AutismKB 2.0

Annotation Detail for FGA


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Basic Information Top
Gene Symbol:FGA ( Fib2,MGC119422,MGC119423,MGC119425 )
Gene Full Name: fibrinogen alpha chain
Band: 4q31.3
Quick LinksEntrez ID:2243; OMIM: 134820; Uniprot ID:FIBA_HUMAN; ENSEMBL ID: ENSG00000171560; HGNC ID: 3661
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04610Complement and coagulation cascades
Pathway IDPathway Name
Hemostasis
Integrin cell surface interactions
No data
Pathway IDPathway Name
P00050Plasminogen activating cascade
P00011Blood coagulation
Pathway IDPathway Name
500303Common Pathway
Related Diseases/Disorders Top
Desease IDDesease Name
Circulatory system diseases
Hematologic diseases
H00223Inherited thrombophilia
H00222Afibrinogenemia
Desease IDDesease Name
1856Obesity
1858Hemorrhagic disorder
1914Cerebrovascular disorder
1963Amyloidosis
Desease Name
HEMATOLOGICAL
renal amyloidosis
plasma fibrinogen levels in smokers and non-smokers
CARDIOVASCULAR
fibrinogen
angina
METABOLIC
post-trauma fibrinogen increase
fibrinogen myocardial infarct
thromboembolism, venous
No data
Desease Name
Afibrinogenemia, congenital
Dysfibrinogenemia, alpha type, causing recurrent thrombosis
Amyloidosis, hereditary renal
Dysfibrinogenemia, alpha type, causing bleeding diathesis
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen results in increased expression of FGA mRNAincreases expression 17522070
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of FGA proteinaffects expression 20106945
D000643 Ammonium Chloride Ammonium Chloride affects the expression of FGA mRNAaffects expression 16483693
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of FGA mRNAdecreases expression 18061397
C095105 bexarotene bexarotene results in decreased expression of FGA mRNAdecreases expression 16648578
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of FGA mRNAaffects expression 16239168
D002725 Chloroform Chloroform results in increased expression of FGA mRNAincreases expression 17522070
D002995 Clofibric Acid [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of FGA mRNAaffects cotreatment|affects expression 17602206
D016572 Cyclosporine Cyclosporine results in decreased expression of FGA mRNAdecreases expression 20106945
C023635 dienogest [Ethinyl Estradiol co-treated with dienogest] results in increased expression of [FGA protein binds to FGB protein binds to FGG protein]affects binding|affects cotreatment|increases expression 15288212
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of FGA mRNAaffects cotreatment|affects expression 17602206
D004918 Erythromycin Estolate Erythromycin Estolate results in increased expression of FGA mRNAincreases expression 17522070
D004958 Estradiol Estradiol results in decreased expression of FGA mRNAdecreases expression 20106945
D004958 Estradiol [Progesterone co-treated with Estradiol] results in increased expression of FGA mRNAaffects cotreatment|increases expression 17404688
C454300 estradiol valerate-dienogest [Ethinyl Estradiol co-treated with estradiol valerate-dienogest] results in increased expression of [FGA protein binds to FGB protein binds to FGG protein]affects binding|affects cotreatment|increases expression 15288212
D004997 Ethinyl Estradiol [Ethinyl Estradiol co-treated with dienogest] results in increased expression of [FGA protein binds to FGB protein binds to FGG protein]affects binding|affects cotreatment|increases expression 15288212
D004997 Ethinyl Estradiol [Ethinyl Estradiol co-treated with estradiol valerate-dienogest] results in increased expression of [FGA protein binds to FGB protein binds to FGG protein]affects binding|affects cotreatment|increases expression 15288212
D004997 Ethinyl Estradiol [Ethinyl Estradiol co-treated with Gestodene] results in increased expression of [FGA protein binds to FGB protein binds to FGG protein]affects binding|affects cotreatment|increases expression 12616983
12616980
12618251
D004997 Ethinyl Estradiol [Ethinyl Estradiol co-treated with Levonorgestrel] results in increased expression of [FGA protein binds to FGB protein binds to FGG protein]affects binding|affects cotreatment|increases expression 12618251
15288212
D004997 Ethinyl Estradiol [Ethinyl Estradiol co-treated with Norethindrone] results in increased expression of [FGA protein binds to FGB protein binds to FGG protein]affects binding|affects cotreatment|increases expression 14561536
D004997 Ethinyl Estradiol [Ethinyl Estradiol co-treated with norgestimate] results in increased expression of [FGA protein binds to FGB protein binds to FGG protein]affects binding|affects cotreatment|increases expression 12618251
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of FGA mRNAdecreases expression 17108234
C442659 ethinyl estradiol-desogestrel combination ethinyl estradiol-desogestrel combination results in increased expression of [FGA protein binds to FGB protein binds to FGG protein]affects binding|increases expression 12616983
12616980
12618251
14981370
D005492 Folic Acid Folic Acid results in increased expression of FGA mRNAincreases expression 17868486
C039281 furan furan results in decreased expression of FGA mRNAdecreases expression 15120968
C033273 Gestodene [Ethinyl Estradiol co-treated with Gestodene] results in increased expression of [FGA protein binds to FGB protein binds to FGG protein]affects binding|affects cotreatment|increases expression 12616983
12618251
12616980
C029424 hydrazine hydrazine results in increased expression of FGA mRNAincreases expression 15282401
C075954 indolo(3,2-b)carbazole indolo(3,2-b)carbazole results in decreased expression of FGA mRNAdecreases expression 18061397
D008701 Methapyrilene Methapyrilene results in decreased expression of FGA mRNAdecreases expression 15120968
D008727 Methotrexate Methotrexate results in decreased expression of FGA mRNAdecreases expression 15120968
D015058 1-Naphthylisothiocyanate 1-Naphthylisothiocyanate results in increased expression of FGA mRNAincreases expression 17522070
D009640 Norethindrone [Ethinyl Estradiol co-treated with Norethindrone] results in increased expression of [FGA protein binds to FGB protein binds to FGG protein]affects binding|affects cotreatment|increases expression 14561536
C017576 norgestimate [Ethinyl Estradiol co-treated with norgestimate] results in increased expression of [FGA protein binds to FGB protein binds to FGG protein]affects binding|affects cotreatment|increases expression 12618251
D016912 Levonorgestrel [Ethinyl Estradiol co-treated with Levonorgestrel] results in increased expression of [FGA protein binds to FGB protein binds to FGG protein]affects binding|affects cotreatment|increases expression 12618251
15288212
C023036 perfluorooctanoic acid perfluorooctanoic acid results in decreased expression of FGA mRNAdecreases expression 18467677
C023036 perfluorooctanoic acid PPARA protein promotes the reaction [perfluorooctanoic acid results in decreased expression of FGA mRNA]decreases expression|increases reaction 18467677
D010634 Phenobarbital Phenobarbital results in increased expression of FGA mRNAincreases expression 12082028
C006253 pirinixic acid pirinixic acid results in decreased expression of FGA mRNAdecreases expression 16221962
C006253 pirinixic acid pirinixic acid results in decreased expression of FGA mRNAdecreases expression 12832660
D010936 Plant Extracts Plant Extracts results in decreased expression of FGA mRNAdecreases expression 18061397
D011374 Progesterone [Progesterone co-treated with Estradiol] results in increased expression of FGA mRNAaffects cotreatment|increases expression 17404688
D011802 Quinidine Quinidine results in increased expression of FGA mRNAincreases expression 17522070
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of FGA mRNAdecreases expression 20106945
18061397
11489354
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of FGA proteinincreases expression 16083274
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of FGA mRNAdecreases expression 15703262
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of FGA mRNAincreases expression 16267337
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of FGA mRNAincreases expression 15644576
D013752 Tetracycline Tetracycline results in increased expression of FGA mRNAincreases expression 17522070
D013806 Theophylline Theophylline results in increased expression of FGA mRNAincreases expression 17522070
C066340 tolcapone tolcapone binds to FGA proteinaffects binding 19783845
C496197 trans-10,cis-12-conjugated linoleic acid trans-10,cis-12-conjugated linoleic acid results in decreased expression of FGA mRNAdecreases expression 17951470
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Methotrexate 12.0212039119
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 12.026195326
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 12.0215322242 14514962 11752688
MESH:D000138 Acidosis Ammonium Chloride 3.1718287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 10.9817505938
MESH:D000152 Acne Vulgaris norgestimate 10.9817505938
MESH:D058186 Acute Kidney Injury Folic Acid 3.9816316344 16595132 17003819
MESH:D055371 Acute Lung Injury pirinixic acid 2.7618653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 6.3420127859 20464547
MESH:D000230 Adenocarcinoma Estradiol 6.3411473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 6.3414692618
MESH:D000236 Adenoma Benzo(a)pyrene 9.916695378
MESH:D000236 Adenoma Diethylnitrosamine 9.916695378 10737359
MESH:D000236 Adenoma Folic Acid 9.9116963246
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 21.6119061943 16434500 17620307 17162532 19052882 18056438
MESH:D018248 Adenoma, Liver Cell Phenobarbital 21.6117620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 21.6116434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 21.6116835633
MESH:C531603 Afibrinogenemia congenital marker/mechanism
MESH:D017109 Akathisia, Drug-Induced tolcapone 5.8911080934
MESH:D000544 Alzheimer Disease Folic Acid 6.3517116317
MESH:D000544 Alzheimer Disease Plant Extracts 6.3516962711
MESH:D000544 Alzheimer Disease tolcapone 6.3520150427
MESH:C538249 Amyloidosis, familial visceral marker/mechanism
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.6111748828
MESH:D000799 Angioedema Acetaminophen 3.4410982225
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.6919183758
MESH:D001145 Arrhythmias, Cardiac Quinidine 4.8218724381 18057881
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.0811256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 6.7015885639
MESH:D001169 Arthritis, Experimental Plant Extracts 6.7014686799
MESH:D001172 Arthritis, Rheumatoid Methotrexate 3.0017286800
MESH:D001249 Asthma Theophylline 3.749701106 12113382
MESH:D001321 Autistic Disorder Acetaminophen 2.1618445737
MESH:D001321 Autistic Disorder Folic Acid 2.1621388746
MESH:D001778 Blood Coagulation Disorders marker/mechanism
MESH:D001778 Blood Coagulation Disorders pirinixic acid 7.6019483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 7.6012125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.3915340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.5115746008
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 4.9417868700
MESH:D001930 Brain Injuries Progesterone 3.8715845082 15380490 15665606
MESH:D002545 Brain Ischemia Plant Extracts 4.3416041641
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 4.3620146248 17474063
MESH:D001943 Breast Neoplasms bexarotene 4.3616818667 16344269
MESH:D001943 Breast Neoplasms Diethylnitrosamine 4.3617474063
MESH:D001943 Breast Neoplasms Estradiol 4.3616675129 17261762 12948864 18497071 17289903 19861407 14630087 17018787
MESH:D001943 Breast Neoplasms Folic Acid 4.3616777985
MESH:D001943 Breast Neoplasms Methotrexate 4.3616978400
MESH:D001943 Breast Neoplasms Progesterone 4.3616175315 15562024 17614352
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 4.3620435547
MESH:D002057 Burns, Chemical Plant Extracts 4.939625245
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.0716111702
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.4018705752 15700767 16050911 15673190 3786805 16227642 16097048 15721981 16192424 10355542 16011737 16124888
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.4916835633
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 12.933084413
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 12.9321507988 12907637 12619106
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 12.9318788625
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 12.9320084675 19539802 18506893 18788625 18785209 17173139 11831363 20512989 20524982 19171122 19701751 20514400 19519916 20214788 16807293 16328049 19394651 19052882 3581430 17138121 18494052 16288022 20007298 10672840 18691550 18393292 16830150 16569478 17162532 10737359 17428255 19919837 19822196 19418558 18971187 19208518 16540662 16935385 16681979 16878318 20101231 18665156 16698587 18210153 19107877 16502159 19335982 20727157 19383236 17055752 18056438 17978847 16779866 17761372 21159647 3084413 20432363 18978308 20935162
MESH:D006528 Carcinoma, Hepatocellular Estradiol 12.9316924424
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 12.931701930 20935162 17173139 6705139 20007298
MESH:D006528 Carcinoma, Hepatocellular Plant Extracts 12.9318834353
MESH:D002289 Carcinoma, Non-Small-Cell Lung bexarotene 3.0816247446
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 1.9320419170
MESH:D006332 Cardiomegaly Plant Extracts 6.2317645561
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 6.2318850075 18670907 16120746
MESH:D002318 Cardiovascular Diseases Folic Acid 3.6816755160
MESH:D002386 Cataract Acetaminophen 2.3510977129
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 9.5712371664
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 9.5717174075 21159647 2727394 7505956
MESH:D002471 Cell Transformation, Neoplastic Estradiol 9.5718566989
MESH:D002493 Central Nervous System Diseases Phenobarbital 3.874080065
MESH:D002637 Chest Pain Theophylline 5.4715238202
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 8.2319052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 8.2316835633
MESH:D002761 Cholangitis 1-Naphthylisothiocyanate 5.8012912871
MESH:D002779 Cholestasis 1-Naphthylisothiocyanate 22.2218590720 15913567 7624871 19486331 16629650 15500046 12927374 18164287
MESH:D002779 Cholestasis Cyclosporine 22.2219486331
MESH:D002779 Cholestasis Ethinyl Estradiol 22.2216105132 17681005 16919318 11677210 17333356 15861022 17110522
MESH:D002779 Cholestasis Levonorgestrel 22.2215861022
MESH:D002779 Cholestasis pirinixic acid 22.2219176532
MESH:D002780 Cholestasis, Intrahepatic 1-Naphthylisothiocyanate 5.4519407337 10220858
MESH:D002971 Cleft Lip Folic Acid 3.7721254359
MESH:D002972 Cleft Palate Folic Acid 5.518946559 21254359
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.518697196 12621046 15340226 15668235 16354765
MESH:D015179 Colorectal Neoplasms Folic Acid 2.6917245555 17087956 16985020 16963246 17116713
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.7317141729 14669216
MESH:D019465 Craniofacial Abnormalities Methotrexate 2.629562676 12039119
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.6220055451 10048152 15322242
MESH:D003550 Cystic Fibrosis Methotrexate 3.9019747007
MESH:D003866 Depressive Disorder tolcapone 4.037768276 11224284
MESH:D003865 Depressive Disorder, Major tolcapone 4.5710440460
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.2418249437
MESH:D003882 Dermatomyositis Methotrexate 4.7520191521
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 6.5420387270
MESH:D003924 Diabetes Mellitus, Type 2 Folic Acid 6.5416886840
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 6.5417107852
MESH:D003928 Diabetic Nephropathies Estradiol 8.0919279558
MESH:D003928 Diabetic Nephropathies Plant Extracts 8.0919706694
MESH:D003929 Diabetic Neuropathies Progesterone 4.1117187935
MESH:D056486 Drug-Induced Liver Injury 1-Naphthylisothiocyanate 23.3317522070 20133375 7624871 18289764
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 23.3311834606 15619225 17906064 12540782 16227642 17562736 12705907 19370779 15968718 11739529 19085960 11461765 16781746 19416960 14986274 10663392 16177239 10774834 16081117 16485898 10915739 19164858 12958197 16393943 11287661 18071297 19739265 12153990 16109766 18713872 14725611 19420014 2444490 14550746 17522070 11529661 11421492 12392966 19923254 12594235 11743745
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 23.332869522 15998439 21278145 3732212 6884620 7179309 10092053 7440962 10915739 19336974 4309450 11566570 16177239 3786805 17522070 15027814 19085960 6623471 15968718 7120509 16227642 9327722
MESH:D056486 Drug-Induced Liver Injury Chloroform 23.336623471 3732212 7120509 6884620 7440962 3104120 2862719 17522070
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 23.3319107877
MESH:D056486 Drug-Induced Liver Injury Erythromycin Estolate 23.3317522070 14998559
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 23.3320420201
MESH:D056486 Drug-Induced Liver Injury Tetracycline 23.3317522070
MESH:D056486 Drug-Induced Liver Injury tolcapone 23.3316604736 19783845
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.7019426721
MESH:D004362 Drug Toxicity marker/mechanism 15805072
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.4711462148
MESH:D004409 Dyskinesia, Drug-Induced tolcapone 5.0011455177
MESH:D004421 Dystonia Phenobarbital 3.641851702
MESH:D004487 Edema perfluorooctanoic acid 13.6217259670 12083418
MESH:D004487 Edema pirinixic acid 13.6212083418
MESH:D004487 Edema Plant Extracts 13.6212787963
MESH:D004487 Edema Tetrachlorodibenzodioxin 13.6211000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.5018230668 16714409 15322242
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 7.7912538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 7.7917692515
MESH:D016889 Endometrial Neoplasms Estradiol 6.8819148513 18566989 11473722
MESH:D016889 Endometrial Neoplasms Folic Acid 6.8817301261
MESH:D004715 Endometriosis Progesterone 7.8016134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 7.8010568697 9294722
MESH:D004719 Endomyocardial Fibrosis Plant Extracts 5.2815268973
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 3.723659116
MESH:D004828 Epilepsies, Partial Phenobarbital 3.473922381 11558140
MESH:D004827 Epilepsy Phenobarbital 6.2620417680
MESH:D004827 Epilepsy Plant Extracts 6.2619700373 19439326
MESH:D004832 Epilepsy, Absence Phenobarbital 3.216401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 3.877750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 3.633659116
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 4.7116302075
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 1.9116530937
MESH:D017889 Exfoliation Syndrome Folic Acid 5.1016504073
MESH:D054908 Extensively Drug-Resistant Tuberculosis tolcapone 5.5419578428
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.7211564622
MESH:D005234 Fatty Liver Carbon Tetrachloride 31.5819224547 16239168 12795759 16045604 61145 17595544 15959796 12631006
MESH:D005234 Fatty Liver Cyclosporine 31.5819224547
MESH:D005234 Fatty Liver Diethylnitrosamine 31.5821071580 20387270
MESH:D005234 Fatty Liver Ethinyl Estradiol 31.5815345470
MESH:D005234 Fatty Liver pirinixic acid 31.5820131406 19236843
MESH:D005234 Fatty Liver Plant Extracts 31.5815975614
MESH:D005234 Fatty Liver Tetracycline 31.5819224547 16917069
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.0711858732
MESH:D005355 Fibrosis Carbon Tetrachloride 12.4918705752
MESH:D005355 Fibrosis Cyclosporine 12.4912639820 12168785
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 12.4920067830
MESH:D005756 Gastritis Acetaminophen 9.9416983495
MESH:D005756 Gastritis Folic Acid 9.9417171786
MESH:D005885 Gingival Hyperplasia Cyclosporine 3.828708960
MESH:D005901 Glaucoma Folic Acid 4.7116504073
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.1910696789
MESH:D006086 Graft vs Host Disease Methotrexate 4.7616518429
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 9.9620471113
MESH:D006330 Heart Defects, Congenital Folic Acid 9.9616524890 17286298
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 9.9610048152 11294989
MESH:D006333 Heart Failure pirinixic acid 6.4220558911
MESH:D006333 Heart Failure Plant Extracts 6.4218097624
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.0315720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 2.9811000095
MESH:D006505 Hepatitis 1-Naphthylisothiocyanate 8.4218590720
MESH:D006505 Hepatitis Carbon Tetrachloride 8.4219110552 19900420
MESH:D006529 Hepatomegaly perfluorooctanoic acid 17.543609246
MESH:D006529 Hepatomegaly Phenobarbital 17.5416109766
MESH:D006529 Hepatomegaly pirinixic acid 17.5416221962 18467677 19176532 19772884
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 17.5415340226 12621046 16120746
MESH:D006558 Herpes Genitalis Estradiol 4.6315709030
MESH:D006561 Herpes Simplex Plant Extracts 4.2310715843
MESH:D015658 HIV Infections Plant Extracts 3.4712878215
MESH:D006679 HIV Seropositivity Folic Acid 5.1017209195
MESH:D019584 Hot Flashes Estradiol 9.0017088409
MESH:D019584 Hot Flashes Plant Extracts 9.0014716179 16566672 17454163
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.6416354765 15340226 18606429 8697196 16959395
MESH:D006930 Hyperalgesia Acetaminophen 6.8316870215
MESH:D006930 Hyperalgesia perfluorooctanoic acid 6.8312083418
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.1416899240
MESH:D006943 Hyperglycemia pirinixic acid 2.8420558911
MESH:D020138 Hyperhomocysteinemia Folic Acid 8.6516433478 16395265 16755160 16397167 16865747
MESH:D020138 Hyperhomocysteinemia Plant Extracts 8.6516484555
MESH:D006949 Hyperlipidemias Plant Extracts 4.1115268973 15975614
MESH:D006973 Hypertension Cyclosporine 4.4110903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 4.4118670907 18850075
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.7015338365
MESH:D007021 Hypospadias Ethinyl Estradiol 3.4216569931 16945680
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.0215869954
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.1012013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 6.2917937319
MESH:D007248 Infertility, Male Theophylline 6.2916988215
MESH:D007249 Inflammation Diethylnitrosamine 13.6118785209
MESH:D007249 Inflammation perfluorooctanoic acid 13.6112083418
MESH:D007249 Inflammation Plant Extracts 13.6115997105 16366677 19332304 12787963
MESH:D007249 Inflammation Progesterone 13.6115869954
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 13.6112878042 12200463
MESH:D007333 Insulin Resistance Estradiol 6.3316393666 16627594
MESH:D007333 Insulin Resistance pirinixic acid 6.3316306350
MESH:D007414 Intestinal Neoplasms Plant Extracts 4.2812584176 12351151 12628509
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 2.9816580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.0415604871
MESH:D007674 Kidney Diseases Acetaminophen 8.6212587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 8.628314463 10903974 18776723
MESH:D007674 Kidney Diseases Estradiol 8.6215618244
MESH:D007680 Kidney Neoplasms Cyclosporine 6.2212371664
MESH:D007680 Kidney Neoplasms Estradiol 6.2215610895
MESH:D007805 Language Development Disorders Methotrexate 4.749562676
MESH:D007984 Leydig Cell Tumor perfluorooctanoic acid 4.838812269
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 18.3811408273 17334410 16943688 17174718 17157831 16239168 11903743 16221502 21278145
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 18.3818522880 19638242 20032147 18665156 18407596
MESH:D008103 Liver Cirrhosis Methotrexate 18.3814986274
MESH:D008103 Liver Cirrhosis Phenobarbital 18.3821047994
MESH:D008103 Liver Cirrhosis Plant Extracts 18.3817157831
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 6.1215338365 17976157 15876570 17922224 15370692 15959796 16027843 16116963 17805973 15931870 17525996 17565644 15925388 15052691 12667390 18263696 12632514 16011737 12445418 18317297 17823541 20821823 18277467 17766677 18472094 16097048 12666154 12609069 15730626 18395095 17714472 12741479 17698563 10355542 14512876 12586293 18156304 13678700 12389079 14724832 14748882 17900296 17869086 18205269 15673190 12958196 17481882 17721639 18251166 14716833 18395914 17944888 18418968 15650968 16136751 15893842 14716496 18705752 17557913 15057751 18054572 15996030 16015684 18429990 12898905 16033810 14620537 18481824 16248980 18279442 18472332 18166357 18412020 12632512 18210741 16192424 18006644 17631135 15818738 15362042 17708605 18339082 12445421 18187930 17761835 11481614 17640975 18420326 18376398 15123356 12546737 16638106 12649538
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 6.1214659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 6.1215474484
MESH:D008106 Liver Cirrhosis, Experimental Plant Extracts 6.1215479170
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 6.1212878042
MESH:D008107 Liver Diseases 1-Naphthylisothiocyanate 17.6117184895
MESH:D008107 Liver Diseases Acetaminophen 17.6116611625 19784758 11587558 19014921 16610002 19460945 12587719 12969438
MESH:D008107 Liver Diseases Carbon Tetrachloride 17.6116246199 16964402 17285989 15720792 15830285
MESH:D008107 Liver Diseases Diethylnitrosamine 17.6117034775
MESH:D008107 Liver Diseases Folic Acid 17.6116877991
MESH:D008107 Liver Diseases Phenobarbital 17.6119363144
MESH:D008107 Liver Diseases Plant Extracts 17.6117034775
MESH:D017093 Liver Failure Carbon Tetrachloride 3.7815123358
MESH:D017114 Liver Failure, Acute Acetaminophen 8.2816871587 17185352
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 8.2814706259 16899240
MESH:D008113 Liver Neoplasms Aflatoxin B1 35.002125692 9163691 18177683 15890375
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 35.0020195826 21137059
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 35.0019294768
MESH:D008113 Liver Neoplasms Clofibric Acid 35.0017602206
MESH:D008113 Liver Neoplasms Diethylnitrosamine 35.0019690152 16942905 19254457 21071580 20101389 19256749 18754104 21167192 15175105 19996281 19294768 19255062 20452335 9163691 12771043 19427195 19812893 19833225 19850985 20501860 19551842 20583210 19090486 19073162 2422723 18978307 18977376 2862719 18648771 21047994 21278145 20118626 20137499 15885732 18644402 19642983 12112319 20492335 19426721 10737359 20434301 19638242 19499222 20405173
MESH:D008113 Liver Neoplasms Methapyrilene 35.0015890375
MESH:D008113 Liver Neoplasms perfluorooctanoic acid 35.0018709148 14757943
MESH:D008113 Liver Neoplasms Phenobarbital 35.0021047994 8742319 19073162 19812893 15975961 19482888
MESH:D008113 Liver Neoplasms pirinixic acid 35.0015890375 20007298 16377806
MESH:D008113 Liver Neoplasms Plant Extracts 35.0019168119
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 35.0016984957
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 15.998603461
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 15.9915583823 12014681
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 15.9919539802 19004024 2563599 17174075 18775883 19519916 18079962 18093689 16267830 19126423 19009564 16842330 18544905 9362446 17854601 21159647 18164116 3124819 18253720 18308698 17942915 18282651
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 15.991399818 17172636 6150874 18308698 2563599
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 15.9912151625
MESH:D008133 Long QT Syndrome Quinidine 4.6311989578 15350150
MESH:D017563 Lung Diseases, Interstitial Methotrexate 4.6218516814
MESH:D008175 Lung Neoplasms Aflatoxin B1 7.8114755239
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 7.8120464547 17053015 18569708 20869020 20064080 6695378 20135361 18816296 18520028
MESH:D008175 Lung Neoplasms bexarotene 7.8117849452
MESH:D008175 Lung Neoplasms Diethylnitrosamine 7.8120970405 6695378 20512841 21163286
MESH:D008175 Lung Neoplasms Plant Extracts 7.8120869020
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 7.8111884234 19555203
MESH:D008180 Lupus Erythematosus, Systemic Folic Acid 3.2217718048
MESH:D008223 Lymphoma Methotrexate 3.6717352296
MESH:D016410 Lymphoma, T-Cell, Cutaneous bexarotene 4.7611161223
MESH:D008325 Mammary Neoplasms, Experimental bexarotene 8.5919196722 15591091 19196723
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 8.5911807958 16891317 17203775 11408345
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 8.5917203775 11408345
MESH:D020149 Manganese Poisoning Estradiol 4.0819453300
MESH:D019767 Maxillofacial Abnormalities Folic Acid 5.3016832597
MESH:D008546 Melanoma, Experimental Acetaminophen 3.1819513568
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.3916801185
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 2.8916381670
MESH:D052016 Mucositis Methotrexate 4.8917488658
MESH:D009135 Muscular Diseases pirinixic acid 3.1216239165
MESH:D009203 Myocardial Infarction pirinixic acid 1.9719151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.7112213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 7.2516810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 7.2516411023
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.0817484760
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.409029167 3581430
MESH:D009369 Neoplasms Benzo(a)pyrene 4.1511141357
MESH:D009369 Neoplasms pirinixic acid 4.1517405874
MESH:D009376 Neoplasms, Hormone-Dependent bexarotene 4.3819196722
MESH:D009389 Neovascularization, Pathologic Estradiol 3.3417289903
MESH:D009395 Nephritis, Interstitial Tetracycline 4.389884423
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.0417954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 2.9519348381 18481113
MESH:D009421 Nervous System Malformations Estradiol 8.2211399458 16427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 8.2214600291
MESH:D009436 Neural Tube Defects Folic Acid 3.7017438019
MESH:D019954 Neurobehavioral Manifestations Plant Extracts 4.8017168769
MESH:D019636 Neurodegenerative Diseases Acetaminophen 7.1218514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 7.1220387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 4.7120387270
MESH:D009503 Neutropenia Folic Acid 4.1516322990
MESH:D052556 Niemann-Pick Disease, Type C perfluorooctanoic acid 4.579802331
MESH:D009765 Obesity pirinixic acid 4.3820558911
MESH:D009765 Obesity Plant Extracts 4.3819056576 20132043
MESH:D010018 Osteomalacia Phenobarbital 3.9717016548
MESH:D010024 Osteoporosis Levonorgestrel 4.4212665316
MESH:D010051 Ovarian Neoplasms Estradiol 4.4219401270
MESH:D010051 Ovarian Neoplasms Progesterone 4.4216525653 17393432
MESH:D010146 Pain Acetaminophen 2.0916870215
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 4.7516540662
MESH:D010190 Pancreatic Neoplasms Phenobarbital 4.7516965848
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.3211578682
MESH:D010212 Papilloma Plant Extracts 4.1115173996 16517061
MESH:D010300 Parkinson Disease tolcapone 3.4520334432 19783845 10651109 8739811 11432539 1977408 9754991 20216409 18328768 8635184 17089403 9708959 11793426 9305320 11586115 16758261 11746615 9591521 7566641 19578428 9333106
MESH:D010382 Peliosis Hepatis 1-Naphthylisothiocyanate 12.4520133375
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 12.4512520081
MESH:D010391 Pemphigoid, Bullous Tetracycline 5.0311026799
MESH:D011085 Polycystic Ovary Syndrome ethinyl estradiol-desogestrel combination 5.2517105841
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.1818163543
MESH:D011230 Precancerous Conditions Cyclosporine 13.3612371664
MESH:D011230 Precancerous Conditions Diethylnitrosamine 13.362563599
MESH:D011230 Precancerous Conditions Phenobarbital 13.362563599
MESH:D011297 Prenatal Exposure Delayed Effects perfluorooctanoic acid 8.3617132714
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 8.3611399792 11222880 11896295 11118676
MESH:D017096 Prion Diseases Tetracycline 5.0210903871
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.5320887781
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.7617292933
MESH:D011471 Prostatic Neoplasms Estradiol 2.7616740699
MESH:D011471 Prostatic Neoplasms Plant Extracts 2.7614666653 17804756
MESH:D011537 Pruritus Ethinyl Estradiol 8.6915861022 16919318
MESH:D011537 Pruritus Levonorgestrel 8.6915861022
MESH:D019310 Pseudolymphoma Phenobarbital 4.0912752131
MESH:D011565 Psoriasis Cyclosporine 5.4116882103
MESH:D011565 Psoriasis Methotrexate 5.4117410198
MESH:D029424 Pulmonary Disease, Chronic Obstructive Theophylline 4.8318983928
MESH:D051437 Renal Insufficiency Folic Acid 9.4215728788
MESH:D051437 Renal Insufficiency Methotrexate 9.4217352296
MESH:D015427 Reperfusion Injury pirinixic acid 2.1919058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.4618990726
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.7118045962
MESH:D012559 Schizophrenia Folic Acid 2.8416641680
MESH:D012640 Seizures Phenobarbital 2.4411442880 3137016 16876388 4039156
MESH:D003294 Seizures, Febrile Phenobarbital 4.436407741
MESH:D012871 Skin Diseases Folic Acid 3.1418709164
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 8.3719755658 10029692
MESH:D012878 Skin Neoplasms Plant Extracts 8.3716517061 15173996
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 8.3716192470
MESH:D013088 Spermatocele Ethinyl Estradiol 3.5416709447
MESH:D013118 Spinal Cord Diseases Folic Acid 5.1016361298
MESH:D013119 Spinal Cord Injuries Progesterone 3.8915862959 16503802
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 3.202093021 20155912
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 3.2018456281
MESH:D013274 Stomach Neoplasms Folic Acid 3.2017171786
MESH:D013276 Stomach Ulcer Plant Extracts 3.5617135157 18237397 18193104 12787963 15255614
MESH:D020521 Stroke Folic Acid 4.0216517955
MESH:D013576 Syndactyly Methotrexate 4.669562676
MESH:D013705 Temporomandibular Joint Disorders Plant Extracts 5.0817997062
MESH:D013921 Thrombocytopenia 1-Naphthylisothiocyanate 4.4120133375
MESH:D019851 Thrombophilia Ethinyl Estradiol 16.3711994571
MESH:D019851 Thrombophilia ethinyl estradiol-desogestrel combination 16.3711994571
MESH:D019851 Thrombophilia Gestodene 16.3711994571
MESH:D013927 Thrombosis Ethinyl Estradiol 8.4515669648
MESH:D013927 Thrombosis Gestodene 8.4515669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.5012697716
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 6.197505956
MESH:D013964 Thyroid Neoplasms Phenobarbital 6.191399818
MESH:D013978 Tibial Fractures Estradiol 4.2819048282
MESH:D018088 Tuberculosis, Multidrug-Resistant tolcapone 5.5419578428
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 2.0217053015
MESH:D014581 Urticaria Acetaminophen 2.6210982225
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 2.9314692618
MESH:D014605 Uveitis Cyclosporine 3.581336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.1912125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 15.9014671159 15869587
MESH:D020246 Venous Thrombosis ethinyl estradiol-desogestrel combination 15.9015869587
MESH:D020246 Venous Thrombosis Levonorgestrel 15.9015869587
MESH:D018487 Ventricular Dysfunction, Left Plant Extracts 4.3618097624
MESH:D020257 Ventricular Remodeling Plant Extracts 4.9218097624
MESH:D014820 Vitiligo tolcapone 4.8210573327
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.8515886252
MESH:D014947 Wounds and Injuries Plant Extracts 3.9319894650 20213670
MESH:D014985 Xerophthalmia Cyclosporine 4.0417120751
Pathway ID Pathway Name
KEGG:04610 Complement and coagulation cascades
REACT:604 Hemostasis
REACT:13552 Integrin cell surface interactions
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA429
    • No data
    Releated disease ID Related disease Name
    PA443291Afibrinogenemia
    Releated drug ID Related drug Name
    PA165290929norelgestromin/ethinyl estradiol
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00009 - Alteplase Thrombolytic Agents
    DB00015 - Reteplase Thrombolytic Agents
    DB00029 - Anistreplase Thrombolytic Agents
    DB00031 - Tenecteplase Thrombolytic Agents
    DB00364 antagonist Sucralfate Anti-Ulcer Agents
    DB02944 - Alpha-D-Mannose
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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