AutismKB 2.0

Annotation Detail for FER


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Basic Information Top
Gene Symbol:FER ( TYK3 )
Gene Full Name: fer (fps/fes related) tyrosine kinase
Band: 5q21.3
Quick LinksEntrez ID:2241; OMIM: 176942; Uniprot ID:FER_HUMAN; ENSEMBL ID: ENSG00000151422; HGNC ID: 3655
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04520Adherens junction
No data
Pathway IDPathway Name
200033Signaling events mediated by PTP1B
200003Fc-epsilon receptor I signaling in mast cells
200156Signaling events mediated by Stem cell factor receptor (c-Kit)
200127PDGFR-beta signaling pathway
200180N-cadherin signaling events
Pathway IDPathway Name
P00012Cadherin signaling pathway
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of FER mRNAdecreases expression 20106945
D008727 Methotrexate FER protein affects the susceptibility to Methotrexateaffects response to substance 16217747
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of FER mRNAaffects binding|decreases expression|increases activity 19710929
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Methotrexate 4.9812039119
MESH:D055371 Acute Lung Injury pirinixic acid 3.6418653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 2.0620127859 20464547
MESH:D000236 Adenoma Benzo(a)pyrene 2.886695378
MESH:D018248 Adenoma, Liver Cell pirinixic acid 4.2216434500
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.7319183758
MESH:D001172 Arthritis, Rheumatoid Methotrexate 3.1717286800
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.6319483382
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.3720146248 17474063
MESH:D001943 Breast Neoplasms Methotrexate 2.3716978400
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.1420419170
MESH:D002779 Cholestasis pirinixic acid 3.1519176532
MESH:D019465 Craniofacial Abnormalities Methotrexate 2.6712039119 9562676
MESH:D003550 Cystic Fibrosis Methotrexate 4.6819747007
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5918249437
MESH:D003882 Dermatomyositis Methotrexate 5.7120191521
MESH:D004487 Edema pirinixic acid 2.9612083418
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 2.0916530937
MESH:D005234 Fatty Liver pirinixic acid 3.2520131406 19236843
MESH:D006086 Graft vs Host Disease Methotrexate 5.8016518429
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 2.8520471113
MESH:D006333 Heart Failure pirinixic acid 2.7820558911
MESH:D006529 Hepatomegaly pirinixic acid 3.6419176532 18467677 19772884 16221962
MESH:D006943 Hyperglycemia pirinixic acid 3.6320558911
MESH:D007333 Insulin Resistance pirinixic acid 2.9016306350
MESH:D007805 Language Development Disorders Methotrexate 5.639562676
MESH:D008103 Liver Cirrhosis Methotrexate 3.9114986274
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 1.3515474484
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 4.8120195826 21137059
MESH:D008113 Liver Neoplasms pirinixic acid 4.8120007298 16377806 15890375
MESH:D017563 Lung Diseases, Interstitial Methotrexate 5.8918516814
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 1.5720869020 18816296 20064080 18569708 20135361 18520028 17053015 20464547 6695378
MESH:D008223 Lymphoma Methotrexate 4.2617352296
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.5316381670
MESH:D052016 Mucositis Methotrexate 6.0217488658
MESH:D009135 Muscular Diseases pirinixic acid 4.1616239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2919151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.2916411023
MESH:D009369 Neoplasms Benzo(a)pyrene 5.4411141357
MESH:D009369 Neoplasms pirinixic acid 5.4417405874
MESH:D009765 Obesity pirinixic acid 1.8920558911
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.9017292933
MESH:D011565 Psoriasis Methotrexate 3.5517410198
MESH:D051437 Renal Insufficiency Methotrexate 5.3617352296
MESH:D015427 Reperfusion Injury pirinixic acid 2.5619058328
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 2.5410029692 19755658
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.5620155912 2093021
MESH:D013576 Syndactyly Methotrexate 5.629562676
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 2.3117053015
Pathway ID Pathway Name
KEGG:04520 Adherens junction
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA28095
    • No data
    No data
    Releated drug ID Related drug Name
    PA10804imatinib
    Drug Bank Top

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    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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