AutismKB 2.0

Annotation Detail for MPEG1


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Basic Information Top
Gene Symbol:MPEG1 ( MGC132657,MGC138435,MPG1 )
Gene Full Name: macrophage expressed 1
Band: 11q12.1
Quick LinksEntrez ID:219972; OMIM: 610390; Uniprot ID:MPEG1_HUMAN; ENSEMBL ID: ENSG00000197629; HGNC ID: 29619
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C028474 1,4-bis(2-(3,5-dichloropyridyloxy))benzene 1,4-bis(2-(3,5-dichloropyridyloxy))benzene affects the expression of MPEG1 mRNAaffects expression 18281256
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of MPEG1 mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of MPEG1 mRNAaffects expression 17562736
D000643 Ammonium Chloride Ammonium Chloride affects the expression of MPEG1 mRNAaffects expression 16483693
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of MPEG1 mRNAdecreases expression 20064835
D004041 Dietary Fats Dietary Fats results in decreased expression of MPEG1 mRNAdecreases expression 18042831
D004041 Dietary Fats Dietary Fats results in increased expression of MPEG1 mRNAincreases expression 15238619
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of MPEG1 mRNAincreases expression 15834898
C041786 palm oil palm oil results in decreased expression of MPEG1 mRNAdecreases expression 18042831
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of MPEG1 mRNAaffects binding|decreases expression|increases activity 19710929
C006253 pirinixic acid pirinixic acid results in decreased expression of MPEG1 mRNAdecreases expression 16985257
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 3.8418287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.2617505938
MESH:D055371 Acute Lung Injury pirinixic acid 3.3418653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 4.3220127859 20464547
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.3214692618
MESH:D000236 Adenoma Benzo(a)pyrene 2.766695378
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.7616434500
MESH:D000799 Angioedema Acetaminophen 4.1610982225
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.3319183758
MESH:D001161 Arteriosclerosis Dietary Fats 10.7915238619
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 10.7911256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.7815885639
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.3519483382
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.0920146248 17474063
MESH:D001943 Breast Neoplasms Dietary Fats 2.0920435547
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 2.9016705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 2.903084413
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.1020419170
MESH:D002386 Cataract Acetaminophen 2.6910977129
MESH:D002779 Cholestasis Ethinyl Estradiol 8.2517681005 11677210 16105132 17333356 16919318 17110522 15861022
MESH:D002779 Cholestasis pirinixic acid 8.2519176532
MESH:D003490 Cyanosis 2,4-dinitrotoluene 4.2718551238
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5118249437
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 3.8918551238 21346803
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 3.8919923254 19739265 11529661 15968718 2444490 14986274 12153990 17906064 19164858 11287661 19370779 12540782 10774834 18071297 12392966 16227642 18713872 11834606 16393943 11421492 16109766 16781746 17562736 17522070 16177239 14725611 11739529 11461765 12594235 19416960 11743745 12705907 16081117 14550746 19085960 10915739 16485898 12958197 15619225 19420014 10663392
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.4219426721
MESH:D050171 Dyslipidemias Dietary Fats 3.6018367378
MESH:D004487 Edema pirinixic acid 2.6812083418
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.4212538720
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 2.0516530937
MESH:D005234 Fatty Liver Dietary Fats 14.2819004024 17967931 19551842 18296743
MESH:D005234 Fatty Liver Ethinyl Estradiol 14.2815345470
MESH:D005234 Fatty Liver pirinixic acid 14.2820131406 19236843
MESH:D005355 Fibrosis Dietary Fats 3.7818296743
MESH:D005756 Gastritis Acetaminophen 3.9916983495
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 2.7520471113
MESH:D006333 Heart Failure pirinixic acid 2.6520558911
MESH:D006529 Hepatomegaly 1,4-bis(2-(3,5-dichloropyridyloxy))benzene 9.8216109766
MESH:D006529 Hepatomegaly pirinixic acid 9.8216221962 19772884 19176532 18467677
MESH:D006930 Hyperalgesia Acetaminophen 2.8616870215
MESH:D006937 Hypercholesterolemia Dietary Fats 3.8021332399
MESH:D006943 Hyperglycemia pirinixic acid 3.3820558911
MESH:D006949 Hyperlipidemias Dietary Fats 3.8321332399
MESH:D007021 Hypospadias Ethinyl Estradiol 4.0716945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.6812013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.6217937319
MESH:D007249 Inflammation Dietary Fats 2.5220412841
MESH:D007333 Insulin Resistance Dietary Fats 7.6718457598 11836018
MESH:D007333 Insulin Resistance pirinixic acid 7.6716306350
MESH:D007674 Kidney Diseases Acetaminophen 2.3012587719 15629191
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 3.1416705839
MESH:D008103 Liver Cirrhosis Dietary Fats 2.9818296743
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 1.3515474484
MESH:D008107 Liver Diseases Acetaminophen 1.6716611625 12969438 12587719 19014921 16610002 19784758 11587558 19460945
MESH:D017114 Liver Failure, Acute Acetaminophen 3.4316871587 17185352
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 4.5921137059 20195826
MESH:D008113 Liver Neoplasms pirinixic acid 4.5916377806 15890375 20007298
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 1.5618816296 6695378 18569708 17053015 20064080 20464547 20869020 18520028 20135361
MESH:D008546 Melanoma, Experimental Acetaminophen 3.8319513568
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.3516381670
MESH:D009135 Muscular Diseases pirinixic acid 3.7616239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2119151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.1016411023
MESH:D009336 Necrosis 2,4-dinitrotoluene 4.1418551238
MESH:D009369 Neoplasms Benzo(a)pyrene 5.1311141357
MESH:D009369 Neoplasms pirinixic acid 5.1317405874
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.0418514411
MESH:D009765 Obesity Dietary Fats 4.5818457598 21332399 16723640 17217161 11836018 18674790 20132043 20518802 19632207
MESH:D009765 Obesity pirinixic acid 4.5820558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 3.6212819281 16049721
MESH:D010146 Pain Acetaminophen 2.5616870215
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.9111578682
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.9417292933
MESH:D011537 Pruritus Ethinyl Estradiol 3.6015861022 16919318
MESH:D015427 Reperfusion Injury pirinixic acid 2.4719058328
MESH:D012640 Seizures 2,4-dinitrotoluene 2.6618551238
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 2.4519755658 10029692
MESH:D013088 Spermatocele Ethinyl Estradiol 4.2616709447
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.5620155912 2093021
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.8411994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.3315669648
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 5.2016049721
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 5.2017053015
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.6010091137
MESH:D014581 Urticaria Acetaminophen 3.2010982225
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.5414692618
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.7514671159 15869587
MESH:D015430 Weight Gain Dietary Fats 3.9216723640
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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