AutismKB 2.0

Annotation Detail for FES


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Basic Information Top
Gene Symbol:FES ( FPS )
Gene Full Name: feline sarcoma oncogene
Band: 15q26.1
Quick LinksEntrez ID:2242; OMIM: 190030; Uniprot ID:FES_HUMAN; ENSEMBL ID: ENSG00000182511; HGNC ID: 3657
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04360Axon guidance
Pathway IDPathway Name
Axon guidance
Pathway IDPathway Name
200066Angiopoietin receptor Tie2-mediated signaling
200018IL4-mediated signaling events
200161Signaling events mediated by VEGFR1 and VEGFR2
Pathway IDPathway Name
P00007Axon guidance mediated by semaphorins
Pathway IDPathway Name
500075SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
Related Diseases/Disorders Top
No data
Desease IDDesease Name
2009Sarcoma
2053Colon cancer
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D008769 Methylnitronitrosoguanidine Methylnitronitrosoguanidine results in increased expression of FES mRNAincreases expression 12634122
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of FES mRNAaffects binding|decreases expression|increases activity 19710929
D024505 Tocopherols Tocopherols results in increased expression of FES mRNAincreases expression 17056531
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D055371 Acute Lung Injury pirinixic acid 3.6418653653
MESH:D018248 Adenoma, Liver Cell pirinixic acid 4.2216434500
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.6319483382
MESH:D002471 Cell Transformation, Neoplastic Methylnitronitrosoguanidine 4.282727394
MESH:D002779 Cholestasis pirinixic acid 3.1519176532
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5918249437
MESH:D004487 Edema pirinixic acid 2.9612083418
MESH:D005234 Fatty Liver pirinixic acid 3.2519236843 20131406
MESH:D006333 Heart Failure pirinixic acid 2.7820558911
MESH:D006529 Hepatomegaly pirinixic acid 3.6419176532 16221962 19772884 18467677
MESH:D006943 Hyperglycemia pirinixic acid 3.6320558911
MESH:D007333 Insulin Resistance pirinixic acid 2.9016306350
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 1.3515474484
MESH:D008113 Liver Neoplasms pirinixic acid 1.9420007298 16377806 15890375
MESH:D008325 Mammary Neoplasms, Experimental Tocopherols 4.3417927505
MESH:D008654 Mesothelioma Tocopherols 4.2415878867
MESH:D053842 Microsatellite Instability Methylnitronitrosoguanidine 6.6317671175
MESH:D009135 Muscular Diseases pirinixic acid 4.1616239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2919151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.2916411023
MESH:D009369 Neoplasms pirinixic acid 2.1217405874
MESH:D009765 Obesity pirinixic acid 1.8920558911
MESH:D011471 Prostatic Neoplasms Tocopherols 4.5312504091
MESH:D015427 Reperfusion Injury pirinixic acid 2.5619058328
Pathway ID Pathway Name
KEGG:04360 Axon guidance
REACT:18266 Axon guidance
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA28098
    • No data
    No data
    Releated drug ID Related drug Name
    PA448976choline
    PA448478l-arginine
    PA450635nitric oxide
    Drug Bank Top

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    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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