AutismKB 2.0

Annotation Detail for JMJD1C


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:JMJD1C ( DKFZp761F0118,FLJ14374,KIAA1380,RP11-10C13.2,TRIP8 )
Gene Full Name: jumonji domain containing 1C
Band: 10q21.3
Quick LinksEntrez ID:221037; OMIM: 604503; Uniprot ID:JHD2C_HUMAN; ENSEMBL ID: ENSG00000171988; HGNC ID: 12313
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
Desease IDDesease Name
2124Autistic disorder
Desease Name
HEMATOLOGICAL
mean platelet volume
plasma levels of liver enzymes
METABOLIC
Desease Name
Plasma levels of liver enzymes
Mean platelet volume
Platelet aggregation
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene results in decreased expression of JMJD1C mRNAdecreases expression 20406850
D000082 Acetaminophen Acetaminophen affects the expression of JMJD1C mRNAaffects expression 17562736
D006710 Homocysteine Homocysteine results in decreased expression of JMJD1C mRNAdecreases expression 17326132
D000643 Ammonium Chloride Ammonium Chloride affects the expression of JMJD1C mRNAaffects expression 16483693
D017638 Asbestos, Crocidolite Asbestos, Crocidolite results in increased expression of JMJD1C mRNAincreases expression 18687144
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of JMJD1C mRNAdecreases expression 19150397
20018196
D006830 Hydralazine [Hydralazine co-treated with Valproic Acid] results in increased expression of JMJD1C mRNAaffects cotreatment|increases expression 17183730
D016685 Mitomycin JMJD1C protein affects the susceptibility to Mitomycinaffects response to substance 16217747
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of JMJD1C mRNAaffects binding|increases activity|increases expression 19710929
D014635 Valproic Acid [Hydralazine co-treated with Valproic Acid] results in increased expression of JMJD1C mRNAaffects cotreatment|increases expression 17183730
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 3.728875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 4.1019490988
MESH:D000138 Acidosis Ammonium Chloride 3.8018287403
MESH:D055371 Acute Lung Injury pirinixic acid 3.3018653653
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.7216434500
MESH:D000550 Amblyopia Valproic Acid 5.5017688650
MESH:D000799 Angioedema Acetaminophen 4.1110982225
MESH:D001008 Anxiety Disorders Valproic Acid 3.7117497229
MESH:D001321 Autistic Disorder marker/mechanism 17290275
MESH:D001321 Autistic Disorder Acetaminophen 2.2718445737
MESH:D001321 Autistic Disorder Homocysteine 2.2720468076 16297937
MESH:D001321 Autistic Disorder Valproic Acid 2.2718177632 15238991 17688650 19460635 16609825 17507914 18775368 19232924 18940202 18558336 17157402 18985861 18396377 18316065 20603192
MESH:D001714 Bipolar Disorder Valproic Acid 3.1520046352 17594078
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.3219483382
MESH:D001848 Bone Diseases, Developmental Valproic Acid 3.518888407
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 2.8916705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 2.893084413
MESH:D002386 Cataract Acetaminophen 2.6710977129
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 7.036135515
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7.0320889678
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.7620734317
MESH:D002779 Cholestasis pirinixic acid 2.9519176532
MESH:D003324 Coronary Artery Disease Homocysteine 3.8116379339
MESH:D019465 Craniofacial Abnormalities Valproic Acid 1.9016575769 8888407 17688650
MESH:D003490 Cyanosis 2,6-dinitrotoluene 4.2318551238
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4918249437
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 6.4618551238 21346803
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.4614550746 17906064 12540782 18071297 16393943 11834606 19923254 17522070 2444490 11739529 11529661 10915739 15619225 11461765 12392966 14986274 12594235 11421492 16485898 16227642 19370779 11287661 17562736 19085960 19420014 12958197 10663392 15968718 18713872 16081117 10774834 12705907 19164858 14725611 12153990 11743745 16781746 19416960 16109766 16177239 19739265
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 6.4619641884 1733752
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.3619426721
MESH:D004421 Dystonia Valproic Acid 4.231851702
MESH:D004487 Edema pirinixic acid 2.6512083418
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 4.373659116 17275665
MESH:D004828 Epilepsies, Partial Valproic Acid 4.1816628512 3922381
MESH:D004827 Epilepsy Valproic Acid 3.0118234410 20417680
MESH:D004832 Epilepsy, Absence Valproic Acid 3.746254150 6426943 7562514
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.517750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 4.303659116
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.1120426865
MESH:D017889 Exfoliation Syndrome Homocysteine 5.9416504073
MESH:D005234 Fatty Liver pirinixic acid 8.3019236843 20131406
MESH:D005234 Fatty Liver Valproic Acid 8.3014986274 19224547
MESH:D005315 Fetal Diseases Valproic Acid 5.1516575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.338888407 18558336
MESH:D005756 Gastritis Acetaminophen 3.9416983495
MESH:D005901 Glaucoma Homocysteine 5.4716504073
MESH:D006330 Heart Defects, Congenital Homocysteine 4.0919638421
MESH:D006333 Heart Failure pirinixic acid 2.6320558911
MESH:D006529 Hepatomegaly pirinixic acid 3.2118467677 16221962 19772884 19176532
MESH:D006849 Hydrocephalus Valproic Acid 5.1017688650
MESH:D006930 Hyperalgesia Acetaminophen 2.8416870215
MESH:D006943 Hyperglycemia pirinixic acid 3.3420558911
MESH:D020138 Hyperhomocysteinemia Homocysteine 4.8617369066 18234410 17292331
MESH:D046110 Hypertension, Pregnancy-Induced Hydralazine 4.8416612254
MESH:D007333 Insulin Resistance pirinixic acid 2.7416306350
MESH:D007674 Kidney Diseases Acetaminophen 2.2915629191 12587719
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 3.1216705839
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 2.1717596541 16294345
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 1.3415474484
MESH:D008107 Liver Diseases Acetaminophen 1.6612587719 12969438 11587558 19014921 16611625 19460945 16610002 19784758
MESH:D017114 Liver Failure, Acute Acetaminophen 3.4016871587 17185352
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 7.877678174
MESH:D008113 Liver Neoplasms Mitomycin 7.8715113037
MESH:D008113 Liver Neoplasms pirinixic acid 7.8720007298 15890375 16377806
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 2.646135515 2876784 2876786
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.5317228818
MESH:D055370 Lung Injury Asbestos, Crocidolite 4.2417365036
MESH:D008546 Melanoma, Experimental Acetaminophen 3.7819513568
MESH:D008591 Meningomyelocele Homocysteine 5.7516602021
MESH:D008654 Mesothelioma Asbestos, Crocidolite 3.2416166281 16966607 18303189
MESH:D008881 Migraine Disorders Valproic Acid 3.3118803445 18765137
MESH:D009135 Muscular Diseases pirinixic acid 3.7216239165
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 4.208888407
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 3.2417596541
MESH:D009203 Myocardial Infarction Homocysteine 6.2017412321
MESH:D009203 Myocardial Infarction pirinixic acid 6.2019151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.0816411023
MESH:D009336 Necrosis 2,6-dinitrotoluene 4.107678174 18551238
MESH:D009369 Neoplasms pirinixic acid 2.0217405874
MESH:D009436 Neural Tube Defects Valproic Acid 3.238888407 16359493
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.0118514411
MESH:D009765 Obesity pirinixic acid 1.8520558911
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 3.5916049721
MESH:D010146 Pain Acetaminophen 2.5316870215
MESH:D010190 Pancreatic Neoplasms Mitomycin 3.5015113037
MESH:D010300 Parkinson Disease Homocysteine 3.6316275827
MESH:D010995 Pleural Diseases Asbestos, Crocidolite 5.1110923243
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 4.0720603192
MESH:D019310 Pseudolymphoma Valproic Acid 4.8112752131 11422049
MESH:D011658 Pulmonary Fibrosis Asbestos, Crocidolite 3.0817975199 17365031 17322281 15814490
MESH:D015427 Reperfusion Injury pirinixic acid 2.4619058328
MESH:D012208 Rhabdomyosarcoma Valproic Acid 4.3619155313
MESH:D012559 Schizophrenia Homocysteine 4.0416641680
MESH:D012559 Schizophrenia Valproic Acid 4.0415737665 19110320
MESH:D012640 Seizures 2,6-dinitrotoluene 6.3218551238
MESH:D012640 Seizures Valproic Acid 6.323137016 11738929 14763951 15475178 1511512 17978042 11044598 16876388
MESH:D016135 Spinal Dysraphism Valproic Acid 3.9119490988
MESH:D013226 Status Epilepticus Valproic Acid 4.8112833885
MESH:D014178 Translocation, Genetic Valproic Acid 5.5017262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.763119515
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 2.3416049721
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.868888407
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.5610091137
MESH:D014581 Urticaria Acetaminophen 3.1610982225
Pathway ID Pathway Name
REACT:604 Hemostasis
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA128394767
    • No data
    Releated disease ID Related disease Name
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    No data
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


    Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved