LinksEntrez ID:219699; OMIM: 607870; Uniprot ID:UNC5B_HUMAN; ENSEMBL ID: ENSG00000107731; HGNC ID: 12568
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04360Axon guidance
Pathway IDPathway Name
Axon guidance
Apoptosis
Pathway IDPathway Name
200074Netrin-mediated signaling
Pathway IDPathway Name
P00009Axon guidance mediated by netrin
Pathway IDPathway Name
500088Netrin-1 signaling
500280Role of DCC in regulating apoptosis
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1934Cancer
Desease Name
ADHD
PSYCH
attention-deficit hyperactivity disorder
Desease Name
Attention deficit hyperactivity disorder
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in decreased expression of UNC5B mRNAdecreases expression 18648102
D000082 Acetaminophen Acetaminophen affects the expression of UNC5B mRNAaffects expression 17562736
D000643 Ammonium Chloride Ammonium Chloride affects the expression of UNC5B mRNAaffects expression 16483693
D002713 Chlorine [Ozone co-treated with Chlorine] results in decreased expression of UNC5B mRNAaffects cotreatment|decreases expression 18636392
D002995 Clofibric Acid Clofibric Acid affects the expression of UNC5B mRNAaffects expression 17602206
D016572 Cyclosporine Cyclosporine results in increased expression of UNC5B mRNAincreases expression 20106945
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of UNC5B mRNAaffects cotreatment|increases expression 17942748
D005472 Fluorouracil Fluorouracil affects the expression of UNC5B mRNAaffects expression 16584549
D010126 Ozone [Ozone co-treated with Chlorine] results in decreased expression of UNC5B mRNAaffects cotreatment|decreases expression 18636392
D010126 Ozone Ozone results in decreased expression of UNC5B mRNAdecreases expression 16330353
C006253 pirinixic acid pirinixic acid results in increased expression of UNC5B mRNAincreases expression 18301758
D012643 Selenium Selenium results in increased expression of UNC5B mRNAincreases expression 19244175
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of UNC5B mRNAaffects cotreatment|increases expression 17942748
C025643 vinclozolin vinclozolin affects the expression of UNC5B mRNAaffects expression 19015723
C025643 vinclozolin vinclozolin results in decreased expression of UNC5B mRNAdecreases expression 18042343
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.9611752688 14514962 15322242
MESH:D000138 Acidosis Ammonium Chloride 3.6818287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.0817505938
MESH:D055371 Acute Lung Injury Chlorine 9.4420601635
MESH:D055371 Acute Lung Injury pirinixic acid 9.4418653653
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.4014692618
MESH:D000230 Adenocarcinoma Fluorouracil 4.4017638652
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.803712494
MESH:D018248 Adenoma, Liver Cell pirinixic acid 10.3016434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 10.3016835633
MESH:D000544 Alzheimer Disease Ozone 2.4515513908
MESH:D000740 Anemia Fluorouracil 8.9415504547 16511603 17963324
MESH:D000740 Anemia Tetrachlorodibenzodioxin 8.9411748828
MESH:D000799 Angioedema Acetaminophen 3.9810982225
MESH:D001008 Anxiety Disorders vinclozolin 3.7019015723
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.5711256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.7115885639
MESH:D001172 Arthritis, Rheumatoid Ozone 2.5715570426
MESH:D001249 Asthma Ozone 2.6617854713 16373670
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.1511289319 1440618
MESH:D001778 Blood Coagulation Disorders pirinixic acid 9.0419483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 9.0412125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.9215340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8115746008
MESH:D001943 Breast Neoplasms Fluorouracil 2.0516110121 18608205 18357371 16595493 16557594 19217205 15136595
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.0520435547
MESH:D016535 Bronchial Hyperreactivity Ozone 3.7418417511 17626835 18315731 14754758 15516495 16777450 19059883
MESH:D002100 Cachexia Ozone 4.8616183385
MESH:D002276 Carcinoid Tumor Fluorouracil 4.8016051944
MESH:D002277 Carcinoma Fluorouracil 8.4017121937
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 8.4016835633
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 4.627296757 3581430
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.623084413
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 4.6216332177 17088986 16799960 17971768 17045692 18930000
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 6.617296757
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 6.6118695887
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 2.5118986760 16757204 17066447 16280240
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4118850075 16120746 18670907
MESH:D002386 Cataract Acetaminophen 2.6310977129
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 6.757505956
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 6.7512371664
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.2316835633
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 19.7219486331 9022650
MESH:D002779 Cholestasis Cyclosporine 19.7219486331
MESH:D002779 Cholestasis Ethinyl Estradiol 19.7216105132 17110522 16919318 15861022 17681005 17333356 11677210
MESH:D002779 Cholestasis pirinixic acid 19.7219176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.138697196 15340226 16354765 15668235 12621046
MESH:D003092 Colitis Selenium 3.8817936198
MESH:D003110 Colonic Neoplasms Fluorouracil 2.2416510598 17172411 16340194 17287894 18772588 17725105 17169374 15001691 17018589 17016597
MESH:D015179 Colorectal Neoplasms Fluorouracil 2.0018802399 16331619 20501625 16282729 18448328 15148649 16391804 16524972 15289873 14970324 18949393 17695437 18383874 17594712 16303861 17454858 18288408 18509181 17401013 17094418 17016601 17255274
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1314669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2615322242 20055451 10048152
MESH:D003456 Cryptorchidism vinclozolin 4.4414966744
MESH:D007644 Darier Disease Fluorouracil 4.9116733453
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 2.9018759878 8970840 12868966 2524372 11298694 11906362 8156756 14531868
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4618249437
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.583621924 2952479
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6817107852
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 9.1411289319 16192314 6482804 7440962 18648102 1440618 18692083 9328219 9022650 6679447 18289764 8291058 9653073
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 9.1418071297 19370779 11529661 14725611 14550746 16781746 19416960 11834606 11743745 16081117 11739529 17522070 12540782 15619225 17906064 12153990 10915739 18713872 11461765 10663392 12705907 15968718 19739265 2444490 11287661 19923254 16177239 11421492 12958197 12392966 10774834 16485898 19085960 16109766 19420014 17562736 16393943 16227642 14986274 12594235 19164858
MESH:D056486 Drug-Induced Liver Injury Selenium 9.1415131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 9.1420420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.2319426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8211462148
MESH:D004417 Dyspnea Chlorine 4.7620016425
MESH:D004487 Edema pirinixic acid 6.8112083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.8111000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.0416714409 15322242 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.2812538720
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.1010568697 9294722
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 4.593581430
MESH:D004938 Esophageal Neoplasms Fluorouracil 4.5916481741 16785472 16337965 17638652 15173087
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0711564622
MESH:D005234 Fatty Liver Cyclosporine 13.4819224547
MESH:D005234 Fatty Liver Ethinyl Estradiol 13.4815345470
MESH:D005234 Fatty Liver pirinixic acid 13.4820131406 19236843
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.5611858732
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.156705139
MESH:D005355 Fibrosis Cyclosporine 8.8312168785 12639820
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 8.8320067830
MESH:D005739 Gas Poisoning Chlorine 5.1420016425
MESH:D005756 Gastritis Acetaminophen 3.8116983495
MESH:D030342 Genetic Diseases, Inborn vinclozolin 5.0516973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.4316417039
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.348708960
MESH:D005910 Glioma Fluorouracil 2.9016145905
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.127505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.7310696789
MESH:D006258 Head and Neck Neoplasms Fluorouracil 3.4415102660 15162350 18337622
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.3710048152 11294989
MESH:D006333 Heart Failure pirinixic acid 7.1120558911
MESH:D006333 Heart Failure Selenium 7.1117162251
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.5415720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.4211000095
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.616705139
MESH:D006529 Hepatomegaly pirinixic acid 8.6119772884 18467677 16221962 19176532
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 8.6116120746 12621046 15340226
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.1816959395 18606429 8697196 15340226 16354765
MESH:D006930 Hyperalgesia Acetaminophen 2.7616870215
MESH:D006943 Hyperglycemia pirinixic acid 3.2620558911
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.0415034207
MESH:D006973 Hypertension Cyclosporine 5.0410903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.0418670907 18850075
MESH:D007021 Hypospadias Ethinyl Estradiol 3.9116569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.5512013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 6.8417937319
MESH:D007248 Infertility, Male vinclozolin 6.8416467254
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.8912200463 12878042
MESH:D007251 Influenza, Human Selenium 4.3316624496
MESH:D007333 Insulin Resistance pirinixic acid 2.6816306350
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.158074119 9022650
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.4216580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.5815604871
MESH:D007674 Kidney Diseases Acetaminophen 5.9415629191 12587719
MESH:D007674 Kidney Diseases Cyclosporine 5.9418776723 10903974 8314463
MESH:D007676 Kidney Failure, Chronic Selenium 3.9716518626
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 12.816582329
MESH:D007680 Kidney Neoplasms Cyclosporine 12.8112371664
MESH:D007680 Kidney Neoplasms Fluorouracil 12.8116985049
MESH:D007984 Leydig Cell Tumor vinclozolin 4.8516417039
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.2415034207 9327722
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.1615474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.1612878042
MESH:D008107 Liver Diseases Acetaminophen 1.6519460945 16610002 19784758 16611625 19014921 12969438 12587719 11587558
MESH:D017114 Liver Failure, Acute Acetaminophen 3.3117185352 16871587
MESH:D008113 Liver Neoplasms Clofibric Acid 10.9517602206
MESH:D008113 Liver Neoplasms Fluorouracil 10.9516603448 18383874 17045692 15113037
MESH:D008113 Liver Neoplasms pirinixic acid 10.9516377806 20007298 15890375
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 10.9516984957
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 5.891399818 3712494 6587162 598648
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 5.8912151625
MESH:D008171 Lung Diseases Ozone 3.438266340 19066396
MESH:D055370 Lung Injury Ozone 3.9520417186
MESH:D008175 Lung Neoplasms Fluorouracil 3.5015246190
MESH:D008175 Lung Neoplasms Ozone 3.508597069 7614698
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.5019555203 11884234
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 4.9115086387
MESH:D008325 Mammary Neoplasms, Experimental Selenium 2.8115318939
MESH:D008546 Melanoma, Experimental Acetaminophen 3.6719513568
MESH:D008654 Mesothelioma Selenium 2.8215107826
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.9216801185
MESH:D008679 Metaplasia Ozone 5.2410496685
MESH:D009062 Mouth Neoplasms Fluorouracil 3.6916757204 18986760
MESH:D009135 Muscular Diseases pirinixic acid 3.6116239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.1719151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.0812213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.0116411023
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.503581430
MESH:D009369 Neoplasms Fluorouracil 5.1118600527 18239605 16928823
MESH:D009369 Neoplasms pirinixic acid 5.1117405874
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.5817954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.3619348381 18481113
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.3114600291
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 2.966679447
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.9418514411
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.4916436463
MESH:D009765 Obesity pirinixic acid 1.8320558911
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.506482804 4026338
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.153988306
MESH:D010146 Pain Acetaminophen 2.4616870215
MESH:D010190 Pancreatic Neoplasms Fluorouracil 2.6916500647 19003803 15113037 16929163
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.7711578682
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.597296757
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.3812520081
MESH:D010538 Peritonitis Ozone 4.2316369182
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.606228378
MESH:D010954 Plasmacytoma Selenium 5.0215087411
MESH:D011014 Pneumonia Ozone 4.5118381685 18929643 18007984
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.6518163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.2912371664
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 9.8811399792 11896295 11222880 11118676
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 9.8818220299 19015723 18042343
MESH:D011469 Prostatic Diseases vinclozolin 5.0518220299
MESH:D011471 Prostatic Neoplasms Fluorouracil 3.4018626508 19082440
MESH:D011472 Prostatitis vinclozolin 5.0518629315
MESH:D011537 Pruritus Ethinyl Estradiol 3.4316919318 15861022
MESH:D011565 Psoriasis Cyclosporine 2.2516882103
MESH:D012004 Rectal Neoplasms Fluorouracil 4.0815538739 16160472 18286688 18722050
MESH:D015427 Reperfusion Injury pirinixic acid 2.4219058328
MESH:D012120 Respiration Disorders Chlorine 5.3518579056
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.9318990726
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.433692021
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.0816192470
MESH:D013088 Spermatocele Ethinyl Estradiol 4.0816709447
MESH:D013274 Stomach Neoplasms Fluorouracil 2.0019015929 17172411 16951190 16424979 15786421 17498489 17522103 18396642 18567086 19084572
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.7111994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.2215669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.0412697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 2.951399818 7505956 3712494 6587162 6582329
MESH:D014062 Tongue Neoplasms Fluorouracil 4.0616280240
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 2.308074119
MESH:D014581 Urticaria Acetaminophen 3.0610982225
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 3.9516803524
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.3914692618
MESH:D014605 Uveitis Cyclosporine 4.121336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.7312125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.6215869587 14671159
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.3815886252
MESH:D014985 Xerophthalmia Cyclosporine 4.5817120751
Pathway ID Pathway Name
REACT:578 Apoptosis
KEGG:04360 Axon guidance
REACT:18266 Axon guidance
Pharmacogenomics Knowledge Base Top
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Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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