AutismKB 2.0

Annotation Detail for ALDOA


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Basic Information Top
Gene Symbol:ALDOA ( ALDA,GSD12,MGC10942,MGC17716,MGC17767 )
Gene Full Name: aldolase A, fructose-bisphosphate
Band: 16p11.2
Quick LinksEntrez ID:226; OMIM: 103850; Uniprot ID:ALDOA_HUMAN; ENSEMBL ID: ENSG00000149925; HGNC ID: 414
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Pathway IDPathway Name
GLYCOLYSISglycolysis I
PWY66-373sucrose degradation
PWY-5484glycolysis II
GLUCONEO-PWYgluconeogenesis I
ANAGLYCOLYSIS-PWYglycolysis III
Pathway IDPathway Name
hsa00010Glycolysis / Gluconeogenesis
hsa00030Pentose phosphate pathway
hsa01100Metabolic pathways
hsa00051Fructose and mannose metabolism
Pathway IDPathway Name
Metabolism of carbohydrates
Hemostasis
Pathway IDPathway Name
200172HIF-1-alpha transcription factor network
Pathway IDPathway Name
P00024Glycolysis
P02744Fructose galactose metabolism
No data
Related Diseases/Disorders Top
No data
No data
No data
No data
Desease Name
Glycogen storage disease XII
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of ALDOA mRNAaffects expression 21346803
C035207 4-amino-2,6-dinitrotoluene 4-amino-2,6-dinitrotoluene affects the expression of ALDOA mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of ALDOA mRNAaffects expression 17562736
D000082 Acetaminophen Acetaminophen results in increased expression of ALDOA proteinincreases expression 15800402
D000643 Ammonium Chloride Ammonium Chloride affects the expression of ALDOA mRNAaffects expression 16483693
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of ALDOA proteinincreases expression 17292933
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of ALDOA mRNAdecreases expression 20440473
C095105 bexarotene bexarotene results in increased expression of ALDOA mRNAincreases expression 16648578
C006780 bisphenol A bisphenol A results in decreased expression of ALDOA mRNAdecreases expression 18180321
D019328 Buthionine Sulfoximine Buthionine Sulfoximine results in increased expression of ALDOA mRNAincreases expression 11841787
D019328 Buthionine Sulfoximine Buthionine Sulfoximine results in increased expression of ALDOA proteinincreases expression 11841787
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in increased expression of ALDOA mRNAincreases expression 15003993
D002251 Carbon Tetrachloride Carbon Tetrachloride results in increased expression of ALDOA mRNAincreases expression 17522070
C099555 CD 437 CD 437 results in decreased expression of ALDOA mRNAdecreases expression 12958071
D002509 Cephaloridine Cephaloridine affects the expression of ALDOA mRNAaffects expression 18172885
D002725 Chloroform Chloroform results in increased expression of ALDOA mRNAincreases expression 17522070
D002995 Clofibric Acid [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of ALDOA mRNAaffects cotreatment|affects expression 17602206
D003024 Clozapine Clozapine results in increased expression of ALDOA mRNAincreases expression 15860345
D003474 Curcumin Curcumin results in decreased expression of ALDOA mRNAdecreases expression 16880289
D003907 Dexamethasone Dexamethasone results in increased expression of ALDOA mRNAincreases expression 17522070
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of ALDOA mRNAaffects cotreatment|affects expression 17602206
D004052 Diethylnitrosamine Diethylnitrosamine results in increased expression of ALDOA mRNAincreases expression 19638242
D004054 Diethylstilbestrol Diethylstilbestrol results in increased expression of ALDOA mRNAincreases expression 15289156
D004958 Estradiol Estradiol results in increased expression of ALDOA mRNAincreases expression 15289156
D004958 Estradiol Estradiol results in increased expression of ALDOA mRNAincreases expression 17522070
D000431 Ethanol Ethanol results in increased expression of ALDOA mRNAincreases expression 15513904
D000431 Ethanol Ethanol results in increased expression of ALDOA mRNAincreases expression 17920746
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of ALDOA mRNAdecreases expression 16954407
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of ALDOA mRNAincreases expression 19400957
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ALDOA mRNAaffects cotreatment|increases expression 17942748
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of ALDOA mRNAincreases expression 17557909
19400957
D005485 Flutamide Flutamide results in increased expression of ALDOA mRNAincreases expression 17702527
C056933 fumonisin B1 fumonisin B1 results in increased expression of ALDOA mRNAincreases expression 16221962
D019833 Genistein Genistein results in increased expression of ALDOA mRNAincreases expression 15289156
D006220 Haloperidol Haloperidol results in increased expression of ALDOA mRNAincreases expression 15860345
D007657 Ketone Bodies Ketone Bodies results in increased expression of ALDOA mRNAincreases expression 15469884
D008701 Methapyrilene Methapyrilene results in increased expression of ALDOA mRNAincreases expression 16393664
D015741 Metribolone Metribolone results in increased expression of ALDOA mRNAincreases expression 17010196
D009151 Mustard Gas Mustard Gas affects the expression of ALDOA mRNAaffects expression 15651846
D015058 1-Naphthylisothiocyanate 1-Naphthylisothiocyanate results in increased expression of ALDOA mRNAincreases expression 17522070
C022838 nickel chloride nickel chloride results in increased expression of ALDOA mRNAincreases expression 12839937
D009582 Nitrofurantoin Nitrofurantoin results in increased expression of ALDOA mRNAincreases expression 11841787
D009582 Nitrofurantoin Nitrofurantoin results in increased expression of ALDOA proteinincreases expression 11841787
D010665 Phenylpropanolamine Phenylpropanolamine results in decreased expression of ALDOA mRNAdecreases expression 16465460
C018637 phorone phorone results in increased expression of ALDOA mRNAincreases expression 11841787
C018637 phorone phorone results in increased expression of ALDOA proteinincreases expression 11841787
C006253 pirinixic acid pirinixic acid results in increased expression of ALDOA mRNAincreases expression 18301758
16221962
C031280 pyrazole pyrazole results in increased expression of ALDOA mRNAincreases expression 17945193
C030984 pyrene pyrene results in decreased expression of ALDOA mRNAdecreases expression 15963578
D011794 Quercetin Quercetin results in increased expression of ALDOA proteinincreases expression 17292933
D011794 Quercetin Quercetin results in decreased expression of ALDOA proteindecreases expression 18095365
D011802 Quinidine Quinidine results in increased expression of ALDOA mRNAincreases expression 17522070
D012643 Selenium Selenium results in increased expression of ALDOA mRNAincreases expression 19244175
C009277 sodium arsenate sodium arsenate results in increased expression of ALDOA mRNAincreases expression 16882884
C017947 sodium arsenite sodium arsenite results in increased expression of ALDOA proteinincreases expression 15899475
D013629 Tamoxifen Tamoxifen results in increased expression of ALDOA mRNAincreases expression 19400957
D013629 Tamoxifen Tamoxifen results in increased expression of ALDOA mRNAincreases expression 19400957
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ALDOA mRNAaffects cotreatment|increases expression 17942748
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of ALDOA mRNAdecreases expression 15667827
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of ALDOA mRNAincreases expression 16267337
D013752 Tetracycline Tetracycline results in increased expression of ALDOA mRNAincreases expression 17522070
D014810 Vitamin E Vitamin E results in increased expression of ALDOA mRNAincreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.0414745880
MESH:D000014 Abnormalities, Drug-Induced 4-amino-2,6-dinitrotoluene 11.467525203
MESH:D000014 Abnormalities, Drug-Induced Ethanol 11.4618926900 17676605
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 11.4611752688 14514962 15322242
MESH:D000138 Acidosis Ammonium Chloride 8.8218287403
MESH:D000138 Acidosis Ethanol 8.8211192467
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.4317505938
MESH:D055371 Acute Lung Injury pirinixic acid 2.6618653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 8.8920127859 20464547
MESH:D000230 Adenocarcinoma Estradiol 8.8911473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 8.8914692618
MESH:D000230 Adenocarcinoma Genistein 8.8911473722
MESH:D000236 Adenoma Benzo(a)pyrene 5.626695378
MESH:D000236 Adenoma Diethylnitrosamine 5.6210737359 6695378
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 14.4017620307 19052882 17162532 19061943 18056438 16434500
MESH:D018248 Adenoma, Liver Cell pirinixic acid 14.4016434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 14.4016835633
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.1915276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 4.3916712894 17306315
MESH:D000380 Agranulocytosis Clozapine 4.5714617031 12649775 16160616
MESH:D020268 Alcohol-Induced Disorders, Nervous System Ethanol 4.8115451040 15451039
MESH:D019973 Alcohol-Related Disorders Curcumin 4.5717887948
MESH:D000544 Alzheimer Disease Curcumin 2.5015590663
MESH:D000686 Amyloidosis Diethylstilbestrol 4.0115469931
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.5211748828
MESH:D000743 Anemia, Hemolytic Quercetin 3.7917084956
MESH:D000799 Angioedema Acetaminophen 3.3410982225
MESH:D000853 Anophthalmos Ethanol 4.3315513904
MESH:D000855 Anorexia Phenylpropanolamine 5.3017684035
MESH:D001008 Anxiety Disorders Ethanol 3.6111141031
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.5919183758
MESH:D001145 Arrhythmias, Cardiac Quinidine 4.7218724381 18057881
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 2.9811256880
MESH:D001169 Arthritis, Experimental Dexamethasone 6.3117659584
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 6.3115885639
MESH:D001172 Arthritis, Rheumatoid Curcumin 2.6116807698
MESH:D001249 Asthma Mustard Gas 2.5510378619
MESH:D001260 Ataxia Telangiectasia Quercetin 4.4815336622
MESH:D050197 Atherosclerosis Curcumin 3.0218704882
MESH:D001321 Autistic Disorder Acetaminophen 2.1318445737
MESH:D001321 Autistic Disorder Haloperidol 2.1318080171 19368416
MESH:D001327 Autoimmune Diseases Curcumin 9.2519761891
MESH:D001327 Autoimmune Diseases Quercetin 9.2519761891
MESH:D001768 Blister Mustard Gas 4.6619167455
MESH:D001778 Blood Coagulation Disorders pirinixic acid 7.2919483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 7.2912125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.2815340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.4315746008
MESH:D001862 Bone Resorption bisphenol A 3.4211985600
MESH:D002545 Brain Ischemia Curcumin 3.8416770732
MESH:D001932 Brain Neoplasms Curcumin 3.5117596214
MESH:D001943 Breast Neoplasms marker/mechanism 20562527
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 7.5020146248 17474063
MESH:D001943 Breast Neoplasms bexarotene 7.5016818667 16344269
MESH:D001943 Breast Neoplasms bisphenol A 7.5017123778
MESH:D001943 Breast Neoplasms Curcumin 7.5019250217 18462866 18593918 16243823
MESH:D001943 Breast Neoplasms Diethylnitrosamine 7.5017474063
MESH:D001943 Breast Neoplasms Diethylstilbestrol 7.5015324884 17129689
MESH:D001943 Breast Neoplasms Estradiol 7.5016675129 12948864 17261762 17289903 19861407 17018787 14630087 18497071
MESH:D001943 Breast Neoplasms Genistein 7.5017200150 16541309 16873071
MESH:D001943 Breast Neoplasms Quercetin 7.5018628248
MESH:D001943 Breast Neoplasms Tamoxifen 7.5019059307 19487384 18997820 17440819 19142967 20390343 20005174 20859285 21138602 19200415 20065188 17049068 18351453 15668708 18425577 19084267 18984771 17261762 16202921 19011961 19103187 21152245 19410462 19288272 18855134 11161223 19244106 17893378 16818667 18815881 16873071 20135344 18821012 19115204 16273361 19189210 17242785 15565566 19066611 18629630 19289846 19155303 19189212 19221464 20544844
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 7.5020435547
MESH:D001989 Bronchiolitis Obliterans Mustard Gas 4.6615286001
MESH:D029481 Bronchitis, Chronic Mustard Gas 4.4717687719 10378619
MESH:D002056 Burns Ethanol 4.1716374292
MESH:D002105 Cadmium Poisoning Quercetin 5.0416962696
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 3.9616111702
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 8.3215700767 16192424 16227642 16011737 3786805 16097048 15721981 16124888 10355542 18705752 15673190 16050911
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 8.3216050911
MESH:D002277 Carcinoma Curcumin 6.9718593918
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 6.9716835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.0219066611
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 23.6716705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 23.673084413
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 23.6718788625
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 23.6711831363 18785209 20432363 19394651 16698587 3084413 18494052 19701751 16779866 20935162 18056438 17761372 18978308 18788625 18691550 17428255 16681979 19539802 17162532 17978847 20007298 18393292 16830150 3581430 20524982 19335982 20101231 20084675 16540662 18210153 19107877 16288022 19383236 19519916 20512989 16807293 19822196 17173139 21159647 18506893 20214788 19052882 18665156 17138121 16502159 16878318 19208518 19171122 20727157 19919837 10737359 18971187 16935385 20514400 17055752 16328049 19418558 10672840 16569478
MESH:D006528 Carcinoma, Hepatocellular Diethylstilbestrol 23.6716924424 15948411
MESH:D006528 Carcinoma, Hepatocellular Estradiol 23.6716924424
MESH:D006528 Carcinoma, Hepatocellular Ethanol 23.6718788625 15763234 15289165
MESH:D006528 Carcinoma, Hepatocellular Genistein 23.6716924424
MESH:D006528 Carcinoma, Hepatocellular Quercetin 23.6712508355 19519916
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 23.6715276417 17306315 16507464
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 23.6716924424
MESH:D002278 Carcinoma in Situ bisphenol A 4.4917123778
MESH:D002289 Carcinoma, Non-Small-Cell Lung bexarotene 5.1916247446
MESH:D002289 Carcinoma, Non-Small-Cell Lung Curcumin 5.1918414057
MESH:D021441 Carcinoma, Pancreatic Ductal Quercetin 4.4717234771
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 6.5720419170
MESH:D002294 Carcinoma, Squamous Cell Curcumin 6.5718462866
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 6.5718572023
MESH:D002295 Carcinoma, Transitional Cell Nitrofurantoin 8.5715028437
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 8.5717572228
MESH:D006332 Cardiomegaly Ethanol 9.7619332462
MESH:D006332 Cardiomegaly Quercetin 9.7619794523
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 9.7618670907 18850075 16120746
MESH:D002318 Cardiovascular Diseases Genistein 2.9616332659
MESH:D002375 Catalepsy Haloperidol 4.411977408 15215559
MESH:D002386 Cataract 4-amino-2,6-dinitrotoluene 6.4014694615
MESH:D002386 Cataract Acetaminophen 6.4010977129
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 9.1817174075 2727394 7505956 21159647
MESH:D002471 Cell Transformation, Neoplastic Estradiol 9.1818566989
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 9.1820056578 19524636
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 7.9319052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 7.9316835633
MESH:D002761 Cholangitis 1-Naphthylisothiocyanate 5.6912912871
MESH:D002779 Cholestasis 1-Naphthylisothiocyanate 11.3718164287 12927374 16629650 7624871 15500046 18590720 19486331 15913567
MESH:D002779 Cholestasis Ethinyl Estradiol 11.3715861022 16919318 17110522 11677210 17333356 17681005 16105132
MESH:D002779 Cholestasis pirinixic acid 11.3719176532
MESH:D002780 Cholestasis, Intrahepatic 1-Naphthylisothiocyanate 5.3519407337 10220858
MESH:D002971 Cleft Lip Ethanol 3.3115513904
MESH:D002972 Cleft Palate Ethanol 5.1815513904
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.188697196 15668235 16354765 15340226 12621046
MESH:D003072 Cognition Disorders Clozapine 4.4817123785
MESH:D003092 Colitis Curcumin 8.0616804969 18200517 16782535
MESH:D003092 Colitis Selenium 8.0617936198
MESH:D003103 Coloboma Curcumin 4.1018809619
MESH:D003110 Colonic Neoplasms Curcumin 7.3716340194 19359593
MESH:D003110 Colonic Neoplasms Dexamethasone 7.3715824018
MESH:D003110 Colonic Neoplasms Genistein 7.3717182828
MESH:D003110 Colonic Neoplasms Quercetin 7.3711134977 16640504 17148506 19056647 15741050 17191121 19440933
MESH:D015179 Colorectal Neoplasms Quercetin 2.1818852136 18095365
MESH:D000013 Congenital Abnormalities 4-amino-2,6-dinitrotoluene 7.7915095906
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 7.7914669216 17141729
MESH:D016510 Corneal Neovascularization Curcumin 4.4118497527
MESH:D019465 Craniofacial Abnormalities Dexamethasone 6.5917728286
MESH:D019465 Craniofacial Abnormalities Ethanol 6.5911873399 19302082 15451040 15451039 15513904 11198716 10194807
MESH:D019465 Craniofacial Abnormalities sodium arsenate 6.5910525206
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 6.5910048152 20055451 15322242
MESH:D019465 Craniofacial Abnormalities Vitamin E 6.5919769572
MESH:D003456 Cryptorchidism Diethylstilbestrol 4.0816002989 12952375
MESH:D003490 Cyanosis 2,4-dinitrotoluene 3.5318551238
MESH:D016757 Death, Sudden, Cardiac Haloperidol 4.3820210726
MESH:D003704 Dementia Haloperidol 4.1311575062
MESH:D003711 Demyelinating Diseases Tamoxifen 3.8819031437
MESH:D017449 Dermatitis, Allergic Contact Dexamethasone 2.9512438553
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.1818249437
MESH:D003921 Diabetes Mellitus, Experimental Quercetin 3.3319496084
MESH:D003924 Diabetes Mellitus, Type 2 Clozapine 12.0416402076
MESH:D003924 Diabetes Mellitus, Type 2 Curcumin 12.0418403477
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 12.0420387270
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 12.0416647724
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 12.0417107852
MESH:D003928 Diabetic Nephropathies Curcumin 12.6118204486
MESH:D003928 Diabetic Nephropathies Estradiol 12.6119279558
MESH:D003928 Diabetic Nephropathies Tamoxifen 12.6119279558
MESH:D003967 Diarrhea Dexamethasone 3.247237001
MESH:D006970 Disorders of Excessive Somnolence Clozapine 5.0515331141
MESH:D056486 Drug-Induced Liver Injury 1-Naphthylisothiocyanate 44.5017522070 20133375 7624871 18289764
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 44.5018551238 21346803
MESH:D056486 Drug-Induced Liver Injury 4-amino-2,6-dinitrotoluene 44.5021346803
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 44.5011287661 11461765 14986274 12540782 10915739 11739529 12958197 11529661 14725611 19416960 17906064 19739265 16781746 12153990 17522070 18713872 11421492 10663392 18071297 14550746 11834606 11743745 16227642 15619225 12705907 17562736 19085960 10774834 16485898 2444490 19420014 16393943 12392966 16081117 19923254 15968718 19164858 16109766 12594235 16177239 19370779
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 44.5016227642 7179309 16177239 6884620 15968718 2869522 7440962 10092053 19085960 15027814 10915739 9327722 21278145 6623471 7120509 11566570 17522070 15998439 19336974 3732212 4309450 3786805
MESH:D056486 Drug-Induced Liver Injury Chloroform 44.503732212 7440962 7120509 17522070 3104120 2862719 6884620 6623471
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 44.5019107877
MESH:D056486 Drug-Induced Liver Injury Ethanol 44.5011566570
MESH:D056486 Drug-Induced Liver Injury fumonisin B1 44.5016221962
MESH:D056486 Drug-Induced Liver Injury Nitrofurantoin 44.508373174 19214031 19789166 1551546
MESH:D056486 Drug-Induced Liver Injury pyrazole 44.5012499123
MESH:D056486 Drug-Induced Liver Injury Selenium 44.5015131321
MESH:D056486 Drug-Induced Liver Injury sodium arsenate 44.5018186108
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 44.5020420201
MESH:D056486 Drug-Induced Liver Injury Tetracycline 44.5017522070
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.5919426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.3911462148
MESH:D004381 Duodenal Ulcer Curcumin 3.5817351913
MESH:D050171 Dyslipidemias Clozapine 3.8216402076
MESH:C538011 Eales disease Vitamin E 4.209068938
MESH:D004485 Eczema Dexamethasone 3.9912438553
MESH:D004487 Edema Dexamethasone 12.8419703484
MESH:D004487 Edema Mustard Gas 12.849260866 11428631 11428647 11402378
MESH:D004487 Edema pirinixic acid 12.8412083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 12.8412711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.3915322242 16714409 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 7.3812538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 7.3819031437
MESH:D004714 Endometrial Hyperplasia Diethylstilbestrol 10.2416402032
MESH:D004714 Endometrial Hyperplasia Genistein 10.2416402032
MESH:D016889 Endometrial Neoplasms Diethylstilbestrol 15.0415700306 16804899
MESH:D016889 Endometrial Neoplasms Estradiol 15.0418566989 19148513 11473722
MESH:D016889 Endometrial Neoplasms Genistein 15.0411473722
MESH:D016889 Endometrial Neoplasms Tamoxifen 15.0416202921 20544844 17893378 19155303
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.5910568697 9294722
MESH:D004890 Erythema Mustard Gas 4.669357497
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 4.6116302075
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.0916530937
MESH:D004938 Esophageal Neoplasms Ethanol 4.0916704527
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.6411564622
MESH:D005234 Fatty Liver Carbon Tetrachloride 35.5315959796 16239168 12795759 19224547 17595544 61145 12631006 16045604
MESH:D005234 Fatty Liver Curcumin 35.5319297423
MESH:D005234 Fatty Liver Diethylnitrosamine 35.5320387270 21071580
MESH:D005234 Fatty Liver Ethanol 35.5319236843 18620774 16409862
MESH:D005234 Fatty Liver Ethinyl Estradiol 35.5315345470
MESH:D005234 Fatty Liver pirinixic acid 35.5320131406 19236843
MESH:D005234 Fatty Liver Tamoxifen 35.5314986274 19224547
MESH:D005234 Fatty Liver Tetracycline 35.5319224547 16917069
MESH:D005235 Fatty Liver, Alcoholic Ethanol 5.1617920746
MESH:D052776 Female Urogenital Diseases Diethylstilbestrol 7.1616611131 16002989 16534752 16513791 15751030
MESH:D052776 Female Urogenital Diseases Tamoxifen 7.1616709447
MESH:D005310 Fetal Alcohol Syndrome Ethanol 4.8016946407 15513904 15451040 10194807
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 2.9711858732
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.0314745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 3.6819069698
MESH:D005355 Fibrosis Carbon Tetrachloride 17.2218705752
MESH:D005355 Fibrosis Curcumin 17.2218705752
MESH:D005355 Fibrosis Quercetin 17.2219474275
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 17.2220067830
MESH:D005756 Gastritis Acetaminophen 9.4416983495
MESH:D005756 Gastritis Ethanol 9.4415046732
MESH:D005770 Gastrointestinal Neoplasms Curcumin 4.2118462866
MESH:D005833 Genital Neoplasms, Female Diethylstilbestrol 11.1616452187
MESH:D005833 Genital Neoplasms, Female sodium arsenite 11.1616452187
MESH:D005909 Glioblastoma Curcumin 10.0617596214
MESH:D005909 Glioblastoma Genistein 10.0616598420
MESH:D005909 Glioblastoma Quercetin 10.0619804834
MESH:D005910 Glioma Quercetin 2.8417643826
MESH:D018149 Glucose Intolerance sodium arsenate 4.6219446573
OMIM:611881 GLYCOGEN STORAGE DISEASE XII marker/mechanism
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.0910696789
MESH:D006258 Head and Neck Neoplasms Curcumin 3.3118829502 18462866
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 9.4720471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 9.4711294989 10048152
MESH:D006330 Heart Defects, Congenital Vitamin E 9.4716080930
MESH:D006333 Heart Failure pirinixic acid 5.8920558911
MESH:D006333 Heart Failure Selenium 5.8917162251
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 2.8911000095
MESH:D006505 Hepatitis 1-Naphthylisothiocyanate 8.0918590720
MESH:D006505 Hepatitis Carbon Tetrachloride 8.0919900420 19110552
MESH:D006521 Hepatitis, Chronic Nitrofurantoin 5.4614986274
MESH:D006529 Hepatomegaly fumonisin B1 11.6916221962
MESH:D006529 Hepatomegaly pirinixic acid 11.6916221962 18467677 19772884 19176532
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 11.6916120746 15340226 12621046
MESH:D015417 Hereditary Sensory and Motor Neuropathy Curcumin 4.5517701891
MESH:D006548 Hernia, Diaphragmatic Dexamethasone 5.317520565
MESH:D006548 Hernia, Diaphragmatic Vitamin E 5.3116863852 16490937
MESH:D006558 Herpes Genitalis Estradiol 4.5215709030
MESH:D006689 Hodgkin Disease sodium arsenite 2.7512676792
MESH:D019584 Hot Flashes Estradiol 8.3717088409
MESH:D019584 Hot Flashes Vitamin E 8.3714716179
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.5418606429 15340226 16354765 16959395 8697196
MESH:D006930 Hyperalgesia Acetaminophen 6.5016870215
MESH:D006930 Hyperalgesia Ethanol 6.5018783367
MESH:D017588 Hyperandrogenism Flutamide 4.9515356085
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.0316899240
MESH:D006937 Hypercholesterolemia Curcumin 3.6118704882
MESH:D006943 Hyperglycemia pirinixic acid 7.8120558911
MESH:D006943 Hyperglycemia Quercetin 7.8118262572 11834736
MESH:D006948 Hyperkinesis Clozapine 4.4116046005
MESH:D006965 Hyperplasia Diethylstilbestrol 3.9512960047 14722030
MESH:D006973 Hypertension Dexamethasone 7.4517042910
MESH:D006973 Hypertension Quercetin 7.4518356687
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 7.4518850075 18670907
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.6015338365
MESH:D007021 Hypospadias Diethylstilbestrol 9.6316002989
MESH:D007021 Hypospadias Ethinyl Estradiol 9.6316569931 16945680
MESH:D007246 Infertility Diethylstilbestrol 3.8815036965
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.0012013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 5.5117937319
MESH:D007248 Infertility, Male sodium arsenite 5.5112646999 15346721
MESH:D007249 Inflammation Curcumin 16.3517151092 16956363 18403477
MESH:D007249 Inflammation Dexamethasone 16.3511099482 8960868
MESH:D007249 Inflammation Diethylnitrosamine 16.3518785209
MESH:D007249 Inflammation Mustard Gas 16.3511402378 8975870 11428631 17524151 9357497 9260866 11428647 11428620 16001271
MESH:D007249 Inflammation Tamoxifen 16.3519457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 16.3512200463 12878042
MESH:D015212 Inflammatory Bowel Diseases Curcumin 2.9918200517 18596194
MESH:D007251 Influenza, Human Quercetin 15.6816624496
MESH:D007251 Influenza, Human Selenium 15.6816624496
MESH:D007251 Influenza, Human Vitamin E 15.6816624496
MESH:D007333 Insulin Resistance bisphenol A 10.3716393666
MESH:D007333 Insulin Resistance Estradiol 10.3716627594 16393666
MESH:D007333 Insulin Resistance pirinixic acid 10.3716306350
MESH:D007414 Intestinal Neoplasms Curcumin 3.7910783313
MESH:D007569 Jaw Abnormalities Ethanol 8.6415513904
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 8.6416580747
MESH:D007627 Keloid Quercetin 4.4717086741
MESH:D007674 Kidney Diseases Acetaminophen 15.8515629191 12587719
MESH:D007674 Kidney Diseases Estradiol 15.8515618244
MESH:D007674 Kidney Diseases Quercetin 15.8516962696
MESH:D007674 Kidney Diseases sodium arsenite 15.8520008137
MESH:D007674 Kidney Diseases Vitamin E 15.8512488133
MESH:D007676 Kidney Failure, Chronic Selenium 3.4416518626
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 14.4616705839
MESH:D007680 Kidney Neoplasms Diethylstilbestrol 14.4615003126 14681315 16762066
MESH:D007680 Kidney Neoplasms Estradiol 14.4615610895
MESH:D007680 Kidney Neoplasms Tamoxifen 14.4618625569
MESH:D007859 Learning Disorders Diethylstilbestrol 8.1817184923
MESH:D007859 Learning Disorders Ethanol 8.1815451040
MESH:D007889 Leiomyoma Curcumin 4.1118555241
MESH:D007938 Leukemia Curcumin 9.0518462866
MESH:D007938 Leukemia Genistein 9.0518980019 17468513
MESH:D007938 Leukemia Quercetin 9.0517468513
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Curcumin 3.7616106398
MESH:D015458 Leukemia, T-Cell Curcumin 4.2916106398
MESH:D017880 Limb Deformities, Congenital Ethanol 3.4517676605
MESH:D008064 Lipidoses Clozapine 6.8717567588
MESH:D008064 Lipidoses Tamoxifen 6.8715342952 17567588
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 9.3911408273 17334410 16943688 17157831 16239168 17174718 16221502 11903743 21278145
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 9.3918522880 18665156 19638242 20032147 18407596
MESH:D008103 Liver Cirrhosis Ethanol 9.3915289165
MESH:D008104 Liver Cirrhosis, Alcoholic Ethanol 4.6018295389
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 18.9612546737 15996030 17708605 18263696 17525996 14716833 12958196 10355542 17640975 15052691 12632514 17721639 15673190 18279442 17714472 17900296 17761835 13678700 15876570 18205269 17631135 16097048 12445421 16033810 15730626 15650968 17557913 16011737 18376398 15123356 18418968 16027843 12632512 17976157 18187930 15362042 12667390 18339082 15818738 18395095 12898905 18429990 18156304 12609069 17766677 18420326 16192424 12586293 18251166 15959796 15925388 12741479 17869086 14512876 16136751 12445418 17944888 15057751 16015684 18210741 17481882 18481824 14724832 17823541 17565644 14620537 12666154 18317297 12389079 18006644 18277467 17805973 17922224 17698563 20821823 18472332 18054572 15338365 14748882 14716496 11481614 18166357 15370692 16638106 18412020 18472094 12649538 16116963 18705752 15931870 16248980 15893842 18395914
MESH:D008106 Liver Cirrhosis, Experimental Curcumin 18.9617355460 18006644 18705752
MESH:D008106 Liver Cirrhosis, Experimental Dexamethasone 18.9616718785
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 18.9614716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Ethanol 18.9618166357
MESH:D008106 Liver Cirrhosis, Experimental Genistein 18.9617823541
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 18.9615474484
MESH:D008106 Liver Cirrhosis, Experimental Quercetin 18.9612741479
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 18.9618564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 18.9612878042
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 18.9616169303
MESH:D008107 Liver Diseases 1-Naphthylisothiocyanate 13.8417184895
MESH:D008107 Liver Diseases Acetaminophen 13.8411587558 19784758 16611625 12969438 12587719 19460945 16610002 19014921
MESH:D008107 Liver Diseases Carbon Tetrachloride 13.8415720792 16246199 17285989 16964402 15830285
MESH:D008107 Liver Diseases Curcumin 13.8416956363
MESH:D008107 Liver Diseases Diethylnitrosamine 13.8417034775
MESH:D008107 Liver Diseases Nitrofurantoin 13.8414966256
MESH:D008108 Liver Diseases, Alcoholic Ethanol 4.1717347304 17207112
MESH:D017093 Liver Failure Carbon Tetrachloride 3.6815123358
MESH:D017114 Liver Failure, Acute Acetaminophen 7.9717185352 16871587
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 7.9714706259 16899240
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 33.6720195826 21137059
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 33.6719294768
MESH:D008113 Liver Neoplasms Clofibric Acid 33.6717602206
MESH:D008113 Liver Neoplasms Diethylnitrosamine 33.6719551842 19426721 2422723 19638242 15175105 18754104 19254457 20492335 19642983 19499222 19090486 18644402 19294768 21278145 2862719 19812893 18648771 10737359 20101389 21047994 21071580 19256749 18977376 20452335 19255062 9163691 19073162 12112319 15885732 20405173 19427195 12771043 20501860 20137499 19996281 19690152 16942905 19833225 20434301 20118626 19850985 21167192 18978307 20583210
MESH:D008113 Liver Neoplasms Diethylstilbestrol 33.6716712894 15890375
MESH:D008113 Liver Neoplasms Methapyrilene 33.6715890375
MESH:D008113 Liver Neoplasms pirinixic acid 33.6720007298 15890375 16377806
MESH:D008113 Liver Neoplasms Quercetin 33.6718980244
MESH:D008113 Liver Neoplasms sodium arsenite 33.6715276417 16712894
MESH:D008113 Liver Neoplasms Tamoxifen 33.6716684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 33.6716984957
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 11.4715583823 12014681
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 11.472563599 18544905 9362446 19539802 19519916 18093689 18164116 19009564 18253720 3124819 16842330 17942915 19004024 16267830 17854601 18775883 18282651 18079962 19126423 17174075 18308698 21159647
MESH:D008114 Liver Neoplasms, Experimental Quercetin 11.4719519916
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 11.4712151625
MESH:D008133 Long QT Syndrome Quinidine 4.5511989578 15350150
MESH:D008171 Lung Diseases Mustard Gas 14.8518702808 18161513
MESH:D008171 Lung Diseases Nitrofurantoin 14.859429087 14966256
MESH:D008171 Lung Diseases sodium arsenite 14.8519095001
MESH:D008171 Lung Diseases Vitamin E 14.8516863852
MESH:D017563 Lung Diseases, Interstitial Nitrofurantoin 5.4618516814
MESH:D055370 Lung Injury Nitrofurantoin 4.851313237
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 18.6118520028 18569708 20464547 20064080 17053015 6695378 20869020 20135361 18816296
MESH:D008175 Lung Neoplasms bexarotene 18.6117849452
MESH:D008175 Lung Neoplasms Curcumin 18.6118462866 19359593 16243823
MESH:D008175 Lung Neoplasms Dexamethasone 18.6111195469 15824018
MESH:D008175 Lung Neoplasms Diethylnitrosamine 18.6121163286 20512841 20970405 6695378
MESH:D008175 Lung Neoplasms Mustard Gas 18.613148597 8781369
MESH:D008175 Lung Neoplasms Quercetin 18.6116280456
MESH:D008175 Lung Neoplasms sodium arsenite 18.6117306315 19931552 16712894 15276417 17077188
MESH:D008175 Lung Neoplasms Tamoxifen 18.6118625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 18.6111884234 19555203
MESH:D008175 Lung Neoplasms Vitamin E 18.6111062179
MESH:D008181 Lupus Nephritis Diethylstilbestrol 4.6515166399
MESH:D008223 Lymphoma Curcumin 6.5918462866
MESH:D008223 Lymphoma Diethylstilbestrol 6.5915700306
MESH:D016399 Lymphoma, T-Cell Curcumin 4.2116173963
MESH:D016410 Lymphoma, T-Cell, Cutaneous bexarotene 4.6611161223
MESH:D052801 Male Urogenital Diseases Diethylstilbestrol 5.0116002989
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.2719428831
MESH:D008325 Mammary Neoplasms, Experimental bexarotene 15.3219196723 19196722 15591091
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 15.3211408345 16891317 17203775 11807958
MESH:D008325 Mammary Neoplasms, Experimental Genistein 15.3214578162 12929590
MESH:D008325 Mammary Neoplasms, Experimental Selenium 15.3215318939
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 15.3216827153 11731420 19196722 14580682 19196723
MESH:D020149 Manganese Poisoning Estradiol 10.9619453300
MESH:D020149 Manganese Poisoning Tamoxifen 10.9619453300
MESH:D008545 Melanoma Curcumin 4.5218462866 17885582
MESH:D008545 Melanoma sodium arsenite 4.5216487513 19082730
MESH:D008545 Melanoma Tamoxifen 4.5219393235 12393984
MESH:D018328 Melanoma, Amelanotic Tamoxifen 3.6815990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.0819513568
MESH:D008569 Memory Disorders Curcumin 8.1917263510
MESH:D008569 Memory Disorders Ethanol 8.1918411066 15451040
MESH:D001523 Mental Disorders Clozapine 6.7316856516
MESH:D001523 Mental Disorders Haloperidol 6.7316856516
MESH:D008654 Mesothelioma Selenium 2.5815107826
MESH:D024821 Metabolic Syndrome X Clozapine 4.0019142101
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 2.8116381670
MESH:D009101 Multiple Myeloma Curcumin 6.3919372569
MESH:D009101 Multiple Myeloma Dexamethasone 6.3916118317 15867202 15744524
MESH:D009134 Muscular Atrophy, Spinal Curcumin 4.4217962980
MESH:D009135 Muscular Diseases pirinixic acid 3.0216239165
MESH:D009139 Musculoskeletal Abnormalities sodium arsenate 4.4118186108
MESH:D009190 Myelodysplastic Syndromes Dexamethasone 3.249809623
MESH:D009203 Myocardial Infarction Genistein 8.1517141266
MESH:D009203 Myocardial Infarction pirinixic acid 8.1519151258
MESH:D009203 Myocardial Infarction Quercetin 8.1519595682
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.6212213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 17.1316810080
MESH:D015428 Myocardial Reperfusion Injury Genistein 17.1317141266
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 17.1316411023
MESH:D015428 Myocardial Reperfusion Injury Quercetin 17.1319207477
MESH:D009336 Necrosis 2,4-dinitrotoluene 3.3618551238
MESH:D009361 Neoplasm Invasiveness Curcumin 3.9018495463
MESH:D009362 Neoplasm Metastasis marker/mechanism 20562527
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 4.999029167 3581430
MESH:D009362 Neoplasm Metastasis Tamoxifen 4.9919393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.3419410462
MESH:D009369 Neoplasms Benzo(a)pyrene 12.8911141357
MESH:D009369 Neoplasms Diethylstilbestrol 12.8915313581
MESH:D009369 Neoplasms pirinixic acid 12.8917405874
MESH:D009369 Neoplasms Quercetin 12.8915185748
MESH:D009369 Neoplasms sodium arsenite 12.8911559025
MESH:D009374 Neoplasms, Experimental sodium arsenite 3.1920056578
MESH:D009376 Neoplasms, Hormone-Dependent bexarotene 15.3819196722
MESH:D009376 Neoplasms, Hormone-Dependent Curcumin 15.3812497104
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 15.3819189210 19196722 19200415
MESH:D009389 Neovascularization, Pathologic Estradiol 3.2417289903
MESH:D009395 Nephritis, Interstitial Nitrofurantoin 9.6219214031
MESH:D009395 Nephritis, Interstitial Tetracycline 9.629884423
MESH:D009421 Nervous System Malformations bisphenol A 25.7411399458 16427766
MESH:D009421 Nervous System Malformations Diethylstilbestrol 25.7411399458
MESH:D009421 Nervous System Malformations Estradiol 25.7416427766 11399458
MESH:D009421 Nervous System Malformations Genistein 25.7416427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 25.7414600291
MESH:D009423 Nervous System Neoplasms Curcumin 5.1218462866
MESH:D009436 Neural Tube Defects sodium arsenate 6.5311749123 10525206 19446573 18186108
MESH:D009436 Neural Tube Defects sodium arsenite 6.5312854658
MESH:D019636 Neurodegenerative Diseases Acetaminophen 6.8318514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 6.8320387270
MESH:D020078 Neurogenic Inflammation Quercetin 3.9017929310
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 4.6120387270
MESH:D009503 Neutropenia Mustard Gas 3.5216761898 7688884
MESH:D009765 Obesity Clozapine 6.6519142110 18515891
MESH:D009765 Obesity Curcumin 6.6519297423
MESH:D009765 Obesity pirinixic acid 6.6520558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 7.7012819281 16049721
MESH:D009784 Occupational Diseases 4-amino-2,6-dinitrotoluene 7.7014694615
MESH:D010024 Osteoporosis Curcumin 6.3018719352
MESH:D010024 Osteoporosis Genistein 6.3019401787
MESH:D015663 Osteoporosis, Postmenopausal Genistein 8.6216169203
MESH:D015663 Osteoporosis, Postmenopausal Quercetin 8.6219495926
MESH:D010049 Ovarian Diseases bisphenol A 4.4911985600
MESH:D010051 Ovarian Neoplasms CD 437 16.4917474084
MESH:D010051 Ovarian Neoplasms Curcumin 16.4919020741 18462866
MESH:D010051 Ovarian Neoplasms Estradiol 16.4919401270
MESH:D010051 Ovarian Neoplasms Genistein 16.4919005980
MESH:D010051 Ovarian Neoplasms Quercetin 16.4919005980
MESH:D010051 Ovarian Neoplasms sodium arsenite 16.4915276417 17306315
MESH:D010146 Pain Acetaminophen 2.0016870215
MESH:D010190 Pancreatic Neoplasms Curcumin 10.7017440100 19196508 19401701
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 10.7016540662
MESH:D010190 Pancreatic Neoplasms Ethanol 10.7012384795
MESH:D010190 Pancreatic Neoplasms Quercetin 10.7016965848
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.2311578682
MESH:D010382 Peliosis Hepatis 1-Naphthylisothiocyanate 12.1020133375
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 12.1012520081
MESH:D010391 Pemphigoid, Bullous Tetracycline 4.9211026799
MESH:D010900 Pituitary Diseases Diethylstilbestrol 4.6614722030
MESH:D010911 Pituitary Neoplasms Diethylstilbestrol 4.1816977796 15687265
MESH:D010954 Plasmacytoma Selenium 4.3815087411
MESH:D011041 Poisoning Mustard Gas 3.3515727166
MESH:D011085 Polycystic Ovary Syndrome Flutamide 4.5615356085
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.0918163543
MESH:D011230 Precancerous Conditions Diethylnitrosamine 7.832563599
MESH:D011230 Precancerous Conditions Quercetin 7.8319056647
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Dexamethasone 3.2521297632
MESH:D011248 Pregnancy Complications Nitrofurantoin 5.3219789166
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 13.4110548101
MESH:D011297 Prenatal Exposure Delayed Effects Diethylstilbestrol 13.4117184923
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 13.4111399792 11896295 11222880 11118676
MESH:D017096 Prion Diseases Tetracycline 4.9110903871
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 9.0720887781
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 9.0720887781
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 3.9017292933
MESH:D011471 Prostatic Neoplasms bisphenol A 3.9016740699
MESH:D011471 Prostatic Neoplasms Curcumin 3.9015129424 18156803 10851300 18226269 11398177 18769126 12497104
MESH:D011471 Prostatic Neoplasms Diethylstilbestrol 3.9017136230 15846301 15046698
MESH:D011471 Prostatic Neoplasms Estradiol 3.9016740699
MESH:D011471 Prostatic Neoplasms Flutamide 3.903169114
MESH:D011471 Prostatic Neoplasms Genistein 3.9015378649 15256057 16925846
MESH:D011471 Prostatic Neoplasms Quercetin 3.9014715546 17292933
MESH:D011471 Prostatic Neoplasms sodium arsenite 3.9016039940
MESH:D011471 Prostatic Neoplasms Tamoxifen 3.9015067354
MESH:D011471 Prostatic Neoplasms Vitamin E 3.9015084515
MESH:D011537 Pruritus Ethinyl Estradiol 7.8816919318 15861022
MESH:D011537 Pruritus Mustard Gas 7.8818058305
MESH:D011595 Psychomotor Agitation Haloperidol 4.4711575062
MESH:D011618 Psychotic Disorders Clozapine 7.9415331141
MESH:D011618 Psychotic Disorders Haloperidol 7.9411575062
MESH:D011629 Puberty, Precocious bisphenol A 4.2910548101
MESH:D011654 Pulmonary Edema Nitrofurantoin 5.289429087
MESH:D011656 Pulmonary Emphysema Curcumin 4.0919168576
MESH:D011658 Pulmonary Fibrosis Mustard Gas 5.6810334151 17720292 17266442 17620002 17894541
MESH:D011658 Pulmonary Fibrosis Nitrofurantoin 5.681551546
MESH:D015427 Reperfusion Injury pirinixic acid 2.1319058328
MESH:D012128 Respiratory Distress Syndrome, Adult Curcumin 7.7918379247 10666014
MESH:D012128 Respiratory Distress Syndrome, Adult Dexamethasone 7.7918379247 11700416
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.3618990726
MESH:D012509 Sarcoma Curcumin 3.6918462866
MESH:D012554 Schistosomiasis japonica Quercetin 5.0416862918
MESH:D012559 Schizophrenia Clozapine 3.7917667964 20580759 17123785 20521326 20452607 11763009 20521320 17726453 18806925 20107430 19369910 20168265 11151749 16141801 18855531
MESH:D012559 Schizophrenia Haloperidol 3.7919369910 1830565 20107430 18513383
MESH:D012640 Seizures 2,4-dinitrotoluene 4.9618551238
MESH:D012640 Seizures Ethanol 4.969754883
MESH:D018805 Sepsis Curcumin 3.6718389075
MESH:D012871 Skin Diseases Mustard Gas 4.5112880345 15451306 16961503
MESH:D012871 Skin Diseases Vitamin E 4.5118709164
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 11.4419755658 10029692
MESH:D012878 Skin Neoplasms sodium arsenite 11.4418572023 19524636
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 11.448532709
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 11.4416192470
MESH:D013088 Spermatocele Diethylstilbestrol 17.1916002989 16709447
MESH:D013088 Spermatocele Ethinyl Estradiol 17.1916709447
MESH:D013088 Spermatocele Tamoxifen 17.1916709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 3.5419457130
MESH:D016135 Spinal Dysraphism sodium arsenite 3.4112854658
MESH:D013272 Stomach Diseases Dexamethasone 3.8315472012
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 3.062093021 20155912
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 3.0618456281
MESH:D013274 Stomach Neoplasms Ethanol 3.0618456281
MESH:D013276 Stomach Ulcer Curcumin 9.6419188055 16631530
MESH:D013276 Stomach Ulcer Dexamethasone 9.6415138204
MESH:D013276 Stomach Ulcer Ethanol 9.6411906479 17189318 17918041 9562338 16755016 9211565
MESH:D020521 Stroke Vitamin E 3.1316517955
MESH:D019966 Substance-Related Disorders bisphenol A 3.4916684133 16045194
MESH:D013375 Substance Withdrawal Syndrome Ethanol 3.829754883
MESH:D017180 Tachycardia, Ventricular Haloperidol 4.2420210726
MESH:D013733 Testicular Diseases pyrazole 4.326499806
MESH:D013921 Thrombocytopenia 1-Naphthylisothiocyanate 4.3220133375
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.1611994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.7315669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.3912697716
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 2.617505956
MESH:D013978 Tibial Fractures Estradiol 4.1819048282
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 28.7116049721
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 28.7117053015
MESH:D001749 Urinary Bladder Neoplasms CD 437 28.7116720286
MESH:D001749 Urinary Bladder Neoplasms Curcumin 28.7118593936
MESH:D001749 Urinary Bladder Neoplasms Diethylstilbestrol 28.7117306315 16712894 16452187
MESH:D001749 Urinary Bladder Neoplasms Nitrofurantoin 28.7115028437
MESH:D001749 Urinary Bladder Neoplasms Quercetin 28.7116720314
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 28.7116712894 16452187 11723127 17306315
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 28.7116712894 8653321 17572228
MESH:D014552 Urinary Tract Infections Nitrofurantoin 6.071551546
MESH:D014565 Urogenital Neoplasms Curcumin 4.7718462866
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 3.8210091137
MESH:D014581 Urticaria Acetaminophen 2.5210982225
MESH:D002583 Uterine Cervical Neoplasms Diethylstilbestrol 8.1016175088
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 8.1011813266
MESH:D014591 Uterine Diseases bisphenol A 12.1314652134
MESH:D014591 Uterine Diseases Diethylstilbestrol 12.1314652134
MESH:D014594 Uterine Neoplasms Diethylstilbestrol 7.9115809267 16690809
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 7.9114692618
MESH:D014605 Uveitis Dexamethasone 4.311336536
MESH:D014625 Vaginal Neoplasms Diethylstilbestrol 3.9516002989 16513791
MESH:D014652 Vascular Diseases sodium arsenite 3.9317056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.0912125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.0914671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.7415886252
MESH:D015430 Weight Gain Clozapine 4.0520564506 20107430 16402076 20521320 16141801 17502770
MESH:D015431 Weight Loss Clozapine 4.5817933447
Pathway ID Pathway Name
KEGG:00051 Fructose and mannose metabolism
KEGG:00010 Glycolysis / Gluconeogenesis
REACT:604 Hemostasis
KEGG:01100 Metabolic pathways
REACT:474 Metabolism of carbohydrates
KEGG:00030 Pentose phosphate pathway
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA24707
    • No data
    No data
    Releated drug ID Related drug Name
    PA165107975fructose 1,6 bisphosphate
    PA164754789conjugated estrogens
    PA164745534dienestrol
    PA449307diethylstilbestrol
    PA449503estradiol
    PA449509estrogens
    PA449512estrone
    PA164768822chlorotrianisene
    PA449527ethinyl estradiol
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB02512 - 1,6-Fructose Diphosphate (Linear Form)
    DB04326 - 1,3-Dihydroxyacetonephosphate
    DB04733 - 1,6-DI-O-PHOSPHONO-D-MANNITOL
    DB08240 - N-(4-CHLOROPHENYL)-3-(PHOSPHONOOXY)NAPHTHALENE-2-CARBOXAMIDE
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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