AutismKB 2.0

Annotation Detail for SPATA13


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Basic Information Top
Gene Symbol:SPATA13 ( ARHGEF29,ASEF2,FLJ31208,FLJ35435,MGC129988,MGC129989 )
Gene Full Name: spermatogenesis associated 13
Band: 13q12.12
Quick LinksEntrez ID:221178; OMIM: 613324; Uniprot ID:SPT13_HUMAN; ENSEMBL ID: ENSG00000182957; HGNC ID: 23222
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Pathway IDPathway Name
200165Regulation of RAC1 activity
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Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C548651 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of SPATA13 mRNAdecreases expression 19933214
D001104 Arbutin Arbutin results in increased expression of SPATA13 mRNAincreases expression 17103032
C006632 arsenic trioxide arsenic trioxide results in increased expression of SPATA13 mRNAincreases expression 20458559
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of SPATA13 mRNAdecreases expression 19150397
D004958 Estradiol ESR1 protein affects the reaction [Estradiol promotes the reaction [NCOA3 protein binds to SPATA13 gene]]affects binding|affects reaction|increases reaction 17962382
D004958 Estradiol Estradiol promotes the reaction [ESR1 protein binds to SPATA13 gene]affects binding|increases reaction 17962382
D004958 Estradiol Estradiol results in increased expression of SPATA13 mRNAincreases expression 17962382
D020849 Raloxifene Raloxifene results in increased expression of SPATA13 mRNAincreases expression 17962382
D013629 Tamoxifen Tamoxifen results in increased expression of SPATA13 mRNAincreases expression 17962382
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.9914745880
MESH:D000230 Adenocarcinoma arsenic trioxide 4.5819825857 11798837
MESH:D000230 Adenocarcinoma Estradiol 4.5811473722
MESH:D000419 Albuminuria Raloxifene 4.9217308373 17451421
MESH:D000544 Alzheimer Disease Raloxifene 2.5915800139
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 3.9516206674
MESH:D001930 Brain Injuries Raloxifene 4.8316580743
MESH:D001943 Breast Neoplasms Estradiol 1.9419861407 16675129 17289903 17261762 18497071 12948864 17018787 14630087
MESH:D001943 Breast Neoplasms Raloxifene 1.9415775269 17049068 15572757 17952589 15758505 17261762 16912660 16837676 17893378 17440819 17595753 17242785
MESH:D001943 Breast Neoplasms Tamoxifen 1.9419011961 17242785 17440819 19103187 20859285 18351453 16873071 19221464 16273361 15565566 17049068 19155303 21138602 18629630 21152245 19142967 19410462 19066611 19084267 18815881 20390343 15668708 19200415 19059307 19288272 16818667 17261762 17893378 19487384 16202921 20005174 20065188 20544844 18821012 18425577 18984771 11161223 18855134 19189212 19115204 18997820 19289846 20135344 19244106 19189210
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.6311589617
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.8616111702
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.8719066611
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 4.8015073043 16217749 15553829 11135700 14691202
MESH:D006528 Carcinoma, Hepatocellular Estradiol 4.8016924424
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 4.8016924424
MESH:D002291 Carcinoma, Papillary arsenic trioxide 5.3219014326
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.3812490120
MESH:D002295 Carcinoma, Transitional Cell Raloxifene 10.4017572228
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 10.4017572228
MESH:D002318 Cardiovascular Diseases Raloxifene 3.6315775269
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7.2620889678
MESH:D002471 Cell Transformation, Neoplastic Estradiol 7.2618566989
MESH:D003072 Cognition Disorders Raloxifene 4.9815800139
MESH:D015179 Colorectal Neoplasms arsenic trioxide 1.8620501625
MESH:D023903 Coronary Restenosis arsenic trioxide 4.5112609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 1.8910525206
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.4015213294
MESH:D003711 Demyelinating Diseases Tamoxifen 4.7219031437
MESH:D003865 Depressive Disorder, Major Raloxifene 4.4117474826
MESH:D003928 Diabetic Nephropathies Estradiol 16.5219279558
MESH:D003928 Diabetic Nephropathies Raloxifene 16.5217308373 15920148 17451421
MESH:D003928 Diabetic Nephropathies Tamoxifen 16.5219279558
MESH:D004487 Edema Raloxifene 3.6115860553
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Raloxifene 10.3615845917
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 10.3619031437
MESH:D016889 Endometrial Neoplasms Estradiol 7.9618566989 19148513 11473722
MESH:D016889 Endometrial Neoplasms Tamoxifen 7.9619155303 17893378 16202921 20544844
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.6620426865
MESH:D004938 Esophageal Neoplasms arsenic trioxide 4.6612903497
MESH:D005234 Fatty Liver arsenic trioxide 14.9215073043
MESH:D005234 Fatty Liver Raloxifene 14.9217473493
MESH:D005234 Fatty Liver Tamoxifen 14.9219224547 14986274
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.3916709447
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.9214745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.5819069698
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.5916904648
MESH:D006331 Heart Diseases Raloxifene 3.7211110106
MESH:D006558 Herpes Genitalis Estradiol 5.4815709030
MESH:D019584 Hot Flashes Estradiol 4.1917088409
MESH:D006973 Hypertension Raloxifene 2.9517577099 15787275
MESH:D007249 Inflammation Tamoxifen 2.4819457130
MESH:D007333 Insulin Resistance Estradiol 3.1316627594 16393666
MESH:D007674 Kidney Diseases Estradiol 2.7215618244
MESH:D007680 Kidney Neoplasms Estradiol 8.1815610895
MESH:D007680 Kidney Neoplasms Tamoxifen 8.1818625569
MESH:D007889 Leiomyoma Raloxifene 4.8016973256
MESH:D007938 Leukemia arsenic trioxide 2.9515070760
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 4.0812560223 17077332
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.7016972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.6314633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 4.0419077051
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 2.1720471514 16968895 19850784 16467208 17050201
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 3.3817649720 16891316 11468182 16966277 16823087 11161223 17712046 15213294 19035177 19075265 16330433 19225113 19642359 15622746 12712474 12679006 16331271 17869043 9834237 12018890 15336539 17217047 17107899 15748426 16112521
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.6816882451
MESH:D008064 Lipidoses Tamoxifen 3.3517567588 15342952
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 2.5114716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 2.5118564211
MESH:D008113 Liver Neoplasms arsenic trioxide 4.9214682389
MESH:D008113 Liver Neoplasms Tamoxifen 4.9216684651
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 2.8920377131
MESH:D008133 Long QT Syndrome arsenic trioxide 3.5615213294
MESH:D008175 Lung Neoplasms arsenic trioxide 2.5411798837 19825857
MESH:D008175 Lung Neoplasms Tamoxifen 2.5418625569
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 4.1519428831
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 6.5316891317 11408345 11807958 17203775
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 6.5311731420 19196722 19196723 16827153 14580682
MESH:D020149 Manganese Poisoning Estradiol 14.1719453300
MESH:D020149 Manganese Poisoning Tamoxifen 14.1719453300
MESH:D008545 Melanoma Tamoxifen 1.9119393235 12393984
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.5815990972
MESH:D018200 Mixed Tumor, Mullerian Raloxifene 6.0015863610
MESH:D009101 Multiple Myeloma arsenic trioxide 8.0614977855 19417148 19549372 11468182 15949261
MESH:D009101 Multiple Myeloma Raloxifene 8.0616497877
MESH:D009182 Mycosis Fungoides arsenic trioxide 5.1218349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 3.2816105982 16882451
MESH:D015428 Myocardial Reperfusion Injury Estradiol 3.4916810080
MESH:D009232 Myxoma Raloxifene 6.0016343187
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 4.2916624393
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.6419393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.5919410462
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.4419189210 19200415 19196722
MESH:D009389 Neovascularization, Pathologic Estradiol 4.1317289903
MESH:D009421 Nervous System Malformations Estradiol 3.9811399458 16427766
MESH:D009436 Neural Tube Defects arsenic trioxide 3.2810525206
MESH:D010024 Osteoporosis Raloxifene 3.5515775268 19059307 17882678
MESH:D015663 Osteoporosis, Postmenopausal Raloxifene 4.5317893378 15579764 15758505 17823083
MESH:D010051 Ovarian Neoplasms arsenic trioxide 5.0719769630 16624393 12452020
MESH:D010051 Ovarian Neoplasms Estradiol 5.0719401270
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 2.6015580305
MESH:D010235 Paraganglioma arsenic trioxide 4.4719927285
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 4.1720887781
MESH:D011471 Prostatic Neoplasms arsenic trioxide 2.0519131511
MESH:D011471 Prostatic Neoplasms Estradiol 2.0516740699
MESH:D011471 Prostatic Neoplasms Raloxifene 2.0516536755 15731164 16220300
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.0515067354
MESH:D011693 Purpura Raloxifene 6.0015770314
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 4.2916646077
MESH:D013088 Spermatocele Tamoxifen 4.7416709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 4.4319457130
MESH:D013274 Stomach Neoplasms arsenic trioxide 1.8617007042
MESH:D020521 Stroke Raloxifene 4.0416837676
MESH:D013964 Thyroid Neoplasms arsenic trioxide 3.2919014326
MESH:D013978 Tibial Fractures Estradiol 15.2419048282
MESH:D013978 Tibial Fractures Raloxifene 15.2419048282
MESH:D016171 Torsades de Pointes arsenic trioxide 4.3615213294
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 8.9311780464 12973940 12845720 20435036
MESH:D001749 Urinary Bladder Neoplasms Raloxifene 8.9317572228
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 8.938653321 16712894 17572228
MESH:D054556 Venous Thromboembolism Raloxifene 5.6516837676
MESH:D014846 Vulvar Neoplasms Raloxifene 6.0016343187
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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