AutismKB 2.0

Annotation Detail for DAGLB


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Basic Information Top
Gene Symbol:DAGLB ( DAGLBETA,FLJ33624,FLJ33909,FLJ45532,KCCR13L )
Gene Full Name: diacylglycerol lipase, beta
Band: 7p22.1
Quick LinksEntrez ID:221955; OMIM: NA; Uniprot ID:DGLB_HUMAN; ENSEMBL ID: ENSG00000164535; HGNC ID: 28923
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
No data
Pathway IDPathway Name
Signaling by GPCR
Hemostasis
Pathway IDPathway Name
200180N-cadherin signaling events
No data
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C036535 1,6-bis(cyclohexyloximinocarbonyl)hexane 1,6-bis(cyclohexyloximinocarbonyl)hexane results in decreased activity of DAGLB proteindecreases activity 18657971
C075809 1-stearoyl-2-arachidonoylglycerol DAGLB protein results in increased metabolism of 1-stearoyl-2-arachidonoylglycerolincreases metabolic processing 18657971
C094503 2-arachidonylglycerol DAGLB protein results in increased chemical synthesis of 2-arachidonylglycerolincreases chemical synthesis 18657971
D000082 Acetaminophen Acetaminophen affects the expression of DAGLB mRNAaffects expression 17562736
D016572 Cyclosporine Cyclosporine results in increased expression of DAGLB mRNAincreases expression 20106945
C051890 irinotecan irinotecan analog results in decreased expression of DAGLB mRNAdecreases expression 18927307
C104810 methyl arachidonylfluorophosphonate methyl arachidonylfluorophosphonate results in decreased activity of DAGLB proteindecreases activity 18657971
C055122 orlistat orlistat results in decreased activity of DAGLB proteindecreases activity 18657971
D018038 Sodium Selenite Sodium Selenite results in increased expression of DAGLB mRNAincreases expression 18175754
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with AHR gene mutant form] results in decreased expression of DAGLB mRNAaffects cotreatment|decreases expression 19465110
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.0815322242 11752688 14514962
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.6116835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.1111748828
MESH:D000799 Angioedema Acetaminophen 4.1110982225
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.2112125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.0615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8715746008
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.6920435547
MESH:D019121 Burkholderia Infections orlistat 6.9117874328
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9316835633
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 1.393084413
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4516120746 18670907 18850075
MESH:D002386 Cataract Acetaminophen 2.6710977129
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 2.6412371664
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.3116835633
MESH:D002779 Cholestasis Cyclosporine 3.0419486331
MESH:D019457 Chromosome Breakage Sodium Selenite 4.9715894690
MESH:D002916 Chylothorax orlistat 6.9117003701
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1615340226 16354765 8697196 12621046 15668235
MESH:D003110 Colonic Neoplasms irinotecan 2.6217725105 17287894
MESH:D015179 Colorectal Neoplasms irinotecan 2.3615273666 18259882 18509181 16391804 16303861 17159606 17454858
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.2114669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2610048152 15322242 20055451
MESH:D048909 Diabetes Complications orlistat 6.1019207292
MESH:D003920 Diabetes Mellitus Sodium Selenite 3.9316285004
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7017107852
MESH:D003967 Diarrhea orlistat 4.9120002075
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.4211743745 19923254 18071297 16485898 11739529 17522070 17906064 19370779 18713872 16393943 12705907 11421492 14725611 14550746 16781746 12153990 16109766 19420014 14986274 17562736 16081117 12540782 10915739 2444490 11834606 10774834 11461765 12958197 19739265 11529661 11287661 12594235 19085960 15619225 15968718 19164858 16177239 12392966 19416960 10663392 16227642
MESH:D056486 Drug-Induced Liver Injury Sodium Selenite 6.4215131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 6.4220420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.3619426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8911462148
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.5512711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.1715322242 16714409 18230668
MESH:D004660 Encephalitis 2-arachidonylglycerol 7.2116364651
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.1810568697 9294722
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1411564622
MESH:D005234 Fatty Liver Cyclosporine 3.0319224547
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.6711858732
MESH:D005355 Fibrosis Cyclosporine 9.2112639820 12168785
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 9.2120067830
MESH:D005414 Flatulence orlistat 6.9120002075
MESH:D005756 Gastritis Acetaminophen 3.9416983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.468708960
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.8610696789
MESH:D016489 Head Injuries, Closed 2-arachidonylglycerol 7.2116364651
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4110048152 11294989
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.6615720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.5111000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.1115340226 12621046 16120746
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.318697196 16959395 15340226 16354765 18606429
MESH:D006930 Hyperalgesia Acetaminophen 2.8416870215
MESH:D006949 Hyperlipidemias orlistat 5.2721332399
MESH:D006973 Hypertension Cyclosporine 5.1410903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.1418670907 18850075
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.9312878042 12200463
MESH:D007333 Insulin Resistance orlistat 8.3817201808
MESH:D007333 Insulin Resistance Sodium Selenite 8.3814714311
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.5116580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.7115604871
MESH:D007674 Kidney Diseases Acetaminophen 6.1015629191 12587719
MESH:D007674 Kidney Diseases Cyclosporine 6.1010903974 8314463 18776723
MESH:C531755 Kidney disorder involving deposition of calcium and oxalate or phosphate in the renal tubules orlistat 6.9117185156
MESH:D007680 Kidney Neoplasms Cyclosporine 2.8812371664
MESH:D008103 Liver Cirrhosis orlistat 4.4317404856
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 1.2412878042
MESH:D008107 Liver Diseases Acetaminophen 1.6619014921 16611625 19460945 12587719 19784758 12969438 16610002 11587558
MESH:D017114 Liver Failure, Acute Acetaminophen 3.4016871587 17185352
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 1.7716984957
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 2.2012151625
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 1.2419555203 11884234
MESH:D008207 Lymphatic Metastasis orlistat 6.0818770866 20805790
MESH:D016393 Lymphoma, B-Cell Sodium Selenite 4.2414737004
MESH:D008545 Melanoma orlistat 3.4420805790 18770866
MESH:D008546 Melanoma, Experimental Acetaminophen 3.7819513568
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.0516801185
MESH:D052016 Mucositis irinotecan 5.2517159606
MESH:D009135 Muscular Diseases orlistat 5.6618430571
MESH:D009164 Mycobacterium Infections orlistat 5.7621442799
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1612213967
MESH:D009362 Neoplasm Metastasis irinotecan 3.2318259882
MESH:D009369 Neoplasms orlistat 3.9618710210
MESH:D009374 Neoplasms, Experimental orlistat 5.2719381703
MESH:D009389 Neovascularization, Pathologic orlistat 5.5817012255
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.7117954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.4419348381 18481113
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.4114600291
MESH:D009447 Neuroblastoma irinotecan 3.568761367
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.0118514411
MESH:D017599 Neuroectodermal Tumors irinotecan 4.978761367
MESH:C541083 Non-alcoholic Fatty Liver Disease orlistat 5.7317404856
MESH:D009765 Obesity orlistat 3.7918773755 21442799 20065556 19461584 19046740 20599501 16938137 21438711 20002075 20518802 19207292 20540997
MESH:D010146 Pain Acetaminophen 2.5316870215
MESH:D010195 Pancreatitis orlistat 5.0320065556 16938137
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.5112520081
MESH:D011085 Polycystic Ovary Syndrome orlistat 5.4617201808
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.7618163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.3712371664
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.4311896295 11118676 11222880 11399792
MESH:D011471 Prostatic Neoplasms Sodium Selenite 3.3718760546
MESH:D011565 Psoriasis Cyclosporine 2.2816882103
MESH:D012035 Refsum Disease orlistat 6.3120871815
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.0418990726
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.1116192470
MESH:D013274 Stomach Neoplasms irinotecan 3.2215723263
MESH:D013274 Stomach Neoplasms orlistat 3.2219381703
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.1712697716
MESH:D014581 Urticaria Acetaminophen 3.1610982225
MESH:D014605 Uveitis Cyclosporine 4.251336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.8612125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.5115886252
MESH:D014985 Xerophthalmia Cyclosporine 4.7117120751
Pathway ID Pathway Name
REACT:604 Hemostasis
REACT:14797 Signaling by GPCR
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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