AutismKB 2.0

Annotation Detail for FCER1G


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:FCER1G ( FCRG )
Gene Full Name: Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide
Band: 1q23.3
Quick LinksEntrez ID:2207; OMIM: 147139; Uniprot ID:FCERG_HUMAN; ENSEMBL ID: ENSG00000158869; HGNC ID: 3611
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04650Natural killer cell mediated cytotoxicity
hsa05310Asthma
hsa04664Fc epsilon RI signaling pathway
Pathway IDPathway Name
Hemostasis
Pathway IDPathway Name
200003Fc-epsilon receptor I signaling in mast cells
No data
Pathway IDPathway Name
500288Collagen adhesion via GPVI
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in decreased expression of FCER1G mRNAdecreases expression 18648102
D000082 Acetaminophen Acetaminophen affects the expression of FCER1G mRNAaffects expression 17562736
D000643 Ammonium Chloride Ammonium Chloride affects the expression of FCER1G mRNAaffects expression 16483693
C014347 decitabine decitabine results in increased expression of FCER1G mRNAincreases expression 19194470
D004041 Dietary Fats Dietary Fats results in decreased expression of FCER1G mRNAdecreases expression 18042831
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of FCER1G mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of FCER1G mRNAaffects cotreatment|increases expression 17942748
D010126 Ozone Ozone results in increased expression of FCER1G mRNAincreases expression 16716893
C041786 palm oil palm oil results in decreased expression of FCER1G mRNAdecreases expression 18042831
D028321 Plant Preparations Plant Preparations affects the expression of FCER1G mRNAaffects expression 16251609
C004648 testosterone enanthate testosterone enanthate affects the expression of FCER1G mRNAaffects expression 17440010
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of FCER1G mRNAaffects cotreatment|increases expression 17942748
D014212 Tretinoin Tretinoin results in increased expression of FCER1G mRNAincreases expression 17218384
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.0011752688 15322242 14514962
MESH:D000138 Acidosis Ammonium Chloride 3.7118287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.1217505938
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8314692618
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.813712494
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.5316835633
MESH:D000505 Alopecia Tretinoin 3.7015955085
MESH:D000544 Alzheimer Disease Ozone 2.4615513908
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.0511748828
MESH:D000799 Angioedema Acetaminophen 4.0210982225
MESH:D001161 Arteriosclerosis Dietary Fats 10.3815238619
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 10.3811256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 7.4215885639
MESH:D001169 Arthritis, Experimental Tretinoin 7.4216412693
MESH:D001172 Arthritis, Rheumatoid Ozone 4.7515570426
MESH:D001172 Arthritis, Rheumatoid Tretinoin 4.7516292516
MESH:D001249 Asthma Ozone 5.0517854713 16373670
MESH:D001249 Asthma Tretinoin 5.0516456186
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001471 Barrett Esophagus Tretinoin 4.5316935849
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.191440618 11289319
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 9.3112125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 9.3116206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.9615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8315746008
MESH:D001943 Breast Neoplasms decitabine 2.3919208741 18320071
MESH:D001943 Breast Neoplasms Dietary Fats 2.3920435547
MESH:D001943 Breast Neoplasms Plant Preparations 2.3917398067
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.3920435547
MESH:D001943 Breast Neoplasms Tretinoin 2.3916873071 16443354 16166294
MESH:D016535 Bronchial Hyperreactivity Ozone 3.7615516495 18315731 16777450 18417511 19059883 17626835 14754758
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.7416813970
MESH:D002100 Cachexia Ozone 4.8916183385
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.8916835633
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.3316168501
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 4.617296757 3581430
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.613084413
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 4.611917145
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.727296757
MESH:D002294 Carcinoma, Squamous Cell decitabine 7.9319215824
MESH:D002294 Carcinoma, Squamous Cell Plant Preparations 7.9317418620
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 7.9316051514 16096774
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4218850075 18670907 16120746
MESH:D002318 Cardiovascular Diseases Plant Preparations 4.4716862667
MESH:D016893 Carotid Stenosis Plant Preparations 6.2915158307
MESH:D002386 Cataract Acetaminophen 7.4310977129
MESH:D002386 Cataract Tretinoin 7.4317460283
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 2.837505956
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.7416129372
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.2616835633
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 8.1319486331 9022650
MESH:D002779 Cholestasis Ethinyl Estradiol 8.1311677210 16105132 17333356 16919318 17110522 17681005 15861022
MESH:D002822 Choriocarcinoma Tretinoin 5.3316461808
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.9012621046 15668235 16354765 8697196 15340226
MESH:D002972 Cleft Palate Tretinoin 5.909407595
MESH:D003092 Colitis Tretinoin 3.8417035595
MESH:D003110 Colonic Neoplasms decitabine 2.3517616700
MESH:D015179 Colorectal Neoplasms decitabine 2.1018981723
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1617141729 14669216
MESH:D003324 Coronary Artery Disease Plant Preparations 4.0215158307
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.4815322242 20055451 10048152
MESH:D019465 Craniofacial Abnormalities Tretinoin 2.489142499 17551590 8800419 10589399 16925845 9664655 9224671 9125849 9211117 14991402
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 2.9414531868 12868966 11906362 18759878 11298694 2524372 8970840 8156756
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.613621924 2952479
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6917107852
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 6.299022650 16192314 11289319 18289764 9328219 6482804 8291058 18648102 18692083 9653073 6679447 1440618 7440962
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.2912153990 19416960 12540782 19085960 18713872 11834606 19164858 16109766 14550746 14986274 15619225 18071297 19923254 12594235 10774834 12958197 10663392 19739265 19370779 16177239 17562736 11461765 16485898 10915739 12392966 11287661 2444490 16081117 16393943 15968718 12705907 11421492 11739529 17906064 16781746 17522070 14725611 16227642 11743745 19420014 11529661
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 6.2920420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.2719426721
MESH:D004362 Drug Toxicity Plant Preparations 8.7511033412
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 8.7511462148
MESH:D050171 Dyslipidemias Dietary Fats 3.5318367378
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.4812711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 12.5315322242 18230668 16714409
MESH:D004489 Edema, Cardiac Tretinoin 12.5318230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.3112538720
MESH:D004701 Endocrine Gland Neoplasms decitabine 5.2919294695
MESH:D016889 Endometrial Neoplasms Tretinoin 3.1816569247
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.129294722 10568697
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 5.033581430
MESH:D004938 Esophageal Neoplasms Plant Preparations 5.0316510608
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 9.1111564622
MESH:D005124 Eye Abnormalities Tretinoin 9.1116938888 9664655
MESH:D005234 Fatty Liver Dietary Fats 8.0918296743 19551842 17967931 19004024
MESH:D005234 Fatty Liver Ethinyl Estradiol 8.0915345470
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.5911858732
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.196705139
MESH:D005355 Fibrosis Dietary Fats 15.6118296743
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 15.6120067830
MESH:D005355 Fibrosis Tretinoin 15.6117994277
MESH:D005756 Gastritis Acetaminophen 3.8516983495
MESH:D005909 Glioblastoma Tretinoin 3.0717312396
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.157505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.7710696789
MESH:D006258 Head and Neck Neoplasms decitabine 8.0719215824
MESH:D006258 Head and Neck Neoplasms Tretinoin 8.0716096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.3316084493
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.7210048152 11294989
MESH:D006330 Heart Defects, Congenital Tretinoin 6.729664655 14991402
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.4411000095
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.646705139
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.0315340226 12621046 16120746
MESH:D019247 HIV Wasting Syndrome testosterone enanthate 5.9217440010
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.2216354765 16959395 15340226 18606429 8697196
MESH:D006930 Hyperalgesia Acetaminophen 7.9216870215
MESH:D006930 Hyperalgesia Tretinoin 7.9216870215
MESH:D006937 Hypercholesterolemia Dietary Fats 3.7021332399
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.7116778211
MESH:D006949 Hyperlipidemias Dietary Fats 3.7321332399
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.0815034207
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9418850075 18670907
MESH:D007021 Hypospadias Ethinyl Estradiol 3.9516569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.5812013081
MESH:D007248 Infertility, Male decitabine 6.9617581917
MESH:D007248 Infertility, Male Ethinyl Estradiol 6.9617937319
MESH:D007249 Inflammation Dietary Fats 5.0920412841
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.0912200463 12878042
MESH:D007333 Insulin Resistance Dietary Fats 3.1711836018 18457598
MESH:D007410 Intestinal Diseases Tretinoin 3.9017994277
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.199022650 8074119
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 10.3016580747
MESH:D007569 Jaw Abnormalities Tretinoin 10.3015992940 17551590
MESH:D007674 Kidney Diseases Acetaminophen 2.2615629191 12587719
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 3.066582329
MESH:D007938 Leukemia decitabine 6.6018980019 19235587
MESH:D007938 Leukemia Tretinoin 6.6017143497
MESH:D007951 Leukemia, Myeloid decitabine 9.9319117987 17236224 18454857
MESH:D007951 Leukemia, Myeloid Tretinoin 9.9316482212 16932348 19285840
MESH:D015470 Leukemia, Myeloid, Acute decitabine 4.0317679729 18206229 18460780 18704418 19010910 19387464
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 4.0316294345 17596541 19850784
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 5.6418055864
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.229834237 17649720 17361223 16891316 19075265 19029980 16331271 19225113 17339181 16140955 17294898 17506722 16788101 16935935 19035177 12679006 17107899 17217047 19642359 17368321 16766008 17301526 16823087 17712046 15748426
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.389224671
MESH:D008103 Liver Cirrhosis Dietary Fats 2.9318296743
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.2615034207 9327722
MESH:D008106 Liver Cirrhosis, Experimental Plant Preparations 3.7017724770
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.7012878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 3.7016248980 18397230
MESH:D008107 Liver Diseases Acetaminophen 1.6519460945 11587558 19014921 12587719 19784758 16610002 12969438 16611625
MESH:D017114 Liver Failure, Acute Acetaminophen 3.3417185352 16871587
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 1.7516984957
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 5.95598648 3712494 1399818 6587162
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 5.9512151625
MESH:D008171 Lung Diseases Ozone 3.4519066396 8266340
MESH:D055370 Lung Injury Ozone 3.9920417186
MESH:D008175 Lung Neoplasms Ozone 2.417614698 8597069
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.4119555203 11884234
MESH:D008223 Lymphoma decitabine 3.4919470736
MESH:D008527 Medulloblastoma Tretinoin 2.8217453147
MESH:D008545 Melanoma decitabine 3.4716505122 17785578
MESH:D008545 Melanoma Tretinoin 3.4716752155
MESH:D008546 Melanoma, Experimental Acetaminophen 3.7119513568
MESH:D008591 Meningomyelocele Tretinoin 4.5616940565
MESH:D008679 Metaplasia Ozone 5.2810496685
MESH:D009062 Mouth Neoplasms Plant Preparations 4.8617418620
MESH:D009101 Multiple Myeloma decitabine 3.4218172295
MESH:D009190 Myelodysplastic Syndromes decitabine 7.6819010910 18608210 16882708 19157545
MESH:D009190 Myelodysplastic Syndromes Tretinoin 7.6817596541
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1112213967
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.513581430
MESH:D009369 Neoplasms decitabine 5.3617925555 19116145 19470736
MESH:D009369 Neoplasms Tretinoin 5.3616946489 16594593
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 9.9414600291
MESH:D009421 Nervous System Malformations Tretinoin 9.949125849
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 7.466679447
MESH:D009436 Neural Tube Defects Tretinoin 7.469142499
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.9618514411
MESH:D009765 Obesity Dietary Fats 2.3121332399 18457598 17217161 11836018 20132043 16723640 18674790 20518802 19632207
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.524026338 6482804
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.193988306
MESH:D010051 Ovarian Neoplasms decitabine 5.0719259094 19331143
MESH:D010051 Ovarian Neoplasms Tretinoin 5.0716936753
MESH:D010146 Pain Acetaminophen 6.8916870215
MESH:D010146 Pain Tretinoin 6.8916870215
MESH:D010190 Pancreatic Neoplasms decitabine 5.5019294695
MESH:D010190 Pancreatic Neoplasms Tretinoin 5.5015976015
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.8011578682
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.627296757
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.4212520081
MESH:D010538 Peritonitis Ozone 4.2716369182
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.646228378
MESH:D011014 Pneumonia Ozone 4.5518929643 18381685 18007984
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.6918163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.3411118676 11399792 11222880 11896295
MESH:D055728 Primary Myelofibrosis decitabine 4.8717616702
MESH:D011507 Proteinuria Tretinoin 3.7216636307
MESH:D011537 Pruritus Ethinyl Estradiol 3.4715861022 16919318
MESH:D011625 Pterygium Tretinoin 4.9516723453
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.9618990726
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.463692021
MESH:D012208 Rhabdomyosarcoma decitabine 11.3419155313
MESH:D012208 Rhabdomyosarcoma Tretinoin 11.3416283617 16116481
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.7216192470
MESH:D012878 Skin Neoplasms Tretinoin 5.7216467112
MESH:D013088 Spermatocele Ethinyl Estradiol 4.1216709447
MESH:D013274 Stomach Neoplasms decitabine 2.5719037991
MESH:D013274 Stomach Neoplasms Tretinoin 2.5717261132
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.7411994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.2515669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.0812697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 12.507505956 6582329 6587162 1399818 3712494
MESH:D013964 Thyroid Neoplasms decitabine 12.5017967635
MESH:D013964 Thyroid Neoplasms Tretinoin 12.5017045167 16026305
MESH:D014062 Tongue Neoplasms Tretinoin 3.8916051514
MESH:D014376 Tuberculosis Tretinoin 3.2916040207
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 8.778074119
MESH:D001749 Urinary Bladder Neoplasms decitabine 8.7717616700 19087683
MESH:D001749 Urinary Bladder Neoplasms Plant Preparations 8.7711251952
MESH:D014581 Urticaria Acetaminophen 3.0910982225
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 3.7816129372
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.4214692618
MESH:D014604 Uveal Neoplasms decitabine 13.4217785578
MESH:D014604 Uveal Neoplasms Tretinoin 13.4216752155
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.7712125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.6515869587 14671159
MESH:D014820 Vitiligo Tretinoin 4.1816761959
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.4215886252
MESH:D015430 Weight Gain Dietary Fats 3.8316723640
MESH:D009396 Wilms Tumor Tretinoin 4.0716287080
Pathway ID Pathway Name
KEGG:05310 Asthma
KEGG:04664 Fc epsilon RI signaling pathway
REACT:604 Hemostasis
KEGG:04650 Natural killer cell mediated cytotoxicity
KEGG:05152 Tuberculosis
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA28057
    • No data
    No data
    Releated drug ID Related drug Name
    PA450952phospholipids
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00895 potentiator Benzylpenicilloyl Polylysine
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


    Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved