AutismKB 2.0

Annotation Detail for GPC5


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Basic Information Top
Gene Symbol:GPC5 ( - )
Gene Full Name: glypican 5
Band: 13q31.3
Quick LinksEntrez ID:2262; OMIM: 602446; Uniprot ID:GPC5_HUMAN; ENSEMBL ID: ENSG00000179399; HGNC ID: 4453
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
Desease IDDesease Name
2239Lymphoma
Desease Name
height
CANCER
multiple sclerosis
IMMUNE
METABOLIC
lung cancer
DEVELOPMENTAL
serum metabolites
Desease Name
Height
Serum metabolites
Multiple sclerosis
Lung cancer
HIV-1 control
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of GPC5 mRNAincreases expression 18648102
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of GPC5 mRNAdecreases expression 20106945
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 2.0720464547 20127859
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 7.443712494
MESH:D000236 Adenoma Benzo(a)pyrene 7.446695378
MESH:D000419 Albuminuria therapeutic 21441931
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.8419183758
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 6.091440618 11289319
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.9820146248 17474063
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 1.783581430 7296757
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.867296757
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.1520419170
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 3.087505956
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 3.5119486331 9022650
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 3.5514531868 8156756 2524372 11906362 8970840 12868966 11298694 18759878
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 4.103621924 2952479
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 2.0618289764 6482804 18692083 6679447 9328219 9653073 16192314 1440618 7440962 11289319 18648102 8291058 9022650
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 4.683581430
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.6816530937
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 6.096705139
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.647505956
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 2.8720471113
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 4.196705139
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.7015034207
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 6.099022650 8074119
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 3.406582329
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.479327722 15034207
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 2.1820195826 21137059
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 2.803712494 598648 1399818 6587162
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 1.5717053015 20464547 20064080 18569708 6695378 18816296 20135361 20869020 18520028
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.5716381670
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.623581430
MESH:D009369 Neoplasms Benzo(a)pyrene 2.3611141357
MESH:D009404 Nephrotic Syndrome therapeutic 21441931
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 3.216679447
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.924026338 6482804
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 6.093988306
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 4.247296757
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 5.546228378
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.9017292933
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.743692021
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 2.5519755658 10029692
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.5620155912 2093021
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 3.266582329 1399818 6587162 7505956 3712494
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 5.478074119
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 5.4717053015
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA28834
    • No data
    Releated disease ID Related disease Name
    PA444987Multiple Sclerosis
    PA444987Multiple Sclerosis
    PA444818Lung Neoplasms
    Releated drug ID Related drug Name
    PA450037interferon beta-1a
    PA450039interferon beta-1b
    PA451999interferons
    Drug Bank Top

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    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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