AutismKB 2.0

Annotation Detail for FGF12


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Basic Information Top
Gene Symbol:FGF12 ( FGF12B,FHF1 )
Gene Full Name: fibroblast growth factor 12
Band: 3q28-q29
Quick LinksEntrez ID:2257; OMIM: 601513; Uniprot ID:FGF12_HUMAN; ENSEMBL ID: ENSG00000114279; HGNC ID: 3668
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04010MAPK signaling pathway
hsa04810Regulation of actin cytoskeleton
hsa05218Melanoma
hsa05200Pathways in cancer
No data
No data
Pathway IDPathway Name
P00021FGF signaling pathway
No data
Related Diseases/Disorders Top
No data
No data
Desease Name
METABOLIC
serum metabolites
Desease Name
Serum metabolites
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000643 Ammonium Chloride Ammonium Chloride affects the expression of FGF12 mRNAaffects expression 16483693
D002251 Carbon Tetrachloride Carbon Tetrachloride results in decreased expression of FGF12 mRNAdecreases expression 17484886
D003976 Diazinon Diazinon affects the expression of FGF12 mRNAaffects expression 19130878
D004026 Dieldrin Dieldrin results in decreased expression of FGF12 mRNAdecreases expression 19130878
C011890 kojic acid kojic acid results in increased expression of FGF12 mRNAincreases expression 16595896
D009151 Mustard Gas Mustard Gas results in decreased expression of FGF12 mRNAdecreases expression 15674843
D010656 Phenylephrine Phenylephrine results in increased expression of FGF12 mRNAincreases expression 18158353
D014212 Tretinoin Tretinoin results in decreased expression of FGF12 mRNAdecreases expression 17045167
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 3.9018287403
MESH:D000382 Agricultural Workers' Diseases Diazinon 4.6716487989
MESH:D000505 Alopecia Tretinoin 3.8115955085
MESH:D001145 Arrhythmias, Cardiac Phenylephrine 4.3417460149
MESH:D001169 Arthritis, Experimental Tretinoin 3.2116412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.3116292516
MESH:D001249 Asthma Mustard Gas 5.1910378619
MESH:D001249 Asthma Tretinoin 5.1916456186
MESH:D001471 Barrett Esophagus Tretinoin 4.6816935849
MESH:D001768 Blister Mustard Gas 5.5019167455
MESH:D001778 Blood Coagulation Disorders Tretinoin 3.8516206674 16197459
MESH:D001919 Bradycardia Phenylephrine 4.8815306635
MESH:D001943 Breast Neoplasms Dieldrin 2.5611859874 15770527
MESH:D001943 Breast Neoplasms Tretinoin 2.5616443354 16873071 16166294
MESH:D001989 Bronchiolitis Obliterans Mustard Gas 5.5015286001
MESH:D029481 Bronchitis, Chronic Mustard Gas 5.3517687719 10378619
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.9316813970
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 4.083786805 18705752 16050911 10355542 16227642 16192424 15673190 16011737 16097048 16124888 15700767 15721981
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.5416168501
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 3.1318788625
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 3.131917145
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 2.3416096774 16051514
MESH:D006332 Cardiomegaly Phenylephrine 3.6511754973 16170337 17124262 17287366 15728586 11179087
MESH:D002386 Cataract Tretinoin 3.2217460283
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.9316129372
MESH:D002822 Choriocarcinoma Tretinoin 5.5416461808
MESH:D002972 Cleft Palate Tretinoin 2.759407595
MESH:D003092 Colitis Tretinoin 4.0117035595
MESH:D019465 Craniofacial Abnormalities Tretinoin 1.8316925845 9211117 17551590 14991402 10589399 9142499 9125849 9664655 9224671 8800419
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 2.0915998439 9327722 6623471 15968718 4309450 21278145 11566570 16177239 17522070 10915739 10092053 7440962 6884620 16227642 3786805 2869522 19336974 19085960 3732212 7120509 7179309 15027814
MESH:D004417 Dyspnea Diazinon 5.1816487989
MESH:D004487 Edema Mustard Gas 3.5511428647 9260866 11402378 11428631
MESH:D004489 Edema, Cardiac Tretinoin 4.8418230668
MESH:D016889 Endometrial Neoplasms Tretinoin 3.2516569247
MESH:D004890 Erythema Mustard Gas 5.509357497
MESH:D005124 Eye Abnormalities Tretinoin 3.7516938888 9664655
MESH:D005234 Fatty Liver Carbon Tetrachloride 3.4119224547 12795759 17595544 15959796 16239168 16045604 61145 12631006
MESH:D005355 Fibrosis Carbon Tetrachloride 9.8418705752
MESH:D005355 Fibrosis Tretinoin 9.8417994277
MESH:D005909 Glioblastoma Tretinoin 3.1517312396
MESH:D006258 Head and Neck Neoplasms Tretinoin 3.3416096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.5416084493
MESH:D006330 Heart Defects, Congenital Tretinoin 3.0114991402 9664655
MESH:D006505 Hepatitis Carbon Tetrachloride 10.5719900420 19110552
MESH:D006505 Hepatitis Diazinon 10.5716487989
MESH:D006930 Hyperalgesia Tretinoin 3.4016870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.8716899240
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.8816778211
MESH:D006973 Hypertension Phenylephrine 3.158949925 12717712
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.3915338365
MESH:D006984 Hypertrophy Phenylephrine 4.8018502941 12791704
MESH:D007247 Infertility, Female Dieldrin 5.2010630421
MESH:D007248 Infertility, Male Diazinon 3.9712948887 16466525
MESH:D007249 Inflammation Mustard Gas 2.8916001271 11428620 9357497 9260866 11428647 8975870 11402378 17524151 11428631
MESH:D007410 Intestinal Diseases Tretinoin 4.0717994277
MESH:D007569 Jaw Abnormalities Tretinoin 4.1417551590 15992940
MESH:D007938 Leukemia Tretinoin 2.8717143497
MESH:D007951 Leukemia, Myeloid Tretinoin 3.9419285840 16932348 16482212
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.1116294345 17596541 19850784
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.3016331271 17649720 17368321 17294898 17506722 16823087 17217047 16788101 19225113 17361223 16140955 16891316 19029980 19035177 16766008 17107899 12679006 17339181 15748426 19642359 16935935 17712046 17301526 9834237 19075265
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.479224671
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.9211408273 17174718 16943688 17334410 21278145 17157831 16239168 16221502 11903743
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 2.5517761835 18277467 12586293 18472094 15673190 18251166 15996030 15931870 15730626 16248980 12958196 18210741 12632514 16015684 17708605 15925388 12741479 16638106 18339082 14620537 17698563 12445418 18263696 18006644 18418968 12898905 15370692 17557913 16097048 17805973 16027843 17714472 12445421 15338365 17721639 18412020 14716833 14748882 14512876 16136751 12666154 15818738 18187930 17869086 12667390 18472332 17631135 18376398 10355542 12546737 12632512 17481882 15123356 12649538 15959796 18054572 15362042 18395914 14716496 17922224 18317297 18205269 15650968 18420326 15057751 17823541 17900296 16033810 18481824 18166357 16116963 18156304 15876570 17976157 15893842 18705752 18279442 17640975 15052691 17766677 17525996 17565644 12609069 16192424 17944888 18429990 14724832 13678700 20821823 16011737 18395095 11481614 12389079
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 2.5516248980 18397230
MESH:D008107 Liver Diseases Carbon Tetrachloride 2.1315720792 16964402 17285989 16246199 15830285
MESH:D017093 Liver Failure Carbon Tetrachloride 4.4715123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.9216899240 14706259
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 5.2519294768
MESH:D008113 Liver Neoplasms Dieldrin 5.258742319 9539021
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 6.6812014681 15583823
MESH:D008114 Liver Neoplasms, Experimental kojic acid 6.6818544905
MESH:D008171 Lung Diseases Mustard Gas 3.6018702808 18161513
MESH:D008175 Lung Neoplasms Mustard Gas 2.178781369 3148597
MESH:D008527 Medulloblastoma Tretinoin 2.8617453147
MESH:D008545 Melanoma Tretinoin 1.9716752155
MESH:D008591 Meningomyelocele Tretinoin 4.7316940565
MESH:D009190 Myelodysplastic Syndromes Tretinoin 3.2017596541
MESH:D009369 Neoplasms Dieldrin 5.828820588
MESH:D009369 Neoplasms Tretinoin 5.8216946489 16594593
MESH:D009421 Nervous System Malformations Tretinoin 4.069125849
MESH:D009436 Neural Tube Defects Tretinoin 3.209142499
MESH:D009503 Neutropenia Mustard Gas 4.237688884 16761898
MESH:D010051 Ovarian Neoplasms Tretinoin 2.4016936753
MESH:D010146 Pain Tretinoin 3.1016870215
MESH:D010190 Pancreatic Neoplasms Tretinoin 2.5315976015
MESH:D010300 Parkinson Disease Dieldrin 3.6016809432 11445065 16112328 11181820 17291500
MESH:D011041 Poisoning Diazinon 9.9017603234
MESH:D011041 Poisoning Mustard Gas 9.9015727166
MESH:D011507 Proteinuria Tretinoin 3.8616636307
MESH:D011537 Pruritus Mustard Gas 4.4318058305
MESH:D011625 Pterygium Tretinoin 5.1316723453
MESH:D011658 Pulmonary Fibrosis Mustard Gas 3.0017620002 17266442 17720292 17894541 10334151
MESH:D012208 Rhabdomyosarcoma Tretinoin 4.3616116481 16283617
MESH:D012852 Sinusitis Phenylephrine 5.047327846
MESH:D012871 Skin Diseases Mustard Gas 2.7615451306 12880345 16961503
MESH:D012878 Skin Neoplasms Tretinoin 2.7016467112
MESH:D013274 Stomach Neoplasms Tretinoin 1.8017261132
MESH:D013964 Thyroid Neoplasms Tretinoin 3.2116026305 17045167
MESH:D014062 Tongue Neoplasms Tretinoin 4.0216051514
MESH:D014376 Tuberculosis Tretinoin 3.3616040207
MESH:D014570 Urologic Diseases Diazinon 5.6516487989
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 3.9016129372
MESH:D014604 Uveal Neoplasms Tretinoin 4.9916752155
MESH:D014820 Vitiligo Tretinoin 4.3416761959
MESH:D009396 Wilms Tumor Tretinoin 4.1816287080
Pathway ID Pathway Name
KEGG:04010 MAPK signaling pathway
KEGG:05218 Melanoma
KEGG:05200 Pathways in cancer
KEGG:04810 Regulation of actin cytoskeleton
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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