AutismKB 2.0

Annotation Detail for FGF9


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:FGF9 ( GAF,HBFG-9,MGC119914,MGC119915,SYNS3 )
Gene Full Name: fibroblast growth factor 9 (glia-activating factor)
Band: 13q12.11
Quick LinksEntrez ID:2254; OMIM: 600921; Uniprot ID:FGF9_HUMAN; ENSEMBL ID: ENSG00000102678; HGNC ID: 3687
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04010MAPK signaling pathway
hsa04810Regulation of actin cytoskeleton
hsa05218Melanoma
hsa05200Pathways in cancer
Pathway IDPathway Name
Signaling by Insulin receptor
Signaling by FGFR
No data
Pathway IDPathway Name
P00021FGF signaling pathway
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1831Prostate cancer
1901Endometriosis
2084Gonadal dysgenesis
No data
No data
Desease Name
Multiple synostoses syndrome 3
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C026486 1,2,5,6-dibenzanthracene 1,2,5,6-dibenzanthracene results in increased expression of FGF9 mRNAincreases expression 19358281
C038890 2,3,4,7,8-pentachlorodibenzofuran 2,3,4,7,8-pentachlorodibenzofuran results in increased expression of FGF9 mRNAincreases expression 19358281
C023035 3,4,5,3',4'-pentachlorobiphenyl 3,4,5,3',4'-pentachlorobiphenyl results in increased expression of FGF9 mRNAincreases expression 19358281
C090942 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Benzo(a)pyrene results in increased expression of FGF9 mRNA]decreases reaction|increases expression 20464547
C090942 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Particulate Matter results in increased expression of FGF9 mRNA]decreases reaction|increases expression 20464547
D019386 Alendronate Alendronate affects the expression of FGF9 mRNAaffects expression 16079270
D000643 Ammonium Chloride Ammonium Chloride affects the expression of FGF9 mRNAaffects expression 16483693
C030935 benz(a)anthracene benz(a)anthracene results in increased expression of FGF9 mRNAincreases expression 19358281
C022921 benzo(k)fluoranthene benzo(k)fluoranthene results in increased expression of FGF9 mRNAincreases expression 19358281
D001564 Benzo(a)pyrene 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Benzo(a)pyrene results in increased expression of FGF9 mRNA]decreases reaction|increases expression 20464547
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of FGF9 mRNAincreases expression 19358281
20464547
16002475
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of FGF9 proteinincreases expression 20464547
D001564 Benzo(a)pyrene PD 98059 inhibits the reaction [Benzo(a)pyrene results in increased expression of FGF9 mRNA]decreases reaction|increases expression 20464547
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of FGF9 mRNAincreases expression 20382639
D002101 Cacodylic Acid Cacodylic Acid results in increased expression of FGF9 mRNAincreases expression 17720352
D002118 Calcium Calcium affects the expression of FGF9 mRNAaffects expression 15913539
D002251 Carbon Tetrachloride Carbon Tetrachloride results in increased expression of FGF9 proteinincreases expression 17662249
D004390 Chlorpyrifos Chlorpyrifos affects the expression of FGF9 mRNAaffects expression 18502319
D003976 Diazinon Diazinon affects the expression of FGF9 mRNAaffects expression 19130878
D002945 Cisplatin FGF9 protein affects the susceptibility to Cisplatinaffects response to substance 16217747
D004026 Dieldrin Dieldrin results in increased expression of FGF9 mRNAincreases expression 19130878
D004958 Estradiol Estradiol results in increased expression of FGF9 mRNAincreases expression 21098263
12072406
14602803
D004958 Estradiol Estradiol results in increased expression of FGF9 proteinincreases expression 12072406
D004958 Estradiol [Progesterone co-treated with Estradiol] results in decreased expression of FGF9 mRNAaffects cotreatment|decreases expression 17404688
D004967 Estrogens FGF9 protein promotes the reaction [Estrogens results in increased expression of TBX3 protein]increases expression|increases reaction 21098263
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of FGF9 mRNAaffects expression 16079270
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of FGF9 mRNAdecreases expression 16551644
C070081 fulvestrant fulvestrant results in decreased expression of FGF9 mRNAdecreases expression 14602803
C051890 irinotecan irinotecan analog results in decreased expression of FGF9 mRNAdecreases expression 18927307
C004809 isopentenyl pyrophosphate isopentenyl pyrophosphate results in increased expression of FGF9 mRNAincreases expression 14704367
C004809 isopentenyl pyrophosphate isopentenyl pyrophosphate results in increased expression of FGF9 proteinincreases expression 14704367
D008070 Lipopolysaccharides Lipopolysaccharides results in increased expression of FGF9 mRNAincreases expression 12057914
D008070 Lipopolysaccharides [Lipopolysaccharides co-treated with Thymic Factor, Circulating co-treated with Zinc] results in increased expression of FGF9 proteinaffects cotreatment|increases expression 12639846
D009151 Mustard Gas IL10 protein affects the reaction [Mustard Gas affects the expression of FGF9 mRNA]affects expression|affects reaction 16173061
D010126 Ozone Ozone results in decreased expression of FGF9 mRNAdecreases expression 12763052
D052638 Particulate Matter 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Particulate Matter results in increased expression of FGF9 mRNA]decreases reaction|increases expression 20464547
D052638 Particulate Matter Particulate Matter results in increased expression of FGF9 mRNAincreases expression 20464547
D052638 Particulate Matter Particulate Matter results in increased expression of FGF9 proteinincreases expression 20464547
D052638 Particulate Matter PD 98059 inhibits the reaction [Particulate Matter results in increased expression of FGF9 mRNA]decreases reaction|increases expression 20464547
C093973 PD 98059 PD 98059 inhibits the reaction [Benzo(a)pyrene results in increased expression of FGF9 mRNA]decreases reaction|increases expression 20464547
C093973 PD 98059 PD 98059 inhibits the reaction [Particulate Matter results in increased expression of FGF9 mRNA]decreases reaction|increases expression 20464547
C008954 polychlorodibenzo-4-dioxin polychlorodibenzo-4-dioxin results in increased expression of FGF9 mRNAincreases expression 19358281
D011084 Polycyclic Hydrocarbons, Aromatic Polycyclic Hydrocarbons, Aromatic results in increased expression of FGF9 mRNAincreases expression 16002475
20464547
D011084 Polycyclic Hydrocarbons, Aromatic Polycyclic Hydrocarbons, Aromatic results in increased expression of FGF9 mRNAincreases expression 16002475
D011374 Progesterone [Progesterone co-treated with Estradiol] results in decreased expression of FGF9 mRNAaffects cotreatment|decreases expression 17404688
D020849 Raloxifene Raloxifene affects the expression of FGF9 mRNAaffects expression 16079270
D014284 Triiodothyronine Triiodothyronine promotes the reaction [FGF9 protein results in increased phosphorylation of MAPK1 protein]increases phosphorylation|increases reaction 16150908
D014284 Triiodothyronine Triiodothyronine promotes the reaction [FGF9 protein results in increased phosphorylation of MAPK3 protein]increases phosphorylation|increases reaction 16150908
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of FGF9 mRNAincreases expression 19358281
20106945
D013935 Thymic Factor, Circulating [Lipopolysaccharides co-treated with Thymic Factor, Circulating co-treated with Zinc] results in increased expression of FGF9 proteinaffects cotreatment|increases expression 12639846
D014028 Tobacco Smoke Pollution Tobacco Smoke Pollution results in increased expression of FGF9 mRNAincreases expression 20464547
D014212 Tretinoin Tretinoin results in increased expression of FGF9 mRNAincreases expression 7656983
15621532
C066075 vanadium pentoxide vanadium pentoxide results in decreased expression of FGF9 mRNAdecreases expression 17459161
D015032 Zinc [Lipopolysaccharides co-treated with Thymic Factor, Circulating co-treated with Zinc] results in increased expression of FGF9 proteinaffects cotreatment|increases expression 12639846
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.4515322242 14514962 11752688
MESH:D000138 Acidosis Ammonium Chloride 3.1518287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.5317505938
MESH:D000169 Acrodermatitis Zinc 5.0016889938 17190629 17202136
MESH:D058186 Acute Kidney Injury Cisplatin 3.6017670903 15814532 12690470
MESH:D055371 Acute Lung Injury Lipopolysaccharides 8.5711850527 18653653
MESH:D055371 Acute Lung Injury Particulate Matter 8.5712396868
MESH:D000230 Adenocarcinoma marker/mechanism 20464547
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 9.1920127859 20464547
MESH:D000230 Adenocarcinoma Cisplatin 9.1911798837 17638652
MESH:D000230 Adenocarcinoma Estradiol 9.1911473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 9.1914692618
MESH:D002282 Adenocarcinoma, Bronchiolo-Alveolar Tobacco Smoke Pollution 5.1115814487
MESH:D000236 Adenoma Benzo(a)pyrene 2.416695378
MESH:D018248 Adenoma, Liver Cell 3,4,5,3',4'-pentachlorobiphenyl 9.1916628245
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 9.1916835633
MESH:D000382 Agricultural Workers' Diseases Chlorpyrifos 7.8317119214 16611668 11874814
MESH:D000382 Agricultural Workers' Diseases Diazinon 7.8316487989
MESH:D000419 Albuminuria Raloxifene 4.2117308373 17451421
MESH:D000505 Alopecia Tretinoin 3.2915955085
MESH:D000544 Alzheimer Disease Ozone 8.6615513908
MESH:D000544 Alzheimer Disease Particulate Matter 8.6615513908
MESH:D000544 Alzheimer Disease Raloxifene 8.6615800139
MESH:D000544 Alzheimer Disease Zinc 8.6617119284 16325427 16410023 16580781
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.6011748828
MESH:D000755 Anemia, Sickle Cell Zinc 4.5116916123
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.6819183758
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.0711256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 6.3515885639
MESH:D001169 Arthritis, Experimental Tretinoin 6.3516412693
MESH:D001172 Arthritis, Rheumatoid Ozone 6.8715570426
MESH:D001172 Arthritis, Rheumatoid Tobacco Smoke Pollution 6.8719898480
MESH:D001172 Arthritis, Rheumatoid Tretinoin 6.8716292516
MESH:D001249 Asthma Mustard Gas 10.1710378619
MESH:D001249 Asthma Ozone 10.1716373670 17854713
MESH:D001249 Asthma Tretinoin 10.1716456186
MESH:D001249 Asthma Zinc 10.1717085522
MESH:D001284 Atrophy fulvestrant 4.4611514358
MESH:D001471 Barrett Esophagus Tretinoin 4.0216935849
MESH:D001768 Blister Mustard Gas 4.7519167455
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 7.7312125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 7.7316206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.3815340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.5015746008
MESH:D019046 Bone Marrow Neoplasms Cisplatin 4.4714601052
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 4.9217868700
MESH:D001930 Brain Injuries Progesterone 16.1615665606 15380490 15845082
MESH:D001930 Brain Injuries Raloxifene 16.1616580743
MESH:D001930 Brain Injuries Zinc 16.1617109824
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 6.4820146248 17474063
MESH:D001943 Breast Neoplasms Cacodylic Acid 6.4817474063
MESH:D001943 Breast Neoplasms Cisplatin 6.4819526202 18382427
MESH:D001943 Breast Neoplasms Dieldrin 6.4811859874 15770527
MESH:D001943 Breast Neoplasms Estradiol 6.4817261762 17289903 17018787 12948864 18497071 16675129 19861407 14630087
MESH:D001943 Breast Neoplasms fulvestrant 6.4818984771
MESH:D001943 Breast Neoplasms Progesterone 6.4815562024 17614352 16175315
MESH:D001943 Breast Neoplasms Raloxifene 6.4816912660 17595753 15572757 17261762 16837676 17440819 15775269 17049068 15758505 17242785 17952589 17893378
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 6.4820435547
MESH:D001943 Breast Neoplasms Tretinoin 6.4816873071 16443354 16166294
MESH:D016535 Bronchial Hyperreactivity Ozone 3.3617626835 15516495 14754758 18417511 16777450 18315731 19059883
MESH:D001989 Bronchiolitis Obliterans Mustard Gas 4.7515286001
MESH:D001991 Bronchitis vanadium pentoxide 5.8217459161
MESH:D029481 Bronchitis, Chronic Mustard Gas 4.5617687719 10378619
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.1816813970
MESH:D002100 Cachexia Ozone 4.3316183385
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.0616111702
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.3818705752 15700767 16097048 15673190 16192424 15721981 10355542 16227642 16050911 3786805 16011737 16124888
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.4816835633
MESH:D018236 Carcinoma, Embryonal Tretinoin 4.7416168501
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 8.0818788625
MESH:D006528 Carcinoma, Hepatocellular Cisplatin 8.0817982673
MESH:D006528 Carcinoma, Hepatocellular Estradiol 8.0816924424
MESH:D006528 Carcinoma, Hepatocellular Estrogens 8.0815341023
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 8.081917145
MESH:D002289 Carcinoma, Non-Small-Cell Lung marker/mechanism 19358281
MESH:D002289 Carcinoma, Non-Small-Cell Lung Cisplatin 5.4312023789 16685392
MESH:D002289 Carcinoma, Non-Small-Cell Lung Tobacco Smoke Pollution 5.4311212258
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 12.9320419170
MESH:D002294 Carcinoma, Squamous Cell Cisplatin 12.9317066447 18337622 6189445
MESH:D002294 Carcinoma, Squamous Cell Tobacco Smoke Pollution 12.9311212258
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 12.9316096774 16051514
MESH:D002294 Carcinoma, Squamous Cell Zinc 12.9316543248
MESH:D002295 Carcinoma, Transitional Cell Raloxifene 3.7217572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.1418850075 16120746 18670907
MESH:D002318 Cardiovascular Diseases Particulate Matter 10.8212396868
MESH:D002318 Cardiovascular Diseases Raloxifene 10.8215775269
MESH:D002318 Cardiovascular Diseases Zinc 10.8216936243
MESH:D002386 Cataract Tretinoin 2.8517460283
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 5.7120889678
MESH:D002471 Cell Transformation, Neoplastic Estradiol 5.7118566989
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.1816129372
MESH:D018281 Cholangiocarcinoma 3,4,5,3',4'-pentachlorobiphenyl 8.6816628245
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 8.6816835633
MESH:D002779 Cholestasis Ethinyl Estradiol 2.5711677210 17681005 17110522 16919318 15861022 16105132 17333356
MESH:D002822 Choriocarcinoma Tretinoin 4.7416461808
MESH:D002971 Cleft Lip marker/mechanism 17963255
MESH:D002972 Cleft Palate marker/mechanism 17963255
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.168697196 15668235 15340226 16354765 12621046
MESH:D002972 Cleft Palate Tretinoin 5.169407595
MESH:D003072 Cognition Disorders Raloxifene 4.2215800139
MESH:D003092 Colitis Tretinoin 3.3117035595
MESH:D003110 Colonic Neoplasms irinotecan 2.5217287894 17725105
MESH:D015179 Colorectal Neoplasms Cisplatin 2.7415273666
MESH:D015179 Colorectal Neoplasms irinotecan 2.7415273666 16391804 17159606 18259882 17454858 16303861 18509181
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.7217141729 14669216
MESH:D019465 Craniofacial Abnormalities 3,4,5,3',4'-pentachlorobiphenyl 5.0417686920
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 5.0415322242 10048152 20055451
MESH:D019465 Craniofacial Abnormalities Tretinoin 5.049125849 10589399 9224671 17551590 9142499 16925845 8800419 9664655 14991402 9211117
MESH:D019465 Craniofacial Abnormalities Zinc 5.0419302082
MESH:D016638 Critical Illness Estrogens 5.5416670151
MESH:D003865 Depressive Disorder, Major Raloxifene 3.8217474826
MESH:D003920 Diabetes Mellitus Zinc 3.8616479319
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.5617107852
MESH:D003928 Diabetic Nephropathies Estradiol 7.8819279558
MESH:D003928 Diabetic Nephropathies Raloxifene 7.8815920148 17451421 17308373
MESH:D003929 Diabetic Neuropathies Progesterone 4.0917187935
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 3.3010915739 3786805 16177239 19336974 9327722 11566570 17522070 15998439 4309450 7179309 16227642 10092053 15968718 15027814 7120509 3732212 19085960 6884620 6623471 2869522 7440962 21278145
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 3.3020420201
MESH:D004362 Drug Toxicity Cisplatin 7.1812649298 12231392 15033597 19839026
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 7.1811462148
MESH:D004417 Dyspnea Diazinon 4.3916487989
MESH:D004487 Edema Mustard Gas 9.4711402378 9260866 11428631 11428647
MESH:D004487 Edema Raloxifene 9.4715860553
MESH:D004487 Edema Tetrachlorodibenzodioxin 9.4712711302 11000095
MESH:D004489 Edema, Cardiac 3,4,5,3',4'-pentachlorobiphenyl 18.7017686920
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 18.7015322242 18230668 16714409
MESH:D004489 Edema, Cardiac Tretinoin 18.7018230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 13.1512538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 13.1517692515
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Raloxifene 13.1515845917
MESH:D016889 Endometrial Neoplasms Estradiol 6.5211473722 18566989 19148513
MESH:D016889 Endometrial Neoplasms Tretinoin 6.5216569247
MESH:D004715 Endometriosis 2,3,4,7,8-pentachlorodibenzofuran 13.499294722
MESH:D004715 Endometriosis Progesterone 13.4916134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 13.499294722 10568697
MESH:D019446 Endotoxemia Lipopolysaccharides 3.9917637181 15821434 15328337
MESH:D004890 Erythema Mustard Gas 4.759357497
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 9.4420426865
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 9.4416530937
MESH:D004938 Esophageal Neoplasms Cisplatin 9.4417638652 15464296 16785472 15173087 16481741
MESH:D004938 Esophageal Neoplasms Zinc 9.4416543248
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 7.8311564622
MESH:D005124 Eye Abnormalities Tretinoin 7.839664655 16938888
MESH:D005234 Fatty Liver Carbon Tetrachloride 11.0761145 15959796 16239168 12631006 19224547 12795759 16045604 17595544
MESH:D005234 Fatty Liver Ethinyl Estradiol 11.0715345470
MESH:D005234 Fatty Liver Raloxifene 11.0717473493
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.0611858732
MESH:D005334 Fever Lipopolysaccharides 3.669205823 11852909
MESH:D005355 Fibrosis Carbon Tetrachloride 12.4718705752
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 12.4720067830
MESH:D005355 Fibrosis Tretinoin 12.4717994277
MESH:D005756 Gastritis Zinc 4.3817241300
MESH:D005909 Glioblastoma Tretinoin 2.7417312396
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.1810696789
MESH:D006130 Growth Disorders Zinc 3.7017217573
MESH:D006258 Head and Neck Neoplasms Cisplatin 6.9915102660 15464296
MESH:D006258 Head and Neck Neoplasms Tretinoin 6.9916096774
MESH:D034381 Hearing Loss Cisplatin 3.9619898482
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 4.7416084493
MESH:D006319 Hearing Loss, Sensorineural Cisplatin 4.0915464296
MESH:D006330 Heart Defects, Congenital 2,3,4,7,8-pentachlorodibenzofuran 28.3311294989
MESH:D006330 Heart Defects, Congenital 3,4,5,3',4'-pentachlorobiphenyl 28.3320471113 17686920
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 28.3320471113
MESH:D006330 Heart Defects, Congenital benzo(k)fluoranthene 28.3320471113
MESH:D006330 Heart Defects, Congenital polychlorodibenzo-4-dioxin 28.3311294989
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 28.3311294989 10048152
MESH:D006330 Heart Defects, Congenital Tretinoin 28.339664655 14991402
MESH:D006331 Heart Diseases Raloxifene 3.2511110106
MESH:D006333 Heart Failure Zinc 3.3617162251
MESH:D006335 Heart Injuries Zinc 5.3517074742
MESH:D016481 Helicobacter Infections Zinc 4.1617241300
MESH:D006463 Hemolytic-Uremic Syndrome Lipopolysaccharides 4.0316366002
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 2.9711000095
MESH:D006505 Hepatitis Carbon Tetrachloride 8.3319110552 19900420
MESH:D006505 Hepatitis Diazinon 8.3316487989
MESH:D006527 Hepatolenticular Degeneration Zinc 4.2917276780
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 2.5016120746 15340226 12621046
MESH:D006558 Herpes Genitalis Estradiol 4.6215709030
MESH:D006689 Hodgkin Disease Cisplatin 3.2616200630 16170182
MESH:D019584 Hot Flashes Estradiol 3.3417088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.6316959395 18606429 15340226 16354765 8697196
MESH:D006930 Hyperalgesia Alendronate 7.3116769263
MESH:D006930 Hyperalgesia Tretinoin 7.3116870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.1216899240
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.1716778211
MESH:D006973 Hypertension Raloxifene 4.6715787275 17577099
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 4.6718850075 18670907
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.6915338365
MESH:D007021 Hypospadias Ethinyl Estradiol 3.4116945680 16569931
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.0015869954
MESH:D007247 Infertility, Female Dieldrin 9.0510630421
MESH:D007247 Infertility, Female Ethinyl Estradiol 9.0512013081
MESH:D007248 Infertility, Male Diazinon 9.8212948887 16466525
MESH:D007248 Infertility, Male Ethinyl Estradiol 9.8217937319
MESH:D007248 Infertility, Male fulvestrant 9.8211514358
MESH:D007249 Inflammation Lipopolysaccharides 13.549205823 17237260 17963957 12878042 17255318
MESH:D007249 Inflammation Mustard Gas 13.548975870 11428647 17524151 11428631 11428620 16001271 9260866 9357497 11402378
MESH:D007249 Inflammation Progesterone 13.5415869954
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 13.5412878042 12200463
MESH:D007249 Inflammation Tobacco Smoke Pollution 13.5418590791
MESH:D007333 Insulin Resistance Estradiol 2.7016627594 16393666
MESH:D007410 Intestinal Diseases Tretinoin 3.3717994277
MESH:D019189 Iron Metabolism Disorders Lipopolysaccharides 4.2617255318
MESH:D007511 Ischemia Zinc 4.2316584753
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 8.7216580747
MESH:D007569 Jaw Abnormalities Tretinoin 8.7217551590 15992940
MESH:D007673 Kidney Cortex Necrosis Cisplatin 4.7315464296
MESH:D007674 Kidney Diseases Cisplatin 8.8519839026 15190930 18289764 12649298 12231392
MESH:D007674 Kidney Diseases Estradiol 8.8515618244
MESH:D007674 Kidney Diseases Zinc 8.8516960431
MESH:D007676 Kidney Failure, Chronic Zinc 4.0616518626
MESH:D007680 Kidney Neoplasms Estradiol 2.6615610895
MESH:D007683 Kidney Tubular Necrosis, Acute Calcium 10.5116316344
MESH:D007683 Kidney Tubular Necrosis, Acute Cisplatin 10.5111231351
MESH:D007889 Leiomyoma Raloxifene 4.1216973256
MESH:D007938 Leukemia Tretinoin 2.5617143497
MESH:D007948 Leukemia, Monocytic, Acute PD 98059 4.8216972261
MESH:D007951 Leukemia, Myeloid Tretinoin 3.3419285840 16482212 16932348
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.0017596541 16294345 19850784
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 2.8819225113 17712046 19029980 17294898 17301526 12679006 16766008 17649720 16935935 16823087 15748426 17107899 16331271 19075265 16140955 19642359 17339181 9834237 17368321 16788101 17217047 16891316 19035177 17361223 17506722
MESH:D007970 Leukopenia Lipopolysaccharides 4.2915821434
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.029224671
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.5816943688 11903743 11408273 21278145 16221502 17157831 16239168 17174718 17334410
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 6.1018251166 17805973 16033810 18054572 15123356 18412020 15893842 15338365 17900296 17714472 17766677 18472332 17640975 17869086 12667390 12632514 16027843 12898905 18156304 15818738 18429990 17557913 15052691 12389079 12958196 17481882 17631135 15673190 13678700 12649538 17525996 15925388 12586293 17761835 16192424 15730626 11481614 12546737 17721639 15931870 14724832 18277467 12609069 18472094 15876570 15370692 18263696 18395914 15650968 12445418 18376398 17922224 15362042 14512876 16097048 16638106 16011737 17708605 18395095 16248980 12741479 18006644 18418968 18210741 18279442 17698563 12445421 14748882 15996030 14620537 10355542 16136751 18205269 16015684 14716833 17565644 12632512 18705752 18187930 18481824 17976157 17944888 18339082 17823541 15959796 18317297 20821823 14716496 18420326 15057751 12666154 16116963 18166357
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 6.1014716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Lipopolysaccharides 6.1012878042
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 6.1012878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 6.1018397230 16248980
MESH:D008107 Liver Diseases Carbon Tetrachloride 4.0415830285 17285989 15720792 16246199 16964402
MESH:D008107 Liver Diseases Chlorpyrifos 4.0415991261
MESH:D017093 Liver Failure Carbon Tetrachloride 3.7715123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.3416899240 14706259
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 9.3520195826 21137059
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 9.3519294768
MESH:D008113 Liver Neoplasms Dieldrin 9.358742319 9539021
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 9.3516984957
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 4.9112014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 4.9112151625
MESH:D008171 Lung Diseases Mustard Gas 6.7018702808 18161513
MESH:D008171 Lung Diseases Ozone 6.7019066396 8266340
MESH:D055370 Lung Injury Lipopolysaccharides 7.9221114838
MESH:D055370 Lung Injury Ozone 7.9220417186
MESH:D008175 Lung Neoplasms marker/mechanism 20464547
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 11.9320464547 20135361 18816296 18520028 20064080 6695378 20869020 17053015 18569708
MESH:D008175 Lung Neoplasms Cisplatin 11.9311798837 6189445 17225452
MESH:D008175 Lung Neoplasms Mustard Gas 11.938781369 3148597
MESH:D008175 Lung Neoplasms Ozone 11.938597069 7614698
MESH:D008175 Lung Neoplasms Polycyclic Hydrocarbons, Aromatic 11.9310814675
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 11.9319555203 11884234
MESH:D008175 Lung Neoplasms Tobacco Smoke Pollution 11.9316288123 12111688 11091918 3440675
MESH:D008175 Lung Neoplasms vanadium pentoxide 11.9312376484
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 8.5311807958 16891317 11408345 17203775
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 8.5317203775 11408345
MESH:D008325 Mammary Neoplasms, Experimental Zinc 8.5312773700
MESH:D020149 Manganese Poisoning Estradiol 4.0719453300
MESH:D008527 Medulloblastoma Tretinoin 2.6217453147
MESH:D008545 Melanoma Cisplatin 3.2412393984 16432458 18176117 15577323 11135225 16248763 12374674 17023156 12883367 16809738 18332650 18505091 17761969
MESH:D008545 Melanoma Tretinoin 3.2416752155
MESH:D018328 Melanoma, Amelanotic Cisplatin 4.3715990972
MESH:D008591 Meningomyelocele Tretinoin 4.0316940565
MESH:D008654 Mesothelioma Cisplatin 3.0817638057
MESH:D008679 Metaplasia Ozone 4.6910496685
MESH:D018200 Mixed Tumor, Mullerian Raloxifene 5.1415863610
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 7.7616381670
MESH:D009062 Mouth Neoplasms Tobacco Smoke Pollution 7.7615006635
MESH:D052016 Mucositis irinotecan 4.6017159606
MESH:D009101 Multiple Myeloma Raloxifene 3.1516497877
OMIM:612961 MULTIPLE SYNOSTOSES SYNDROME 3 marker/mechanism
MESH:D009190 Myelodysplastic Syndromes Tretinoin 2.8417596541
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.7012213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 2.9716810080
MESH:D009205 Myocarditis Particulate Matter 5.5512563109
MESH:D009232 Myxoma Raloxifene 5.1416343187
MESH:D009362 Neoplasm Metastasis irinotecan 3.0018259882
MESH:D009369 Neoplasms Benzo(a)pyrene 10.1911141357
MESH:D009369 Neoplasms Cisplatin 10.1916773208
MESH:D009369 Neoplasms Dieldrin 10.198820588
MESH:D009369 Neoplasms Tretinoin 10.1916946489 16594593
MESH:D009389 Neovascularization, Pathologic Estradiol 3.3317289903
MESH:D009395 Nephritis, Interstitial Cisplatin 4.0815464296
MESH:D009421 Nervous System Malformations Estradiol 14.1011399458 16427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 14.1014600291
MESH:D009421 Nervous System Malformations Tretinoin 14.109125849
MESH:D009436 Neural Tube Defects Tretinoin 2.799142499
MESH:D009447 Neuroblastoma Cisplatin 6.508761367
MESH:D009447 Neuroblastoma irinotecan 6.508761367
MESH:D017599 Neuroectodermal Tumors Cisplatin 10.118761367
MESH:D017599 Neuroectodermal Tumors irinotecan 10.118761367
MESH:D020258 Neurotoxicity Syndromes Chlorpyrifos 3.8915081274
MESH:D009503 Neutropenia Mustard Gas 3.607688884 16761898
MESH:D010024 Osteoporosis Alendronate 10.6917882678
MESH:D010024 Osteoporosis Calcium 10.6917882678
MESH:D010024 Osteoporosis Raloxifene 10.6919059307 17882678 15775268
MESH:D015663 Osteoporosis, Postmenopausal Raloxifene 3.8517823083 15579764 17893378 15758505
MESH:D010051 Ovarian Neoplasms Cisplatin 10.1419769630 6897625 15464296 17225452
MESH:D010051 Ovarian Neoplasms Estradiol 10.1419401270
MESH:D010051 Ovarian Neoplasms Progesterone 10.1416525653 17393432
MESH:D010051 Ovarian Neoplasms Tretinoin 10.1416936753
MESH:D010146 Pain Tretinoin 2.5916870215
MESH:D010190 Pancreatic Neoplasms Cisplatin 4.9319003803
MESH:D010190 Pancreatic Neoplasms Tretinoin 4.9315976015
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.3111578682
MESH:D010300 Parkinson Disease Dieldrin 3.3716112328 17291500 16809432 11181820 11445065
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.8312520081
MESH:D010523 Peripheral Nervous System Diseases Cisplatin 3.9215464296
MESH:D010538 Peritonitis Ozone 3.7416369182
MESH:D010997 Pleural Neoplasms Cisplatin 4.9317638057
MESH:D011014 Pneumonia Lipopolysaccharides 9.7511605937 12224865
MESH:D011014 Pneumonia Ozone 9.7518929643 18381685 18007984
MESH:D011041 Poisoning Diazinon 7.7817603234
MESH:D011041 Poisoning Mustard Gas 7.7815727166
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.1718163543
MESH:D011225 Pre-Eclampsia Zinc 3.8617114810
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 2.7911896295 11399792 11118676 11222880
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.5220887781
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.1917292933
MESH:D011471 Prostatic Neoplasms Estradiol 2.1916740699
MESH:D011471 Prostatic Neoplasms Raloxifene 2.1916536755 16220300 15731164
MESH:D011471 Prostatic Neoplasms Zinc 2.1916517595 16700911 12429649 16606632
MESH:D011507 Proteinuria Tretinoin 3.2316636307
MESH:D011537 Pruritus Ethinyl Estradiol 8.1715861022 16919318
MESH:D011537 Pruritus Mustard Gas 8.1718058305
MESH:D011625 Pterygium Tretinoin 4.3816723453
MESH:D011658 Pulmonary Fibrosis Mustard Gas 5.7810334151 17894541 17720292 17266442 17620002
MESH:D011658 Pulmonary Fibrosis Particulate Matter 5.7812475806
MESH:D011693 Purpura Raloxifene 5.1415770314
MESH:D051437 Renal Insufficiency Cisplatin 4.0115464296
MESH:D012130 Respiratory Hypersensitivity Lipopolysaccharides 3.4610835634
MESH:D012135 Respiratory Sounds Chlorpyrifos 8.8316611668 11874814 17119214
MESH:D012135 Respiratory Sounds Tobacco Smoke Pollution 8.8318410779
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.4518990726
MESH:D012140 Respiratory Tract Diseases Chlorpyrifos 4.4816611668 17119214
MESH:D012162 Retinal Degeneration Zinc 3.8216584753
MESH:D012208 Rhabdomyosarcoma Tretinoin 3.7316283617 16116481
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.7018045962
MESH:D012512 Sarcoma, Ewing's Cisplatin 4.0414601052
MESH:D012729 Sex Chromosome Aberrations Chlorpyrifos 5.676418539
MESH:D012871 Skin Diseases Mustard Gas 2.6015451306 16961503 12880345
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 11.9219755658 10029692
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 11.9216192470
MESH:D012878 Skin Neoplasms Tobacco Smoke Pollution 11.9218590791
MESH:D012878 Skin Neoplasms Tretinoin 11.9216467112
MESH:D055752 Small Cell Lung Carcinoma Cisplatin 4.9315464296
MESH:D013088 Spermatocele Ethinyl Estradiol 3.5316709447
MESH:D013119 Spinal Cord Injuries Progesterone 3.8715862959 16503802
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 4.362093021 20155912
MESH:D013274 Stomach Neoplasms Cisplatin 4.3615958060 17522103 18396642
MESH:D013274 Stomach Neoplasms irinotecan 4.3615723263
MESH:D013274 Stomach Neoplasms Tretinoin 4.3617261132
MESH:D020521 Stroke Raloxifene 3.5016837676
MESH:D013736 Testicular Neoplasms Cisplatin 4.2615464296 17225452
MESH:D013921 Thrombocytopenia Lipopolysaccharides 3.8115821434
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.2511994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.8115669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.4912697716
MESH:D013964 Thyroid Neoplasms Tretinoin 2.7216026305 17045167
MESH:D013978 Tibial Fractures Estradiol 12.3319048282
MESH:D013978 Tibial Fractures Raloxifene 12.3319048282
MESH:D014062 Tongue Neoplasms Tretinoin 8.8116051514
MESH:D014062 Tongue Neoplasms Zinc 8.8116543248
MESH:D014376 Tuberculosis Tretinoin 2.9716040207
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 14.0217053015
MESH:D001749 Urinary Bladder Neoplasms Cacodylic Acid 14.0215537745
MESH:D001749 Urinary Bladder Neoplasms Cisplatin 14.0212973940 15464296 17225452
MESH:D001749 Urinary Bladder Neoplasms Raloxifene 14.0217572228
MESH:D001749 Urinary Bladder Neoplasms Tobacco Smoke Pollution 14.0212846360
MESH:D014570 Urologic Diseases Diazinon 4.8616487989
MESH:D002583 Uterine Cervical Neoplasms Cisplatin 8.4016803524
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 8.4016129372
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 2.9214692618
MESH:D014604 Uveal Neoplasms Tretinoin 4.2016752155
MESH:D014625 Vaginal Neoplasms Cisplatin 4.2115577323
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.1812125929
MESH:D054556 Venous Thromboembolism Raloxifene 4.7916837676
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.1814671159 15869587
MESH:D014820 Vitiligo Tretinoin 3.6716761959
MESH:D014839 Vomiting Cisplatin 4.3011897121
MESH:D014846 Vulvar Neoplasms Raloxifene 5.1416343187
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.8315886252
MESH:D009396 Wilms Tumor Tretinoin 3.6316287080
MESH:D014947 Wounds and Injuries Estrogens 4.4111172683
Pathway ID Pathway Name
KEGG:04010 MAPK signaling pathway
KEGG:05218 Melanoma
KEGG:05200 Pathways in cancer
KEGG:04810 Regulation of actin cytoskeleton
REACT:9470 Signaling by FGFR
REACT:498 Signaling by Insulin receptor
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA28126
    • Releated gene ID Related gene Name
    PA293PTGS2
    Releated disease ID Related disease Name
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    Releated drug ID Related drug Name
    PA450626nicotine
    PA450379mercaptopurine
    PA450428methotrexate
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB03965 - Fucose
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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