AutismKB 2.0

Annotation Detail for FBN1


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Basic Information Top
Gene Symbol:FBN1 ( FBN,MASS,MFS1,OCTD,SGS,SSKS,WMS )
Gene Full Name: fibrillin 1
Band: 15q21.1
Quick LinksEntrez ID:2200; OMIM: 134797; Uniprot ID:FBN1_HUMAN; ENSEMBL ID: ENSG00000166147; HGNC ID: 3603
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
No data
Pathway IDPathway Name
Integrin cell surface interactions
No data
No data
Pathway IDPathway Name
500004Integrin cell surface interactions
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1818Systemic scleroderma
1824Bone disease
1870Drug abuse
1960Mitral valve disease
2027Connective tissue disease
2029Tuberculosis
2041Myelofibrosis
2060Glaucoma
2126Encephalopathies
2129Thyroid cancer
Desease Name
aortic stiffness and disease severity
scleroderma
aortic stiffness
mitral valve prolapse.
CARDIOVASCULAR
height
Coronary Artery Disease
CANCER
systemic sclerosis
Marfan Syndrome
breast cancer
cardiovascular
mitral valve prolapse
Marfan phenotype
DEVELOPMENTAL
Desease Name
Breast cancer
Desease Name
MASS syndrome
Ectopia lentis, familial
Weill-Marchesani syndrome, dominant
Stiff skin syndrome
Aortic aneurysm, ascending, and dissection
Marfan syndrome
Shprintzen-Goldberg syndrome
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of FBN1 mRNAaffects expression 17562736
D000109 Acetylcholine FBN1 protein affects the susceptibility to [Acetylcholine co-treated with Indomethacin]affects cotreatment|affects response to substance 17641673
D000643 Ammonium Chloride Ammonium Chloride affects the expression of FBN1 mRNAaffects expression 16483693
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of FBN1 mRNAdecreases expression 20713471
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of FBN1 mRNAaffects expression 16239168
D002251 Carbon Tetrachloride Carbon Tetrachloride results in increased expression of FBN1 proteinincreases expression 14661032
D002330 Carmustine Carmustine results in decreased expression of FBN1 mRNAdecreases expression 15980968
D016572 Cyclosporine Cyclosporine results in increased expression of FBN1 mRNAincreases expression 20106945
D004041 Dietary Fats Dietary Fats results in increased expression of FBN1 mRNAincreases expression 18042831
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of FBN1 mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of FBN1 mRNAaffects cotreatment|increases expression 17942748
C010176 halofuginone halofuginone inhibits the reaction [Thioacetamide results in increased expression of FBN1 protein]decreases reaction|increases expression 17180598
C010176 halofuginone halofuginone results in increased expression of FBN1 mRNAincreases expression 17180598
D019796 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid FBN1 protein affects the susceptibility to 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acidaffects response to substance 17641673
D007213 Indomethacin FBN1 protein affects the susceptibility to [Acetylcholine co-treated with Indomethacin]affects cotreatment|affects response to substance 17641673
D009151 Mustard Gas Mustard Gas results in decreased expression of FBN1 mRNAdecreases expression 15674843
D017239 Paclitaxel Paclitaxel results in increased expression of FBN1 mRNAincreases expression 19682730
C041786 palm oil palm oil results in increased expression of FBN1 mRNAincreases expression 18042831
D010656 Phenylephrine FBN1 protein affects the reaction [Phenylephrine results in increased secretion of Epoprostenol metabolite]affects reaction|increases secretion 17641673
D010656 Phenylephrine FBN1 protein affects the reaction [Phenylephrine results in increased secretion of Thromboxane A2 metabolite]affects reaction|increases secretion 17641673
D010656 Phenylephrine FBN1 protein affects the reaction [PTGS1 protein affects the susceptibility to Phenylephrine]affects reaction|affects response to substance 17641673
D011374 Progesterone Progesterone results in increased expression of FBN1increases expression 17510236
D011464 Epoprostenol FBN1 protein affects the reaction [Phenylephrine results in increased secretion of Epoprostenol metabolite]affects reaction|increases secretion 17641673
D012176 Retinoids Retinoids analog results in increased expression of FBN1 proteinincreases expression 16055107
C507164 seletinoid G seletinoid G results in increased expression of FBN1 proteinincreases expression 16055107
C017947 sodium arsenite sodium arsenite results in decreased expression of FBN1 mRNAdecreases expression 18812580
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of FBN1 mRNAaffects cotreatment|increases expression 17942748
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of FBN1 mRNAincreases expression 17942748
D013853 Thioacetamide halofuginone inhibits the reaction [Thioacetamide results in increased expression of FBN1 protein]decreases reaction|increases expression 17180598
D013853 Thioacetamide Thioacetamide results in increased expression of FBN1 proteinincreases expression 17180598
D013928 Thromboxane A2 FBN1 protein affects the reaction [Phenylephrine results in increased secretion of Thromboxane A2 metabolite]affects reaction|increases secretion 17641673
C025643 vinclozolin vinclozolin affects the expression of FBN1 mRNAaffects expression 19015723
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.6615322242 11752688 14514962
MESH:D000138 Acidosis Ammonium Chloride 3.3718287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.7517505938
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 6.8020127859 20464547
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 6.8014692618
MESH:D000230 Adenocarcinoma Indomethacin 6.8016537180
MESH:D000236 Adenoma Benzo(a)pyrene 6.496695378
MESH:D000236 Adenoma Indomethacin 6.4911497255
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.1916835633
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.5115276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 4.7117306315 16712894
MESH:D016301 Alveolar Bone Loss Indomethacin 5.1817225004
MESH:D000544 Alzheimer Disease Indomethacin 2.6617627676 15579461
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.7811748828
MESH:D000799 Angioedema Acetaminophen 3.6510982225
MESH:D001008 Anxiety Disorders vinclozolin 3.4919015723
MESH:D001014 Aortic Aneurysm Indomethacin 4.6610231640
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 11.0819183758
MESH:D017544 Aortic Aneurysm, Abdominal Indomethacin 11.0810388637
MESH:D001145 Arrhythmias, Cardiac Phenylephrine 3.9517460149
MESH:D001161 Arteriosclerosis Dietary Fats 9.2815238619
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 9.2811256880
MESH:D018771 Arthralgia Indomethacin 4.982160914
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.5515885639
MESH:D001172 Arthritis, Rheumatoid Indomethacin 2.7811248219
MESH:D001249 Asthma Mustard Gas 2.6510378619
MESH:D001321 Autistic Disorder Acetaminophen 1.4418445737
MESH:D001477 Bartter Syndrome Indomethacin 4.7910684365
MESH:D001768 Blister Mustard Gas 4.9719167455
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 8.5712125929
MESH:D001778 Blood Coagulation Disorders Thioacetamide 8.5719483382
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.6015340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.6415746008
MESH:D001859 Bone Neoplasms Paclitaxel 4.3915867366
MESH:D001919 Bradycardia Phenylephrine 4.3515306635
MESH:D001929 Brain Edema Indomethacin 4.8311481608
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.1417868700
MESH:D001930 Brain Injuries Progesterone 4.0715665606 15380490 15845082
MESH:D002545 Brain Ischemia Indomethacin 4.2312524144
MESH:D001932 Brain Neoplasms Carmustine 4.2216187019
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 3.6520146248 17474063
MESH:D001943 Breast Neoplasms Dietary Fats 3.6520435547
MESH:D001943 Breast Neoplasms Indomethacin 3.6517401462
MESH:D001943 Breast Neoplasms Paclitaxel 3.6511325840 18323546 16115903 18223236 16273361 18234424 16244791 15136595
MESH:D001943 Breast Neoplasms Progesterone 3.6517614352 15562024 16175315
MESH:D001943 Breast Neoplasms Retinoids 3.6517491551 19340624 17368321
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 3.6520435547
MESH:D001989 Bronchiolitis Obliterans Mustard Gas 4.9715286001
MESH:D029481 Bronchitis, Chronic Mustard Gas 4.7817687719 10378619
MESH:D002056 Burns Indomethacin 4.5210459503
MESH:D002100 Cachexia Indomethacin 4.8115141370 16537180 11239499 15625704
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.5916011737 3786805 16227642 16050911 15673190 16192424 16097048 15700767 10355542 15721981 16124888 18705752
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.6516835633
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 10.993084413
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 10.9918788625
MESH:D006528 Carcinoma, Hepatocellular Indomethacin 10.9916391822
MESH:D006528 Carcinoma, Hepatocellular Paclitaxel 10.9916313753
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 10.9917306315 16507464 15276417
MESH:D006528 Carcinoma, Hepatocellular Thioacetamide 10.9917997003
MESH:D018827 Carcinoma, Lewis Lung Indomethacin 4.5311053908
MESH:D018276 Carcinoma, Medullary Indomethacin 5.1611352223 14736730 18791128
MESH:D002292 Carcinoma, Renal Cell Indomethacin 3.2917341418
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 7.2520419170
MESH:D002294 Carcinoma, Squamous Cell Indomethacin 7.2515482327 12636206
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 7.2518572023
MESH:D006332 Cardiomegaly Phenylephrine 6.5316170337 15728586 11754973 17124262 17287366 11179087
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 6.5318850075 18670907 16120746
MESH:D002386 Cataract Acetaminophen 2.4710977129
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 6.2212371664
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 6.2220056578 19524636
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 9.0116835633
MESH:D018281 Cholangiocarcinoma Thioacetamide 9.0118291259
MESH:D002764 Cholecystitis Indomethacin 4.9811181007
MESH:D002779 Cholestasis Cyclosporine 7.3119486331
MESH:D002779 Cholestasis Ethinyl Estradiol 7.3117333356 16919318 11677210 17110522 15861022 17681005 16105132
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.0312621046 15340226 15668235 16354765 8697196
MESH:D003110 Colonic Neoplasms Indomethacin 2.5615637740 11260862 15936596 15625704 15963497 15786552
MESH:D015179 Colorectal Neoplasms Indomethacin 2.8518059344 12606626 11197048 17054584
MESH:D015179 Colorectal Neoplasms Paclitaxel 2.8518802399
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.9017141729 14669216
MESH:D003233 Conjunctivitis, Allergic Thromboxane A2 6.6415351322
MESH:D018352 Coronavirus Infections Indomethacin 5.5217302372
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2520055451 10048152 15322242
MESH:D003456 Cryptorchidism vinclozolin 4.1614966744
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6217107852
MESH:D003929 Diabetic Neuropathies Progesterone 4.3017187935
MESH:D003967 Diarrhea Indomethacin 3.617907874 7237001
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 8.5012594235 11287661 19370779 10915739 19164858 10663392 14550746 12153990 11529661 19739265 16485898 16081117 19420014 10774834 18713872 18071297 12540782 14986274 11743745 15968718 11739529 16227642 19923254 11461765 2444490 19085960 17562736 12705907 15619225 19416960 16393943 16177239 12392966 11834606 16109766 17522070 12958197 14725611 16781746 17906064 11421492
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 8.5019336974 15968718 7120509 10915739 15027814 19085960 7179309 17522070 3732212 7440962 6884620 21278145 10092053 4309450 3786805 2869522 11566570 16177239 16227642 9327722 6623471 15998439
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 8.5020420201
MESH:D056486 Drug-Induced Liver Injury Thioacetamide 8.5012963478
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.9119426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.6211462148
MESH:D004374 Ductus Arteriosus, Patent Indomethacin 4.9618043480 16326151 18446180 17190690 16133044 12774134
MESH:D004381 Duodenal Ulcer Indomethacin 3.9517151854 11595431 16699067 10671773 17045617 17351913 17329845 11595415 11535926 11991626 17202747
MESH:D050171 Dyslipidemias Dietary Fats 3.3218367378
OMIM:129600 ECTOPIA LENTIS, ISOLATED, AUTOSOMAL DOMINANT marker/mechanism
MESH:D004487 Edema Indomethacin 10.578985016 7907874 8273558 16100529 10653021 19703484 7990266
MESH:D004487 Edema Mustard Gas 10.5711428631 9260866 11402378 11428647
MESH:D004487 Edema Tetrachlorodibenzodioxin 10.5712711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.7115322242 16714409 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 8.4212538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 8.4217692515
MESH:D004715 Endometriosis Indomethacin 14.3315652904
MESH:D004715 Endometriosis Progesterone 14.3316134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 14.3310568697 9294722
MESH:D019446 Endotoxemia Indomethacin 4.3118509659
MESH:D004751 Enteritis Indomethacin 4.5510567023 17763956 16328016
MESH:D020345 Enterocolitis, Necrotizing Indomethacin 4.7917980183
MESH:D004802 Eosinophilia Indomethacin 9.2511298111
MESH:D004802 Eosinophilia Thromboxane A2 9.2512689652
MESH:D004890 Erythema Mustard Gas 4.979357497
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 7.0916530937
MESH:D004938 Esophageal Neoplasms Indomethacin 7.0911005569
MESH:D004938 Esophageal Neoplasms Paclitaxel 7.0916481741
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.8711564622
MESH:D015785 Eye Diseases, Hereditary Retinoids 5.7716968212
MESH:D005218 Fat Necrosis Thioacetamide 5.5316456712
MESH:D005234 Fatty Liver Carbon Tetrachloride 17.3315959796 17595544 12631006 16239168 12795759 61145 16045604 19224547
MESH:D005234 Fatty Liver Cyclosporine 17.3319224547
MESH:D005234 Fatty Liver Dietary Fats 17.3317967931 19004024 19551842 18296743
MESH:D005234 Fatty Liver Ethinyl Estradiol 17.3315345470
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.2711858732
MESH:D005334 Fever Indomethacin 3.9511852909 17627676 10431976
MESH:D005354 Fibrosarcoma Indomethacin 4.7010962813
MESH:D005355 Fibrosis Carbon Tetrachloride 25.7218705752
MESH:D005355 Fibrosis Cyclosporine 25.7212639820 12168785
MESH:D005355 Fibrosis Dietary Fats 25.7218296743
MESH:D005355 Fibrosis Indomethacin 25.7217994277
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 25.7220067830
MESH:D005499 Folliculitis Indomethacin 4.9811298111
MESH:D005756 Gastritis Acetaminophen 10.5016983495
MESH:D005756 Gastritis Indomethacin 10.5015046732
MESH:D030342 Genetic Diseases, Inborn vinclozolin 4.7416973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.1116417039
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.4916452187
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.038708960
MESH:D005909 Glioblastoma Carmustine 7.2516187019
MESH:D005909 Glioblastoma Indomethacin 7.2512870263
MESH:D005910 Glioma Indomethacin 3.1516487511 18371953
MESH:D005923 Glomerulosclerosis, Focal Segmental Indomethacin 4.1311849393
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.4010696789
MESH:D006073 Gout Indomethacin 5.1611248219
MESH:D006258 Head and Neck Neoplasms Indomethacin 8.1615482327
MESH:D006258 Head and Neck Neoplasms Retinoids 8.1617368321
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.1220471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.1210048152 11294989
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.2315720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.1611000095
MESH:D006501 Hepatic Encephalopathy Indomethacin 10.3615633222
MESH:D006501 Hepatic Encephalopathy Thioacetamide 10.3617276928 15929193 18665440
MESH:D006505 Hepatitis Carbon Tetrachloride 8.8719110552 19900420
MESH:D006505 Hepatitis Thioacetamide 8.8716456712
MESH:D019698 Hepatitis C, Chronic Indomethacin 4.5015135802
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 2.7115340226 16120746 12621046
MESH:D006689 Hodgkin Disease sodium arsenite 3.0012676792
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.8516354765 15340226 18606429 16959395 8697196
MESH:D006930 Hyperalgesia Acetaminophen 7.3316870215
MESH:D006930 Hyperalgesia Indomethacin 7.3312727271
MESH:D034321 Hyperamylasemia Indomethacin 5.5217883296
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.3416899240
MESH:D006937 Hypercholesterolemia Dietary Fats 3.4221332399
MESH:D006940 Hyperemia Indomethacin 4.8112524144
MESH:D006949 Hyperlipidemias Dietary Fats 8.7521332399
MESH:D006949 Hyperlipidemias Indomethacin 8.7517546600
MESH:D006965 Hyperplasia halofuginone 5.0611874485
MESH:D006973 Hypertension Cyclosporine 8.1810903974
MESH:D006973 Hypertension Phenylephrine 8.188949925 12717712
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 8.1818670907 18850075
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.9015338365
MESH:D006976 Hypertension, Pulmonary Epoprostenol 5.3515302794
MESH:D006984 Hypertrophy Phenylephrine 4.3812791704 18502941
MESH:D007021 Hypospadias Ethinyl Estradiol 3.6216945680 16569931
MESH:D007077 Ileal Diseases Indomethacin 4.8318306037 10574470
MESH:D007079 Ileitis Indomethacin 5.1610651667 16133968 10647630
MESH:D007235 Infant, Premature, Diseases Indomethacin 5.1816133044
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.2115869954
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.2812013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 10.4817937319
MESH:D007248 Infertility, Male sodium arsenite 10.4812646999 15346721
MESH:D007248 Infertility, Male vinclozolin 10.4816467254
MESH:D007249 Inflammation Dietary Fats 14.8220412841
MESH:D007249 Inflammation Indomethacin 14.8212568917 3291741 7812673
MESH:D007249 Inflammation Mustard Gas 14.8211428647 9260866 16001271 17524151 11402378 8975870 9357497 11428620 11428631
MESH:D007249 Inflammation Progesterone 14.8215869954
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 14.8212878042 12200463
MESH:D007333 Insulin Resistance Dietary Fats 2.9818457598 11836018
MESH:D007410 Intestinal Diseases Indomethacin 4.1415831440 11855677 17329856 17994277 11713966 11686837 10210152 18236018 15610444
MESH:D019586 Intracranial Hypertension Indomethacin 5.1815241188
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.1616580747
MESH:D007579 Jejunal Diseases Indomethacin 4.8310574470 16133968 18306037
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.2515604871
MESH:D007674 Kidney Diseases Acetaminophen 13.5515629191 12587719
MESH:D007674 Kidney Diseases Cyclosporine 13.558314463 10903974 18776723
MESH:D007674 Kidney Diseases Indomethacin 13.5517190690
MESH:D007674 Kidney Diseases sodium arsenite 13.5520008137
MESH:D007680 Kidney Neoplasms Cyclosporine 2.5812371664
MESH:D016773 Leishmaniasis, Cutaneous Indomethacin 3.7511703811 10320625 12228301
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive Indomethacin 3.7816572323 10785260 15631656
MESH:D007951 Leukemia, Myeloid Retinoids 5.3216482212
MESH:D015470 Leukemia, Myeloid, Acute Indomethacin 2.6018360721
MESH:D007964 Leukocytosis Indomethacin 5.1816537180
MESH:D007969 Leukomalacia, Periventricular Indomethacin 5.5217980183
MESH:D007984 Leydig Cell Tumor vinclozolin 4.5416417039
MESH:D008080 Liposarcoma Paclitaxel 4.6417353645
MESH:D008101 Liver Abscess, Amebic Indomethacin 5.5211479899
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 10.5817334410 17157831 11408273 16943688 16239168 21278145 11903743 17174718 16221502
MESH:D008103 Liver Cirrhosis Dietary Fats 10.5818296743
MESH:D008103 Liver Cirrhosis halofuginone 10.5817180598
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 6.5115818738 16248980 17557913 17631135 17922224 17766677 18006644 15362042 12666154 15338365 17481882 18187930 14512876 18339082 15370692 17805973 12898905 17708605 12632514 17761835 17869086 12632512 18472332 18210741 14620537 16192424 16015684 15123356 16136751 17721639 17698563 13678700 14748882 16027843 18472094 18317297 18277467 12741479 12546737 18279442 15730626 18054572 12649538 18429990 12389079 18205269 15673190 11481614 18395914 18263696 18251166 20821823 18376398 18418968 18412020 17525996 17714472 17640975 15931870 17944888 17823541 18395095 14716496 18481824 15925388 17976157 16638106 16033810 12445418 15650968 12958196 15876570 14716833 17565644 15959796 15052691 12667390 17900296 15057751 16097048 18166357 10355542 12445421 15893842 16011737 18705752 12586293 12609069 16116963 18420326 18156304 15996030 14724832
MESH:D008106 Liver Cirrhosis, Experimental halofuginone 6.5111172339 14739098 16489207 12175628 18458672
MESH:D008106 Liver Cirrhosis, Experimental Indomethacin 6.5118194892
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 6.5112878042
MESH:D008106 Liver Cirrhosis, Experimental Thioacetamide 6.5118606216 15288472 18416461 17355460 15316131 11682029 17050028 15474484 12085344 16343077 16098781 15158331 15288473 15095483 12557150 15078482 18032466 15716488 16511523 17629604 15075984 11172339 16097051 18295389 16489207 18031379 18263696 17292413 16126171 18458672 12531686 12175628 12891558 16248980 15465738 18380797 18395095 15362042 18615449 11481614 14739098 15334695 12679928 17127702 10677585
MESH:D008107 Liver Diseases Acetaminophen 6.2611587558 19460945 12587719 12969438 16610002 19784758 16611625 19014921
MESH:D008107 Liver Diseases Carbon Tetrachloride 6.2615830285 15720792 16964402 16246199 17285989
MESH:D008107 Liver Diseases Thioacetamide 6.2615158337 18374380 16337175
MESH:D017093 Liver Failure Carbon Tetrachloride 3.9715123358
MESH:D017114 Liver Failure, Acute Acetaminophen 21.9616871587 17185352
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 21.9614706259 16899240
MESH:D017114 Liver Failure, Acute Epoprostenol 21.9615633222
MESH:D017114 Liver Failure, Acute Thioacetamide 21.9617276928 15313186 12479984 15633222
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 10.0820195826 21137059
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 10.0819294768
MESH:D008113 Liver Neoplasms sodium arsenite 10.0815276417 16712894
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 10.0816984957
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 5.3712014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 5.3712151625
MESH:D008171 Lung Diseases Mustard Gas 7.1218161513 18702808
MESH:D008171 Lung Diseases sodium arsenite 7.1219095001
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 6.3418520028 18816296 20135361 20464547 17053015 18569708 6695378 20869020 20064080
MESH:D008175 Lung Neoplasms Indomethacin 6.3411497255 16537180 11053908
MESH:D008175 Lung Neoplasms Mustard Gas 6.343148597 8781369
MESH:D008175 Lung Neoplasms sodium arsenite 6.3417077188 16712894 19931552 17306315 15276417
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 6.3419555203 11884234
MESH:D008228 Lymphoma, Non-Hodgkin Paclitaxel 3.9314749477
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 2.7517203775 11408345
MESH:D008382 Marfan Syndrome marker/mechanism 19430350 18212506 17657824
MESH:C536030 MASS syndrome marker/mechanism
MESH:D008415 Mastocytosis Retinoids 6.3916953078
MESH:D008545 Melanoma Carmustine 5.1112393984
MESH:D008545 Melanoma Paclitaxel 5.1116342250 12025231 12040289
MESH:D008545 Melanoma sodium arsenite 5.1116487513 19082730
MESH:D008546 Melanoma, Experimental Acetaminophen 3.3819513568
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.5916801185
MESH:D008881 Migraine Disorders Indomethacin 3.5411903285
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 8.1816381670
MESH:D009062 Mouth Neoplasms Indomethacin 8.1812636206
MESH:D009101 Multiple Myeloma Paclitaxel 3.5514749477
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.8712213967
MESH:D009362 Neoplasm Metastasis Indomethacin 5.9611239499 11053908 16537180
MESH:D009362 Neoplasm Metastasis Paclitaxel 5.9615867366
MESH:D009369 Neoplasms Benzo(a)pyrene 8.0211141357
MESH:D009369 Neoplasms Epoprostenol 8.0217264769
MESH:D009369 Neoplasms sodium arsenite 8.0211559025
MESH:D009374 Neoplasms, Experimental Indomethacin 8.6515625704 10663608
MESH:D009374 Neoplasms, Experimental sodium arsenite 8.6520056578
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.2517954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.1219348381 18481113
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.0314600291
MESH:D009436 Neural Tube Defects sodium arsenite 3.0212854658
MESH:D019636 Neurodegenerative Diseases Acetaminophen 7.8818514411
MESH:D019636 Neurodegenerative Diseases Indomethacin 7.8812349958
MESH:D009503 Neutropenia Mustard Gas 3.797688884 16761898
MESH:D009765 Obesity Dietary Fats 2.2420518802 11836018 17217161 19632207 21332399 16723640 18457598 20132043 18674790
MESH:D007752 Obstetric Labor, Premature Indomethacin 4.986374098
MESH:D010003 Osteoarthritis Indomethacin 3.557009135
MESH:D010014 Osteolysis Paclitaxel 4.7915867366
MESH:D010051 Ovarian Neoplasms Paclitaxel 7.6511161223
MESH:D010051 Ovarian Neoplasms Progesterone 7.6516525653 17393432
MESH:D010051 Ovarian Neoplasms sodium arsenite 7.6517306315 15276417
MESH:D010146 Pain Acetaminophen 6.2816870215
MESH:D010146 Pain Indomethacin 6.2817627676 3291741 17440234 13679232
MESH:D010149 Pain, Postoperative Indomethacin 4.4918702446 12538197
MESH:D010195 Pancreatitis Indomethacin 3.7415028970 17883296
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.5111578682
MESH:D010257 Paraneoplastic Syndromes Indomethacin 5.5216537180
MESH:D020734 Parkinsonian Disorders Indomethacin 3.9512349958
MESH:D051302 Paroxysmal Hemicrania Indomethacin 5.5211903285
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.0612520081
MESH:D010437 Peptic Ulcer Indomethacin 4.9611148446
MESH:D010518 Periodontitis Indomethacin 4.7217225004
MESH:D011041 Poisoning Mustard Gas 3.6215727166
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.3718163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.0612371664
MESH:D047928 Premature Birth Indomethacin 4.9417000239
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 8.8511118676 11222880 11399792 11896295
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 8.8518042343 18220299 19015723
MESH:D011469 Prostatic Diseases vinclozolin 4.7418220299
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.2217292933
MESH:D011471 Prostatic Neoplasms Paclitaxel 2.2216729912 17172428 17136230 16356831
MESH:D011471 Prostatic Neoplasms Retinoids 2.2216166285 16724957
MESH:D011471 Prostatic Neoplasms sodium arsenite 2.2216039940
MESH:D011472 Prostatitis vinclozolin 4.7418629315
MESH:D011507 Proteinuria Indomethacin 3.9811849393
MESH:D011537 Pruritus Ethinyl Estradiol 8.8816919318 15861022
MESH:D011537 Pruritus Mustard Gas 8.8818058305
MESH:D011565 Psoriasis Cyclosporine 2.1616882103
MESH:D011658 Pulmonary Fibrosis Mustard Gas 2.8617894541 17720292 17266442 10334151 17620002
MESH:D012130 Respiratory Hypersensitivity Acetylcholine 4.129413022
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.6518990726
MESH:D012220 Rhinitis Thromboxane A2 5.7412689652
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.7918045962
OMIM:182212 SHPRINTZEN-GOLDBERG CRANIOSYNOSTOSIS SYNDROME marker/mechanism
MESH:D012852 Sinusitis Phenylephrine 4.517327846
MESH:D012871 Skin Diseases halofuginone 5.2511874485
MESH:D012871 Skin Diseases Mustard Gas 5.2515451306 12880345 16961503
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 12.9019755658 10029692
MESH:D012878 Skin Neoplasms Retinoids 12.9017538947
MESH:D012878 Skin Neoplasms sodium arsenite 12.9018572023 19524636
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 12.9016192470
MESH:D013088 Spermatocele Ethinyl Estradiol 3.7516709447
MESH:D013119 Spinal Cord Injuries Progesterone 4.0915862959 16503802
MESH:D016135 Spinal Dysraphism sodium arsenite 3.6512854658
OMIM:184900 STIFF SKIN SYNDROME marker/mechanism
MESH:D013272 Stomach Diseases Indomethacin 4.2316184426 18209964 15472012 17638125 17160473 16280098 17207306 16113693 15038085 10192188 18545984 10486359 10215738
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 3.392093021 20155912
MESH:D013274 Stomach Neoplasms Indomethacin 3.3915609394
MESH:D013274 Stomach Neoplasms Paclitaxel 3.3918396642 18506536
MESH:D013276 Stomach Ulcer Indomethacin 3.4217895592 17657623 16150113 17918041 15104355 11906479 10750652 18193104 17627676 16397915 17977527 16169175 15138204 12787963 10423059 18181030 1323529 14567935 18543354 12077510 10878458 11523592 17135157 15255614 16631530 16755016 18431645 11595415 12498302 12467913 18726076 12500499 16252198 11145282 18087811 11595431 18299717 18237397 16934674 18209962 11729361 17654042
MESH:D024801 Tauopathies Paclitaxel 4.6216930453
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.4411994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.9915669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.7112697716
MESH:D013964 Thyroid Neoplasms Indomethacin 7.5711352223 14736730 18791128
MESH:D013964 Thyroid Neoplasms Retinoids 7.5716940797
MESH:D014456 Ulcer Indomethacin 4.7017380554 10574470
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 4.8017053015
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 4.8017306315 16452187 16712894 11723127
MESH:D014581 Urticaria Acetaminophen 2.8010982225
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 3.6011813266
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.1214692618
MESH:D014605 Uveitis Cyclosporine 3.791336536
MESH:D014652 Vascular Diseases sodium arsenite 4.2317056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.4012125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.3714671159 15869587
MESH:D014839 Vomiting Indomethacin 4.5511897121
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.0615886252
MESH:D015430 Weight Gain Dietary Fats 3.5816723640
OMIM:608328 WEILL-MARCHESANI SYNDROME, AUTOSOMAL DOMINANT marker/mechanism
MESH:D014985 Xerophthalmia Cyclosporine 4.2517120751
Pathway ID Pathway Name
REACT:13552 Integrin cell surface interactions
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA28016
    • No data
    Releated disease ID Related disease Name
    PA444880Marfan Syndrome
    No data
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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