AutismKB 2.0

Annotation Detail for FGFR1


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:FGFR1 ( BFGFR,CD331,CEK,FGFBR,FLG,FLJ99988,FLT2,HBGFR,KAL2,N-SAM,OGD )
Gene Full Name: fibroblast growth factor receptor 1
Band: 8p11.23
Quick LinksEntrez ID:2260; OMIM: 136350; Uniprot ID:FGFR1_HUMAN; ENSEMBL ID: ENSG00000077782; HGNC ID: 3688
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04010MAPK signaling pathway
hsa04520Adherens junction
hsa04810Regulation of actin cytoskeleton
hsa05218Melanoma
hsa05215Prostate cancer
hsa05200Pathways in cancer
Pathway IDPathway Name
Axon guidance
Signaling by Insulin receptor
Signaling by FGFR
Pathway IDPathway Name
200189FGF signaling pathway
200180N-cadherin signaling events
200021Glypican 1 network
Pathway IDPathway Name
P00005Angiogenesis
P00021FGF signaling pathway
Pathway IDPathway Name
500236FGFR1 ligand binding and activation
500079NCAM signaling for neurite out-growth
500100Signal transduction by L1
500238FGFR1c ligand binding and activation
500239FGFR1c and Klotho ligand binding and activation
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1755Cleft palate
1804Chronic obstructive airway disease
1930Graves' disease
1934Cancer
1955Urogenital abnormalities
2201Myeloproliferative disease
2249Craniosynostosis
No data
No data
Desease Name
Trigonocephaly
Osteoglophonic dysplasia
Pfeiffer syndrome
Jackson-Weiss syndrome
Hypogonadotropic hypogonadism
Kallmann syndrome 2
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C548651 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of FGFR1 mRNAdecreases expression 19933214
C117011 3-(4-dimethylamino-benzylidenyl)-2-indolinone 3-(4-dimethylamino-benzylidenyl)-2-indolinone results in decreased activity of FGFR1 proteindecreases activity 15728459
C027576 4-hydroxy-2-nonenal 4-hydroxy-2-nonenal results in decreased expression of FGFR1 mRNAdecreases expression 12419474
D000117 Acetylglucosamine Acetylglucosamine analog promotes the reaction [FGF2 protein binds to FGFR1 protein]affects binding|increases reaction 12440867
D020106 Acrylamide Acrylamide analog promotes the reaction [FGF2 protein binds to FGFR1 protein]affects binding|increases reaction 12440867
D020106 Acrylamide Acrylamide analog promotes the reaction [FGFR1 protein binds to FGFR1 protein]affects binding|increases reaction 14733594
D013196 Dihydrotestosterone Dihydrotestosterone results in decreased expression of FGFR1 mRNAdecreases expression 17023530
D000643 Ammonium Chloride Ammonium Chloride affects the expression of FGFR1 mRNAaffects expression 16483693
D003913 Dextroamphetamine Dextroamphetamine results in decreased expression of FGFR1 mRNAdecreases expression 12558987
C463061 AP20187 AP20187 results in increased activity of FGFR1 protein mutant formincreases activity 12654294
C006632 arsenic trioxide arsenic trioxide results in decreased expression of FGFR1 mRNAdecreases expression 15761015
19128835
C006632 arsenic trioxide arsenic trioxide results in decreased phosphorylation of FGFR1 protein mutant formdecreases phosphorylation 17027752
C006632 arsenic trioxide arsenic trioxide results in increased expression of FGFR1 mRNAincreases expression 20458559
17258074
C006780 bisphenol A bisphenol A results in increased expression of FGFR1 mRNAincreases expression 20678512
D001786 Blood Glucose FGFR1 protein affects the abundance of Blood Glucoseaffects abundance 11130726
D019256 Cadmium Chloride Cadmium Chloride results in decreased expression of FGFR1 mRNAdecreases expression 12760830
D002118 Calcium [Calcium co-treated with Calcitriol] affects the expression of FGFR1 mRNAaffects cotreatment|affects expression 15913539
D002251 Carbon Tetrachloride Carbon Tetrachloride results in decreased expression of FGFR1 mRNAdecreases expression 17484886
D003513 Cycloheximide Cycloheximide inhibits the reaction [Triiodothyronine results in increased expression of FGFR1 mRNA]decreases reaction|increases expression 12805413
D003609 Dactinomycin Dactinomycin inhibits the reaction [Triiodothyronine results in increased expression of FGFR1 mRNA]decreases reaction|increases expression 12805413
C014347 decitabine decitabine results in decreased expression of FGFR1 mRNAdecreases expression 17785578
D003976 Diazinon Diazinon results in decreased expression of FGFR1 mRNAdecreases expression 17589599
D003976 Diazinon Diazinon results in increased expression of FGFR1 mRNAincreases expression 19130878
D004026 Dieldrin Dieldrin affects the expression of FGFR1 mRNAaffects expression 19130878
D004041 Dietary Fats Dietary Fats results in decreased expression of FGFR1 mRNAdecreases expression 18042831
D004052 Diethylnitrosamine FGFR1 protein results in increased susceptibility to Diethylnitrosamineincreases response to substance 19009564
D002117 Calcitriol [Calcium co-treated with Calcitriol] affects the expression of FGFR1 mRNAaffects cotreatment|affects expression 15913539
C472511 dimethylarsinous acid dimethylarsinous acid results in decreased expression of FGFR1 mRNAdecreases expression 16507463
D004610 Ellagic Acid Ellagic Acid results in decreased expression of FGFR1 mRNAdecreases expression 12002526
C024552 estrone benzoate estrone benzoate inhibits the reaction [Progesterone results in decreased expression of FGFR1 mRNA alternative form]decreases expression|decreases reaction 15120423
D005576 Forskolin Forskolin results in increased expression of FGFR1 mRNAincreases expression 10320526
D019812 Heparan Sulfate Proteoglycans [Heparan Sulfate Proteoglycans binds to FGF2 protein binds to FGFR1 protein] which binds to KAL1 proteinaffects binding 15548653
D019812 Heparan Sulfate Proteoglycans Heparan Sulfate Proteoglycans promotes the reaction [FGF1 protein binds to and results in increased activity of FGFR1 protein]affects binding|increases activity|increases reaction 15767480
D019812 Heparan Sulfate Proteoglycans Heparan Sulfate Proteoglycans affects the reaction [FGF1 protein binds to FGFR1 protein]affects binding|affects reaction 10336501
D019812 Heparan Sulfate Proteoglycans Heparan Sulfate Proteoglycans affects the reaction [FGF2 protein binds to FGFR1 protein]affects binding|affects reaction 10336501
D019812 Heparan Sulfate Proteoglycans Heparan Sulfate Proteoglycans affects the activity of FGFR1 proteinaffects activity 15923150
D006493 Heparin Heparin promotes the reaction [FGF2 protein binds to FGFR1 protein]affects binding|increases reaction 12440867
D006493 Heparin Heparin binds to FGFR1 protein binds to FGF2 proteinaffects binding 15096041
D006493 Heparin Heparin promotes the reaction [FGFR1 protein binds to FGF1 protein]affects binding|increases reaction 1379594
D006493 Heparin Heparin promotes the reaction [FGFR1 protein binds to FGF2 protein]affects binding|increases reaction 1379594
D006493 Heparin Heparin promotes the reaction [FGF2 protein results in increased activity of FGFR1 protein]increases activity|increases reaction 12799194
D006497 Heparitin Sulfate SULF1 protein inhibits the reaction [Heparitin Sulfate results in increased activity of FGFR1 protein]decreases reaction|increases activity 15051888
D006497 Heparitin Sulfate FGF1 protein binds to Heparitin Sulfate binds to FGFR1 proteinaffects binding 12604602
D006497 Heparitin Sulfate Heparitin Sulfate analog results in increased activity of FGFR1 protein alternative formincreases activity 12460940
D006861 Hydrogen Peroxide Hydrogen Peroxide promotes the reaction [FGF2 protein binds to FGFR1 protein]affects binding|increases reaction 8849686
D006861 Hydrogen Peroxide Hydrogen Peroxide results in decreased expression of FGFR1 mRNAdecreases expression 12419474
D007608 Kainic Acid Kainic Acid results in increased expression of FGFR1 mRNAincreases expression 7649223
D008727 Methotrexate FGFR1 protein affects the susceptibility to Methotrexateaffects response to substance 16217747
D008748 Methylcholanthrene Methylcholanthrene results in increased expression of FGFR1 mRNAincreases expression 20713471
D008770 Methylnitrosourea Methylnitrosourea results in increased expression of and affects the localization of FGFR1 proteinaffects localization|increases expression 15581186
D009020 Morphine Morphine results in increased expression of FGFR1 mRNAincreases expression 15183518
D009287 Naphthyridines Naphthyridines analog results in decreased activity of FGFR1 proteindecreases activity 16000000
D009844 Oligosaccharides Oligosaccharides promotes the reaction [FGF1 protein binds to and results in increased activity of FGFR1 protein]affects binding|increases activity|increases reaction 11714710
D009844 Oligosaccharides Oligosaccharides promotes the reaction [FGF1 protein binds to FGFR1 protein alternative form]affects binding|increases reaction 9174673
C041786 palm oil palm oil results in decreased expression of FGFR1 mRNAdecreases expression 18042831
C107527 PD 161570 PD 161570 inhibits the reaction [FGFR1 protein results in increased phosphorylation of FGFR1 protein]decreases reaction|increases phosphorylation 12805413
C113399 PD 166866 PD 166866 results in decreased activity of FGFR1 proteindecreases activity 15522930
C113399 PD 166866 PD 166866 inhibits the reaction [FGF1 protein results in increased expression of FGFR1 protein]decreases reaction|increases expression 15773903
C113399 PD 166866 PD 166866 inhibits the reaction [FGFR1 protein results in increased phosphorylation of FGFR1 protein]decreases reaction|increases phosphorylation 12805413
C113399 PD 166866 PD 166866 results in decreased activity of FGFR1 proteindecreases activity 15121739
15773903
D030421 Peroxynitrous Acid FGFR1 protein alternative form affects the susceptibility to Peroxynitrous Acidaffects response to substance 12573278
C006253 pirinixic acid pirinixic acid results in increased expression of FGFR1 mRNAincreases expression 12832660
D011374 Progesterone estrone benzoate inhibits the reaction [Progesterone results in decreased expression of FGFR1 mRNA alternative form]decreases expression|decreases reaction 15120423
D011374 Progesterone Progesterone results in decreased expression of FGFR1 mRNA alternative formdecreases expression 15120423
C059514 resveratrol resveratrol results in increased expression of FGFR1 mRNAincreases expression 12002526
C010327 salinomycin salinomycin results in decreased expression of FGFR1 mRNAdecreases expression 19682730
D012643 Selenium Selenium results in increased expression of FGFR1 proteinincreases expression 18583539
C017947 sodium arsenite sodium arsenite results in decreased expression of FGFR1 mRNAdecreases expression 16876216
C016104 sodium bichromate sodium bichromate results in decreased expression of FGFR1 mRNAdecreases expression 12760830
C105686 SU 5402 SU 5402 results in decreased activity of FGFR1 proteindecreases activity 16188231
16091734
16154193
C105686 SU 5402 SU 5402 results in decreased activity of FGFR1 protein mutant formdecreases activity 16103074
C105686 SU 5402 SU 5402 results in decreased activity of FGFR1 proteindecreases activity 12421715
C105686 SU 5402 SU 5402 results in increased expression of FGFR1 mRNA alternative formincreases expression 12421715
C105686 SU 5402 SU 5402 results in decreased activity of FGFR1 proteindecreases activity 15631803
15936332
15298682
16326079
16103074
12704805
15255957
C412603 SU 6668 SU 6668 results in decreased phosphorylation of and results in decreased activity of FGFR1 proteindecreases activity|decreases phosphorylation 16144927
C412603 SU 6668 SU 6668 results in decreased activity of FGFR1 proteindecreases activity 15788688
15551349
14760097
16132614
D014284 Triiodothyronine Triiodothyronine results in increased expression of FGFR1 mRNAincreases expression 16150908
D014284 Triiodothyronine Cycloheximide inhibits the reaction [Triiodothyronine results in increased expression of FGFR1 mRNA]decreases reaction|increases expression 12805413
D014284 Triiodothyronine Dactinomycin inhibits the reaction [Triiodothyronine results in increased expression of FGFR1 mRNA]decreases reaction|increases expression 12805413
D014284 Triiodothyronine Triiodothyronine promotes the reaction [FGF2 protein promotes the reaction [FGFR1 protein results in increased phosphorylation of FGFR1 protein]]increases phosphorylation|increases reaction 12805413
D014284 Triiodothyronine Triiodothyronine results in increased expression of FGFR1 mRNAincreases expression 12805413
D014284 Triiodothyronine Triiodothyronine results in increased expression of FGFR1 proteinincreases expression 12805413
D013629 Tamoxifen FGFR1 protein results in decreased susceptibility to Tamoxifendecreases response to substance 20179196
D013654 Taurine Taurine results in decreased expression of FGFR1 mRNAdecreases expression 16579726
D013739 Testosterone Testosterone results in increased expression of FGFR1 mRNAincreases expression 7536664
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin inhibits the reaction [EGF protein results in increased expression of FGFR1 mRNA]decreases reaction|increases expression 15667827
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of FGFR1 mRNAdecreases expression 19933214
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of FGFR1 mRNAincreases expression 17586704
D014028 Tobacco Smoke Pollution Tobacco Smoke Pollution results in decreased expression of FGFR1 mRNAdecreases expression 15289447
D024505 Tocopherols Tocopherols results in decreased expression of FGFR1 mRNAdecreases expression 15144885
D014212 Tretinoin Tretinoin results in increased expression of FGFR1 mRNAincreases expression 16604517
D014212 Tretinoin Tretinoin results in increased expression of FGFR1 proteinincreases expression 15389522
D014508 Urea Urea analog results in decreased activity of FGFR1 proteindecreases activity 16000000
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 3.9214745880
MESH:D000014 Abnormalities, Drug-Induced Methotrexate 6.5612039119
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 6.5615322242 14514962 11752688
MESH:D000138 Acidosis Ammonium Chloride 2.9518287403
MESH:D000168 Acrocephalosyndactylia marker/mechanism
MESH:D058186 Acute Kidney Injury resveratrol 3.3016538975
MESH:D055371 Acute Lung Injury pirinixic acid 2.5518653653
MESH:D000230 Adenocarcinoma arsenic trioxide 4.1119825857 11798837
MESH:D000230 Adenocarcinoma Methylnitrosourea 4.1115113128 15688392
MESH:D002282 Adenocarcinoma, Bronchiolo-Alveolar Tobacco Smoke Pollution 4.9015814487
MESH:D000236 Adenoma Diethylnitrosamine 9.0510737359 6695378
MESH:D000236 Adenoma Methylcholanthrene 9.0510545420 6695378
MESH:D000236 Adenoma resveratrol 9.0515688382
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 13.7219052882 18056438 19061943 17162532 17620307 16434500
MESH:D018248 Adenoma, Liver Cell pirinixic acid 13.7216434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 13.7216835633
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.0715276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 4.2716712894 17306315
MESH:D000382 Agricultural Workers' Diseases Diazinon 3.7316487989
MESH:D000505 Alopecia Tretinoin 3.1215955085
MESH:D000544 Alzheimer Disease resveratrol 2.4116183991 16162502
MESH:D000690 Amyotrophic Lateral Sclerosis 4-hydroxy-2-nonenal 3.6910965797
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.4111748828
MESH:D000987 Antisocial Personality Disorder Testosterone 5.227506515
MESH:C537780 Antley-Bixler syndrome marker/mechanism
MESH:D001161 Arteriosclerosis Dietary Fats 3.2915238619
MESH:D001169 Arthritis, Experimental resveratrol 6.1517115116
MESH:D001169 Arthritis, Experimental Tretinoin 6.1516412693
MESH:D001172 Arthritis, Rheumatoid Methotrexate 6.4617286800
MESH:D001172 Arthritis, Rheumatoid Tobacco Smoke Pollution 6.4619898480
MESH:D001172 Arthritis, Rheumatoid Tretinoin 6.4616292516
MESH:D001249 Asthma Tretinoin 2.1316456186
MESH:D050197 Atherosclerosis Methylcholanthrene 5.6511922910
MESH:D050197 Atherosclerosis resveratrol 5.6517967414 16873680
MESH:D001471 Barrett Esophagus Tretinoin 3.8116935849
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 17.4116206674
MESH:D001778 Blood Coagulation Disorders pirinixic acid 17.4119483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 17.4112125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 17.4116206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.1615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.3415746008
MESH:D019046 Bone Marrow Neoplasms Dactinomycin 4.9114601052
MESH:D001862 Bone Resorption bisphenol A 3.3111985600
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 4.7117868700
MESH:D001930 Brain Injuries Progesterone 3.6615845082 15380490 15665606
MESH:D002545 Brain Ischemia Morphine 8.5819211983
MESH:D002545 Brain Ischemia resveratrol 8.5817600658
MESH:D001932 Brain Neoplasms SU 6668 5.4115739567
MESH:D001943 Breast Neoplasms marker/mechanism 20179196
MESH:D001943 Breast Neoplasms Acrylamide 15.8616253758 18183576
MESH:D001943 Breast Neoplasms bisphenol A 15.8617123778
MESH:D001943 Breast Neoplasms Calcitriol 15.8611237771
MESH:D001943 Breast Neoplasms decitabine 15.8619208741 18320071
MESH:D001943 Breast Neoplasms Dieldrin 15.8611859874 15770527
MESH:D001943 Breast Neoplasms Dietary Fats 15.8620435547
MESH:D001943 Breast Neoplasms Diethylnitrosamine 15.8617474063
MESH:D001943 Breast Neoplasms Methotrexate 15.8616978400
MESH:D001943 Breast Neoplasms Methylcholanthrene 15.8617474063
MESH:D001943 Breast Neoplasms Methylnitrosourea 15.8616253758 14633655 11306469
MESH:D001943 Breast Neoplasms Progesterone 15.8616175315 15562024 17614352
MESH:D001943 Breast Neoplasms resveratrol 15.8617534123 17651959 16393696
MESH:D001943 Breast Neoplasms salinomycin 15.8619682730
MESH:D001943 Breast Neoplasms Tamoxifen 15.8619084267 18351453 20544844 19487384 19155303 19059307 18629630 18425577 19142967 20065188 15565566 19289846 16202921 16818667 15668708 19244106 18855134 17049068 20135344 19066611 11161223 17440819 19011961 21138602 18815881 19288272 17261762 18821012 20390343 16273361 19115204 18984771 19221464 20005174 17893378 19103187 19189212 18997820 19189210 16873071 21152245 20859285 19200415 17242785 19410462
MESH:D001943 Breast Neoplasms Testosterone 15.8617261762
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 15.8620435547
MESH:D001943 Breast Neoplasms Tretinoin 15.8616873071 16443354 16166294
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 3.9716813970
MESH:D002051 Burkitt Lymphoma arsenic trioxide 3.7611589617
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.1810355542 16124888 3786805 18705752 15721981 16050911 15700767 16192424 16227642 16097048 15673190 16011737
MESH:D002277 Carcinoma Methylcholanthrene 6.6810545420
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 6.6816835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 3.9019066611
MESH:D018236 Carcinoma, Embryonal Tretinoin 4.5316168501
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 11.9415553829 14691202 15073043 16217749 11135700
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 11.9418788625
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 11.9417428255 18506893 18971187 3084413 21159647 18393292 18785209 18788625 16779866 19701751 11831363 16569478 19335982 19539802 19822196 18210153 18665156 20935162 16807293 19052882 10737359 17978847 19394651 19919837 20084675 17761372 19418558 16935385 20512989 10672840 20007298 20727157 20432363 17138121 20524982 17055752 18056438 16288022 18691550 17173139 16681979 16878318 3581430 19171122 19519916 20514400 18978308 20214788 16830150 16540662 19208518 19383236 20101231 16502159 18494052 19107877 17162532 16698587 16328049
MESH:D006528 Carcinoma, Hepatocellular resveratrol 11.9419321006 16227395
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 11.9415276417 17306315 16507464
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 11.9416924424
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 11.941917145
MESH:D002278 Carcinoma in Situ bisphenol A 4.3717123778
MESH:D018827 Carcinoma, Lewis Lung resveratrol 3.9816675471
MESH:D002289 Carcinoma, Non-Small-Cell Lung Tobacco Smoke Pollution 3.1811212258
MESH:D002291 Carcinoma, Papillary arsenic trioxide 4.2419014326
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 3.5712490120
MESH:D002294 Carcinoma, Squamous Cell Calcitriol 15.1111237771
MESH:D002294 Carcinoma, Squamous Cell decitabine 15.1119215824
MESH:D002294 Carcinoma, Squamous Cell resveratrol 15.1116227395
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 15.1118572023
MESH:D002294 Carcinoma, Squamous Cell Tobacco Smoke Pollution 15.1111212258
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 15.1116096774 16051514
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.0817572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.0018850075 18670907 16120746
MESH:D002318 Cardiovascular Diseases Hydrogen Peroxide 6.1116936243
MESH:D002318 Cardiovascular Diseases resveratrol 6.1115458977
MESH:D002386 Cataract Methylnitrosourea 6.4312484553
MESH:D002386 Cataract Tretinoin 6.4317460283
MESH:D002418 Cattle Diseases Acrylamide 4.8212510666
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 12.4721159647 17174075 2727394 7505956
MESH:D002471 Cell Transformation, Neoplastic Methylcholanthrene 12.4716192471
MESH:D002471 Cell Transformation, Neoplastic Methylnitrosourea 12.477505956 2727394
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 12.4719524636 20056578
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 3.9716129372
MESH:D002659 Child Development Disorders, Pervasive Testosterone 3.4220678186
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 7.5819052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 7.5816835633
MESH:D002779 Cholestasis pirinixic acid 2.3619176532
MESH:D002822 Choriocarcinoma Tretinoin 4.5316461808
MESH:D002971 Cleft Lip marker/mechanism 17963255
MESH:D002972 Cleft Palate marker/mechanism 17963255
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 4.7615668235 8697196 16354765 15340226 12621046
MESH:D002972 Cleft Palate Tretinoin 4.769407595
MESH:D003092 Colitis resveratrol 12.5716474422
MESH:D003092 Colitis Selenium 12.5717936198
MESH:D003092 Colitis Tretinoin 12.5717035595
MESH:D003110 Colonic Neoplasms decitabine 3.4517616700
MESH:D003110 Colonic Neoplasms resveratrol 3.4516338953
MESH:D015179 Colorectal Neoplasms arsenic trioxide 3.0720501625
MESH:D015179 Colorectal Neoplasms decitabine 3.0718981723
MESH:D015179 Colorectal Neoplasms resveratrol 3.0716550006
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.5414669216 17141729
MESH:D003327 Coronary Disease resveratrol 3.3316507316
MESH:D023903 Coronary Restenosis arsenic trioxide 3.6012609071
MESH:D019465 Craniofacial Abnormalities marker/mechanism 12514106
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 4.6510525206
MESH:D019465 Craniofacial Abnormalities Methotrexate 4.659562676 12039119
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 4.6515322242 10048152 20055451
MESH:D019465 Craniofacial Abnormalities Tretinoin 4.6510589399 16925845 17551590 9224671 9664655 14991402 9142499 9125849 8800419 9211117
MESH:D003550 Cystic Fibrosis Methotrexate 3.7119747007
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 3.5215213294
MESH:D003711 Demyelinating Diseases Tamoxifen 3.7619031437
MESH:D003866 Depressive Disorder marker/mechanism 16861106
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.1118249437
MESH:D003882 Dermatomyositis Methotrexate 4.5420191521
MESH:D003921 Diabetes Mellitus, Experimental resveratrol 3.2616873680
MESH:D003924 Diabetes Mellitus, Type 2 Blood Glucose 6.2419586609
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 6.2420387270
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 6.2417107852
MESH:D058065 Diabetic Cardiomyopathies Taurine 5.4316025228
MESH:D003928 Diabetic Nephropathies resveratrol 7.3016286809
MESH:D003928 Diabetic Nephropathies Tamoxifen 7.3019279558
MESH:D003929 Diabetic Neuropathies Progesterone 3.8917187935
MESH:D003967 Diarrhea Morphine 3.952540324
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 9.5716227642 6884620 19085960 15027814 3732212 11566570 16177239 19336974 21278145 3786805 17522070 10092053 9327722 7179309 10915739 6623471 7440962 7120509 15968718 15998439 4309450 2869522
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 9.5719107877
MESH:D056486 Drug-Induced Liver Injury Selenium 9.5715131321
MESH:D056486 Drug-Induced Liver Injury Taurine 9.579328219
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 9.5720420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.2911462148
MESH:D050171 Dyslipidemias Dietary Fats 2.9918367378
MESH:D004417 Dyspnea Diazinon 4.1816487989
MESH:D004487 Edema pirinixic acid 8.2812083418
MESH:D004487 Edema resveratrol 8.288985016
MESH:D004487 Edema Tetrachlorodibenzodioxin 8.2811000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 9.8518230668 15322242 16714409
MESH:D004489 Edema, Cardiac Tretinoin 9.8518230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Calcitriol 17.1815138306
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 17.1817692515
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental resveratrol 17.1817872969
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 17.1819031437
MESH:D004701 Endocrine Gland Neoplasms decitabine 4.4919294695
MESH:D016889 Endometrial Neoplasms Tamoxifen 6.0120544844 17893378 19155303 16202921
MESH:D016889 Endometrial Neoplasms Tretinoin 6.0116569247
MESH:D004715 Endometriosis Progesterone 7.1416134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 7.1410568697 9294722
MESH:D020345 Enterocolitis, Necrotizing resveratrol 4.2517923197
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 4.4916302075
MESH:D004938 Esophageal Neoplasms arsenic trioxide 2.1312903497
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 7.2611564622
MESH:D005124 Eye Abnormalities Tretinoin 7.269664655 16938888
MESH:D005234 Fatty Liver arsenic trioxide 23.5815073043
MESH:D005234 Fatty Liver Carbon Tetrachloride 23.5815959796 61145 12795759 16045604 12631006 16239168 17595544 19224547
MESH:D005234 Fatty Liver Dietary Fats 23.5818296743 19004024 19551842 17967931
MESH:D005234 Fatty Liver Diethylnitrosamine 23.5820387270 21071580
MESH:D005234 Fatty Liver pirinixic acid 23.5819236843 20131406
MESH:D005234 Fatty Liver Tamoxifen 23.5814986274 19224547
MESH:D052776 Female Urogenital Diseases Tamoxifen 2.8316709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 2.8611858732
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 3.9114745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 3.5719069698
MESH:D005354 Fibrosarcoma Methylcholanthrene 10.1714633661 10962813
MESH:D005354 Fibrosarcoma Methylnitrosourea 10.1711555667
MESH:D005355 Fibrosis Carbon Tetrachloride 16.2418705752
MESH:D005355 Fibrosis Dietary Fats 16.2418296743
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 16.2420067830
MESH:D005355 Fibrosis Tretinoin 16.2417994277
MESH:D005391 Firesetting Behavior Testosterone 5.227506515
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 3.6716904648
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.0616452187
MESH:D005909 Glioblastoma Testosterone 6.0817162496
MESH:D005909 Glioblastoma Tretinoin 6.0817312396
MESH:D005910 Glioma Methylnitrosourea 6.259825942
MESH:D005910 Glioma SU 6668 6.2515739567
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 3.9610696789
MESH:D006086 Graft vs Host Disease Methotrexate 4.5416518429
MESH:D006258 Head and Neck Neoplasms decitabine 6.3719215824
MESH:D006258 Head and Neck Neoplasms Tretinoin 6.3716096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 4.5316084493
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 5.3311294989 10048152
MESH:D006330 Heart Defects, Congenital Tretinoin 5.339664655 14991402
MESH:D006333 Heart Failure pirinixic acid 5.5920558911
MESH:D006333 Heart Failure Selenium 5.5917162251
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 2.7811000095
MESH:D006505 Hepatitis Carbon Tetrachloride 7.6719900420 19110552
MESH:D006505 Hepatitis Diazinon 7.6716487989
MESH:D006529 Hepatomegaly pirinixic acid 6.2816221962 19176532 19772884 18467677
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 6.2815340226 16120746 12621046
MESH:D006561 Herpes Simplex resveratrol 3.5716876885
MESH:D006628 Hirsutism Testosterone 5.0217019078
MESH:D006689 Hodgkin Disease sodium arsenite 2.6512676792
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.4216959395 15340226 18606429 16354765 8697196
MESH:D006930 Hyperalgesia Tretinoin 2.7216870215
MESH:D017588 Hyperandrogenism Testosterone 4.6817019078
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 3.9116899240
MESH:D006937 Hypercholesterolemia Dietary Fats 7.3821332399
MESH:D006937 Hypercholesterolemia resveratrol 7.3817188708
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 3.9616778211
MESH:D006943 Hyperglycemia pirinixic acid 2.6520558911
MESH:D006949 Hyperlipidemias Dietary Fats 7.4021332399
MESH:D006949 Hyperlipidemias resveratrol 7.4016873680
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.6518850075 18670907
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.4915338365
MESH:D017379 Hypertrophy, Left Ventricular resveratrol 3.7617488730
MESH:D007006 Hypogonadism marker/mechanism
MESH:D007006 Hypogonadism Testosterone 4.1312002444
MESH:D007018 Hypopituitarism Testosterone 5.5717426086
MESH:D007174 Impulse Control Disorders Testosterone 5.227506515
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 9.4815869954
MESH:D020244 Infarction, Middle Cerebral Artery resveratrol 9.4817600658
MESH:D007247 Infertility, Female Acrylamide 9.0411020651
MESH:D007247 Infertility, Female Dieldrin 9.0410630421
MESH:D007248 Infertility, Male Acrylamide 16.5712507653 11020651 15355880 15749267
MESH:D007248 Infertility, Male decitabine 16.5717581917
MESH:D007248 Infertility, Male Diazinon 16.5712948887 16466525
MESH:D007248 Infertility, Male Methylnitrosourea 16.577193160
MESH:D007248 Infertility, Male sodium arsenite 16.5715346721 12646999
MESH:D007249 Inflammation Dietary Fats 18.7520412841
MESH:D007249 Inflammation Diethylnitrosamine 18.7518785209
MESH:D007249 Inflammation Progesterone 18.7515869954
MESH:D007249 Inflammation resveratrol 18.7516366677
MESH:D007249 Inflammation Tamoxifen 18.7519457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 18.7512200463 12878042
MESH:D007249 Inflammation Tobacco Smoke Pollution 18.7518590791
MESH:D007251 Influenza, Human resveratrol 8.9916624496
MESH:D007251 Influenza, Human Selenium 8.9916624496
MESH:D007333 Insulin Resistance bisphenol A 9.8516393666
MESH:D007333 Insulin Resistance Dietary Fats 9.8511836018 18457598
MESH:D007333 Insulin Resistance pirinixic acid 9.8516306350
MESH:D007410 Intestinal Diseases Tretinoin 3.1717994277
MESH:C537559 Jackson-Weiss syndrome marker/mechanism
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 8.0916580747
MESH:D007569 Jaw Abnormalities Tretinoin 8.0915992940 17551590
MESH:D017436 Kallmann Syndrome marker/mechanism
MESH:D007674 Kidney Diseases Cadmium Chloride 5.1516962696
MESH:D007674 Kidney Diseases sodium arsenite 5.1520008137
MESH:D007676 Kidney Failure, Chronic Hydrogen Peroxide 8.1816518626
MESH:D007676 Kidney Failure, Chronic Selenium 8.1816518626
MESH:D007680 Kidney Neoplasms Tamoxifen 2.5518625569
MESH:D007683 Kidney Tubular Necrosis, Acute Calcium 4.4216316344
MESH:D007805 Language Development Disorders Methotrexate 4.539562676
MESH:D007938 Leukemia arsenic trioxide 8.4915070760
MESH:D007938 Leukemia decitabine 8.4918980019 19235587
MESH:D007938 Leukemia Tretinoin 8.4917143497
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 3.2417077332 12560223
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 3.6916972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 2.9614633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 12.7919077051
MESH:D007951 Leukemia, Myeloid decitabine 12.7918454857 19117987 17236224
MESH:D007951 Leukemia, Myeloid Tretinoin 12.7916932348 19285840 16482212
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 5.2416467208 17050201 20471514 19850784 16968895
MESH:D015470 Leukemia, Myeloid, Acute decitabine 5.2419010910 18206229 17679729 19387464 18460780 18704418
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 5.2419850784 16294345 17596541
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 4.8318055864
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 10.3011161223 12018890 17649720 16330433 16823087 16331271 16891316 12679006 19035177 15336539 19642359 15622746 19075265 17869043 9834237 19225113 16112521 17217047 12712474 16966277 15213294 15748426 11468182 17107899 17712046
MESH:D015473 Leukemia, Promyelocytic, Acute resveratrol 10.3016087638
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 10.3016823087 16766008 17294898 17217047 17339181 19029980 16891316 16140955 17107899 17368321 17361223 19035177 9834237 16935935 17712046 17301526 19075265 17506722 17649720 19642359 16788101 19225113 15748426 12679006 16331271
MESH:D015458 Leukemia, T-Cell arsenic trioxide 3.7616882451
MESH:D017880 Limb Deformities, Congenital Methylnitrosourea 6.9315526292
MESH:D017880 Limb Deformities, Congenital Tretinoin 6.939224671
MESH:D008064 Lipidoses Tamoxifen 2.7017567588 15342952
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 12.7116943688 21278145 16239168 16221502 11408273 11903743 17157831 17174718 17334410
MESH:D008103 Liver Cirrhosis Dietary Fats 12.7118296743
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 12.7120032147 19638242 18665156 18522880 18407596
MESH:D008103 Liver Cirrhosis Methotrexate 12.7114986274
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 9.2315925388 12741479 14512876 15362042 17557913 17761835 15730626 17721639 18376398 18339082 18210741 10355542 12649538 18279442 15673190 15123356 17805973 12586293 20821823 15996030 14716496 15818738 17869086 18205269 18472094 17708605 17922224 18187930 12898905 18156304 17698563 15057751 16136751 12958196 15650968 18429990 16015684 18481824 12666154 15959796 18277467 14716833 18251166 18263696 18412020 17631135 16248980 17976157 14748882 16011737 12632514 18418968 18472332 18395095 14724832 12609069 18054572 13678700 12445418 16192424 17714472 12667390 15931870 18420326 16638106 12632512 12389079 17525996 12546737 12445421 18395914 17640975 15338365 17766677 15370692 15876570 14620537 17900296 11481614 16097048 17481882 18166357 18006644 16033810 15893842 18705752 17823541 18317297 17944888 15052691 16027843 17565644 16116963
MESH:D008106 Liver Cirrhosis, Experimental Heparin 9.2316904936
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 9.2315474484
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 9.2318564211
MESH:D008106 Liver Cirrhosis, Experimental Taurine 9.2315931870 15893842
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 9.2312878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 9.2316248980 18397230
MESH:D008107 Liver Diseases Carbon Tetrachloride 3.4116246199 15830285 17285989 16964402 15720792
MESH:D008107 Liver Diseases Diethylnitrosamine 3.4117034775
MESH:D017093 Liver Failure Carbon Tetrachloride 3.5615123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.1514706259 16899240
MESH:D008113 Liver Neoplasms arsenic trioxide 24.5514682389
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 24.5519294768
MESH:D008113 Liver Neoplasms Dieldrin 24.558742319 9539021
MESH:D008113 Liver Neoplasms Diethylnitrosamine 24.5519256749 15885732 19638242 20101389 19254457 19996281 18977376 18648771 18754104 21167192 19426721 19255062 19499222 20583210 19690152 15175105 19294768 2422723 12771043 9163691 20452335 19090486 20137499 19073162 21278145 19833225 18644402 20434301 12112319 21047994 19812893 20501860 19850985 20405173 18978307 20118626 19551842 21071580 16942905 20492335 19642983 2862719 10737359 19427195
MESH:D008113 Liver Neoplasms pirinixic acid 24.5520007298 16377806 15890375
MESH:D008113 Liver Neoplasms resveratrol 24.5519812893 20405173 19321006 19073162
MESH:D008113 Liver Neoplasms sodium arsenite 24.5516712894 15276417
MESH:D008113 Liver Neoplasms Tamoxifen 24.5516684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 24.5516984957
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 14.2920377131
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 14.2915583823 12014681
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 14.2917854601 19009564 17942915 18775883 19519916 18079962 2563599 18093689 17174075 19539802 19126423 18544905 19004024 16267830 18253720 18282651 9362446 16842330 3124819 21159647 18164116 18308698
MESH:D008114 Liver Neoplasms, Experimental Methylcholanthrene 14.29598648 1399818
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 14.2912151625
MESH:D008133 Long QT Syndrome arsenic trioxide 2.8715213294
MESH:D038061 Lower Extremity Deformities, Congenital Methylnitrosourea 4.8616080182
MESH:D008171 Lung Diseases sodium arsenite 2.7419095001
MESH:D017563 Lung Diseases, Interstitial Methotrexate 4.3918516814
MESH:D008175 Lung Neoplasms arsenic trioxide 11.0519825857 11798837
MESH:D008175 Lung Neoplasms Diethylnitrosamine 11.0521163286 20970405 6695378 20512841
MESH:D008175 Lung Neoplasms Methylcholanthrene 11.051399818 11893704 16271038 17909032 15390079 20512841 16337739 10545420 7750092 6695378 9230183 20970405 21163286
MESH:D008175 Lung Neoplasms Methylnitrosourea 11.0518062963
MESH:D008175 Lung Neoplasms sodium arsenite 11.0519931552 16712894 17077188 17306315 15276417
MESH:D008175 Lung Neoplasms Tamoxifen 11.0518625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 11.0511884234 19555203
MESH:D008175 Lung Neoplasms Tobacco Smoke Pollution 11.0516288123 12111688 11091918 3440675
MESH:D008223 Lymphoma decitabine 10.1219470736
MESH:D008223 Lymphoma Methotrexate 10.1217352296
MESH:D008223 Lymphoma Methylnitrosourea 10.1216257854 11418001
MESH:D016393 Lymphoma, B-Cell Methylnitrosourea 8.6414633661
MESH:D016393 Lymphoma, B-Cell resveratrol 8.6417088997
MESH:D008228 Lymphoma, Non-Hodgkin resveratrol 3.3614749477
MESH:D015674 Mammary Neoplasms, Animal resveratrol 7.9615688416
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 7.9619428831
MESH:D008325 Mammary Neoplasms, Experimental Methylnitrosourea 22.0714999141 11807958 17020996 19196723 12931682 10767621 16944150 15113128 14633655 15313902 15688392 16619500 17131329 16051031 16827153 11751437 10838139
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 22.0717203775 11408345
MESH:D008325 Mammary Neoplasms, Experimental resveratrol 22.0711606380 8985016
MESH:D008325 Mammary Neoplasms, Experimental salinomycin 22.0719682730
MESH:D008325 Mammary Neoplasms, Experimental Selenium 22.0715318939
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 22.0711731420 19196723 14580682 19196722 16827153
MESH:D008325 Mammary Neoplasms, Experimental Tocopherols 22.0717927505
MESH:D020149 Manganese Poisoning Tamoxifen 3.9219453300
MESH:D008527 Medulloblastoma Tretinoin 2.5017453147
MESH:D008545 Melanoma decitabine 8.1716505122 17785578
MESH:D008545 Melanoma resveratrol 8.1717992120
MESH:D008545 Melanoma sodium arsenite 8.1716487513 19082730
MESH:D008545 Melanoma Tamoxifen 8.1712393984 19393235
MESH:D008545 Melanoma Tretinoin 8.1716752155
MESH:D018328 Melanoma, Amelanotic Tamoxifen 3.5715990972
MESH:D008591 Meningomyelocele Tretinoin 3.8216940565
MESH:D008654 Mesothelioma Selenium 5.7115107826
MESH:D008654 Mesothelioma Tocopherols 5.7115878867
MESH:D008659 Metabolic Diseases resveratrol 3.8217112576
MESH:D009041 Motion Sickness Dextroamphetamine 4.891613127
MESH:D009062 Mouth Neoplasms Tobacco Smoke Pollution 3.8715006635
MESH:D052016 Mucositis Methotrexate 4.6617488658
MESH:D009101 Multiple Myeloma arsenic trioxide 9.5311468182 19417148 15949261 14977855 19549372
MESH:D009101 Multiple Myeloma decitabine 9.5318172295
MESH:D009101 Multiple Myeloma resveratrol 9.5316267019 17049120 17935668 16490592 17164350 14749477
MESH:D009134 Muscular Atrophy, Spinal resveratrol 4.2517962980
MESH:D009135 Muscular Diseases pirinixic acid 2.9116239165
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.0418349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 10.1016882451 16105982
MESH:D009190 Myelodysplastic Syndromes decitabine 10.1019010910 16882708 19157545 18608210
MESH:D009190 Myelodysplastic Syndromes Tretinoin 10.1017596541
MESH:D009203 Myocardial Infarction pirinixic acid 4.7419151258
MESH:D009203 Myocardial Infarction resveratrol 4.7417188708 17015251 16525036 17125593 16317513 16456233
MESH:D017202 Myocardial Ischemia resveratrol 7.3517015251 17125593
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 7.3512213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 2.4616411023
MESH:D009205 Myocarditis resveratrol 4.1417322642
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 3.3716624393
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 4.769029167 3581430
MESH:D009362 Neoplasm Metastasis Tamoxifen 4.7619393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.2819410462
MESH:D009369 Neoplasms decitabine 15.3417925555 19116145 19470736
MESH:D009369 Neoplasms Dieldrin 15.348820588
MESH:D009369 Neoplasms Methylnitrosourea 15.3415533788
MESH:D009369 Neoplasms pirinixic acid 15.3417405874
MESH:D009369 Neoplasms sodium arsenite 15.3411559025
MESH:D009369 Neoplasms Tretinoin 15.3416594593 16946489
MESH:D009374 Neoplasms, Experimental Methylnitrosourea 11.9412696579
MESH:D009374 Neoplasms, Experimental resveratrol 11.948985016
MESH:D009374 Neoplasms, Experimental sodium arsenite 11.9420056578
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 3.3719200415 19189210 19196722
MESH:D009410 Nerve Degeneration Acrylamide 4.2112387366 11264303 12387367
MESH:D009422 Nervous System Diseases Acrylamide 4.4612507653 12164553
MESH:D009421 Nervous System Malformations bisphenol A 12.9911399458 16427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 12.9914600291
MESH:D009421 Nervous System Malformations Tretinoin 12.999125849
MESH:D009436 Neural Tube Defects arsenic trioxide 9.6810525206
MESH:D009436 Neural Tube Defects sodium arsenite 9.6812854658
MESH:D009436 Neural Tube Defects Tretinoin 9.689142499
MESH:D009442 Neurilemmoma Methylnitrosourea 4.8711555667
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 6.8320387270
MESH:D019636 Neurodegenerative Diseases resveratrol 6.8317652729
MESH:D020078 Neurogenic Inflammation resveratrol 3.8317929310
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 4.4920387270
MESH:D009765 Obesity Dietary Fats 3.7820132043 19632207 20518802 17217161 11836018 21332399 18674790 18457598 16723640
MESH:D009765 Obesity pirinixic acid 3.7820558911
OMIM:166250 OSTEOGLOPHONIC DYSPLASIA marker/mechanism
MESH:D010024 Osteoporosis Calcium 3.3817882678
MESH:D015663 Osteoporosis, Postmenopausal resveratrol 3.6917513867
MESH:D010049 Ovarian Diseases bisphenol A 4.3711985600
MESH:D010051 Ovarian Neoplasms arsenic trioxide 12.4019769630 16624393 12452020
MESH:D010051 Ovarian Neoplasms decitabine 12.4019331143 19259094
MESH:D010051 Ovarian Neoplasms Progesterone 12.4016525653 17393432
MESH:D010051 Ovarian Neoplasms sodium arsenite 12.4017306315 15276417
MESH:D010051 Ovarian Neoplasms Tretinoin 12.4016936753
MESH:D010146 Pain Morphine 5.5915275824 16273134 20225289 6776300 15215642 18699797
MESH:D010146 Pain Tretinoin 5.5916870215
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 13.4715580305
MESH:D010190 Pancreatic Neoplasms decitabine 13.4719294695
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 13.4716540662
MESH:D010190 Pancreatic Neoplasms Methylnitrosourea 13.4716965848
MESH:D010190 Pancreatic Neoplasms Tretinoin 13.4715976015
MESH:D010212 Papilloma Hydrogen Peroxide 3.4912065085
MESH:D010235 Paraganglioma arsenic trioxide 3.5919927285
MESH:D010300 Parkinson Disease Dieldrin 3.2717291500 16809432 11181820 11445065 16112328
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.6212520081
MESH:D010523 Peripheral Nervous System Diseases Acrylamide 4.5211510240
MESH:D010787 Photosensitivity Disorders 4-hydroxy-2-nonenal 4.8711550810
MESH:D010954 Plasmacytoma Selenium 4.2615087411
MESH:D011041 Poisoning Diazinon 3.7917603234
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 2.9718163543
MESH:D011230 Precancerous Conditions Diethylnitrosamine 3.032563599
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 12.7410548101
MESH:D011297 Prenatal Exposure Delayed Effects resveratrol 12.7416679765
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 12.7411896295 11222880 11118676 11399792
MESH:D055728 Primary Myelofibrosis decitabine 4.1217616702
MESH:D011470 Prostatic Hyperplasia Calcitriol 4.1615572423
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 9.1320887781
MESH:D019048 Prostatic Intraepithelial Neoplasia Testosterone 9.1320887781
MESH:D011471 Prostatic Neoplasms arsenic trioxide 2.2419131511
MESH:D011471 Prostatic Neoplasms bisphenol A 2.2416740699
MESH:D011471 Prostatic Neoplasms Calcitriol 2.2416289102 12479363 15754350 18247401 16644109
MESH:D011471 Prostatic Neoplasms Methylnitrosourea 2.2415682402 12376480
MESH:D011471 Prostatic Neoplasms resveratrol 2.2416731767 17804756 17718901 17636462 15767336 17675339
MESH:D011471 Prostatic Neoplasms sodium arsenite 2.2416039940
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.2415067354
MESH:D011471 Prostatic Neoplasms Tocopherols 2.2412504091
MESH:D011507 Proteinuria Tretinoin 3.0416636307
MESH:D011565 Psoriasis Methotrexate 3.1817410198
MESH:D011625 Pterygium Tretinoin 4.1716723453
MESH:D011629 Puberty, Precocious bisphenol A 4.1710548101
MESH:D051437 Renal Insufficiency Methotrexate 4.1117352296
MESH:D051436 Renal Insufficiency, Chronic resveratrol 4.9516325855
MESH:D015427 Reperfusion Injury Morphine 9.1019211983
MESH:D015427 Reperfusion Injury pirinixic acid 9.1019058328
MESH:D015427 Reperfusion Injury resveratrol 9.1015827377 16314181 16317513 17058453 17520802
MESH:D012135 Respiratory Sounds Tobacco Smoke Pollution 4.0318410779
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.2518990726
MESH:D012162 Retinal Degeneration Methylnitrosourea 3.9418172121 18155124
MESH:D012175 Retinoblastoma Methylnitrosourea 4.8711555667
MESH:D012208 Rhabdomyosarcoma decitabine 9.0519155313
MESH:D012208 Rhabdomyosarcoma Tretinoin 9.0516116481 16283617
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.6018045962
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 8.6416646077
MESH:D012512 Sarcoma, Ewing's Dactinomycin 8.6414601052
MESH:D012559 Schizophrenia marker/mechanism 16861106
MESH:D012640 Seizures Kainic Acid 3.9614637104 19414003 1641125 18657176 10686065 19186208 16336964 15686955 17827730
MESH:D012735 Sexual Dysfunction, Physiological Testosterone 5.5716631401
MESH:D012851 Sinus Thrombosis, Intracranial Heparin 5.4512269725
MESH:D012878 Skin Neoplasms Hydrogen Peroxide 18.1912065085
MESH:D012878 Skin Neoplasms resveratrol 18.1915837718 8985016
MESH:D012878 Skin Neoplasms sodium arsenite 18.1919524636 18572023
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 18.1916192470
MESH:D012878 Skin Neoplasms Tobacco Smoke Pollution 18.1918590791
MESH:D012878 Skin Neoplasms Tretinoin 18.1916467112
MESH:D012893 Sleep Disorders Kainic Acid 5.0819414003
MESH:D013088 Spermatocele Tamoxifen 3.6616709447
MESH:D013119 Spinal Cord Injuries Progesterone 8.8215862959 16503802
MESH:D013119 Spinal Cord Injuries Tamoxifen 8.8219457130
MESH:D016135 Spinal Dysraphism sodium arsenite 3.3112854658
MESH:D013274 Stomach Neoplasms arsenic trioxide 5.4617007042
MESH:D013274 Stomach Neoplasms decitabine 5.4619037991
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 5.4618456281
MESH:D013274 Stomach Neoplasms Methylnitrosourea 5.4615930296 16257854 18593901
MESH:D013274 Stomach Neoplasms Tretinoin 5.4617261132
OMIM:601367 STROKE, ISCHEMIC resveratrol 3.9416321402
MESH:D019966 Substance-Related Disorders bisphenol A 3.3716684133 16045194
MESH:D013576 Syndactyly Methotrexate 4.459562676
MESH:D013733 Testicular Diseases Acrylamide 4.6215864552
MESH:D013921 Thrombocytopenia Heparin 4.9116893407 16651880
MESH:D013927 Thrombosis Heparin 4.7816893407
MESH:D013953 Thymus Neoplasms Methylnitrosourea 4.6111418001
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.2712697716
MESH:D013964 Thyroid Neoplasms arsenic trioxide 17.4119014326
MESH:D013964 Thyroid Neoplasms decitabine 17.4117967635
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 17.417505956
MESH:D013964 Thyroid Neoplasms Methylnitrosourea 17.417505956 3078959
MESH:D013964 Thyroid Neoplasms Tretinoin 17.4116026305 17045167
MESH:D014062 Tongue Neoplasms resveratrol 8.1116227395
MESH:D014062 Tongue Neoplasms Tretinoin 8.1116051514
MESH:D016171 Torsades de Pointes arsenic trioxide 3.3515213294
OMIM:190440 TRIGONOCEPHALY, NONSYNDROMIC marker/mechanism
MESH:D014376 Tuberculosis Tretinoin 2.8216040207
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 12.7720435036 11780464 12845720 12973940
MESH:D001749 Urinary Bladder Neoplasms decitabine 12.7719087683 17616700
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 12.7717306315 16712894 16452187 11723127
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 12.778653321 16712894 17572228
MESH:D001749 Urinary Bladder Neoplasms Tobacco Smoke Pollution 12.7712846360
MESH:D014570 Urologic Diseases Diazinon 4.6516487989
MESH:D002583 Uterine Cervical Neoplasms resveratrol 12.7717473185
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 12.7711813266
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 12.7716129372
MESH:D014591 Uterine Diseases bisphenol A 4.3814652134
MESH:D014594 Uterine Neoplasms resveratrol 3.5517044934
MESH:D014604 Uveal Neoplasms decitabine 10.7417785578
MESH:D014604 Uveal Neoplasms Tretinoin 10.7416752155
MESH:D014652 Vascular Diseases sodium arsenite 3.8117056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 3.9612125929
MESH:D014657 Vasculitis Heparin 5.4520337814
MESH:D018487 Ventricular Dysfunction, Left resveratrol 3.7017488730
MESH:D014820 Vitiligo Tretinoin 3.4716761959
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.6215886252
MESH:D015430 Weight Gain Dietary Fats 3.2116723640
MESH:D009396 Wilms Tumor Tretinoin 3.4416287080
Pathway ID Pathway Name
KEGG:04520 Adherens junction
REACT:18266 Axon guidance
KEGG:04010 MAPK signaling pathway
KEGG:05218 Melanoma
KEGG:05200 Pathways in cancer
KEGG:05215 Prostate cancer
KEGG:04810 Regulation of actin cytoskeleton
REACT:9470 Signaling by FGFR
REACT:498 Signaling by Insulin receptor
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA28127
    • No data
    Releated disease ID Related disease Name
    PA445062Neoplasms
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    Releated drug ID Related drug Name
    PA164924492brivanib
    PA450635nitric oxide
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00039 - Palifermin Antimucositis Agents
    DB02058 - SU4984
    DB07525 - 3-(3-methoxybenzyl)-1H-pyrrolo[2,3-b]pyridine
    DB07840 - (E)-[4-(3,5-difluorophenyl)-3H-pyrrolo[2,3-b]pyridin-3-ylidene](3-methoxyphenyl)methanol
    DB08577 - 3-[(3-(2-CARBOXYETHYL)-4-METHYLPYRROL-2-YL)METHYLENE]-2-INDOLINONE
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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