AutismKB 2.0

Annotation Detail for THSD7A


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Basic Information Top
Gene Symbol:THSD7A ( KIAA0960 )
Gene Full Name: thrombospondin, type I, domain containing 7A
Band: 7p21.3
Quick LinksEntrez ID:221981; OMIM: 612249; Uniprot ID:THS7A_HUMAN; ENSEMBL ID: ENSG00000005108; HGNC ID: 22207
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene results in decreased expression of THSD7A mRNAdecreases expression 20406850
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of THSD7A mRNAaffects expression 17484886
D016572 Cyclosporine Cyclosporine results in increased expression of THSD7A mRNAincreases expression 20106945
D004958 Estradiol [Progesterone co-treated with Estradiol] results in increased expression of THSD7A mRNAaffects cotreatment|increases expression 17404688
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of THSD7A mRNAaffects binding|increases activity|increases expression 19710929
D011374 Progesterone [Progesterone co-treated with Estradiol] results in increased expression of THSD7A mRNAaffects cotreatment|increases expression 17404688
D011374 Progesterone Progesterone results in increased expression of THSD7A mRNAincreases expression 17404688
D012643 Selenium Selenium results in decreased expression of THSD7A mRNAdecreases expression 19244175
D014635 Valproic Acid Valproic Acid results in increased expression of THSD7A mRNAincreases expression 19101580
C025643 vinclozolin vinclozolin affects the expression of THSD7A mRNAaffects expression 19015723
D014810 Vitamin E Vitamin E results in decreased expression of THSD7A mRNAdecreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 3.728875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 4.1019490988
MESH:D055371 Acute Lung Injury pirinixic acid 3.3018653653
MESH:D000230 Adenocarcinoma Estradiol 2.1311473722
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.7216434500
MESH:D000550 Amblyopia Valproic Acid 5.5017688650
MESH:D001008 Anxiety Disorders Valproic Acid 9.3217497229
MESH:D001008 Anxiety Disorders vinclozolin 9.3219015723
MESH:D001321 Autistic Disorder Valproic Acid 1.9917507914 18316065 18985861 17688650 16609825 17157402 19460635 15238991 18396377 19232924 18940202 18775368 18558336 18177632 20603192
MESH:D001714 Bipolar Disorder Valproic Acid 3.1520046352 17594078
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.3219483382
MESH:D001848 Bone Diseases, Developmental Valproic Acid 3.518888407
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.6017868700
MESH:D001930 Brain Injuries Progesterone 4.4715845082 15665606 15380490
MESH:D001943 Breast Neoplasms Estradiol 2.1917018787 16675129 17289903 12948864 19861407 18497071 17261762 14630087
MESH:D001943 Breast Neoplasms Progesterone 2.1916175315 17614352 15562024
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.7016111702
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 10.6616011737 15700767 18705752 15721981 16124888 3786805 16097048 16227642 16192424 15673190 16050911 10355542
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 10.6616050911
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 4.7016705839
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 4.7018788625
MESH:D006528 Carcinoma, Hepatocellular Estradiol 4.7016924424
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 11.826135515
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 11.8212371664
MESH:D002471 Cell Transformation, Neoplastic Estradiol 11.8218566989
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.7620734317
MESH:D002779 Cholestasis Cyclosporine 8.1819486331
MESH:D002779 Cholestasis pirinixic acid 8.1819176532
MESH:D003092 Colitis Selenium 3.9917936198
MESH:D019465 Craniofacial Abnormalities Valproic Acid 2.7616575769 17688650 8888407
MESH:D019465 Craniofacial Abnormalities Vitamin E 2.7619769572
MESH:D003456 Cryptorchidism vinclozolin 4.5414966744
MESH:D003490 Cyanosis 2,6-dinitrotoluene 4.2318551238
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4918249437
MESH:D003928 Diabetic Nephropathies Estradiol 3.5619279558
MESH:D003929 Diabetic Neuropathies Progesterone 4.7117187935
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 9.3821346803 18551238
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 9.3810092053 10915739 6884620 19336974 3786805 16227642 15998439 16177239 21278145 7440962 15027814 6623471 7179309 4309450 3732212 2869522 15968718 9327722 11566570 19085960 7120509 17522070
MESH:D056486 Drug-Induced Liver Injury Selenium 9.3815131321
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 9.381733752 19641884
MESH:D004421 Dystonia Valproic Acid 4.231851702
MESH:C538011 Eales disease Vitamin E 4.979068938
MESH:D004487 Edema pirinixic acid 2.6512083418
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 3.9817692515
MESH:D016889 Endometrial Neoplasms Estradiol 3.0919148513 11473722 18566989
MESH:D004715 Endometriosis Progesterone 3.9316134523
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 4.3717275665 3659116
MESH:D004828 Epilepsies, Partial Valproic Acid 4.1816628512 3922381
MESH:D004827 Epilepsy Valproic Acid 3.0120417680 18234410
MESH:D004832 Epilepsy, Absence Valproic Acid 3.746254150 7562514 6426943
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.517750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 4.303659116
MESH:D005234 Fatty Liver Carbon Tetrachloride 20.2415959796 12631006 17595544 19224547 16239168 61145 12795759 16045604
MESH:D005234 Fatty Liver Cyclosporine 20.2419224547
MESH:D005234 Fatty Liver pirinixic acid 20.2420131406 19236843
MESH:D005234 Fatty Liver Valproic Acid 20.2419224547 14986274
MESH:D005315 Fetal Diseases Valproic Acid 5.1516575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.3318558336 8888407
MESH:D005355 Fibrosis Carbon Tetrachloride 9.4018705752
MESH:D005355 Fibrosis Cyclosporine 9.4012168785 12639820
MESH:D030342 Genetic Diseases, Inborn vinclozolin 5.1716973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.5716417039
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.468708960
MESH:D006330 Heart Defects, Congenital Vitamin E 3.0716080930
MESH:D006333 Heart Failure pirinixic acid 7.2820558911
MESH:D006333 Heart Failure Selenium 7.2817162251
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.6615720958
MESH:D006505 Hepatitis Carbon Tetrachloride 3.7919900420 19110552
MESH:D006529 Hepatomegaly pirinixic acid 3.2118467677 19772884 16221962 19176532
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.7516863852 16490937
MESH:D006558 Herpes Genitalis Estradiol 5.3015709030
MESH:D019584 Hot Flashes Estradiol 10.9517088409
MESH:D019584 Hot Flashes Vitamin E 10.9514716179
MESH:D006849 Hydrocephalus Valproic Acid 5.1017688650
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.7716899240
MESH:D006943 Hyperglycemia pirinixic acid 3.3420558911
MESH:D006973 Hypertension Cyclosporine 2.1510903974
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.3015338365
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.6215869954
MESH:D007248 Infertility, Male vinclozolin 3.1516467254
MESH:D007249 Inflammation Progesterone 2.6815869954
MESH:D007251 Influenza, Human Selenium 11.8616624496
MESH:D007251 Influenza, Human Vitamin E 11.8616624496
MESH:D007333 Insulin Resistance Estradiol 7.5516393666 16627594
MESH:D007333 Insulin Resistance pirinixic acid 7.5516306350
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.7115604871
MESH:D007674 Kidney Diseases Cyclosporine 10.608314463 10903974 18776723
MESH:D007674 Kidney Diseases Estradiol 10.6015618244
MESH:D007674 Kidney Diseases Vitamin E 10.6012488133
MESH:D007676 Kidney Failure, Chronic Selenium 4.0616518626
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 13.2216705839
MESH:D007680 Kidney Neoplasms Cyclosporine 13.2212371664
MESH:D007680 Kidney Neoplasms Estradiol 13.2215610895
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 2.1716294345 17596541
MESH:D007984 Leydig Cell Tumor vinclozolin 4.9716417039
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.8917157831 16943688 11903743 21278145 16221502 17174718 11408273 17334410 16239168
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 5.0914748882 10355542 18054572 16116963 18006644 18156304 17869086 18205269 18263696 18705752 15893842 15057751 15959796 15876570 16015684 12546737 15925388 18395914 14512876 18420326 16011737 15730626 12649538 16192424 17481882 12632512 15650968 17631135 17976157 18418968 15370692 15673190 14620537 12898905 16638106 17525996 12666154 12609069 18251166 17761835 18472094 18395095 18277467 17565644 15052691 15123356 18472332 18339082 14716496 16097048 12445418 18166357 17714472 17557913 17698563 15818738 16136751 18412020 17823541 18376398 15931870 13678700 17922224 12445421 12389079 18279442 16027843 15338365 17721639 11481614 12667390 20821823 17640975 12586293 17900296 17708605 17805973 18429990 14716833 17766677 18481824 12632514 14724832 18187930 16033810 18210741 12741479 12958196 15996030 17944888 18317297 16248980 15362042
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 5.0914659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 5.0915474484
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 5.0916169303
MESH:D008107 Liver Diseases Carbon Tetrachloride 2.1216246199 15720792 17285989 15830285 16964402
MESH:D017093 Liver Failure Carbon Tetrachloride 4.3815123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.8516899240 14706259
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 7.737678174
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 7.7319294768
MESH:D008113 Liver Neoplasms pirinixic acid 7.7320007298 16377806 15890375
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 6.266135515 2876786 2876784
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 6.2612014681 15583823
MESH:D008171 Lung Diseases Vitamin E 3.2916863852
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.5317228818
MESH:D008175 Lung Neoplasms Vitamin E 1.9011062179
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 10.6211408345 11807958 17203775 16891317
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 10.6217203775 11408345
MESH:D008325 Mammary Neoplasms, Experimental Selenium 10.6215318939
MESH:D020149 Manganese Poisoning Estradiol 4.7519453300
MESH:D008654 Mesothelioma Selenium 2.8515107826
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.0516801185
MESH:D008881 Migraine Disorders Valproic Acid 3.3118803445 18765137
MESH:D009135 Muscular Diseases pirinixic acid 3.7216239165
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 4.208888407
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 3.2417596541
MESH:D009203 Myocardial Infarction pirinixic acid 2.2019151258
MESH:D015428 Myocardial Reperfusion Injury Estradiol 8.6916810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 8.6916411023
MESH:D009336 Necrosis 2,6-dinitrotoluene 4.1018551238 7678174
MESH:D009369 Neoplasms pirinixic acid 2.0217405874
MESH:D009389 Neovascularization, Pathologic Estradiol 3.9717289903
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.7117954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.4418481113 19348381
MESH:D009421 Nervous System Malformations Estradiol 3.8516427766 11399458
MESH:D009436 Neural Tube Defects Valproic Acid 3.238888407 16359493
MESH:D009765 Obesity pirinixic acid 1.8520558911
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 3.5916049721
MESH:D010051 Ovarian Neoplasms Estradiol 5.0319401270
MESH:D010051 Ovarian Neoplasms Progesterone 5.0317393432 16525653
MESH:D010954 Plasmacytoma Selenium 5.1515087411
MESH:D011230 Precancerous Conditions Cyclosporine 3.3712371664
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 10.5320603192
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 10.5318220299 18042343 19015723
MESH:D011469 Prostatic Diseases vinclozolin 5.1718220299
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 4.0620887781
MESH:D011471 Prostatic Neoplasms Estradiol 3.1916740699
MESH:D011471 Prostatic Neoplasms Vitamin E 3.1915084515
MESH:D011472 Prostatitis vinclozolin 5.1718629315
MESH:D019310 Pseudolymphoma Valproic Acid 4.8111422049 12752131
MESH:D011565 Psoriasis Cyclosporine 2.2816882103
MESH:D015427 Reperfusion Injury pirinixic acid 2.4619058328
MESH:D012208 Rhabdomyosarcoma Valproic Acid 4.3619155313
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.9118045962
MESH:D012559 Schizophrenia Valproic Acid 2.0915737665 19110320
MESH:D012640 Seizures 2,6-dinitrotoluene 6.3218551238
MESH:D012640 Seizures Valproic Acid 6.323137016 14763951 1511512 11738929 17978042 16876388 15475178 11044598
MESH:D012871 Skin Diseases Vitamin E 2.4818709164
MESH:D013119 Spinal Cord Injuries Progesterone 4.5215862959 16503802
MESH:D016135 Spinal Dysraphism Valproic Acid 3.9119490988
MESH:D013226 Status Epilepticus Valproic Acid 4.8112833885
MESH:D020521 Stroke Vitamin E 3.6616517955
MESH:D013978 Tibial Fractures Estradiol 4.9519048282
MESH:D014178 Translocation, Genetic Valproic Acid 5.5017262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.763119515
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 2.3416049721
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.868888407
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.5610091137
MESH:D014605 Uveitis Cyclosporine 4.251336536
MESH:D014985 Xerophthalmia Cyclosporine 4.7117120751
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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