AutismKB 2.0

Annotation Detail for FDFT1


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Basic Information Top
Gene Symbol:FDFT1 ( DGPT,ERG9,SQS,SS )
Gene Full Name: farnesyl-diphosphate farnesyltransferase 1
Band: 8p23.1
Quick LinksEntrez ID:2222; OMIM: 184420; Uniprot ID:FDFT_HUMAN; ENSEMBL ID: ENSG00000079459; HGNC ID: 3629
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Pathway IDPathway Name
PWY66-341cholesterol biosynthesis I
PWY66-4cholesterol biosynthesis III (via desmosterol)
PWY66-3cholesterol biosynthesis II (via 24,25-dihydrolanosterol)
PWY-5670epoxysqualene biosynthesis
Pathway IDPathway Name
hsa01100Metabolic pathways
hsa00100Steroid biosynthesis
Pathway IDPathway Name
Metabolism of lipids and lipoproteins
No data
Pathway IDPathway Name
P00014Cholesterol biosynthesis
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1831Prostate cancer
No data
Desease Name
Non-alcoholic fatty liver disease histology (other)
Non-alcoholic fatty liver disease histology (lobular)
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C003585 22-hydroxycholesterol 22-hydroxycholesterol results in decreased expression of FDFT1 mRNAdecreases expression 19426978
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of FDFT1 mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of FDFT1 mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of FDFT1 mRNAaffects expression 17562736
D000082 Acetaminophen Acetaminophen results in decreased expression of FDFT1 mRNAdecreases expression 11264010
C103303 alitretinoin alitretinoin results in increased expression of FDFT1 mRNAincreases expression 16648578
D000638 Amiodarone Amiodarone affects the expression of FDFT1 mRNAaffects expression 19483382
D000643 Ammonium Chloride Ammonium Chloride affects the expression of FDFT1 mRNAaffects expression 16483693
D000965 Antimony Antimony results in decreased expression of FDFT1 mRNAdecreases expression 17547211
D000966 Antimony Potassium Tartrate Antimony Potassium Tartrate results in decreased expression of FDFT1 mRNAdecreases expression 17547211
D001553 Benzbromarone Benzbromarone affects the expression of FDFT1 mRNAaffects expression 19483382
C095105 bexarotene bexarotene results in increased expression of FDFT1 mRNAincreases expression 16648578
C032036 bromobenzene bromobenzene results in decreased expression of FDFT1 mRNAdecreases expression 15056800
D002784 Cholesterol FDFT1 protein results in increased chemical synthesis of Cholesterolincreases chemical synthesis 17483544
D002994 Clofibrate Clofibrate affects the expression of FDFT1 mRNAaffects expression 19483382
D016572 Cyclosporine Cyclosporine results in decreased expression of FDFT1 mRNAdecreases expression 20106945
D004040 Dietary Carbohydrates Dietary Carbohydrates results in decreased expression of FDFT1 mRNAdecreases expression 17490981
D004041 Dietary Fats Dietary Fats results in decreased expression of FDFT1 mRNAdecreases expression 15238619
D004052 Diethylnitrosamine Diethylnitrosamine results in decreased expression of FDFT1 mRNAdecreases expression 19638242
D004128 Dimethylnitrosamine Dimethylnitrosamine results in decreased expression of FDFT1 mRNAdecreases expression 17547211
D004317 Doxorubicin FDFT1 mRNA results in decreased susceptibility to Doxorubicindecreases response to substance 16322897
D004958 Estradiol Estradiol results in increased expression of FDFT1 mRNAincreases expression 14664709
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of FDFT1 mRNAincreases expression 16174780
D005001 Ethionine Ethionine affects the expression of FDFT1 mRNAaffects expression 19483382
D005038 Ethylnitrosourea Ethylnitrosourea results in decreased expression of FDFT1 mRNAdecreases expression 15954086
D005047 Etoposide FDFT1 protein affects the susceptibility to Etoposideaffects response to substance 16217747
C065180 fluvastatin [zoledronic acid co-treated with fluvastatin] results in increased expression of FDFT1 mRNAaffects cotreatment|increases expression 16996129
C056933 fumonisin B1 fumonisin B1 results in decreased expression of FDFT1 mRNAdecreases expression 16221962
D006861 Hydrogen Peroxide [isoquercitrin co-treated with Hydrogen Peroxide] results in increased expression of FDFT1 mRNAaffects cotreatment|increases expression 18032389
D007529 Isoflavones Isoflavones results in increased expression of FDFT1 mRNAincreases expression 17374662
C016527 isoquercitrin [isoquercitrin co-treated with Hydrogen Peroxide] results in increased expression of FDFT1 mRNAaffects cotreatment|increases expression 18032389
D007657 Ketone Bodies Ketone Bodies results in decreased expression of FDFT1 mRNAdecreases expression 16807920
D015741 Metribolone Metribolone results in increased expression of FDFT1 mRNAincreases expression 17483544
D015741 Metribolone Metribolone results in increased expression of FDFT1 proteinincreases expression 17483544
D016685 Mitomycin FDFT1 protein affects the susceptibility to Mitomycinaffects response to substance 16217747
D008942 Mitoxantrone FDFT1 protein affects the susceptibility to Mitoxantroneaffects response to substance 16217747
C014707 nitrosobenzylmethylamine nitrosobenzylmethylamine results in increased expression of FDFT1 mRNAincreases expression 17616710
D009853 Omeprazole Omeprazole affects the expression of FDFT1 mRNAaffects expression 19483382
D010126 Ozone Ozone results in decreased expression of FDFT1 mRNAdecreases expression 16716893
D017239 Paclitaxel FDFT1 protein affects the susceptibility to Paclitaxelaffects response to substance 16217747
D010634 Phenobarbital NR1I3 protein affects the reaction [Phenobarbital results in increased expression of FDFT1 mRNA]affects reaction|increases expression 19482888
D010634 Phenobarbital Phenobarbital results in decreased expression of FDFT1 mRNAdecreases expression 19270015
D010634 Phenobarbital Phenobarbital results in increased expression of FDFT1 mRNAincreases expression 19482888
D010795 Phthalic Acids Phthalic Acids results in decreased expression of FDFT1 mRNAdecreases expression 15728792
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of FDFT1 mRNAaffects binding|decreases expression|increases activity 19710929
C006253 pirinixic acid pirinixic acid results in decreased expression of FDFT1 mRNAdecreases expression 18445702
C006253 pirinixic acid pirinixic acid results in increased expression of FDFT1 mRNAincreases expression 18467677
20059764
16221962
15777286
C006253 pirinixic acid PPARA protein affects the reaction [pirinixic acid results in increased expression of FDFT1 mRNA]affects reaction|increases expression 15777286
C006253 pirinixic acid PPARA protein promotes the reaction [pirinixic acid results in increased expression of FDFT1 mRNA]increases expression|increases reaction 18467677
20059764
C006253 pirinixic acid pirinixic acid affects the expression of FDFT1 mRNAaffects expression 19483382
D011374 Progesterone Progesterone results in increased expression of FDFT1 mRNAincreases expression 18070364
D011441 Propylthiouracil Propylthiouracil affects the expression of FDFT1 mRNAaffects expression 19483382
D012643 Selenium Selenium deficiency results in increased expression of FDFT1 mRNAincreases expression 16170372
D019821 Simvastatin Simvastatin results in increased expression of FDFT1 proteinincreases expression 12518039
C075117 squalestatin 1 squalestatin 1 results in decreased activity of FDFT1 proteindecreases activity 17483544
D014284 Triiodothyronine Triiodothyronine results in increased expression of FDFT1 mRNAincreases expression 15953391
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of FDFT1 mRNAdecreases expression 16960034
D013853 Thioacetamide Thioacetamide affects the expression of FDFT1 mRNAaffects expression 19483382
D019772 Topotecan FDFT1 protein affects the susceptibility to Topotecanaffects response to substance 16217747
C032910 triadimefon triadimefon results in increased expression of FDFT1 mRNAincreases expression 17178688
D014635 Valproic Acid Valproic Acid results in increased expression of FDFT1 mRNAincreases expression 19101580
C088658 zoledronic acid [zoledronic acid co-treated with fluvastatin] results in increased expression of FDFT1 mRNAaffects cotreatment|increases expression 16996129
C088658 zoledronic acid zoledronic acid results in increased expression of FDFT1 mRNAincreases expression 18325729
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 11.006195326
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 11.0015322242 14514962 11752688
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 11.008875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 3.4319490988
MESH:D000138 Acidosis Ammonium Chloride 3.0118287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.3817505938
MESH:D058186 Acute Kidney Injury zoledronic acid 3.9719715164
MESH:D055371 Acute Lung Injury pirinixic acid 2.6118653653
MESH:D000210 Acute-Phase Reaction zoledronic acid 4.9220200999
MESH:D000230 Adenocarcinoma Dimethylnitrosamine 8.7416033868
MESH:D000230 Adenocarcinoma Doxorubicin 8.7417418594
MESH:D000230 Adenocarcinoma Estradiol 8.7411473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 8.7414692618
MESH:D000236 Adenoma Diethylnitrosamine 9.3710737359 6695378
MESH:D000236 Adenoma Dimethylnitrosamine 9.3719555203
MESH:D000236 Adenoma Ethylnitrosourea 9.376695378
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 20.3018056438 17620307 16434500 19061943 17162532 19052882
MESH:D018248 Adenoma, Liver Cell Phenobarbital 20.3017620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 20.3016434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 20.3016835633
MESH:D000419 Albuminuria Doxorubicin 4.0121441931
MESH:D000505 Alopecia Isoflavones 4.2717569567
MESH:D000544 Alzheimer Disease Ozone 2.3015513908
MESH:D000550 Amblyopia Valproic Acid 4.6617688650
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.4611748828
MESH:D000799 Angioedema Acetaminophen 3.2810982225
MESH:D001008 Anxiety Disorders Valproic Acid 3.1317497229
MESH:D001145 Arrhythmias, Cardiac Amiodarone 3.3220041841 18218290 18057881
MESH:D001161 Arteriosclerosis Dietary Fats 8.1115238619
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 8.1111256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.3015885639
MESH:D001172 Arthritis, Rheumatoid Ozone 2.4115570426
MESH:D001249 Asthma Ozone 2.4517854713 16373670
MESH:D050197 Atherosclerosis Cholesterol 3.9016632123
MESH:D001281 Atrial Fibrillation Amiodarone 3.4818651412 19698954
MESH:D001289 Attention Deficit Disorder with Hyperactivity Phthalic Acids 3.9720106747
MESH:D001321 Autistic Disorder Acetaminophen 1.8618445737
MESH:D001321 Autistic Disorder Valproic Acid 1.8617507914 17688650 20603192 17157402 15238991 18775368 18316065 16609825 18558336 18940202 18985861 18177632 18396377 19460635 19232924
MESH:D001714 Bipolar Disorder Valproic Acid 2.7720046352 17594078
MESH:D001778 Blood Coagulation Disorders Amiodarone 48.3719483382
MESH:D001778 Blood Coagulation Disorders Benzbromarone 48.3719483382
MESH:D001778 Blood Coagulation Disorders Clofibrate 48.3719483382
MESH:D001778 Blood Coagulation Disorders Ethionine 48.3719483382
MESH:D001778 Blood Coagulation Disorders Omeprazole 48.3719483382
MESH:D001778 Blood Coagulation Disorders pirinixic acid 48.3719483382
MESH:D001778 Blood Coagulation Disorders Propylthiouracil 48.3719483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 48.3712125929
MESH:D001778 Blood Coagulation Disorders Thioacetamide 48.3719483382
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.2215340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 6.7715746008
MESH:D001848 Bone Diseases, Developmental Valproic Acid 6.778888407
MESH:D019046 Bone Marrow Neoplasms Doxorubicin 10.2714601052
MESH:D019046 Bone Marrow Neoplasms Etoposide 10.2714601052
MESH:D001859 Bone Neoplasms Paclitaxel 9.1315867366
MESH:D001859 Bone Neoplasms zoledronic acid 9.1316778634 19442620 17312309 11697798 15867366 16121404
MESH:D001862 Bone Resorption zoledronic acid 4.2018404659 18496637 8053405 16769263 15845617 11869084
MESH:D001927 Brain Diseases Ethylnitrosourea 4.3914991843
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 4.7717868700
MESH:D001930 Brain Injuries Progesterone 3.7215665606 15845082 15380490
MESH:D001932 Brain Neoplasms Doxorubicin 7.4917150277
MESH:D001932 Brain Neoplasms Ethylnitrosourea 7.4915144691 18412241 16651633 16436596 16357521
MESH:D001943 Breast Neoplasms alitretinoin 7.3516344269
MESH:D001943 Breast Neoplasms bexarotene 7.3516818667 16344269
MESH:D001943 Breast Neoplasms Dietary Fats 7.3520435547
MESH:D001943 Breast Neoplasms Diethylnitrosamine 7.3517474063
MESH:D001943 Breast Neoplasms Doxorubicin 7.3515939500 15136595 18695136 16322301 18628466 17983394 16264153 17426702 16096432 15567936 19526202 15634643 18234424 16115903 11325840 16935488 15692762 15993339 16595493 15994142 18382427 16826403 15668708 17369602
MESH:D001943 Breast Neoplasms Estradiol 7.3517289903 16675129 12948864 17261762 14630087 18497071 19861407 17018787
MESH:D001943 Breast Neoplasms Etoposide 7.3516322251
MESH:D001943 Breast Neoplasms Paclitaxel 7.3518234424 16244791 18223236 15136595 11325840 18323546 16115903 16273361
MESH:D001943 Breast Neoplasms Progesterone 7.3517614352 15562024 16175315
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 7.3520435547
MESH:D001943 Breast Neoplasms zoledronic acid 7.3518695136 16096432
MESH:D016535 Bronchial Hyperreactivity Ozone 3.2317626835 19059883 16777450 18315731 15516495 14754758 18417511
MESH:D001991 Bronchitis Antimony 5.568768112
MESH:D002100 Cachexia Ozone 4.1816183385
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 3.9116111702
MESH:D002276 Carcinoid Tumor Doxorubicin 4.2416051944
MESH:D002277 Carcinoma Dimethylnitrosamine 6.8819555203
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 6.8816835633
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 20.3016705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 20.3016705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 20.303084413
MESH:D006528 Carcinoma, Hepatocellular Benzbromarone 20.301701930
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 20.3020727157 19822196 18788625 3581430 20512989 16779866 20514400 18785209 18971187 19519916 16878318 19394651 10737359 19418558 18665156 11831363 18210153 18056438 17055752 19335982 16502159 20101231 17173139 18494052 10672840 20007298 17978847 16681979 18393292 19107877 17138121 20084675 17761372 19383236 16288022 17162532 20214788 18691550 16935385 20524982 19539802 21159647 19208518 16807293 16569478 16698587 3084413 19701751 19919837 17428255 19052882 18978308 16328049 18506893 19171122 20935162 16830150 16540662 20432363
MESH:D006528 Carcinoma, Hepatocellular Doxorubicin 20.3018059187 17876044 16234567 16023760
MESH:D006528 Carcinoma, Hepatocellular Estradiol 20.3016924424
MESH:D006528 Carcinoma, Hepatocellular Paclitaxel 20.3016313753
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 20.3020007298 17173139 20935162 1701930 6705139
MESH:D006528 Carcinoma, Hepatocellular Thioacetamide 20.3017997003
MESH:D002289 Carcinoma, Non-Small-Cell Lung bexarotene 5.3016247446
MESH:D002289 Carcinoma, Non-Small-Cell Lung zoledronic acid 5.3019233551
MESH:D002292 Carcinoma, Renal Cell Doxorubicin 6.011485588 16201981
MESH:D002292 Carcinoma, Renal Cell zoledronic acid 6.0118507039
MESH:D002294 Carcinoma, Squamous Cell Dimethylnitrosamine 4.3716033868
MESH:D002294 Carcinoma, Squamous Cell Doxorubicin 4.376189445
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.0418670907 16120746 18850075
MESH:D009202 Cardiomyopathies Doxorubicin 3.1516242529 16731534 17974986 18627295 16455267 17329180 17928571 17308081 16952015 17131338 16278810 17519947 17007740 16612575 17924179 16109756 15811867 16269455 17382496 16651473 15792986 16364871 15476868 17351982 15505089
MESH:D002311 Cardiomyopathy, Dilated Amiodarone 8.4015710769 19225199
MESH:D002311 Cardiomyopathy, Dilated Antimony 8.4010334427
MESH:D002311 Cardiomyopathy, Dilated Doxorubicin 8.4017334414 16243910
MESH:D002318 Cardiovascular Diseases Hydrogen Peroxide 6.5216936243
MESH:D002318 Cardiovascular Diseases Isoflavones 6.5217689850
MESH:D002341 Carotid Artery Thrombosis Amiodarone 4.5318974383
MESH:D002386 Cataract Acetaminophen 6.6310977129
MESH:D002386 Cataract Simvastatin 6.6312518039
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 21.236135515
MESH:D002471 Cell Transformation, Neoplastic Clofibrate 21.231399818
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 21.2312371664
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 21.2317174075 21159647 2727394 7505956
MESH:D002471 Cell Transformation, Neoplastic Estradiol 21.2318566989
MESH:D002471 Cell Transformation, Neoplastic Ethylnitrosourea 21.2316003739
MESH:D002493 Central Nervous System Diseases Phenobarbital 3.714080065
MESH:D016543 Central Nervous System Neoplasms Ethylnitrosourea 5.4217160924
MESH:D002637 Chest Pain Omeprazole 4.5415447763
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.4820734317
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 13.3919052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 13.3916835633
MESH:D018281 Cholangiocarcinoma Thioacetamide 13.3918291259
MESH:D002779 Cholestasis Cyclosporine 10.9019486331
MESH:D002779 Cholestasis Ethinyl Estradiol 10.9017681005 17110522 16919318 11677210 16105132 17333356 15861022
MESH:D002779 Cholestasis pirinixic acid 10.9019176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.2715668235 15340226 16354765 8697196 12621046
MESH:D002972 Cleft Palate triadimefon 5.2716781842
MESH:D003092 Colitis Selenium 3.2417936198
MESH:D015179 Colorectal Neoplasms Doxorubicin 3.3018259882 18802399
MESH:D015179 Colorectal Neoplasms Isoflavones 3.3017116718
MESH:D015179 Colorectal Neoplasms Paclitaxel 3.3018802399
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.5914669216 17141729
MESH:D003327 Coronary Disease fluvastatin 4.4416142594
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 3.4620055451 15322242 10048152
MESH:D019465 Craniofacial Abnormalities triadimefon 3.4616875885 15834900
MESH:D019465 Craniofacial Abnormalities Valproic Acid 3.4617688650 8888407 16575769
MESH:D003490 Cyanosis 2,4-dinitrotoluene 9.0918551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 9.0918551238
MESH:D003550 Cystic Fibrosis Simvastatin 4.4719747007
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.1418249437
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 3.6520387270
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 3.6517107852
MESH:D003928 Diabetic Nephropathies Estradiol 2.9419279558
MESH:D003929 Diabetic Neuropathies Progesterone 3.9517187935
MESH:D004283 Dog Diseases Antimony 5.1012019027
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 35.9318551238 21346803
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 35.9321346803 18551238
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 35.9312540782 11287661 14550746 14986274 11739529 16227642 11743745 16081117 18071297 19923254 11461765 10915739 12594235 15619225 17562736 11421492 18713872 2444490 19370779 19416960 16485898 14725611 12392966 12958197 19420014 17906064 11529661 11834606 12153990 19085960 16393943 19739265 10663392 15968718 10774834 17522070 19164858 16781746 12705907 16177239 16109766
MESH:D056486 Drug-Induced Liver Injury Amiodarone 35.9315265979 18218290
MESH:D056486 Drug-Induced Liver Injury bromobenzene 35.9310092053 12628495
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 35.9319107877
MESH:D056486 Drug-Induced Liver Injury Dimethylnitrosamine 35.938172417
MESH:D056486 Drug-Induced Liver Injury Doxorubicin 35.9317416283
MESH:D056486 Drug-Induced Liver Injury fumonisin B1 35.9316221962
MESH:D056486 Drug-Induced Liver Injury Selenium 35.9315131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 35.9320420201
MESH:D056486 Drug-Induced Liver Injury Thioacetamide 35.9312963478
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 35.931733752 19641884
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.5319426721
MESH:D004362 Drug Toxicity Doxorubicin 6.7118602426
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 6.7111462148
MESH:D004381 Duodenal Ulcer Omeprazole 3.8117151854 21218061 15991576 16613094
MESH:D050171 Dyslipidemias Clofibrate 7.4516707586
MESH:D050171 Dyslipidemias Dietary Fats 7.4518367378
MESH:D004421 Dystonia Phenobarbital 8.731851702
MESH:D004421 Dystonia Valproic Acid 8.731851702
MESH:D004476 Ectodermal Dysplasia Ethylnitrosourea 5.4218357618
MESH:D004487 Edema pirinixic acid 4.9212083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 4.9211000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.3316714409 15322242 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 7.2912538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 7.2917692515
MESH:D016889 Endometrial Neoplasms Doxorubicin 6.2717359293
MESH:D016889 Endometrial Neoplasms Estradiol 6.2718566989 19148513 11473722
MESH:D004715 Endometriosis Progesterone 7.3216134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 7.3210568697 9294722
MESH:D004719 Endomyocardial Fibrosis Doxorubicin 4.5918037988
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 8.993659116
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 8.9917275665 3659116
MESH:D004828 Epilepsies, Partial Phenobarbital 8.093922381 11558140
MESH:D004828 Epilepsies, Partial Valproic Acid 8.093922381 16628512
MESH:D004827 Epilepsy Phenobarbital 5.6220417680
MESH:D004827 Epilepsy Valproic Acid 5.6218234410 20417680
MESH:D004832 Epilepsy, Absence Phenobarbital 7.306401628
MESH:D004832 Epilepsy, Absence Valproic Acid 7.306254150 7562514 6426943
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 9.507750514
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 9.507750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 8.633659116
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 8.633659116
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 4.5516302075
MESH:D004938 Esophageal Neoplasms Dimethylnitrosamine 6.4617016578
MESH:D004938 Esophageal Neoplasms nitrosobenzylmethylamine 6.4616704527 16510608 15623463 15878914 15150132 15264214 16805852 15547733 15547721
MESH:D004938 Esophageal Neoplasms Paclitaxel 6.4616481741
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.5911564622
MESH:D005218 Fat Necrosis Thioacetamide 5.1516456712
MESH:D005234 Fatty Liver Amiodarone 34.6014986274
MESH:D005234 Fatty Liver Clofibrate 34.6019224547
MESH:D005234 Fatty Liver Cyclosporine 34.6019224547
MESH:D005234 Fatty Liver Dietary Fats 34.6017967931 19004024 18296743 19551842
MESH:D005234 Fatty Liver Diethylnitrosamine 34.6020387270 21071580
MESH:D005234 Fatty Liver Ethinyl Estradiol 34.6015345470
MESH:D005234 Fatty Liver pirinixic acid 34.6020131406 19236843
MESH:D005234 Fatty Liver Valproic Acid 34.6019224547 14986274
MESH:D005264 Femoral Fractures zoledronic acid 5.2716234978
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 2.9111858732
MESH:D005315 Fetal Diseases Valproic Acid 4.3216575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 3.608888407 18558336
MESH:D018222 Fibromatosis, Aggressive Doxorubicin 4.0319069698
MESH:D005355 Fibrosis Cyclosporine 11.5912168785 12639820
MESH:D005355 Fibrosis Dietary Fats 11.5918296743
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 11.5920067830
MESH:D005756 Gastritis Acetaminophen 3.1116983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 3.668708960
MESH:D005909 Glioblastoma Doxorubicin 6.2917150277
MESH:D005909 Glioblastoma Ethylnitrosourea 6.2916436596
MESH:D005910 Glioma Ethylnitrosourea 3.2516651633 16357521 18412241
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.0310696789
MESH:D006258 Head and Neck Neoplasms Doxorubicin 3.1415692506
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.0210048152 11294989
MESH:D006331 Heart Diseases Doxorubicin 6.7416144979 18006777 16244371 16707910 17888722 18674790 16330681 16495754 12587719 17875725 16244372 14766674 16879835
MESH:D006331 Heart Diseases Mitoxantrone 6.7416019553
MESH:D006333 Heart Failure Doxorubicin 9.7017481944
MESH:D006333 Heart Failure pirinixic acid 9.7020558911
MESH:D006333 Heart Failure Selenium 9.7017162251
MESH:D006394 Hemangiosarcoma Doxorubicin 3.4115692506
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 3.8615720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 2.8411000095
MESH:D006501 Hepatic Encephalopathy Thioacetamide 4.0718665440 17276928 15929193
MESH:D006505 Hepatitis Thioacetamide 3.6916456712
MESH:D006529 Hepatomegaly Amiodarone 26.7615265979
MESH:D006529 Hepatomegaly fumonisin B1 26.7616221962
MESH:D006529 Hepatomegaly Phenobarbital 26.7616109766
MESH:D006529 Hepatomegaly pirinixic acid 26.7619772884 16221962 18467677 19176532
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 26.7615340226 12621046 16120746
MESH:D006529 Hepatomegaly triadimefon 26.7617178689 17178688
MESH:D006558 Herpes Genitalis Estradiol 4.4615709030
MESH:D006561 Herpes Simplex Etoposide 4.0110809021
MESH:D006689 Hodgkin Disease Doxorubicin 6.2015147373 17606976 18501091
MESH:D006689 Hodgkin Disease Etoposide 6.2018180244 16200630 15147373 16135485 17606976
MESH:D019584 Hot Flashes Estradiol 8.5417088409
MESH:D019584 Hot Flashes Isoflavones 8.5417290160 14716179
MESH:D006849 Hydrocephalus Valproic Acid 4.3117688650
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.4815340226 16959395 8697196 16354765 18606429
MESH:D006930 Hyperalgesia Acetaminophen 6.5316870215
MESH:D006930 Hyperalgesia zoledronic acid 6.5316769263
MESH:D006934 Hypercalcemia zoledronic acid 4.5519622757 18089816
MESH:D006937 Hypercholesterolemia Amiodarone 12.608137927 9751232
MESH:D006937 Hypercholesterolemia Cholesterol 12.6016933029
MESH:D006937 Hypercholesterolemia Dietary Fats 12.6021332399
MESH:D006943 Hyperglycemia pirinixic acid 2.7020558911
MESH:D006949 Hyperlipidemias Dietary Fats 3.1121332399
MESH:D006938 Hyperlipoproteinemia Type II Simvastatin 4.7616238680
MESH:D006973 Hypertension Cyclosporine 4.1410903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 4.1418670907 18850075
MESH:D006996 Hypocalcemia zoledronic acid 5.6312669777
MESH:D007021 Hypospadias Ethinyl Estradiol 3.2716569931 16945680
MESH:D007037 Hypothyroidism Amiodarone 9.8117991464 18020914
MESH:D007037 Hypothyroidism Propylthiouracil 9.8118031379 8137927
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 3.8615869954
MESH:D007247 Infertility, Female Ethinyl Estradiol 2.9512013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.1117937319
MESH:D007249 Inflammation Dietary Fats 9.3520412841
MESH:D007249 Inflammation Diethylnitrosamine 9.3518785209
MESH:D007249 Inflammation Progesterone 9.3515869954
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 9.3512878042 12200463
MESH:D007251 Influenza, Human Selenium 3.6316624496
MESH:D007333 Insulin Resistance Dietary Fats 10.0818457598 11836018
MESH:D007333 Insulin Resistance Estradiol 10.0816627594 16393666
MESH:D007333 Insulin Resistance pirinixic acid 10.0816306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 8.6616580747
MESH:D007569 Jaw Abnormalities triadimefon 8.6615992940 15834900
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 3.8715604871
MESH:D017492 Keratosis, Seborrheic alitretinoin 5.0816144296
MESH:D007674 Kidney Diseases Acetaminophen 11.6015629191 12587719
MESH:D007674 Kidney Diseases Cyclosporine 11.6010903974 8314463 18776723
MESH:D007674 Kidney Diseases Doxorubicin 11.6015699352 15369732 16775033
MESH:D007674 Kidney Diseases Estradiol 11.6015618244
MESH:D007676 Kidney Failure, Chronic Doxorubicin 13.8616707910
MESH:D007676 Kidney Failure, Chronic Hydrogen Peroxide 13.8616518626
MESH:D007676 Kidney Failure, Chronic Selenium 13.8616518626
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 18.5216705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 18.5216705839
MESH:D007680 Kidney Neoplasms Cyclosporine 18.5212371664
MESH:D007680 Kidney Neoplasms Estradiol 18.5215610895
MESH:D007680 Kidney Neoplasms Ethylnitrosourea 18.5217379185
MESH:D007859 Learning Disorders Cholesterol 4.5617134702
MESH:D007896 Leishmaniasis Antimony 4.3421182181 21063981 12019027 15220340 10953559
MESH:D016773 Leishmaniasis, Cutaneous Antimony 7.508889330 19141829 11475954
MESH:D016773 Leishmaniasis, Cutaneous Omeprazole 7.5019248655
MESH:D007897 Leishmaniasis, Mucocutaneous Antimony 4.9310651420 7854095 9643325 11370249 10881086
MESH:D007898 Leishmaniasis, Visceral Antimony 7.307875148 7554475 7854095 20495762 11105143 1899875 8142506
MESH:D007898 Leishmaniasis, Visceral Antimony Potassium Tartrate 7.3012707265
MESH:D004915 Leukemia, Erythroblastic, Acute Doxorubicin 4.5916085563
MESH:D015451 Leukemia, Lymphocytic, Chronic, B-Cell Mitoxantrone 3.5318172266
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell zoledronic acid 4.2718089816
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 2.0417596541 16294345
MESH:D015473 Leukemia, Promyelocytic, Acute Antimony Potassium Tartrate 4.149834237
MESH:D008064 Lipidoses Amiodarone 3.1015342952 17567588
MESH:D008080 Liposarcoma Paclitaxel 4.3117353645
MESH:D008103 Liver Cirrhosis Dietary Fats 9.1018296743
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 9.1020032147 19638242 18407596 18665156 18522880
MESH:D008103 Liver Cirrhosis Phenobarbital 9.1021047994
MESH:D008106 Liver Cirrhosis, Experimental Dimethylnitrosamine 7.5215864749 15793283 17881167 14643895 15492853 18629640 17666798 16009107 12925901 15723089 17036385 14726149 15339415 15161499 17432682 15733078 17640959 15591649 14709902 17201889 15763062 16627068 14659978 15571005 18672772 18567088 17348192 17724770 18210741 16603200 18364076 15577212 18371158 17534399 17196135 12918455 16270385 18239293 15298665 15744066 15067225 15842777 15081153 15798949 15942678 16570917 18095165 17203207 16544323 15369754 16042886 14568256 15366600 15383259 18237412 15504291 15138612 18637143 15086199 17719030 17465448 17198567 16169303 15479170 15099470
MESH:D008106 Liver Cirrhosis, Experimental Doxorubicin 7.5216439617 16595196
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 7.5214716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 7.5215474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 7.5212878042
MESH:D008106 Liver Cirrhosis, Experimental Thioacetamide 7.5217127702 16126171 15334695 18031379 16489207 16343077 15362042 11682029 18263696 17292413 18416461 15078482 11481614 11172339 16098781 16248980 17629604 15474484 12175628 15716488 18295389 18458672 14739098 18032466 12531686 18380797 18395095 15095483 12679928 15316131 10677585 15288472 15288473 18606216 15465738 18615449 16097051 15158331 17050028 12085344 15075984 16511523 12891558 17355460 12557150
MESH:D008107 Liver Diseases Acetaminophen 10.6012969438 19014921 19784758 16610002 19460945 11587558 16611625 12587719
MESH:D008107 Liver Diseases Diethylnitrosamine 10.6017034775
MESH:D008107 Liver Diseases Phenobarbital 10.6019363144
MESH:D008107 Liver Diseases Thioacetamide 10.6018374380 16337175 15158337
MESH:D008107 Liver Diseases triadimefon 10.6019363144
MESH:D017114 Liver Failure, Acute Acetaminophen 13.5416871587 17185352
MESH:D017114 Liver Failure, Acute Dimethylnitrosamine 13.5417457977
MESH:D017114 Liver Failure, Acute Thioacetamide 13.5415633222 15313186 12479984 17276928
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 21.617678174
MESH:D008113 Liver Neoplasms Diethylnitrosamine 21.6110737359 12771043 20492335 19638242 21167192 20452335 19833225 18648771 20501860 19812893 15885732 20137499 2862719 15175105 19073162 12112319 21047994 19254457 19255062 18644402 21071580 18977376 9163691 20101389 19642983 18754104 16942905 19690152 18978307 19850985 19996281 19090486 20583210 19551842 19499222 20434301 20405173 19294768 19427195 2422723 19426721 21278145 19256749 20118626
MESH:D008113 Liver Neoplasms Dimethylnitrosamine 21.6115890375 3113478
MESH:D008113 Liver Neoplasms Mitomycin 21.6115113037
MESH:D008113 Liver Neoplasms Phenobarbital 21.618742319 19812893 19482888 19073162 21047994 15975961
MESH:D008113 Liver Neoplasms pirinixic acid 21.6120007298 15890375 16377806
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 21.6116984957
MESH:D008113 Liver Neoplasms triadimefon 21.6119028983
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 22.662876784 6135515 2876786
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 22.669362446 18079962 18093689 18544905 21159647 18775883 17942915 19539802 18308698 17854601 17174075 19009564 18282651 16267830 19126423 2563599 19519916 19004024 18253720 16842330 18164116 3124819
MESH:D008114 Liver Neoplasms, Experimental Dimethylnitrosamine 22.661848544 6150874 15603536
MESH:D008114 Liver Neoplasms, Experimental Doxorubicin 22.6617085340 16842330
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 22.661399818 2563599 17172636 6150874 18308698
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 22.6612151625
MESH:D008114 Liver Neoplasms, Experimental triadimefon 22.6617178689
MESH:D008133 Long QT Syndrome Amiodarone 3.1511989578 15350150 17391786
MESH:D008171 Lung Diseases Amiodarone 6.3012587719
MESH:D008171 Lung Diseases Ozone 6.308266340 19066396
MESH:D017563 Lung Diseases, Interstitial Amiodarone 9.3818516814
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 9.3817228818
MESH:D055370 Lung Injury Ozone 3.3120417186
MESH:D008175 Lung Neoplasms alitretinoin 11.3316413115
MESH:D008175 Lung Neoplasms bexarotene 11.3317849452
MESH:D008175 Lung Neoplasms Diethylnitrosamine 11.3320970405 6695378 21163286 20512841
MESH:D008175 Lung Neoplasms Dimethylnitrosamine 11.3316061637 19555203 11884234
MESH:D008175 Lung Neoplasms Doxorubicin 11.3317418594 6189445
MESH:D008175 Lung Neoplasms Ethylnitrosourea 11.336695378 16019985 17703301 16271038
MESH:D008175 Lung Neoplasms Ozone 11.337614698 8597069
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 11.3319555203 11884234
MESH:D008223 Lymphoma Doxorubicin 10.4016098063
MESH:D008223 Lymphoma Ethylnitrosourea 10.4015790496
MESH:D008223 Lymphoma Etoposide 10.4012556972 12854902
MESH:D008228 Lymphoma, Non-Hodgkin Doxorubicin 7.4417654614
MESH:D008228 Lymphoma, Non-Hodgkin Paclitaxel 7.4414749477
MESH:D016399 Lymphoma, T-Cell Doxorubicin 9.8915621674
MESH:D016399 Lymphoma, T-Cell Ethylnitrosourea 9.8915375218
MESH:D016410 Lymphoma, T-Cell, Cutaneous bexarotene 4.6011161223
MESH:D008325 Mammary Neoplasms, Experimental bexarotene 22.7719196723 15591091 19196722
MESH:D008325 Mammary Neoplasms, Experimental Doxorubicin 22.7715458769
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 22.7711807958 16891317 11408345 17203775
MESH:D008325 Mammary Neoplasms, Experimental Ethylnitrosourea 22.7718041768 10838139 10767621
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 22.7711408345 17203775
MESH:D008325 Mammary Neoplasms, Experimental Selenium 22.7715318939
MESH:D008325 Mammary Neoplasms, Experimental zoledronic acid 22.7717312309
MESH:D020149 Manganese Poisoning Estradiol 3.9219453300
MESH:D008545 Melanoma Doxorubicin 3.2816827129
MESH:D008545 Melanoma Paclitaxel 3.2816342250 12025231 12040289
MESH:D008546 Melanoma, Experimental Acetaminophen 3.0219513568
MESH:D008579 Meningioma Ethylnitrosourea 5.4217943659
MESH:D008654 Mesothelioma Doxorubicin 8.8517638057
MESH:D008654 Mesothelioma Selenium 8.8515107826
MESH:D008654 Mesothelioma zoledronic acid 8.8516675582
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.2216801185
MESH:D008679 Metaplasia Ozone 4.5410496685
MESH:D008881 Migraine Disorders Valproic Acid 2.7918765137 18803445
MESH:D028361 Mitochondrial Diseases Doxorubicin 4.0015792986
MESH:D052016 Mucositis Doxorubicin 4.2317415656
MESH:D009101 Multiple Myeloma fluvastatin 10.1416996129
MESH:D009101 Multiple Myeloma Paclitaxel 10.1414749477
MESH:D009101 Multiple Myeloma zoledronic acid 10.1418089719 19621390 16996129
MESH:D009135 Muscular Diseases pirinixic acid 2.9716239165
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 3.538888407
MESH:D009181 Mycoses Amiodarone 4.3312754197 17974566
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 2.8217596541
MESH:D009203 Myocardial Infarction Doxorubicin 4.8415857846 19429709
MESH:D009203 Myocardial Infarction pirinixic acid 4.8419151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.5712213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 6.8116810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 6.8116411023
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 3.9217484760
MESH:D009336 Necrosis 2,4-dinitrotoluene 8.5018551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 8.5018551238 7678174
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 11.569029167 3581430
MESH:D009362 Neoplasm Metastasis Doxorubicin 11.5618259882
MESH:D009362 Neoplasm Metastasis Paclitaxel 11.5615867366
MESH:D009362 Neoplasm Metastasis zoledronic acid 11.5617312309 19139120 15867366
MESH:D009369 Neoplasms alitretinoin 6.7216946489
MESH:D009369 Neoplasms Mitoxantrone 6.7216640825
MESH:D009369 Neoplasms pirinixic acid 6.7217405874
MESH:D009374 Neoplasms, Experimental Ethylnitrosourea 3.8716707424
MESH:D009376 Neoplasms, Hormone-Dependent bexarotene 4.2219196722
MESH:D009389 Neovascularization, Pathologic Estradiol 3.1817289903
MESH:D009401 Nephrosis Doxorubicin 4.2216636307 16899518
MESH:D009402 Nephrosis, Lipoid Cyclosporine 3.8717954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 7.7319348381 18481113
MESH:D009404 Nephrotic Syndrome Doxorubicin 7.7315640375 16889571
MESH:D009421 Nervous System Malformations Estradiol 7.7116427766 11399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 7.7114600291
MESH:D009436 Neural Tube Defects Valproic Acid 2.7516359493 8888407
MESH:D009442 Neurilemmoma Ethylnitrosourea 4.8616651423 16003739 17160924
MESH:D009447 Neuroblastoma Doxorubicin 6.2515555623
MESH:D009447 Neuroblastoma Topotecan 6.2515176712
MESH:D019636 Neurodegenerative Diseases Acetaminophen 6.6618514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 6.6620387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 4.5520387270
MESH:D052556 Niemann-Pick Disease, Type C Cholesterol 10.5320557099 9802331
MESH:D052556 Niemann-Pick Disease, Type C Clofibrate 10.539802331
MESH:D009765 Obesity Dietary Fats 3.8620132043 17217161 19632207 21332399 18674790 18457598 11836018 16723640 20518802
MESH:D009765 Obesity pirinixic acid 3.8620558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 7.2812819281 16049721
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 7.2816049721
MESH:D009837 Oligodendroglioma Ethylnitrosourea 5.4217160924
MESH:D010014 Osteolysis Paclitaxel 10.4415867366
MESH:D010014 Osteolysis zoledronic acid 10.4415867366
MESH:D010018 Osteomalacia Phenobarbital 3.8117016548
MESH:D010024 Osteoporosis Isoflavones 6.6716562857
MESH:D010024 Osteoporosis zoledronic acid 6.6717882678
MESH:D012516 Osteosarcoma Doxorubicin 3.6615930896
MESH:D010051 Ovarian Neoplasms Estradiol 6.7519401270
MESH:D010051 Ovarian Neoplasms Paclitaxel 6.7511161223
MESH:D010051 Ovarian Neoplasms Progesterone 6.7516525653 17393432
MESH:D010146 Pain Acetaminophen 5.4816870215
MESH:D010146 Pain zoledronic acid 5.4816475674
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 10.4716540662
MESH:D010190 Pancreatic Neoplasms Etoposide 10.4719003803
MESH:D010190 Pancreatic Neoplasms Mitomycin 10.4715113037
MESH:D010190 Pancreatic Neoplasms Phenobarbital 10.4716965848
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.1711578682
MESH:D010212 Papilloma Hydrogen Peroxide 3.5512065085
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.6812520081
MESH:D010409 Penile Diseases Antimony 5.199643325
MESH:D010493 Pericarditis Antimony 5.5620465667
MESH:D010538 Peritonitis Ozone 3.5916369182
MESH:D003557 Phyllodes Tumor Doxorubicin 4.5917983394
MESH:D010954 Plasmacytoma Selenium 4.3215087411
MESH:D010997 Pleural Neoplasms Doxorubicin 4.5917638057
MESH:D011014 Pneumonia Ozone 3.8418007984 18929643 18381685
MESH:D011085 Polycystic Ovary Syndrome Simvastatin 4.8517105841
MESH:D017499 Porokeratosis alitretinoin 5.4416144296
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.0318163543
MESH:D011230 Precancerous Conditions Cyclosporine 12.5512371664
MESH:D011230 Precancerous Conditions Diethylnitrosamine 12.552563599
MESH:D011230 Precancerous Conditions Phenobarbital 12.552563599
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 7.6211896295 11118676 11399792 11222880
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 7.6220603192
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.3820887781
MESH:D011471 Prostatic Neoplasms Doxorubicin 1.8915749863 16729912 16888761 15897917 16868541 18437689
MESH:D011471 Prostatic Neoplasms Estradiol 1.8916740699
MESH:D011471 Prostatic Neoplasms Etoposide 1.8917172428
MESH:D011471 Prostatic Neoplasms Isoflavones 1.8917571952 16365062 17374662 17219775
MESH:D011471 Prostatic Neoplasms Paclitaxel 1.8916729912 17172428 17136230 16356831
MESH:D011471 Prostatic Neoplasms zoledronic acid 1.8912438248 19103299
MESH:D011537 Pruritus Ethinyl Estradiol 2.7615861022 16919318
MESH:D019310 Pseudolymphoma Phenobarbital 10.3012752131
MESH:D019310 Pseudolymphoma Valproic Acid 10.3012752131 11422049
MESH:D011565 Psoriasis Cyclosporine 2.0116882103
MESH:D011658 Pulmonary Fibrosis Amiodarone 2.6211597910 12490602 12832656
MESH:D051437 Renal Insufficiency Doxorubicin 3.6817922066
MESH:D015427 Reperfusion Injury pirinixic acid 2.0919058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.3118990726
MESH:D012208 Rhabdomyosarcoma Valproic Acid 3.6619155313
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.6318045962
MESH:D012509 Sarcoma Doxorubicin 3.5115625365 15675481 16767912 17710206 17203757 18313854
MESH:D012512 Sarcoma, Ewing's Doxorubicin 14.4014601052 16326096
MESH:D012512 Sarcoma, Ewing's Etoposide 14.4014601052
MESH:D012512 Sarcoma, Ewing's zoledronic acid 14.4016121404
MESH:D012514 Sarcoma, Kaposi Doxorubicin 4.2317846226
MESH:D012559 Schizophrenia Valproic Acid 1.9915737665 19110320
MESH:D012640 Seizures 2,4-dinitrotoluene 10.8518551238
MESH:D012640 Seizures 2,6-dinitrotoluene 10.8518551238
MESH:D012640 Seizures Phenobarbital 10.853137016 16876388 4039156 11442880
MESH:D012640 Seizures Valproic Acid 10.8514763951 17978042 3137016 16876388 11044598 11738929 1511512 15475178
MESH:D003294 Seizures, Febrile Phenobarbital 4.266407741
OMIM:609620 SHORT QT SYNDROME 1 Amiodarone 4.5318724381
MESH:D012878 Skin Neoplasms Doxorubicin 7.8315692506
MESH:D012878 Skin Neoplasms Hydrogen Peroxide 7.8312065085
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 7.8316192470
MESH:D012983 Soft Tissue Neoplasms Doxorubicin 4.0215625365 17203757 16767912
MESH:D013088 Spermatocele Ethinyl Estradiol 3.3816709447
MESH:D013119 Spinal Cord Injuries Progesterone 3.7215862959 16503802
MESH:D016135 Spinal Dysraphism Valproic Acid 3.3419490988
MESH:D013158 Splenic Diseases Dimethylnitrosamine 4.7012587719
MESH:D013226 Status Epilepticus Valproic Acid 3.9712833885
MESH:D013272 Stomach Diseases Omeprazole 4.0618545984
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 4.2018456281
MESH:D013274 Stomach Neoplasms Dimethylnitrosamine 4.2016033868
MESH:D013274 Stomach Neoplasms nitrosobenzylmethylamine 4.2017575124 12958204
MESH:D013274 Stomach Neoplasms Paclitaxel 4.2018506536 18396642
MESH:D013276 Stomach Ulcer Amiodarone 5.9518087811
MESH:D013276 Stomach Ulcer Omeprazole 5.9515991576 18237397 10750652 11906479 16755016 17977527
MESH:D013610 Tachycardia Amiodarone 3.7611238279
MESH:D017180 Tachycardia, Ventricular Amiodarone 3.6619225199
MESH:D024801 Tauopathies Paclitaxel 4.2616930453
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.1111994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.6815669648
MESH:D013953 Thymus Neoplasms Ethylnitrosourea 4.6015790496
MESH:D013959 Thyroid Diseases Amiodarone 10.1619731979
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 10.1612697716
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 17.957505956
MESH:D013964 Thyroid Neoplasms Doxorubicin 17.9516010429 17909728
MESH:D013964 Thyroid Neoplasms Phenobarbital 17.951399818
MESH:D013964 Thyroid Neoplasms Propylthiouracil 17.9515710170
MESH:D013964 Thyroid Neoplasms triadimefon 17.9517178689
MESH:D013971 Thyrotoxicosis Amiodarone 4.3219584973 18020914
MESH:D013978 Tibial Fractures Estradiol 4.1219048282
MESH:D016171 Torsades de Pointes Amiodarone 3.6411989578 17467628
MESH:D014178 Translocation, Genetic Valproic Acid 4.6617262798
MESH:D014352 Trypanosomiasis Antimony 5.3615220340
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 3.963119515
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 6.8816049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 6.8816049721
MESH:D001749 Urinary Bladder Neoplasms Doxorubicin 6.8817653716
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.108888407
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 10.1410091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 10.1410091137
MESH:D014581 Urticaria Acetaminophen 2.4710982225
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 2.7714692618
MESH:D014605 Uveitis Cyclosporine 3.421336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.0312125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.0414671159 15869587
MESH:D018487 Ventricular Dysfunction, Left Doxorubicin 3.6817678736 16364871 17334414 17638931
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.6815886252
MESH:D015430 Weight Gain Dietary Fats 3.2716723640
MESH:D014985 Xerophthalmia Cyclosporine 3.8717120751
Pathway ID Pathway Name
KEGG:01100 Metabolic pathways
REACT:22258 Metabolism of lipids and lipoproteins
KEGG:00100 Steroid biosynthesis
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA28073
    • No data
    Releated disease ID Related disease Name
    PA444513Hypercalcemia
    PA445180Osteogenesis Imperfecta
    PA445190Osteoporosis
    Releated drug ID Related drug Name
    PA448082alendronate
    PA10270ibandronate
    PA450767pamidronate
    PA451255risedronate
    PA10235zoledronate
    PA133950441hmg coa reductase inhibitors
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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