AutismKB 2.0

Annotation Detail for FGB


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:FGB ( MGC104327,MGC120405 )
Gene Full Name: fibrinogen beta chain
Band: 4q31.3
Quick LinksEntrez ID:2244; OMIM: 134830; Uniprot ID:FIBB_HUMAN; ENSEMBL ID: ENSG00000171564; HGNC ID: 3662
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04610Complement and coagulation cascades
Pathway IDPathway Name
Hemostasis
Integrin cell surface interactions
No data
Pathway IDPathway Name
P00050Plasminogen activating cascade
P00011Blood coagulation
Pathway IDPathway Name
500303Common Pathway
Related Diseases/Disorders Top
Desease IDDesease Name
Circulatory system diseases
Hematologic diseases
H00223Inherited thrombophilia
H00222Afibrinogenemia
Desease IDDesease Name
1858Hemorrhagic disorder
2008Liver disease
2111Systemic infection
2197Metabolism disease
2236Cardiovascular disease
Desease Name
HEMATOLOGICAL
Acute Coronary Syndrome
Budd-Chiari Syndrome
cerebral infarct, atherothrombotic
Atherosclerosis
CARDIOVASCULAR
Lupus Nephritis
stroke, lacunar
stroke, ischemic
fibrinogen
angina
nephropathy in other diseases
chronic periodontitis.
RENAL
vascular disease
hypertension
nephritis, lupus
glomerular microthrombus
IMMUNE
peripheral vascular disease
pregnancy loss, recurrent
sepsis
METABOLIC
Stroke
Myocardial Infarction
cerebrovascular disease, ischemic
cholesterol cholesterol, LDL fibrinogen lipoprotein myocardial infarct nitrate triglycerides
post-trauma fibrinogen increase
Lupus
plasma fibrinogen levels
thromboembolism, venous
REPRODUCTION
smoking
INFECTION
Desease Name
Fibrinogen
Desease Name
Afibrinogenemia, congenital
Thrombophilia, dysfibrinogenemic
Dysfibrinogenemia, beta type
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of FGB mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene results in decreased expression of FGB mRNAdecreases expression 20406850
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of FGB mRNAaffects expression 21346803
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of FGB mRNAincreases expression 18648102
D000082 Acetaminophen Acetaminophen affects the expression of FGB mRNAaffects expression 17562736
D000082 Acetaminophen Acetaminophen results in increased expression of FGB mRNAincreases expression 17522070
D000643 Ammonium Chloride Ammonium Chloride affects the expression of FGB mRNAaffects expression 16483693
D001280 Atrazine [Atrazine co-treated with Diuron co-treated with isoproturon] results in decreased expression of FGB mRNAaffects cotreatment|decreases expression 16532367
D019324 beta-Naphthoflavone beta-Naphthoflavone results in decreased expression of FGB mRNAdecreases expression 19737606
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of FGB mRNAdecreases expression 20440473
C095105 bexarotene bexarotene results in decreased expression of FGB mRNAdecreases expression 16648578
D002251 Carbon Tetrachloride Carbon Tetrachloride results in decreased expression of FGB proteindecreases expression 17109383
D002251 Carbon Tetrachloride Carbon Tetrachloride results in increased expression of FGB mRNAincreases expression 17484886
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of FGB mRNAaffects expression 16239168
D002251 Carbon Tetrachloride Carbon Tetrachloride results in increased expression of FGB mRNAincreases expression 17522070
D002994 Clofibrate Clofibrate results in increased expression of FGB mRNAincreases expression 17522070
D003314 Corn Oil Corn Oil affects the expression of FGB mRNAaffects expression 16360708
D016572 Cyclosporine Cyclosporine results in decreased expression of FGB mRNAdecreases expression 20106945
D003907 Dexamethasone Dexamethasone results in decreased expression of FGB mRNAdecreases expression 17522070
C023635 dienogest [Ethinyl Estradiol co-treated with dienogest] results in increased expression of [FGA protein binds to FGB protein binds to FGG protein]affects binding|affects cotreatment|increases expression 15288212
D004237 Diuron [Atrazine co-treated with Diuron co-treated with isoproturon] results in decreased expression of FGB mRNAaffects cotreatment|decreases expression 16532367
D004918 Erythromycin Estolate Erythromycin Estolate results in increased expression of FGB mRNAincreases expression 17522070
D004958 Estradiol Estradiol results in increased expression of FGB mRNAincreases expression 15913882
C454300 estradiol valerate-dienogest [Ethinyl Estradiol co-treated with estradiol valerate-dienogest] results in increased expression of [FGA protein binds to FGB protein binds to FGG protein]affects binding|affects cotreatment|increases expression 15288212
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of FGB mRNAincreases expression 16954407
D004997 Ethinyl Estradiol [Ethinyl Estradiol co-treated with dienogest] results in increased expression of [FGA protein binds to FGB protein binds to FGG protein]affects binding|affects cotreatment|increases expression 15288212
D004997 Ethinyl Estradiol [Ethinyl Estradiol co-treated with estradiol valerate-dienogest] results in increased expression of [FGA protein binds to FGB protein binds to FGG protein]affects binding|affects cotreatment|increases expression 15288212
D004997 Ethinyl Estradiol [Ethinyl Estradiol co-treated with Gestodene] results in increased expression of [FGA protein binds to FGB protein binds to FGG protein]affects binding|affects cotreatment|increases expression 12616983
12616980
12618251
D004997 Ethinyl Estradiol [Ethinyl Estradiol co-treated with Levonorgestrel] results in increased expression of [FGA protein binds to FGB protein binds to FGG protein]affects binding|affects cotreatment|increases expression 12618251
15288212
D004997 Ethinyl Estradiol [Ethinyl Estradiol co-treated with Norethindrone] results in increased expression of [FGA protein binds to FGB protein binds to FGG protein]affects binding|affects cotreatment|increases expression 14561536
D004997 Ethinyl Estradiol [Ethinyl Estradiol co-treated with norgestimate] results in increased expression of [FGA protein binds to FGB protein binds to FGG protein]affects binding|affects cotreatment|increases expression 12618251
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of FGB mRNAaffects cotreatment|increases expression 17942748
C442659 ethinyl estradiol-desogestrel combination ethinyl estradiol-desogestrel combination results in increased expression of [FGA protein binds to FGB protein binds to FGG protein]affects binding|increases expression 12616983
12618251
12616980
14981370
C033273 Gestodene [Ethinyl Estradiol co-treated with Gestodene] results in increased expression of [FGA protein binds to FGB protein binds to FGG protein]affects binding|affects cotreatment|increases expression 12618251
12616980
12616983
D018684 Glycine Agents Glycine Agents results in increased expression of FGB mRNAincreases expression 16532367
C028904 isoproturon [Atrazine co-treated with Diuron co-treated with isoproturon] results in decreased expression of FGB mRNAaffects cotreatment|decreases expression 16532367
D007657 Ketone Bodies Ketone Bodies results in decreased expression of FGB mRNAdecreases expression 15469884
D015058 1-Naphthylisothiocyanate 1-Naphthylisothiocyanate results in increased expression of FGB mRNAincreases expression 17522070
D009640 Norethindrone [Ethinyl Estradiol co-treated with Norethindrone] results in increased expression of [FGA protein binds to FGB protein binds to FGG protein]affects binding|affects cotreatment|increases expression 14561536
C017576 norgestimate [Ethinyl Estradiol co-treated with norgestimate] results in increased expression of [FGA protein binds to FGB protein binds to FGG protein]affects binding|affects cotreatment|increases expression 12618251
D016912 Levonorgestrel [Ethinyl Estradiol co-treated with Levonorgestrel] results in increased expression of [FGA protein binds to FGB protein binds to FGG protein]affects binding|affects cotreatment|increases expression 12618251
15288212
D017239 Paclitaxel Paclitaxel results in decreased expression of FGB mRNAdecreases expression 15585946
C023036 perfluorooctanoic acid perfluorooctanoic acid results in decreased expression of FGB mRNAdecreases expression 18467677
C023036 perfluorooctanoic acid PPARA protein promotes the reaction [perfluorooctanoic acid results in decreased expression of FGB mRNA]decreases expression|increases reaction 18467677
D010634 Phenobarbital Phenobarbital results in increased expression of FGB mRNAincreases expression 12082028
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of FGB mRNAaffects binding|decreases expression|increases activity 19710929
C025299 polyphenols polyphenols results in decreased expression of FGB mRNAdecreases expression 16293270
D011802 Quinidine Quinidine results in increased expression of FGB mRNAincreases expression 17522070
C052785 rebamipide rebamipide results in decreased expression of FGB mRNAdecreases expression 15104358
C020806 tetrabromobisphenol A tetrabromobisphenol A affects the expression of FGB mRNAaffects expression 18976794
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of FGB mRNAincreases expression 17884332
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of FGB mRNAincreases expression 20106945
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin binds to AHR protein] which results in decreased expression of FGB mRNAaffects binding|decreases expression 16214954
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of FGB mRNAaffects cotreatment|increases expression 17942748
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of FGB mRNAdecreases expression 18796159
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of FGB mRNAincreases expression 15644576
D013752 Tetracycline Tetracycline results in increased expression of FGB mRNAincreases expression 17522070
D013806 Theophylline Theophylline results in increased expression of FGB mRNAincreases expression 17522070
C496197 trans-10,cis-12-conjugated linoleic acid trans-10,cis-12-conjugated linoleic acid results in decreased expression of FGB mRNAdecreases expression 17951470
D014425 Turpentine Turpentine results in increased expression of FGB mRNAincreases expression 11779202
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 6.836195326
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 6.8314514962 11752688 15322242
MESH:D000138 Acidosis Ammonium Chloride 3.1218287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 10.8217505938
MESH:D000152 Acne Vulgaris norgestimate 10.8217505938
MESH:D055371 Acute Lung Injury pirinixic acid 2.7118653653
MESH:D000210 Acute-Phase Reaction Turpentine 5.7316044259
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 6.2320127859 20464547
MESH:D000230 Adenocarcinoma Estradiol 6.2311473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 6.2314692618
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 9.643712494
MESH:D000236 Adenoma Benzo(a)pyrene 9.646695378
MESH:D000236 Adenoma beta-Naphthoflavone 9.6419389873
MESH:D018248 Adenoma, Liver Cell Phenobarbital 14.7217620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 14.7216434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 14.7216835633
MESH:C531603 Afibrinogenemia congenital marker/mechanism
MESH:D000382 Agricultural Workers' Diseases Atrazine 3.7911874814
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.5711748828
MESH:D000799 Angioedema Acetaminophen 3.3910982225
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.6419183758
MESH:D001145 Arrhythmias, Cardiac Quinidine 4.7718724381 18057881
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.0311256880
MESH:D001169 Arthritis, Experimental Dexamethasone 6.4417659584
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 6.4415885639
MESH:D001249 Asthma Theophylline 3.7212113382 9701106
MESH:D001321 Autistic Disorder Acetaminophen 1.4718445737
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 4.5711289319 1440618
MESH:D001778 Blood Coagulation Disorders Clofibrate 13.0719483382
MESH:D001778 Blood Coagulation Disorders pirinixic acid 13.0719483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 13.0712125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.3415340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.4715746008
MESH:D001859 Bone Neoplasms Paclitaxel 4.1615867366
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.1817474063 20146248
MESH:D001943 Breast Neoplasms bexarotene 2.1816344269 16818667
MESH:D001943 Breast Neoplasms Estradiol 2.1817289903 14630087 12948864 17261762 17018787 18497071 16675129 19861407
MESH:D001943 Breast Neoplasms Paclitaxel 2.1816115903 15136595 11325840 16244791 18234424 16273361 18223236 18323546
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.1820435547
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.0216111702
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.3516011737 16227642 16050911 15673190 10355542 15700767 16124888 15721981 3786805 16097048 16192424 18705752
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.4516835633
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 15.3816705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 15.3816705839
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 15.387296757 3581430
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 15.383084413
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 15.3818788625
MESH:D006528 Carcinoma, Hepatocellular Estradiol 15.3816924424
MESH:D006528 Carcinoma, Hepatocellular Paclitaxel 15.3816313753
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 15.386705139 17173139 1701930 20007298 20935162
MESH:D002289 Carcinoma, Non-Small-Cell Lung bexarotene 3.0616247446
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.467296757
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 1.9220419170
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.1118850075 18670907 16120746
MESH:D002386 Cataract Acetaminophen 2.3110977129
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 17.826135515
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 17.827505956
MESH:D002471 Cell Transformation, Neoplastic Clofibrate 17.821399818
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 17.8212371664
MESH:D002471 Cell Transformation, Neoplastic Estradiol 17.8218566989
MESH:D002493 Central Nervous System Diseases Phenobarbital 3.824080065
MESH:D002637 Chest Pain Theophylline 5.4215238202
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 2.7916835633
MESH:D002761 Cholangitis 1-Naphthylisothiocyanate 5.7512912871
MESH:D002779 Cholestasis 1-Naphthylisothiocyanate 27.237624871 15913567 16629650 18164287 18590720 15500046 12927374 19486331
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 27.2319486331 9022650
MESH:D002779 Cholestasis Cyclosporine 27.2319486331
MESH:D002779 Cholestasis Ethinyl Estradiol 27.2316919318 17110522 17681005 15861022 16105132 11677210 17333356
MESH:D002779 Cholestasis Levonorgestrel 27.2315861022
MESH:D002779 Cholestasis pirinixic acid 27.2319176532
MESH:D002780 Cholestasis, Intrahepatic 1-Naphthylisothiocyanate 5.4019407337 10220858
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 1.9115668235 15340226 12621046 8697196 16354765
MESH:D003110 Colonic Neoplasms Dexamethasone 3.7715824018
MESH:D003110 Colonic Neoplasms polyphenols 3.7716293270
MESH:D015179 Colorectal Neoplasms Paclitaxel 2.4418802399
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.6914669216 17141729
MESH:D019465 Craniofacial Abnormalities Dexamethasone 2.4617728286
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.4615322242 20055451 10048152
MESH:D003490 Cyanosis 2,4-dinitrotoluene 9.4618551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 9.4618551238
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 5.6411906362 18759878 14531868 8156756 2524372 12868966 8970840 11298694
MESH:D017449 Dermatitis, Allergic Contact Dexamethasone 5.6412438553
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.2118249437
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.093621924 2952479
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.5517107852
MESH:D003928 Diabetic Nephropathies Estradiol 3.0419279558
MESH:D003967 Diarrhea Dexamethasone 3.297237001
MESH:D056486 Drug-Induced Liver Injury 1-Naphthylisothiocyanate 26.3920133375 7624871 17522070 18289764
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 26.3918551238 21346803
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 26.3921346803 18551238
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 26.3918289764 18648102 18692083 6679447 16192314 8291058 6482804 11289319 7440962 9653073 9022650 1440618 9328219
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 26.3912153990 11461765 12540782 10915739 19420014 11287661 14550746 15968718 10774834 17906064 10663392 16081117 12392966 16227642 15619225 18713872 11529661 14986274 16393943 19416960 17562736 19085960 19370779 16109766 12594235 14725611 19923254 16177239 2444490 11739529 11421492 12705907 17522070 16781746 16485898 11834606 19164858 19739265 12958197 18071297 11743745
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 26.396884620 10915739 7179309 17522070 3786805 4309450 15998439 16177239 7120509 7440962 15027814 11566570 6623471 2869522 19336974 16227642 10092053 15968718 3732212 21278145 9327722 19085960
MESH:D056486 Drug-Induced Liver Injury Erythromycin Estolate 26.3914998559 17522070
MESH:D056486 Drug-Induced Liver Injury polyphenols 26.3919370779
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 26.3920420201
MESH:D056486 Drug-Induced Liver Injury Tetracycline 26.3917522070
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.6519426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.4311462148
MESH:D050171 Dyslipidemias Clofibrate 3.7516707586
MESH:D004421 Dystonia Phenobarbital 3.601851702
MESH:D004485 Eczema Dexamethasone 4.0412438553
MESH:D004487 Edema Dexamethasone 13.2519703484
MESH:D004487 Edema perfluorooctanoic acid 13.2512083418 17259670
MESH:D004487 Edema pirinixic acid 13.2512083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 13.2511000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.4516714409 15322242 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 2.7712538720
MESH:D016889 Endometrial Neoplasms Estradiol 2.6911473722 18566989 19148513
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.649294722 10568697
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 3.683659116
MESH:D004828 Epilepsies, Partial Phenobarbital 3.423922381 11558140
MESH:D004827 Epilepsy Phenobarbital 2.6520417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.176401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 3.827750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 3.583659116
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 6.513581430
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 6.5116530937
MESH:D004938 Esophageal Neoplasms Paclitaxel 6.5116481741
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.6811564622
MESH:D005234 Fatty Liver Carbon Tetrachloride 25.6015959796 16239168 12631006 17595544 12795759 61145 16045604 19224547
MESH:D005234 Fatty Liver Clofibrate 25.6019224547
MESH:D005234 Fatty Liver Cyclosporine 25.6019224547
MESH:D005234 Fatty Liver Ethinyl Estradiol 25.6015345470
MESH:D005234 Fatty Liver pirinixic acid 25.6019236843 20131406
MESH:D005234 Fatty Liver Tetracycline 25.6019224547 16917069
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.0211858732
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 4.576705139
MESH:D005355 Fibrosis Carbon Tetrachloride 12.2118705752
MESH:D005355 Fibrosis Cyclosporine 12.2112639820 12168785
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 12.2120067830
MESH:D005756 Gastritis Acetaminophen 3.2216983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 3.788708960
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 3.637505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.1410696789
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 5.6320471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 5.6310048152 11294989
MESH:D006333 Heart Failure pirinixic acid 2.2620558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 3.9815720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 2.9411000095
MESH:D006505 Hepatitis 1-Naphthylisothiocyanate 13.3618590720
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 13.366705139
MESH:D006505 Hepatitis Carbon Tetrachloride 13.3619900420 19110552
MESH:D006529 Hepatomegaly perfluorooctanoic acid 17.153609246
MESH:D006529 Hepatomegaly Phenobarbital 17.1516109766
MESH:D006529 Hepatomegaly pirinixic acid 17.1519176532 16221962 19772884 18467677
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 17.1515340226 16120746 12621046
MESH:D006548 Hernia, Diaphragmatic Dexamethasone 2.907520565
MESH:D006558 Herpes Genitalis Estradiol 4.5815709030
MESH:D019584 Hot Flashes Estradiol 3.3017088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.5915340226 18606429 8697196 16959395 16354765
MESH:D006930 Hyperalgesia Acetaminophen 6.7016870215
MESH:D006930 Hyperalgesia perfluorooctanoic acid 6.7012083418
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.0916899240
MESH:D006943 Hyperglycemia pirinixic acid 2.8020558911
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 3.5115034207
MESH:D006968 Hypersensitivity, Delayed Corn Oil 5.3611484837
MESH:D006973 Hypertension Cyclosporine 7.5110903974
MESH:D006973 Hypertension Dexamethasone 7.5117042910
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 7.5118850075 18670907
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.6615338365
MESH:D007021 Hypospadias Ethinyl Estradiol 3.3816569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.0512013081
MESH:D007248 Infertility, Male Atrazine 9.7512948887
MESH:D007248 Infertility, Male Ethinyl Estradiol 9.7517937319
MESH:D007248 Infertility, Male Theophylline 9.7516988215
MESH:D007249 Inflammation Dexamethasone 10.0311099482 8960868
MESH:D007249 Inflammation perfluorooctanoic acid 10.0312083418
MESH:D007249 Inflammation polyphenols 10.0316366677
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 10.0312878042 12200463
MESH:D007333 Insulin Resistance Estradiol 6.2116627594 16393666
MESH:D007333 Insulin Resistance pirinixic acid 6.2116306350
MESH:D007410 Intestinal Diseases rebamipide 4.7511686837
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 4.578074119 9022650
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 2.9416580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 3.9915604871
MESH:D007674 Kidney Diseases Acetaminophen 8.4412587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 8.448314463 10903974 18776723
MESH:D007674 Kidney Diseases Estradiol 8.4415618244
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 19.5216705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 19.5216705839
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 19.526582329
MESH:D007680 Kidney Neoplasms Cyclosporine 19.5212371664
MESH:D007680 Kidney Neoplasms Estradiol 19.5215610895
MESH:D007984 Leydig Cell Tumor perfluorooctanoic acid 4.798812269
MESH:D008080 Liposarcoma Paclitaxel 4.4117353645
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 5.7911408273 17174718 11903743 16221502 16943688 17157831 17334410 16239168 21278145
MESH:D008103 Liver Cirrhosis Phenobarbital 5.7921047994
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 2.919327722 15034207
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 6.0117823541 18481824 16033810 17640975 18277467 16192424 18472332 18279442 12666154 12667390 14748882 11481614 17900296 18263696 14716496 15730626 16097048 18317297 15052691 15876570 15338365 12586293 17805973 15123356 17714472 20821823 12649538 18187930 16015684 15362042 12445418 12958196 18376398 18418968 18472094 17557913 18251166 12445421 12632514 12609069 15925388 14716833 18054572 18429990 18006644 12546737 15931870 13678700 16136751 16116963 18395914 18205269 14620537 15996030 18210741 17976157 12389079 17631135 17698563 12741479 16638106 15673190 16248980 18339082 18412020 18395095 14512876 17766677 15370692 16027843 17481882 17944888 17761835 16011737 15818738 18156304 17869086 12632512 17922224 10355542 17708605 18705752 12898905 14724832 17721639 15057751 17565644 17525996 15893842 18420326 18166357 15959796 15650968
MESH:D008106 Liver Cirrhosis, Experimental Dexamethasone 6.0116718785
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 6.0114716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 6.0115474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 6.0112878042
MESH:D008107 Liver Diseases 1-Naphthylisothiocyanate 11.1017184895
MESH:D008107 Liver Diseases Acetaminophen 11.1012587719 16610002 11587558 19784758 16611625 19014921 12969438 19460945
MESH:D008107 Liver Diseases Carbon Tetrachloride 11.1017285989 16246199 15830285 16964402 15720792
MESH:D008107 Liver Diseases Phenobarbital 11.1019363144
MESH:D008107 Liver Diseases polyphenols 11.1016698588
MESH:D017093 Liver Failure Carbon Tetrachloride 3.7315123358
MESH:D017114 Liver Failure, Acute Acetaminophen 8.1316871587 17185352
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 8.1314706259 16899240
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 22.687678174
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 22.6820195826 21137059
MESH:D008113 Liver Neoplasms beta-Naphthoflavone 22.6819389873 21295105
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 22.6819294768
MESH:D008113 Liver Neoplasms perfluorooctanoic acid 22.6818709148 14757943
MESH:D008113 Liver Neoplasms Phenobarbital 22.6819073162 19812893 19482888 21047994 8742319 15975961
MESH:D008113 Liver Neoplasms pirinixic acid 22.6820007298 15890375 16377806
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 22.6816984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 19.686135515 2876784 2876786
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 19.681399818 598648 6587162 3712494
MESH:D008114 Liver Neoplasms, Experimental beta-Naphthoflavone 19.6818164116
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 19.6812014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 19.681399818 6150874 17172636 2563599 18308698
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 19.6812151625
MESH:D008133 Long QT Syndrome Quinidine 4.5911989578 15350150
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 4.3620869020 20464547 20135361 6695378 20064080 18816296 17053015 18569708 18520028
MESH:D008175 Lung Neoplasms bexarotene 4.3617849452
MESH:D008175 Lung Neoplasms Dexamethasone 4.3615824018 11195469
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 4.3611884234 19555203
MESH:D008228 Lymphoma, Non-Hodgkin Paclitaxel 3.7314749477
MESH:D016410 Lymphoma, T-Cell, Cutaneous bexarotene 4.7111161223
MESH:D008325 Mammary Neoplasms, Experimental bexarotene 5.3015591091 19196723 19196722
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 5.3017203775 11807958 11408345 16891317
MESH:D020149 Manganese Poisoning Estradiol 4.0319453300
MESH:D008545 Melanoma Paclitaxel 2.5312025231 16342250 12040289
MESH:D008546 Melanoma, Experimental Acetaminophen 3.1419513568
MESH:D008654 Mesothelioma Atrazine 3.341916698
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.3416801185
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 2.8516381670
MESH:D009101 Multiple Myeloma Dexamethasone 6.5916118317 15867202 15744524
MESH:D009101 Multiple Myeloma Paclitaxel 6.5914749477
MESH:D009135 Muscular Diseases pirinixic acid 3.0816239165
MESH:D009190 Myelodysplastic Syndromes Dexamethasone 3.289809623
MESH:D009203 Myocardial Infarction pirinixic acid 1.9519151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.6712213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 7.1216810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 7.1216411023
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.0317484760
MESH:D009336 Necrosis 2,4-dinitrotoluene 8.8718551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 8.877678174 18551238
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 5.313581430
MESH:D009362 Neoplasm Metastasis Paclitaxel 5.3115867366
MESH:D009369 Neoplasms Benzo(a)pyrene 4.0611141357
MESH:D009369 Neoplasms pirinixic acid 4.0617405874
MESH:D009376 Neoplasms, Hormone-Dependent bexarotene 4.3319196722
MESH:D009389 Neovascularization, Pathologic Estradiol 3.2917289903
MESH:D009395 Nephritis, Interstitial Tetracycline 4.349884423
MESH:D009402 Nephrosis, Lipoid Cyclosporine 3.9917954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 2.9118481113 19348381
MESH:D009421 Nervous System Malformations Estradiol 8.0711399458 16427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 8.0714600291
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 2.626679447
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.5118514411
MESH:D052556 Niemann-Pick Disease, Type C Clofibrate 10.629802331
MESH:D052556 Niemann-Pick Disease, Type C perfluorooctanoic acid 10.629802331
MESH:D009765 Obesity pirinixic acid 1.7020558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 12.8516049721 12819281
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 12.8516049721
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 12.854026338 6482804
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 4.573988306
MESH:D010014 Osteolysis Paclitaxel 4.5415867366
MESH:D010018 Osteomalacia Phenobarbital 3.9217016548
MESH:D010024 Osteoporosis Levonorgestrel 4.3812665316
MESH:D010051 Ovarian Neoplasms Estradiol 4.5219401270
MESH:D010051 Ovarian Neoplasms Paclitaxel 4.5211161223
MESH:D010146 Pain Acetaminophen 2.0516870215
MESH:D010190 Pancreatic Neoplasms Phenobarbital 2.3316965848
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.2811578682
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.067296757
MESH:D010300 Parkinson Disease Atrazine 3.1017218051
MESH:D010382 Peliosis Hepatis 1-Naphthylisothiocyanate 12.2820133375
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 12.2812520081
MESH:D010391 Pemphigoid, Bullous Tetracycline 4.9811026799
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.026228378
MESH:D011085 Polycystic Ovary Syndrome ethinyl estradiol-desogestrel combination 5.2117105841
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.1418163543
MESH:D011230 Precancerous Conditions Corn Oil 13.3214668109
MESH:D011230 Precancerous Conditions Cyclosporine 13.3212371664
MESH:D011230 Precancerous Conditions Phenobarbital 13.322563599
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Dexamethasone 3.2921297632
MESH:D011297 Prenatal Exposure Delayed Effects perfluorooctanoic acid 8.2017132714
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 8.2011118676 11222880 11896295 11399792
MESH:D017096 Prion Diseases Tetracycline 4.9710903871
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.4920887781
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.7617292933
MESH:D011471 Prostatic Neoplasms Estradiol 2.7616740699
MESH:D011471 Prostatic Neoplasms Paclitaxel 2.7617172428 17136230 16729912 16356831
MESH:D011537 Pruritus Ethinyl Estradiol 8.5315861022 16919318
MESH:D011537 Pruritus Levonorgestrel 8.5315861022
MESH:D019310 Pseudolymphoma Phenobarbital 4.0412752131
MESH:D011565 Psoriasis Cyclosporine 2.0616882103
MESH:D029424 Pulmonary Disease, Chronic Obstructive Theophylline 4.8018983928
MESH:D015427 Reperfusion Injury pirinixic acid 2.1619058328
MESH:D012128 Respiratory Distress Syndrome, Adult Dexamethasone 3.6118379247 11700416
MESH:D012135 Respiratory Sounds Atrazine 4.0911874814
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.4218990726
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.043692021
MESH:D012640 Seizures 2,4-dinitrotoluene 8.0418551238
MESH:D012640 Seizures 2,6-dinitrotoluene 8.0418551238
MESH:D012640 Seizures Phenobarbital 8.043137016 11442880 4039156 16876388
MESH:D003294 Seizures, Febrile Phenobarbital 4.386407741
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 4.7319755658 10029692
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 4.7316192470
MESH:D013088 Spermatocele Ethinyl Estradiol 3.4916709447
MESH:D013272 Stomach Diseases Dexamethasone 9.2115472012
MESH:D013272 Stomach Diseases rebamipide 9.2116184426
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 3.332093021 20155912
MESH:D013274 Stomach Neoplasms Paclitaxel 3.3318506536 18396642
MESH:D013274 Stomach Neoplasms rebamipide 3.3315993841
MESH:D013276 Stomach Ulcer Dexamethasone 3.1115138204
MESH:D024801 Tauopathies Paclitaxel 4.3716930453
MESH:D013705 Temporomandibular Joint Disorders polyphenols 4.8017997062
MESH:D013921 Thrombocytopenia 1-Naphthylisothiocyanate 4.3720133375
MESH:D019851 Thrombophilia Ethinyl Estradiol 16.1111994571
MESH:D019851 Thrombophilia ethinyl estradiol-desogestrel combination 16.1111994571
MESH:D019851 Thrombophilia Gestodene 16.1111994571
MESH:D013927 Thrombosis Ethinyl Estradiol 8.3115669648
MESH:D013927 Thrombosis Gestodene 8.3115669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.4512697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 6.031399818 6582329 7505956 3712494 6587162
MESH:D013964 Thyroid Neoplasms Phenobarbital 6.031399818
MESH:D013978 Tibial Fractures Estradiol 4.2319048282
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 10.3216049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 10.3216049721
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 10.328074119
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 10.3217053015
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 10.5110091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 10.5110091137
MESH:D014581 Urticaria Acetaminophen 2.5710982225
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 2.8814692618
MESH:D014605 Uveitis Cyclosporine 10.271336536
MESH:D014605 Uveitis Dexamethasone 10.271336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.1412125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 15.6414671159 15869587
MESH:D020246 Venous Thrombosis ethinyl estradiol-desogestrel combination 15.6415869587
MESH:D020246 Venous Thrombosis Levonorgestrel 15.6415869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.8015886252
MESH:D014985 Xerophthalmia Cyclosporine 3.9917120751
Pathway ID Pathway Name
KEGG:04610 Complement and coagulation cascades
REACT:604 Hemostasis
REACT:13552 Integrin cell surface interactions
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA163
    • No data
    No data
    Releated drug ID Related drug Name
    PA451089pravastatin
    PA165290929norelgestromin/ethinyl estradiol
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00364 antagonist Sucralfate Anti-Ulcer Agents
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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