AutismKB 2.0

Annotation Detail for ALDH1A3


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Basic Information Top
Gene Symbol:ALDH1A3 ( ALDH1A6,ALDH6,RALDH3 )
Gene Full Name: aldehyde dehydrogenase 1 family, member A3
Band: 15q26.3
Quick LinksEntrez ID:220; OMIM: 600463; Uniprot ID:AL1A3_HUMAN; ENSEMBL ID: ENSG00000184254; HGNC ID: 409
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Pathway IDPathway Name
PWY-2501fatty acid alpha-oxidation
Pathway IDPathway Name
hsa00360Phenylalanine metabolism
hsa00010Glycolysis / Gluconeogenesis
hsa00980Metabolism of xenobiotics by cytochrome P450
hsa00982Drug metabolism - cytochrome P450
hsa00350Tyrosine metabolism
hsa01100Metabolic pathways
hsa00340Histidine metabolism
No data
No data
Pathway IDPathway Name
P043725-Hydroxytryptamine degredation
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of ALDH1A3 mRNAaffects expression 21346803
D013196 Dihydrotestosterone AR protein promotes the reaction [Dihydrotestosterone results in increased expression of ALDH1A3 mRNA]increases expression|increases reaction 17526768
D013196 Dihydrotestosterone bicalutamide inhibits the reaction [Dihydrotestosterone results in increased expression of ALDH1A3 mRNA]decreases reaction|increases expression 17526768
D013196 Dihydrotestosterone Dihydrotestosterone results in increased activity of ALDH1A3 proteinincreases activity 17526768
D013196 Dihydrotestosterone Dihydrotestosterone results in increased expression of ALDH1A3 mRNAincreases expression 17526768
D000643 Ammonium Chloride Ammonium Chloride affects the expression of ALDH1A3 mRNAaffects expression 16483693
C053541 bicalutamide bicalutamide inhibits the reaction [Dihydrotestosterone results in increased expression of ALDH1A3 mRNA]decreases reaction|increases expression 17526768
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in increased expression of ALDH1A3 mRNAincreases expression 15336504
D003513 Cycloheximide [Tetrachlorodibenzodioxin co-treated with Cycloheximide] results in increased expression of ALDH1A3 mRNAaffects cotreatment|increases expression 19684285
C014347 decitabine decitabine affects the expression of ALDH1A3 mRNAaffects expression 17194187
C014347 decitabine decitabine results in increased expression of ALDH1A3 mRNAincreases expression 16367923
D004052 Diethylnitrosamine [gum mastic co-treated with Diethylnitrosamine] results in decreased expression of ALDH1A3 mRNAaffects cotreatment|decreases expression 18977376
D004958 Estradiol [Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of ALDH1A3 mRNAaffects cotreatment|increases expression 19619570
D004958 Estradiol Estradiol results in increased expression of ALDH1A3 mRNAincreases expression 19619570
D005472 Fluorouracil ALDH1A3 protein affects the susceptibility to Fluorouracilaffects response to substance 15352031
D005472 Fluorouracil Fluorouracil results in decreased expression of ALDH1A3 proteindecreases expression 15352031
C056507 gemcitabine gemcitabine results in increased expression of ALDH1A3 mRNAincreases expression 17039268
D019833 Genistein Genistein results in decreased expression of ALDH1A3 mRNAdecreases expression 15378649
C043285 gum mastic [gum mastic co-treated with Diethylnitrosamine] results in decreased expression of ALDH1A3 mRNAaffects cotreatment|decreases expression 18977376
D007529 Isoflavones Isoflavones affects the expression of ALDH1A3 mRNAaffects expression 16365062
D015741 Metribolone Metribolone results in increased expression of ALDH1A3 mRNAincreases expression 17526768
C007350 nitrofen nitrofen results in increased expression of ALDH1A3 mRNAincreases expression 17270546
D009853 Omeprazole Omeprazole results in increased expression of ALDH1A3 mRNAincreases expression 12040753
D010795 Phthalic Acids Phthalic Acids results in decreased expression of ALDH1A3 mRNAdecreases expression 15728792
D011374 Progesterone Progesterone results in decreased expression of ALDH1A3decreases expression 17510236
D012172 Retinaldehyde ALDH1A3 protein results in increased oxidation of Retinaldehydeincreases oxidation 17526768
D012172 Retinaldehyde ALDH1A3 protein results in increased oxidation of Retinaldehydeincreases oxidation 17473173
C009277 sodium arsenate sodium arsenate results in decreased expression of ALDH1A3 mRNAdecreases expression 12727804
C017947 sodium arsenite sodium arsenite results in decreased expression of ALDH1A3 mRNAdecreases expression 12727804
D014284 Triiodothyronine [Triiodothyronine co-treated with Tetrachlorodibenzodioxin] results in increased expression of ALDH1A3 mRNAaffects cotreatment|increases expression 14761676
C021751 tanshinone tanshinone results in decreased expression of ALDH1A3 mRNAdecreases expression 15849732
C004648 testosterone enanthate testosterone enanthate affects the expression of ALDH1A3 mRNAaffects expression 17440010
D013749 Tetrachlorodibenzodioxin [Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of ALDH1A3 mRNAaffects cotreatment|increases expression 19619570
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Cycloheximide] results in increased expression of ALDH1A3 mRNAaffects cotreatment|increases expression 19684285
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of ALDH1A3 mRNAincreases expression 15345368
19619570
12377990
19684285
17968679
D013749 Tetrachlorodibenzodioxin [Triiodothyronine co-treated with Tetrachlorodibenzodioxin] results in increased expression of ALDH1A3 mRNAaffects cotreatment|increases expression 14761676
D014212 Tretinoin ALDH1A3 protein results in increased chemical synthesis of Tretinoinincreases chemical synthesis 17526768
D014212 Tretinoin ALDH1A3 protein affects the chemical synthesis of Tretinoinaffects chemical synthesis 14623956
D014212 Tretinoin ALDH1A3 protein promotes the reaction [Tretinoin results in increased expression of RARB mRNA]increases expression|increases reaction 17207476
D014212 Tretinoin ALDH1A3 protein results in increased chemical synthesis of Tretinoinincreases chemical synthesis 16836633
16207763
D014212 Tretinoin ALDH1A3 protein results in increased chemical synthesis of Tretinoinincreases chemical synthesis 17473173
D014302 Trinitrobenzenesulfonic Acid Trinitrobenzenesulfonic Acid results in increased expression of ALDH1A3 mRNAincreases expression 17982090
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.6114514962 11752688 15322242
MESH:D000138 Acidosis Ammonium Chloride 3.3118287403
MESH:D000230 Adenocarcinoma Estradiol 6.7711473722
MESH:D000230 Adenocarcinoma Fluorouracil 6.7717638652
MESH:D000230 Adenocarcinoma Genistein 6.7711473722
MESH:D000236 Adenoma Diethylnitrosamine 2.7110737359 6695378
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 9.2319052882 17620307 16434500 18056438 19061943 17162532
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 9.2316835633
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.4515276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 4.6517306315 16712894
MESH:D000505 Alopecia Isoflavones 8.9417569567
MESH:D000505 Alopecia Tretinoin 8.9415955085
MESH:D000740 Anemia Fluorouracil 7.9717963324 15504547 16511603
MESH:D000740 Anemia Tetrachlorodibenzodioxin 7.9711748828
MESH:D001169 Arthritis, Experimental Tretinoin 2.9316412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.2116292516
MESH:D001249 Asthma Tretinoin 2.2716456186
MESH:D001289 Attention Deficit Disorder with Hyperactivity Phthalic Acids 4.2020106747
MESH:D001471 Barrett Esophagus Tretinoin 4.1716935849
MESH:D001778 Blood Coagulation Disorders Omeprazole 14.1619483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 14.1612125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 14.1616206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.5415340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.6115746008
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.0917868700
MESH:D001930 Brain Injuries Progesterone 4.0215845082 15380490 15665606
MESH:D001943 Breast Neoplasms decitabine 6.7518320071 19208741
MESH:D001943 Breast Neoplasms Diethylnitrosamine 6.7517474063
MESH:D001943 Breast Neoplasms Estradiol 6.7512948864 19861407 17289903 18497071 16675129 17018787 14630087 17261762
MESH:D001943 Breast Neoplasms Fluorouracil 6.7516110121 16557594 18357371 19217205 16595493 18608205 15136595
MESH:D001943 Breast Neoplasms gemcitabine 6.7518382427 17039268
MESH:D001943 Breast Neoplasms Genistein 6.7516541309 16873071 17200150
MESH:D001943 Breast Neoplasms Progesterone 6.7516175315 15562024 17614352
MESH:D001943 Breast Neoplasms tanshinone 6.7519885617 15849732
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 6.7520435547
MESH:D001943 Breast Neoplasms Tretinoin 6.7516443354 16873071 16166294
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.3416813970
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.2216111702
MESH:D002276 Carcinoid Tumor Fluorouracil 4.4216051944
MESH:D002277 Carcinoma Fluorouracil 7.5517121937
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 7.5516835633
MESH:D018236 Carcinoma, Embryonal Tretinoin 4.9116168501
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 13.4416705839
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 13.4417173139 10672840 19822196 16830150 19539802 19107877 16779866 16878318 17138121 19383236 3084413 20214788 19052882 16698587 18210153 17162532 20007298 16935385 11831363 18788625 21159647 20514400 19171122 19919837 16502159 20101231 16328049 20512989 17978847 20727157 17761372 18978308 16288022 18494052 18393292 16569478 19701751 17055752 20524982 16540662 19208518 18056438 18506893 18691550 16681979 19335982 19394651 3581430 18665156 20084675 20432363 19519916 10737359 16807293 18785209 19418558 18971187 20935162 17428255
MESH:D006528 Carcinoma, Hepatocellular Estradiol 13.4416924424
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 13.4417088986 16332177 17971768 16799960 17045692 18930000
MESH:D006528 Carcinoma, Hepatocellular Genistein 13.4416924424
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 13.4416507464 17306315 15276417
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 13.441917145
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 2.9018695887
MESH:D002294 Carcinoma, Squamous Cell decitabine 10.2019215824
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 10.2016757204 18986760 16280240 17066447
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 10.2018572023
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 10.2016051514 16096774
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.2318670907 18850075 16120746
MESH:D002318 Cardiovascular Diseases Genistein 7.2016332659
MESH:D002318 Cardiovascular Diseases Isoflavones 7.2017689850
MESH:D002386 Cataract Tretinoin 2.9517460283
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 14.656135515
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 14.652727394 7505956 17174075 21159647
MESH:D002471 Cell Transformation, Neoplastic Estradiol 14.6518566989
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 14.6520056578 19524636
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.3416129372
MESH:D002637 Chest Pain Omeprazole 4.8615447763
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 8.6419052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 8.6416835633
MESH:D002822 Choriocarcinoma Tretinoin 4.9116461808
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.4215668235 8697196 12621046 15340226 16354765
MESH:D002972 Cleft Palate Tretinoin 5.429407595
MESH:D003092 Colitis Tretinoin 8.9717035595
MESH:D003092 Colitis Trinitrobenzenesulfonic Acid 8.9718023891 16804969 16474422 17936198 16867261 17991707 16782535 11698051 18200517
MESH:D003093 Colitis, Ulcerative Trinitrobenzenesulfonic Acid 3.3617276891
MESH:D003110 Colonic Neoplasms decitabine 5.6017616700
MESH:D003110 Colonic Neoplasms Fluorouracil 5.6016340194 17018589 17169374 17016597 15001691 17287894 17725105 17172411 16510598 18772588
MESH:D003110 Colonic Neoplasms Genistein 5.6017182828
MESH:D015179 Colorectal Neoplasms decitabine 3.4818981723
MESH:D015179 Colorectal Neoplasms Fluorouracil 3.4816524972 17016601 14970324 16391804 17454858 18288408 17255274 18949393 17094418 17594712 16331619 15289873 16303861 17695437 17401013 18448328 18509181 18802399 18383874 16282729 20501625 15148649
MESH:D015179 Colorectal Neoplasms Isoflavones 3.4817116718
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.8514669216 17141729
MESH:D019465 Craniofacial Abnormalities nitrofen 5.2611405365
MESH:D019465 Craniofacial Abnormalities sodium arsenate 5.2610525206
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 5.2610048152 20055451 15322242
MESH:D019465 Craniofacial Abnormalities Tretinoin 5.2616925845 14991402 10589399 9664655 17551590 9224671 8800419 9125849 9211117 9142499
MESH:D003490 Cyanosis 2,6-dinitrotoluene 3.7818551238
MESH:D007644 Darier Disease Fluorouracil 4.5416733453
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 6.7320387270
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 6.7316647724
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 6.7317107852
MESH:D003928 Diabetic Nephropathies Estradiol 3.2119279558
MESH:D003929 Diabetic Neuropathies Progesterone 4.2517187935
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 8.3821346803 18551238
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 8.3819107877
MESH:D056486 Drug-Induced Liver Injury sodium arsenate 8.3818186108
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 8.3820420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.5811462148
MESH:D004381 Duodenal Ulcer Omeprazole 4.1016613094 15991576 21218061 17151854
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.1712711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 11.1115322242 18230668 16714409
MESH:D004489 Edema, Cardiac Tretinoin 11.1118230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 3.5517692515
MESH:D004701 Endocrine Gland Neoplasms decitabine 4.8719294695
MESH:D004714 Endometrial Hyperplasia Genistein 4.3416402032
MESH:D016889 Endometrial Neoplasms Estradiol 11.5519148513 18566989 11473722
MESH:D016889 Endometrial Neoplasms Genistein 11.5511473722
MESH:D016889 Endometrial Neoplasms Tretinoin 11.5516569247
MESH:D004715 Endometriosis Progesterone 8.2216134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 8.2210568697 9294722
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 4.8716302075
MESH:D004938 Esophageal Neoplasms Fluorouracil 2.3916337965 16481741 17638652 15173087 16785472
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 8.2411564622
MESH:D005124 Eye Abnormalities Tretinoin 8.2416938888 9664655
MESH:D005234 Fatty Liver Diethylnitrosamine 2.9721071580 20387270
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.2111858732
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 13.4820067830
MESH:D005355 Fibrosis Tretinoin 13.4817994277
MESH:D005355 Fibrosis Trinitrobenzenesulfonic Acid 13.4817994277
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.4316452187
MESH:D005909 Glioblastoma Genistein 6.6816598420
MESH:D005909 Glioblastoma Tretinoin 6.6817312396
MESH:D005910 Glioma Fluorouracil 6.2216145905
MESH:D005910 Glioma tanshinone 6.2216955220
MESH:D018149 Glucose Intolerance sodium arsenate 4.8519446573
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.3410696789
MESH:D006258 Head and Neck Neoplasms decitabine 12.0219215824
MESH:D006258 Head and Neck Neoplasms Fluorouracil 12.0215162350 18337622 15102660
MESH:D006258 Head and Neck Neoplasms Tretinoin 12.0216096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 4.9116084493
MESH:D006330 Heart Defects, Congenital nitrofen 10.5516080930
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 10.5510048152 11294989
MESH:D006330 Heart Defects, Congenital Tretinoin 10.5514991402 9664655
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.1211000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 2.6512621046 15340226 16120746
MESH:D006548 Hernia, Diaphragmatic nitrofen 3.8515707848 15088113 11685700 18280291 10646786 16720372 7576705 16473863 9575882 11588001 10898222 12746050 17270546 12547725 10541330 9476886 10370017 16080930 11051153 18280292 17618886 15793718 12759764 11076806 9859898 15756563 18958481 17245593 12021965 15578192 11329586 11057544 16292651 12904592 7520565 15136996 10693666 12407540 12505043 11584395 10898224 15764645 10359170 16863852 9698600 12194112 7760232 9473106 11409163 16490937 10370016 15185205 8863223
MESH:D006558 Herpes Genitalis Estradiol 4.7815709030
MESH:D019247 HIV Wasting Syndrome testosterone enanthate 5.5017440010
MESH:D006689 Hodgkin Disease sodium arsenite 2.9512676792
MESH:D019584 Hot Flashes Estradiol 9.5917088409
MESH:D019584 Hot Flashes Isoflavones 9.5914716179 17290160
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.8015340226 16354765 8697196 16959395 18606429
MESH:D006930 Hyperalgesia Tretinoin 3.0216870215
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.3316778211
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.8218850075 18670907
MESH:D017379 Hypertrophy, Left Ventricular tanshinone 5.0219662366
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.1615869954
MESH:D007248 Infertility, Male decitabine 6.3717581917
MESH:D007248 Infertility, Male sodium arsenite 6.3715346721 12646999
MESH:D007249 Inflammation Diethylnitrosamine 7.5618785209
MESH:D007249 Inflammation Progesterone 7.5615869954
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 7.5612200463 12878042
MESH:D015212 Inflammatory Bowel Diseases Trinitrobenzenesulfonic Acid 3.4818200517
MESH:D007333 Insulin Resistance Estradiol 2.8116393666 16627594
MESH:D007410 Intestinal Diseases Tretinoin 9.1817994277
MESH:D007410 Intestinal Diseases Trinitrobenzenesulfonic Acid 9.1817994277
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 9.2016580747
MESH:D007569 Jaw Abnormalities Tretinoin 9.2015992940 17551590
MESH:D007674 Kidney Diseases Estradiol 5.6415618244
MESH:D007674 Kidney Diseases sodium arsenite 5.6420008137
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 11.3016705839
MESH:D007680 Kidney Neoplasms Estradiol 11.3015610895
MESH:D007680 Kidney Neoplasms Fluorouracil 11.3016985049
MESH:D016773 Leishmaniasis, Cutaneous Omeprazole 3.9019248655
MESH:D007938 Leukemia decitabine 9.8218980019 19235587
MESH:D007938 Leukemia Genistein 9.8218980019 17468513
MESH:D007938 Leukemia Tretinoin 9.8217143497
MESH:D007951 Leukemia, Myeloid decitabine 8.8318454857 19117987 17236224
MESH:D007951 Leukemia, Myeloid Tretinoin 8.8316932348 16482212 19285840
MESH:D015470 Leukemia, Myeloid, Acute decitabine 3.8118206229 17679729 19387464 18460780 19010910 18704418
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 3.8117596541 16294345 19850784
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 5.2118055864
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 2.9915748426 12679006 17368321 17649720 16766008 17506722 16140955 19225113 9834237 19029980 17712046 16823087 16331271 17301526 17217047 17294898 19035177 16935935 17339181 17107899 16788101 16891316 19075265 17361223 19642359
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.139224671
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 2.6920032147 18665156 18522880 19638242 18407596
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 6.4214659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental Genistein 6.4217823541
MESH:D008106 Liver Cirrhosis, Experimental Retinaldehyde 6.4216248980
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 6.4212878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 6.4218397230 16248980
MESH:D008107 Liver Diseases Diethylnitrosamine 2.0417034775
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 16.767678174
MESH:D008113 Liver Neoplasms Diethylnitrosamine 16.7620492335 12771043 10737359 18754104 20405173 21278145 19090486 19254457 2422723 19073162 21047994 12112319 18978307 19812893 21167192 19426721 20118626 19690152 21071580 19638242 19642983 15175105 19256749 20101389 19833225 16942905 20501860 20137499 9163691 19499222 19551842 18648771 2862719 20452335 20583210 19427195 19850985 18644402 15885732 19294768 20434301 18977376 19996281 19255062
MESH:D008113 Liver Neoplasms Fluorouracil 16.7617045692 16603448 15113037 18383874
MESH:D008113 Liver Neoplasms gum mastic 16.7618977376
MESH:D008113 Liver Neoplasms sodium arsenite 16.7615276417 16712894
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 16.7616984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 8.906135515 2876786 2876784
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 8.9016267830 16842330 19539802 19004024 17854601 17942915 19009564 3124819 21159647 18308698 18282651 19519916 18253720 17174075 18544905 18093689 18164116 9362446 18775883 2563599 19126423 18079962
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 8.9012151625
MESH:D008171 Lung Diseases nitrofen 7.3517245593 9859898 9614859 16863852
MESH:D008171 Lung Diseases sodium arsenite 7.3519095001
MESH:D008175 Lung Neoplasms Diethylnitrosamine 4.596695378 20970405 20512841 21163286
MESH:D008175 Lung Neoplasms Fluorouracil 4.5915246190
MESH:D008175 Lung Neoplasms sodium arsenite 4.5919931552 17077188 16712894 17306315 15276417
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 4.5911884234 19555203
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 4.5415086387
MESH:D008223 Lymphoma decitabine 3.2519470736
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 9.1111807958 17203775 11408345 16891317
MESH:D008325 Mammary Neoplasms, Experimental Genistein 9.1114578162 12929590
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 9.1117203775 11408345
MESH:D020149 Manganese Poisoning Estradiol 4.2319453300
MESH:D008527 Medulloblastoma Tretinoin 2.6917453147
MESH:D008545 Melanoma decitabine 4.8817785578 16505122
MESH:D008545 Melanoma sodium arsenite 4.8819082730 16487513
MESH:D008545 Melanoma Tretinoin 4.8816752155
MESH:D008591 Meningomyelocele Tretinoin 4.1816940565
MESH:D009062 Mouth Neoplasms Fluorouracil 3.4516757204 18986760
MESH:D009101 Multiple Myeloma decitabine 3.1718172295
MESH:D009139 Musculoskeletal Abnormalities sodium arsenate 4.6318186108
MESH:D009190 Myelodysplastic Syndromes decitabine 7.0218608210 19157545 16882708 19010910
MESH:D009190 Myelodysplastic Syndromes Tretinoin 7.0217596541
MESH:D009203 Myocardial Infarction Genistein 2.7617141266
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.8312213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 7.8916810080
MESH:D015428 Myocardial Reperfusion Injury Genistein 7.8917141266
MESH:D009336 Necrosis 2,6-dinitrotoluene 3.627678174 18551238
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.479029167 3581430
MESH:D009369 Neoplasms decitabine 10.8919116145 17925555 19470736
MESH:D009369 Neoplasms Fluorouracil 10.8918239605 18600527 16928823
MESH:D009369 Neoplasms sodium arsenite 10.8911559025
MESH:D009369 Neoplasms Tretinoin 10.8916946489 16594593
MESH:D009374 Neoplasms, Experimental sodium arsenite 3.4320056578
MESH:D009389 Neovascularization, Pathologic Estradiol 3.4917289903
MESH:D009421 Nervous System Malformations Estradiol 21.5011399458 16427766
MESH:D009421 Nervous System Malformations Genistein 21.5016427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 21.5014600291
MESH:D009421 Nervous System Malformations Tretinoin 21.509125849
MESH:D009436 Neural Tube Defects sodium arsenate 11.3519446573 18186108 11749123 10525206
MESH:D009436 Neural Tube Defects sodium arsenite 11.3512854658
MESH:D009436 Neural Tube Defects Tretinoin 11.359142499
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 3.1420387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 4.8720387270
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.2716436463
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 3.2216049721
MESH:D010024 Osteoporosis Genistein 7.0919401787
MESH:D010024 Osteoporosis Isoflavones 7.0916562857
MESH:D015663 Osteoporosis, Postmenopausal Genistein 3.8616169203
MESH:D010051 Ovarian Neoplasms decitabine 17.8419331143 19259094
MESH:D010051 Ovarian Neoplasms Estradiol 17.8419401270
MESH:D010051 Ovarian Neoplasms Genistein 17.8419005980
MESH:D010051 Ovarian Neoplasms Progesterone 17.8416525653 17393432
MESH:D010051 Ovarian Neoplasms sodium arsenite 17.8415276417 17306315
MESH:D010051 Ovarian Neoplasms Tretinoin 17.8416936753
MESH:D010146 Pain Tretinoin 2.7116870215
MESH:D010190 Pancreatic Neoplasms decitabine 15.3819294695
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 15.3816540662
MESH:D010190 Pancreatic Neoplasms Fluorouracil 15.3819003803 16929163 15113037 16500647
MESH:D010190 Pancreatic Neoplasms gemcitabine 15.3811504793 16929163 17440100 18992248 18383843
MESH:D010190 Pancreatic Neoplasms Tretinoin 15.3815976015
MESH:D010195 Pancreatitis Trinitrobenzenesulfonic Acid 3.9817698068
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.0012520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.3218163543
MESH:D011230 Precancerous Conditions Diethylnitrosamine 3.352563599
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 2.9511222880 11896295 11399792 11118676
MESH:D055728 Primary Myelofibrosis decitabine 4.4917616702
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.6620887781
MESH:D011471 Prostatic Neoplasms bicalutamide 1.8915638997 17914592 19240160 18487222 19011039
MESH:D011471 Prostatic Neoplasms Estradiol 1.8916740699
MESH:D011471 Prostatic Neoplasms Fluorouracil 1.8918626508 19082440
MESH:D011471 Prostatic Neoplasms Genistein 1.8915256057 16925846 15378649
MESH:D011471 Prostatic Neoplasms Isoflavones 1.8917571952 16365062 17374662 17219775
MESH:D011471 Prostatic Neoplasms sodium arsenite 1.8916039940
MESH:D011507 Proteinuria Tretinoin 3.3816636307
MESH:D011625 Pterygium Tretinoin 4.5516723453
MESH:D012004 Rectal Neoplasms Fluorouracil 3.8016160472 18722050 18286688 15538739
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.6018990726
MESH:D012208 Rhabdomyosarcoma decitabine 10.1919155313
MESH:D012208 Rhabdomyosarcoma Tretinoin 10.1916116481 16283617
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.7718045962
MESH:D012640 Seizures 2,6-dinitrotoluene 2.3818551238
MESH:D012878 Skin Neoplasms sodium arsenite 12.6118572023 19524636
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 12.618532709
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 12.6116192470
MESH:D012878 Skin Neoplasms Tretinoin 12.6116467112
MESH:D013119 Spinal Cord Injuries Progesterone 4.0316503802 15862959
MESH:D016135 Spinal Dysraphism sodium arsenite 3.6112854658
MESH:D013272 Stomach Diseases Omeprazole 4.3718545984
MESH:D013274 Stomach Neoplasms marker/mechanism 16367923
MESH:D013274 Stomach Neoplasms decitabine 4.5319037991
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 4.5318456281
MESH:D013274 Stomach Neoplasms Fluorouracil 4.5319015929 16424979 17172411 17522103 15786421 17498489 18567086 18396642 19084572 16951190
MESH:D013274 Stomach Neoplasms Tretinoin 4.5317261132
MESH:D013276 Stomach Ulcer Omeprazole 3.5610750652 11906479 17977527 15991576 16755016 18237397
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.6512697716
MESH:D013964 Thyroid Neoplasms decitabine 10.9417967635
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 10.947505956
MESH:D013964 Thyroid Neoplasms Tretinoin 10.9417045167 16026305
MESH:D013978 Tibial Fractures Estradiol 4.4419048282
MESH:D014062 Tongue Neoplasms Fluorouracil 9.1216280240
MESH:D014062 Tongue Neoplasms Tretinoin 9.1216051514
MESH:D014376 Tuberculosis Tretinoin 3.0816040207
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 7.8016049721
MESH:D001749 Urinary Bladder Neoplasms decitabine 7.8017616700 19087683
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 7.8011723127 17306315 16452187 16712894
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.0710091137
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 14.6316803524
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 14.6311813266
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 14.6316129372
MESH:D014604 Uveal Neoplasms decitabine 12.0017785578
MESH:D014604 Uveal Neoplasms Tretinoin 12.0016752155
MESH:D014652 Vascular Diseases sodium arsenite 4.1817056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.3412125929
MESH:D014820 Vitiligo Tretinoin 3.8216761959
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.0015886252
MESH:D009396 Wilms Tumor Tretinoin 3.7616287080
Pathway ID Pathway Name
KEGG:00410 beta-Alanine metabolism
KEGG:00982 Drug metabolism - cytochrome P450
KEGG:00010 Glycolysis / Gluconeogenesis
KEGG:00340 Histidine metabolism
KEGG:01100 Metabolic pathways
KEGG:00980 Metabolism of xenobiotics by cytochrome P450
KEGG:00360 Phenylalanine metabolism
KEGG:00350 Tyrosine metabolism
Pharmacogenomics Knowledge Base Top
Drug Bank Top
Drugbank ID Action Drug Name Description
DB00157 - NADH Dietary supplement;Micronutrient
DB00162 - Z-Mass Pm Vitamin and Mineral Supplement Essential Vitamin;Anti-acne Agents;Vitamins (Vitamin A);Vitamins
No data
No data
No data

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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