AutismKB 2.0

Annotation Detail for GPC4


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Basic Information Top
Gene Symbol:GPC4 ( K-glypican )
Gene Full Name: glypican 4
Band: Xq26.2
Quick LinksEntrez ID:2239; OMIM: 300168; Uniprot ID:GPC4_HUMAN; ENSEMBL ID: ENSG00000076716; HGNC ID: 4452
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of GPC4 mRNAaffects expression 21346803
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of GPC4 mRNAincreases expression 18648102
C006632 arsenic trioxide arsenic trioxide results in decreased expression of GPC4 mRNAdecreases expression 19128835
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of GPC4 mRNAdecreases expression 20064835
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of GPC4 mRNAaffects expression 17484886
D004041 Dietary Fats Dietary Fats results in increased expression of GPC4 mRNAincreases expression 18042831
C041786 palm oil palm oil results in increased expression of GPC4 mRNAincreases expression 18042831
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of GPC4 mRNAaffects binding|decreases expression|increases activity 19710929
C006253 pirinixic acid pirinixic acid results in decreased expression of GPC4 mRNAdecreases expression 17426115
C010327 salinomycin salinomycin results in decreased expression of GPC4 mRNAdecreases expression 19682730
D014635 Valproic Acid Valproic Acid results in increased expression of GPC4 mRNAincreases expression 19101580
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 3.728875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 4.1019490988
MESH:D055371 Acute Lung Injury pirinixic acid 3.3018653653
MESH:D000230 Adenocarcinoma arsenic trioxide 4.4811798837 19825857
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 4.4820127859 20464547
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 6.913712494
MESH:D000236 Adenoma Benzo(a)pyrene 6.916695378
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.7216434500
MESH:D000550 Amblyopia Valproic Acid 5.5017688650
MESH:D001008 Anxiety Disorders Valproic Acid 3.7117497229
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.2919183758
MESH:D001161 Arteriosclerosis Dietary Fats 4.1015238619
MESH:D001321 Autistic Disorder Valproic Acid 1.9918177632 15238991 19232924 18985861 19460635 18316065 17688650 18558336 18775368 20603192 16609825 17507914 18396377 18940202 17157402
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.2811289319 1440618
MESH:D001714 Bipolar Disorder Valproic Acid 3.1520046352 17594078
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 9.5816206674
MESH:D001778 Blood Coagulation Disorders pirinixic acid 9.5819483382
MESH:D001848 Bone Diseases, Developmental Valproic Acid 3.518888407
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.0317474063 20146248
MESH:D001943 Breast Neoplasms Dietary Fats 2.0320435547
MESH:D001943 Breast Neoplasms salinomycin 2.0319682730
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.5111589617
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.9916124888 16192424 16097048 16050911 10355542 15721981 3786805 16227642 18705752 15700767 16011737 15673190
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 6.7716705839
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 6.773581430 7296757
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 6.7714691202 15073043 16217749 15553829 11135700
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 6.7718788625
MESH:D002291 Carcinoma, Papillary arsenic trioxide 5.1419014326
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.757296757
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.2812490120
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.0920419170
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 2.877505956
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.7620734317
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 8.279022650 19486331
MESH:D002779 Cholestasis pirinixic acid 8.2719176532
MESH:D015179 Colorectal Neoplasms arsenic trioxide 1.8620501625
MESH:D023903 Coronary Restenosis arsenic trioxide 4.3812609071
MESH:D019465 Craniofacial Abnormalities marker/mechanism 16759393
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 2.7510525206
MESH:D019465 Craniofacial Abnormalities Valproic Acid 2.7516575769 8888407 17688650
MESH:D003490 Cyanosis 2,4-dinitrotoluene 4.2318551238
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.2815213294
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 3.0118759878 11906362 8156756 14531868 12868966 8970840 11298694 2524372
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4918249437
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.673621924 2952479
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 9.3721346803 18551238
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 9.3718692083 18648102 18289764 16192314 7440962 6482804 9328219 8291058 9022650 9653073 1440618 11289319 6679447
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 9.376623471 9327722 15998439 16177239 7440962 16227642 11566570 10915739 15027814 10092053 7120509 2869522 3732212 6884620 3786805 21278145 19336974 19085960 7179309 4309450 17522070 15968718
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 9.3719641884 1733752
MESH:D050171 Dyslipidemias Dietary Fats 3.5718367378
MESH:D004421 Dystonia Valproic Acid 4.231851702
MESH:D004487 Edema pirinixic acid 2.6512083418
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 4.373659116 17275665
MESH:D004828 Epilepsies, Partial Valproic Acid 4.1816628512 3922381
MESH:D004827 Epilepsy Valproic Acid 3.0118234410 20417680
MESH:D004832 Epilepsy, Absence Valproic Acid 3.746254150 6426943 7562514
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.517750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 4.303659116
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 7.443581430
MESH:D004938 Esophageal Neoplasms arsenic trioxide 7.4412903497
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 7.4416530937
MESH:D005234 Fatty Liver arsenic trioxide 26.6215073043
MESH:D005234 Fatty Liver Carbon Tetrachloride 26.6212631006 16239168 15959796 16045604 12795759 19224547 61145 17595544
MESH:D005234 Fatty Liver Dietary Fats 26.6219004024 17967931 18296743 19551842
MESH:D005234 Fatty Liver pirinixic acid 26.6219236843 20131406
MESH:D005234 Fatty Liver Valproic Acid 26.6219224547 14986274
MESH:D005315 Fetal Diseases Valproic Acid 5.1516575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.338888407 18558336
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.286705139
MESH:D005355 Fibrosis Carbon Tetrachloride 9.5418705752
MESH:D005355 Fibrosis Dietary Fats 9.5418296743
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.4616904648
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.227505956
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 2.7420471113
MESH:D006333 Heart Failure pirinixic acid 2.6320558911
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 9.896705139
MESH:D006505 Hepatitis Carbon Tetrachloride 9.8919900420 19110552
MESH:D006529 Hepatomegaly pirinixic acid 3.2118467677 16221962 19772884 19176532
MESH:D006849 Hydrocephalus Valproic Acid 5.1017688650
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.7716899240
MESH:D006937 Hypercholesterolemia Dietary Fats 3.7621332399
MESH:D006943 Hyperglycemia pirinixic acid 3.3420558911
MESH:D006949 Hyperlipidemias Dietary Fats 3.8021332399
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.1515034207
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.3015338365
MESH:D007249 Inflammation Dietary Fats 2.5120412841
MESH:D007333 Insulin Resistance Dietary Fats 7.6118457598 11836018
MESH:D007333 Insulin Resistance pirinixic acid 7.6116306350
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.288074119 9022650
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 7.8416705839
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 7.846582329
MESH:D007938 Leukemia arsenic trioxide 2.9115070760
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 3.9712560223 17077332
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.5416972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.5514633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 3.9319077051
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 4.0016467208 20471514 17050201 19850784 16968895
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 4.0016294345 17596541
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 3.3217869043 19075265 16330433 17649720 11161223 16823087 15336539 16112521 16331271 19642359 19225113 16891316 15748426 19035177 16966277 15213294 17217047 12018890 12679006 17712046 15622746 17107899 9834237 11468182 12712474
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.5516882451
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 6.9221278145 11408273 17334410 16943688 17174718 11903743 16221502 17157831 16239168
MESH:D008103 Liver Cirrhosis Dietary Fats 6.9218296743
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.309327722 15034207
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 2.3717481882 14724832 17557913 12609069 18395914 16011737 16015684 18187930 14512876 15057751 15370692 15123356 12666154 15959796 17823541 15931870 12546737 15052691 14716496 18263696 18472332 17766677 18006644 16116963 16638106 15893842 15925388 17631135 14748882 13678700 17698563 18705752 12389079 16027843 17761835 17944888 15818738 16033810 12649538 18420326 18054572 16097048 18472094 18317297 17714472 18279442 18277467 12741479 16136751 17900296 18376398 12958196 18251166 15650968 18412020 18156304 14620537 17976157 17922224 10355542 17708605 18166357 12898905 20821823 12445418 15362042 17869086 18429990 15730626 12632512 15338365 17721639 18418968 12586293 12632514 17565644 18210741 16192424 15673190 11481614 16248980 14716833 17525996 18339082 17805973 15996030 12445421 18395095 15876570 18481824 17640975 18205269 12667390
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.3715474484
MESH:D008107 Liver Diseases Carbon Tetrachloride 2.1215830285 16964402 16246199 17285989 15720792
MESH:D017093 Liver Failure Carbon Tetrachloride 4.3815123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.8514706259 16899240
MESH:D008113 Liver Neoplasms arsenic trioxide 11.1814682389
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 11.1820195826 21137059
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 11.1819294768
MESH:D008113 Liver Neoplasms pirinixic acid 11.1816377806 20007298 15890375
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 10.476587162 598648 1399818 3712494
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 10.4720377131
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 10.4712014681 15583823
MESH:D008133 Long QT Syndrome arsenic trioxide 3.4815213294
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.5317228818
MESH:D008175 Lung Neoplasms arsenic trioxide 2.4619825857 11798837
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 2.4618520028 18816296 20135361 20464547 20064080 18569708 6695378 17053015 20869020
MESH:D008325 Mammary Neoplasms, Experimental salinomycin 3.8719682730
MESH:D008881 Migraine Disorders Valproic Acid 3.3118803445 18765137
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.3216381670
MESH:D009101 Multiple Myeloma arsenic trioxide 3.2219417148 14977855 19549372 11468182 15949261
MESH:D009135 Muscular Diseases pirinixic acid 3.7216239165
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 4.208888407
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.9418349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 7.7216105982 16882451
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 7.7217596541
MESH:D009203 Myocardial Infarction pirinixic acid 2.2019151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.0816411023
MESH:D009336 Necrosis 2,4-dinitrotoluene 4.0918551238
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 4.1616624393
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.533581430
MESH:D009369 Neoplasms Benzo(a)pyrene 5.0811141357
MESH:D009369 Neoplasms pirinixic acid 5.0817405874
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 12.776679447
MESH:D009436 Neural Tube Defects arsenic trioxide 12.7710525206
MESH:D009436 Neural Tube Defects Valproic Acid 12.7716359493 8888407
MESH:D009765 Obesity Dietary Fats 4.5621332399 20518802 17217161 20132043 11836018 19632207 18674790 18457598 16723640
MESH:D009765 Obesity pirinixic acid 4.5620558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 9.4316049721 12819281
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 9.434026338 6482804
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.283988306
MESH:D010051 Ovarian Neoplasms arsenic trioxide 2.4512452020 19769630 16624393
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 2.5815580305
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.707296757
MESH:D010235 Paraganglioma arsenic trioxide 4.3519927285
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.736228378
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 4.0720603192
MESH:D011471 Prostatic Neoplasms arsenic trioxide 3.1419131511
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 3.1417292933
MESH:D019310 Pseudolymphoma Valproic Acid 4.8111422049 12752131
MESH:D015427 Reperfusion Injury pirinixic acid 2.4619058328
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.503692021
MESH:D012208 Rhabdomyosarcoma Valproic Acid 4.3619155313
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 4.1616646077
MESH:D012559 Schizophrenia Valproic Acid 2.0915737665 19110320
MESH:D012640 Seizures 2,4-dinitrotoluene 6.3218551238
MESH:D012640 Seizures Valproic Acid 6.3211044598 11738929 14763951 16876388 3137016 17978042 1511512 15475178
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 2.4419755658 10029692
MESH:D016135 Spinal Dysraphism Valproic Acid 3.9119490988
MESH:D013226 Status Epilepticus Valproic Acid 4.8112833885
MESH:D013274 Stomach Neoplasms arsenic trioxide 2.4017007042
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 2.4020155912 2093021
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 7.593712494 6582329 1399818 6587162 7505956
MESH:D013964 Thyroid Neoplasms arsenic trioxide 7.5919014326
MESH:D016171 Torsades de Pointes arsenic trioxide 4.2015213294
MESH:D014178 Translocation, Genetic Valproic Acid 5.5017262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.763119515
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 12.4216049721
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 12.428074119
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 12.4212973940 20435036 11780464 12845720
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 12.4217053015
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.868888407
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.5510091137
MESH:D015430 Weight Gain Dietary Fats 3.8916723640
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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