AutismKB 2.0

Annotation Detail for FGF13


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:FGF13 ( FGF2,FHF-2,FHF2 )
Gene Full Name: fibroblast growth factor 13
Band: Xq26.3-q27.1
Quick LinksEntrez ID:2258; OMIM: 300070; Uniprot ID:FGF13_HUMAN; ENSEMBL ID: ENSG00000129682; HGNC ID: 3670
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04010MAPK signaling pathway
hsa04810Regulation of actin cytoskeleton
hsa05218Melanoma
hsa05200Pathways in cancer
No data
No data
Pathway IDPathway Name
P00021FGF signaling pathway
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of FGF13 proteinaffects expression 20106945
D005680 gamma-Aminobutyric Acid FGF13 protein results in increased uptake of gamma-Aminobutyric Acidincreases uptake 9751161
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of FGF13 mRNAdecreases expression 20106945
20064835
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of FGF13 mRNAincreases expression 20127859
C053541 bicalutamide bicalutamide results in increased expression of FGF13 mRNAincreases expression 15638997
D016572 Cyclosporine Cyclosporine results in increased expression of FGF13 mRNAincreases expression 20106945
D004958 Estradiol [Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of FGF13 mRNAaffects cotreatment|increases expression 19619570
D004958 Estradiol Estradiol results in increased expression of FGF13 mRNAincreases expression 19619570
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of FGF13 mRNAincreases expression 17557909
C533894 LG 100815 LG 100815 results in increased expression of FGF13 mRNAincreases expression 16951191
C014707 nitrosobenzylmethylamine nitrosobenzylmethylamine results in increased expression of FGF13 mRNAincreases expression 17616710
C062198 octa-2,4,6-trienoic acid octa-2,4,6-trienoic acid results in increased expression of FGF13 mRNAincreases expression 16951191
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of FGF13 mRNAaffects binding|decreases expression|increases activity 19710929
D012964 Sodium FGF13 protein promotes the reaction [SCN8A protein affects the transport of Sodium]affects transport|increases reaction 15282281
D013749 Tetrachlorodibenzodioxin [Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of FGF13 mRNAaffects cotreatment|increases expression 19619570
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of FGF13 mRNAincreases expression 19619570
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.9614514962 15322242 11752688
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.0817505938
MESH:D055371 Acute Lung Injury pirinixic acid 3.2018653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 7.1220127859 20464547
MESH:D000230 Adenocarcinoma Estradiol 7.1211473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 7.1214692618
MESH:D000236 Adenoma Benzo(a)pyrene 2.706695378
MESH:D018248 Adenoma, Liver Cell pirinixic acid 10.3016434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 10.3016835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.0211748828
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.1819183758
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.5711256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.7115885639
MESH:D001778 Blood Coagulation Disorders pirinixic acid 9.0419483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 9.0412125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.9215340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8115746008
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.7917474063 20146248
MESH:D001943 Breast Neoplasms Estradiol 1.7917261762 12948864 19861407 17289903 14630087 16675129 18497071 17018787
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.7920435547
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.5816111702
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.8616835633
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 3.0712619106 21507988 12907637
MESH:D006528 Carcinoma, Hepatocellular Estradiol 3.0716924424
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.0720419170
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4118850075 18670907 16120746
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 6.7612371664
MESH:D002471 Cell Transformation, Neoplastic Estradiol 6.7618566989
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.2316835633
MESH:D002779 Cholestasis Cyclosporine 13.7019486331
MESH:D002779 Cholestasis Ethinyl Estradiol 13.7016919318 17110522 16105132 17333356 17681005 11677210 15861022
MESH:D002779 Cholestasis pirinixic acid 13.7019176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1315668235 8697196 12621046 15340226 16354765
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1314669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2610048152 15322242 20055451
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4618249437
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6817107852
MESH:D003928 Diabetic Nephropathies Estradiol 3.4819279558
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 1.5520420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8211462148
MESH:D004487 Edema pirinixic acid 6.8112083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.8111000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.0418230668 15322242 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.2812538720
MESH:D016889 Endometrial Neoplasms Estradiol 3.0311473722 19148513 18566989
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.109294722 10568697
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.6716530937
MESH:D004938 Esophageal Neoplasms nitrosobenzylmethylamine 4.6716510608 15623463 15547733 16704527 15264214 15150132 16805852 15547721 15878914
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0711564622
MESH:D005234 Fatty Liver Cyclosporine 13.4819224547
MESH:D005234 Fatty Liver Ethinyl Estradiol 13.4815345470
MESH:D005234 Fatty Liver pirinixic acid 13.4819236843 20131406
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.5611858732
MESH:D005355 Fibrosis Cyclosporine 8.8312639820 12168785
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 8.8320067830
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.348708960
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.7310696789
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.5820471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.5810048152 11294989
MESH:D006333 Heart Failure pirinixic acid 2.5820558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.5415720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.4211000095
MESH:D006529 Hepatomegaly pirinixic acid 8.6119176532 18467677 19772884 16221962
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 8.6112621046 15340226 16120746
MESH:D006558 Herpes Genitalis Estradiol 5.1715709030
MESH:D019584 Hot Flashes Estradiol 3.8917088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.1815340226 16959395 8697196 18606429 16354765
MESH:D006943 Hyperglycemia pirinixic acid 3.2620558911
MESH:D006973 Hypertension Cyclosporine 5.0410903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.0418670907 18850075
MESH:D007021 Hypospadias Ethinyl Estradiol 3.9116945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.5512013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.5417937319
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.8912878042 12200463
MESH:D007333 Insulin Resistance Estradiol 7.3716627594 16393666
MESH:D007333 Insulin Resistance pirinixic acid 7.3716306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.4216580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.5815604871
MESH:D007674 Kidney Diseases Cyclosporine 6.088314463 10903974 18776723
MESH:D007674 Kidney Diseases Estradiol 6.0815618244
MESH:D007680 Kidney Neoplasms Cyclosporine 7.5012371664
MESH:D007680 Kidney Neoplasms Estradiol 7.5015610895
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 3.4214659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.4215474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.4212878042
MESH:D008113 Liver Neoplasms Aflatoxin B1 10.919163691 15890375 2125692 18177683
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 10.9120195826 21137059
MESH:D008113 Liver Neoplasms pirinixic acid 10.9120007298 16377806 15890375
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 10.9116984957
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 5.978603461
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 5.9712151625
MESH:D008175 Lung Neoplasms Aflatoxin B1 3.4114755239
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 3.4118569708 20869020 20464547 20064080 20135361 17053015 18816296 18520028 6695378
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.4111884234 19555203
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 2.6111807958 16891317 11408345 17203775
MESH:D020149 Manganese Poisoning Estradiol 4.6219453300
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.9216801185
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.2516381670
MESH:D009135 Muscular Diseases pirinixic acid 3.6116239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.1719151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.0812213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 8.4616810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 8.4616411023
MESH:D009369 Neoplasms Benzo(a)pyrene 4.9511141357
MESH:D009369 Neoplasms pirinixic acid 4.9517405874
MESH:D009389 Neovascularization, Pathologic Estradiol 3.8517289903
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.5817954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.3618481113 19348381
MESH:D009421 Nervous System Malformations Estradiol 9.7816427766 11399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 9.7814600291
MESH:D009765 Obesity pirinixic acid 1.8320558911
MESH:D010051 Ovarian Neoplasms Estradiol 2.2419401270
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.7711578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.3812520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.6518163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.2912371664
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.3111896295 11118676 11399792 11222880
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.9720887781
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.6417292933
MESH:D011471 Prostatic Neoplasms bicalutamide 2.6417914592 19240160 19011039 18487222 15638997
MESH:D011471 Prostatic Neoplasms Estradiol 2.6416740699
MESH:D011537 Pruritus Ethinyl Estradiol 3.4315861022 16919318
MESH:D011565 Psoriasis Cyclosporine 2.2516882103
MESH:D015427 Reperfusion Injury pirinixic acid 2.4219058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.9318990726
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 5.5919755658 10029692
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.5916192470
MESH:D013088 Spermatocele Ethinyl Estradiol 4.0816709447
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 2.562093021 20155912
MESH:D013274 Stomach Neoplasms nitrosobenzylmethylamine 2.5617575124 12958204
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.7111994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.2215669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.0412697716
MESH:D013978 Tibial Fractures Estradiol 4.8219048282
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 2.2017053015
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.3914692618
MESH:D014605 Uveitis Cyclosporine 4.121336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.7312125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.6214671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.3815886252
MESH:D014985 Xerophthalmia Cyclosporine 4.5817120751
Pathway ID Pathway Name
KEGG:04010 MAPK signaling pathway
KEGG:05218 Melanoma
KEGG:05200 Pathways in cancer
KEGG:04810 Regulation of actin cytoskeleton
Pharmacogenomics Knowledge Base Top
Drug Bank Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved