AutismKB 2.0

Annotation Detail for FGFR4


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Basic Information Top
Gene Symbol:FGFR4 ( CD334,JTK2,MGC20292,TKF )
Gene Full Name: fibroblast growth factor receptor 4
Band: 5q35.2
Quick LinksEntrez ID:2264; OMIM: 134935; Uniprot ID:FGFR4_HUMAN; ENSEMBL ID: ENSG00000160867; HGNC ID: 3691
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04010MAPK signaling pathway
hsa04144Endocytosis
hsa04810Regulation of actin cytoskeleton
Pathway IDPathway Name
Signaling by Insulin receptor
Signaling by FGFR
Pathway IDPathway Name
200189FGF signaling pathway
Pathway IDPathway Name
P00021FGF signaling pathway
Pathway IDPathway Name
500246FGFR4 ligand binding and activation
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1934Cancer
Desease Name
Cancer progression and tumor cell motility
prostate cancer
melanoma
CANCER
high-grade soft tissue sarcoma
breast cancer
lung cancer
soft tissue sarcoma
head and neck cancer
bone cancer
No data
Desease Name
Cancer progression/metastasis
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of FGFR4 mRNAaffects expression 21346803
C085911 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[FGF2 protein binds to and results in increased activity of FGFR4 protein] which results in increased phosphorylation of MAPK1 protein]affects binding|decreases reaction|increases activity|increases phosphorylation 11336793
D000082 Acetaminophen Acetaminophen affects the expression of FGFR4 mRNAaffects expression 17562736
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of FGFR4 proteinaffects expression 20106945
D001151 Arsenic Arsenic results in decreased expression of FGFR4 mRNAdecreases expression 19654921
D001542 Benomyl Benomyl results in increased expression of FGFR4 mRNAincreases expression 15885261
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of FGFR4 mRNAdecreases expression 20106945
D001647 Bile Acids and Salts FGFR4 protein results in decreased chemical synthesis of Bile Acids and Saltsdecreases chemical synthesis 15750181
D001647 Bile Acids and Salts FGFR4 protein affects the abundance of Bile Acids and Saltsaffects abundance 16213224
D001647 Bile Acids and Salts FGFR4 protein affects the metabolism of and affects the abundance of and affects the secretion of Bile Acids and Saltsaffects abundance|affects metabolic processing|affects secretion 10809780
D002251 Carbon Tetrachloride FGFR4 protein results in decreased susceptibility to Carbon Tetrachloridedecreases response to substance 12466116
D002251 Carbon Tetrachloride Carbon Tetrachloride results in decreased expression of FGFR4 mRNAdecreases expression 17805973
16644059
D002251 Carbon Tetrachloride Carbon Tetrachloride results in increased expression of FGFR4 mRNAincreases expression 17032414
D004390 Chlorpyrifos Chlorpyrifos results in increased expression of FGFR4 mRNAincreases expression 17589599
D002784 Cholesterol FGFR4 protein results in decreased metabolism of Cholesteroldecreases metabolic processing 15750181
D002784 Cholesterol FGFR4 protein affects the metabolism of Cholesterolaffects metabolic processing 11956156
D002791 Cholesterol, Dietary FGFR4 protein affects the metabolism of and affects the abundance of Cholesterol, Dietaryaffects abundance|affects metabolic processing 10809780
D016572 Cyclosporine Cyclosporine results in decreased expression of FGFR4 mRNAdecreases expression 20106945
D016572 Cyclosporine Cyclosporine results in increased expression of FGFR4 proteinincreases expression 15770714
D016572 Cyclosporine [Thioacetamide co-treated with Cyclosporine] results in decreased expression of FGFR4 proteinaffects cotreatment|decreases expression 15770714
D016264 Dextran Sulfate Dextran Sulfate binds to and results in increased phosphorylation of and results in increased activity of FGFR4 proteinaffects binding|increases activity|increases phosphorylation 7774576
D003976 Diazinon Diazinon results in increased expression of FGFR4 mRNAincreases expression 19130878
17589599
D003633 Dichlorodiphenyl Dichloroethylene Dichlorodiphenyl Dichloroethylene results in increased expression of FGFR4 mRNAincreases expression 15885261
D004026 Dieldrin Dieldrin affects the expression of FGFR4 mRNAaffects expression 19130878
D004052 Diethylnitrosamine FGFR4 protein results in decreased susceptibility to Diethylnitrosaminedecreases response to substance 19009564
D004128 Dimethylnitrosamine Dimethylnitrosamine results in increased expression of FGFR4 mRNAincreases expression 17032414
D005485 Flutamide Flutamide results in increased expression of FGFR4 mRNAincreases expression 15885261
C007789 fucoidan fucoidan binds to and results in increased phosphorylation of and results in increased activity of FGFR4 proteinaffects binding|increases activity|increases phosphorylation 7774576
D005665 Furosemide Furosemide affects the expression of FGFR4 mRNAaffects expression 16526316
D019812 Heparan Sulfate Proteoglycans Heparan Sulfate Proteoglycans affects the reaction [FGF1 protein binds to FGFR4 protein]affects binding|affects reaction 10336501
D019812 Heparan Sulfate Proteoglycans Heparan Sulfate Proteoglycans affects the reaction [FGF2 protein binds to FGFR4 protein]affects binding|affects reaction 10336501
D006493 Heparin Heparin analog binds to FGFR4 proteinaffects binding 11278860
D006493 Heparin Heparin promotes the reaction [FGF19 protein binds to FGFR4 protein]affects binding|increases reaction 10525310
D006493 Heparin Heparin promotes the reaction [FGFR4 protein binds to FGFR4 protein]affects binding|increases reaction 10736564
D006493 Heparin Heparin affects the reaction [FGF1 protein binds to FGFR4 protein]affects binding|affects reaction 10336501
D006493 Heparin Heparin affects the reaction [FGF2 protein binds to FGFR4 protein]affects binding|affects reaction 10336501
D006493 Heparin Heparin binds to and results in increased phosphorylation of and results in increased activity of FGFR4 proteinaffects binding|increases activity|increases phosphorylation 7774576
D006497 Heparitin Sulfate Heparitin Sulfate analog binds to FGFR4 proteinaffects binding 11278860
D008770 Methylnitrosourea Methylnitrosourea results in increased expression of and affects the localization of FGFR4 proteinaffects localization|increases expression 15581186
D009532 Nickel Nickel affects the expression of FGFR4 mRNAaffects expression 19130878
D019319 Okadaic Acid Okadaic Acid results in decreased phosphorylation of FGFR4 proteindecreases phosphorylation 8576110
D009844 Oligosaccharides Oligosaccharides analog binds to FGFR4 proteinaffects binding 11278860
D009844 Oligosaccharides Oligosaccharides promotes the reaction [FGF1 protein binds to FGFR4 protein]affects binding|increases reaction 11714710
9174673
C115711 PD 173074 PD 173074 inhibits the reaction [FGF1 protein results in increased phosphorylation of FGFR4 protein]decreases reaction|increases phosphorylation 15709206
C115711 PD 173074 PD 173074 results in decreased activity of FGFR4 proteindecreases activity 15377668
D010795 Phthalic Acids Phthalic Acids results in decreased expression of FGFR4 mRNAdecreases expression 15728792
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of FGFR4 mRNAaffects binding|decreases expression|increases activity 19710929
C009277 sodium arsenate sodium arsenate results in decreased expression of FGFR4 mRNAdecreases expression 16882884
C017947 sodium arsenite sodium arsenite results in increased expression of FGFR4 mRNAincreases expression 12377979
C025462 sulindac sulfide sulindac sulfide results in decreased expression of FGFR4 mRNAdecreases expression 16184548
D013656 Taurocholic Acid FGFR4 protein affects the reaction [Taurocholic Acid results in decreased expression of CYP7A1 mRNA]affects reaction|decreases expression 16284190
D013656 Taurocholic Acid FGFR4 protein affects the reaction [Taurocholic Acid results in decreased expression of PON1 mRNA]affects reaction|decreases expression 16284190
D013853 Thioacetamide [Thioacetamide co-treated with Cyclosporine] results in decreased expression of FGFR4 proteinaffects cotreatment|decreases expression 15770714
D013853 Thioacetamide Thioacetamide results in increased expression of FGFR4 proteinincreases expression 15770714
D014212 Tretinoin Tretinoin results in decreased expression of FGFR4 mRNAdecreases expression 7680553
D014638 Vanadates Vanadates results in increased phosphorylation of FGFR4 proteinincreases phosphorylation 8576110
C009687 wortmannin wortmannin inhibits the reaction [[FGF2 protein binds to and results in increased activity of FGFR4 protein] which results in increased phosphorylation of MAPK1 protein]affects binding|decreases reaction|increases activity|increases phosphorylation 11336793
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D055371 Acute Lung Injury Nickel 7.9716166738
MESH:D055371 Acute Lung Injury pirinixic acid 7.9718653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 6.5720127859 20464547
MESH:D000230 Adenocarcinoma Dimethylnitrosamine 6.5716033868
MESH:D000230 Adenocarcinoma Methylnitrosourea 6.5715113128 15688392
MESH:D000236 Adenoma Benzo(a)pyrene 9.786695378
MESH:D000236 Adenoma Diethylnitrosamine 9.786695378 10737359
MESH:D000236 Adenoma Dimethylnitrosamine 9.7819555203
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 8.7019052882 19061943 17162532 17620307 16434500 18056438
MESH:D018248 Adenoma, Liver Cell pirinixic acid 8.7016434500
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.2715276417
MESH:D018246 Adrenocortical Adenoma Arsenic 12.3717306315
MESH:D018246 Adrenocortical Adenoma sodium arsenite 12.3717306315 16712894
MESH:D000382 Agricultural Workers' Diseases Chlorpyrifos 12.2816611668 11874814 17119214
MESH:D000382 Agricultural Workers' Diseases Diazinon 12.2816487989
MESH:D000382 Agricultural Workers' Diseases Dichlorodiphenyl Dichloroethylene 12.2816487989
MESH:D000505 Alopecia Tretinoin 3.2815955085
MESH:D000544 Alzheimer Disease Cholesterol, Dietary 4.7320157255
MESH:D000544 Alzheimer Disease sulindac sulfide 4.7318759972
MESH:D000799 Angioedema Acetaminophen 3.4210982225
MESH:D000853 Anophthalmos Benomyl 5.6515907663
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.6619183758
MESH:D020261 Arsenic Poisoning Arsenic 2.7416835338 12569548 16251483 18414634
MESH:D001161 Arteriosclerosis Cholesterol, Dietary 5.1815552841
MESH:D001169 Arthritis, Experimental Tretinoin 2.8116412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.1616292516
MESH:D001249 Asthma Tretinoin 2.2116456186
MESH:D050197 Atherosclerosis Arsenic 6.4019371607 12928151
MESH:D050197 Atherosclerosis Cholesterol 6.4016632123
MESH:D001289 Attention Deficit Disorder with Hyperactivity Phthalic Acids 4.0820106747
MESH:D001321 Autistic Disorder Acetaminophen 1.4718445737
MESH:D001471 Barrett Esophagus Tretinoin 4.0016935849
MESH:D001778 Blood Coagulation Disorders pirinixic acid 13.2619483382
MESH:D001778 Blood Coagulation Disorders Thioacetamide 13.2619483382
MESH:D001778 Blood Coagulation Disorders Tretinoin 13.2616206674 16197459
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 3.4617474063 20146248
MESH:D001943 Breast Neoplasms Dichlorodiphenyl Dichloroethylene 3.4615061365
MESH:D001943 Breast Neoplasms Dieldrin 3.4611859874 15770527
MESH:D001943 Breast Neoplasms Diethylnitrosamine 3.4617474063
MESH:D001943 Breast Neoplasms Methylnitrosourea 3.4616253758 14633655 11306469
MESH:D001943 Breast Neoplasms Nickel 3.4615986119
MESH:D001943 Breast Neoplasms Tretinoin 3.4616443354 16873071 16166294
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.1716813970
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.3715721981 18705752 15673190 16124888 16227642 16011737 15700767 10355542 16192424 16050911 16097048 3786805
MESH:D002277 Carcinoma Dimethylnitrosamine 3.6919555203
MESH:D002280 Carcinoma, Basal Cell Arsenic 3.3517687452 15504454
MESH:D018236 Carcinoma, Embryonal Tretinoin 4.7316168501
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 18.2816705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 18.283084413
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 18.2821507988 12907637 12619106
MESH:D006528 Carcinoma, Hepatocellular Arsenic 18.2817306315 16507464
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 18.2818788625
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 18.2817162532 16569478 20935162 16878318 20101231 3084413 18785209 19539802 16807293 20524982 19107877 20007298 19383236 16935385 19519916 19208518 3581430 18788625 19335982 17978847 19394651 20727157 20084675 19701751 18978308 19171122 21159647 20214788 20512989 18393292 16698587 16288022 11831363 19052882 18494052 19919837 16540662 17173139 16779866 17055752 19822196 18506893 16830150 17761372 17428255 17138121 18971187 16502159 18691550 18210153 20432363 16328049 10672840 18665156 10737359 18056438 19418558 16681979 20514400
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 18.2815276417 16507464 17306315
MESH:D006528 Carcinoma, Hepatocellular Thioacetamide 18.2817997003
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 18.281917145
MESH:D002289 Carcinoma, Non-Small-Cell Lung sulindac sulfide 3.2912391285
MESH:D002294 Carcinoma, Squamous Cell Arsenic 12.8618922899 15504454 17687452
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 12.8620419170
MESH:D002294 Carcinoma, Squamous Cell Dimethylnitrosamine 12.8616033868
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 12.8618572023
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 12.8616096774 16051514
MESH:D002295 Carcinoma, Transitional Cell Arsenic 3.7218640142
MESH:D002318 Cardiovascular Diseases Arsenic 3.1615738583 19152805 17938729
MESH:D002340 Carotid Artery Diseases Arsenic 3.9616973168 18022660
MESH:D002386 Cataract Acetaminophen 10.9610977129
MESH:D002386 Cataract Methylnitrosourea 10.9612484553
MESH:D002386 Cataract Tretinoin 10.9617460283
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 13.6712371664
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 13.6717174075 2727394 21159647 7505956
MESH:D002471 Cell Transformation, Neoplastic Methylnitrosourea 13.672727394 7505956
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 13.6719524636 20056578
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.1716129372
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 8.5719052882
MESH:D018281 Cholangiocarcinoma Thioacetamide 8.5718291259
MESH:D002779 Cholestasis Cyclosporine 6.7219486331
MESH:D002779 Cholestasis pirinixic acid 6.7219176532
MESH:D002822 Choriocarcinoma Tretinoin 4.7316461808
MESH:D002972 Cleft Palate Tretinoin 2.499407595
MESH:D003092 Colitis Dextran Sulfate 8.8118023891 12065299 15652231 16375993
MESH:D003092 Colitis Tretinoin 8.8117035595
MESH:D019465 Craniofacial Abnormalities sodium arsenate 2.8410525206
MESH:D019465 Craniofacial Abnormalities Tretinoin 2.8414991402 17551590 8800419 16925845 9224671 10589399 9211117 9125849 9664655 9142499
MESH:D003490 Cyanosis 2,4-dinitrotoluene 3.6118551238
MESH:D017449 Dermatitis, Allergic Contact Nickel 3.5617100760 19470301 17244072
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.2218249437
MESH:D003877 Dermatitis, Contact Nickel 4.252952479
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 2.0820387270
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 16.5018551238 21346803
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 16.5016109766 16781746 14986274 11739529 16081117 11743745 18071297 19416960 11287661 18713872 19739265 14725611 12705907 11461765 11834606 11529661 10915739 12153990 16227642 15619225 16177239 19420014 19085960 2444490 15968718 12540782 17906064 19370779 11421492 12594235 14550746 10663392 12958197 17522070 16393943 19923254 17562736 19164858 10774834 12392966 16485898
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 16.507440962 15998439 19085960 6884620 2869522 7179309 10915739 10092053 9327722 15027814 16227642 6623471 21278145 3732212 16177239 11566570 15968718 3786805 17522070 7120509 4309450 19336974
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 16.5019107877
MESH:D056486 Drug-Induced Liver Injury Dimethylnitrosamine 16.508172417
MESH:D056486 Drug-Induced Liver Injury sodium arsenate 16.5018186108
MESH:D056486 Drug-Induced Liver Injury Thioacetamide 16.5012963478
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.6719426721
MESH:D004417 Dyspnea Diazinon 15.0116487989
MESH:D004417 Dyspnea Dichlorodiphenyl Dichloroethylene 15.0116487989
MESH:D004417 Dyspnea Furosemide 15.0116935035
MESH:D004487 Edema Furosemide 5.9211834646
MESH:D004487 Edema pirinixic acid 5.9212083418
MESH:D004489 Edema, Cardiac Tretinoin 4.0418230668
MESH:D016889 Endometrial Neoplasms Tretinoin 2.8316569247
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 4.6916302075
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.2516530937
MESH:D004938 Esophageal Neoplasms Dimethylnitrosamine 4.2517016578
MESH:D004942 Esophagitis, Peptic Bile Acids and Salts 6.1311346197
MESH:D005124 Eye Abnormalities Benomyl 8.641914497
MESH:D005124 Eye Abnormalities Tretinoin 8.6416938888 9664655
MESH:D005218 Fat Necrosis Thioacetamide 5.2916456712
MESH:D005234 Fatty Liver Carbon Tetrachloride 15.6915959796 17595544 12795759 16239168 12631006 61145 16045604 19224547
MESH:D005234 Fatty Liver Cyclosporine 15.6919224547
MESH:D005234 Fatty Liver Diethylnitrosamine 15.6921071580 20387270
MESH:D005234 Fatty Liver pirinixic acid 15.6919236843 20131406
MESH:D005354 Fibrosarcoma Methylnitrosourea 4.8111555667
MESH:D005355 Fibrosis Carbon Tetrachloride 12.4218705752
MESH:D005355 Fibrosis Cyclosporine 12.4212639820 12168785
MESH:D005355 Fibrosis Tretinoin 12.4217994277
MESH:D005534 Foot Diseases Arsenic 5.136392382
MESH:D005756 Gastritis Acetaminophen 3.2516983495
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.2616452187
MESH:D005885 Gingival Hyperplasia Cyclosporine 3.808708960
MESH:D005909 Glioblastoma Okadaic Acid 6.7917312396
MESH:D005909 Glioblastoma Tretinoin 6.7917312396
MESH:D005910 Glioma Methylnitrosourea 3.399825942
MESH:D018149 Glucose Intolerance sodium arsenate 4.6919446573
MESH:D006258 Head and Neck Neoplasms Tretinoin 2.9016096774
MESH:D034381 Hearing Loss Furosemide 4.4817868369
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 4.7316084493
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 5.8920471113
MESH:D006330 Heart Defects, Congenital Tretinoin 5.899664655 14991402
MESH:D006333 Heart Failure Furosemide 6.4412660669 16011733 16845234
MESH:D006333 Heart Failure pirinixic acid 6.4420558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.0015720958
MESH:D006501 Hepatic Encephalopathy Thioacetamide 4.2018665440 17276928 15929193
MESH:D006505 Hepatitis Carbon Tetrachloride 19.2519110552 19900420
MESH:D006505 Hepatitis Diazinon 19.2516487989
MESH:D006505 Hepatitis Dichlorodiphenyl Dichloroethylene 19.2516487989
MESH:D006505 Hepatitis Thioacetamide 19.2516456712
MESH:D006529 Hepatomegaly pirinixic acid 2.5916221962 18467677 19772884 19176532
MESH:D015658 HIV Infections Nickel 3.5917263646
MESH:D006689 Hodgkin Disease sodium arsenite 2.8112676792
MESH:D006930 Hyperalgesia Acetaminophen 6.5316870215
MESH:D006930 Hyperalgesia Tretinoin 6.5316870215
MESH:D017588 Hyperandrogenism Flutamide 5.0315356085
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.1116899240
MESH:D006934 Hypercalcemia Furosemide 4.7017652376
MESH:D053565 Hypercalciuria Furosemide 5.2317652376
MESH:D006937 Hypercholesterolemia Cholesterol 8.9516933029
MESH:D006937 Hypercholesterolemia Cholesterol, Dietary 8.9510876104
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.1616778211
MESH:D006943 Hyperglycemia pirinixic acid 2.8220558911
MESH:D017488 Hyperkeratosis, Epidermolytic Arsenic 4.0917050553
MESH:D006962 Hyperparathyroidism, Secondary Furosemide 5.4515086907
MESH:D006973 Hypertension Arsenic 4.7316076760 11953799 9931084
MESH:D006973 Hypertension Cyclosporine 4.7310903974
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.6815338365
MESH:D046110 Hypertension, Pregnancy-Induced Furosemide 4.8816612254
MESH:D006987 Hypesthesia Arsenic 5.1316093927
MESH:C537153 Hypomagnesemia primary Furosemide 5.2311041285
MESH:D007019 Hypoproteinemia Furosemide 5.4516096441
MESH:D007022 Hypotension Furosemide 4.2311041285
MESH:D007024 Hypotension, Orthostatic Furosemide 4.9915811171
MESH:D007247 Infertility, Female Dieldrin 4.5510630421
MESH:D007248 Infertility, Male Diazinon 13.8812948887 16466525
MESH:D007248 Infertility, Male Dichlorodiphenyl Dichloroethylene 13.8812948891 17192596
MESH:D007248 Infertility, Male Methylnitrosourea 13.887193160
MESH:D007248 Infertility, Male sodium arsenite 13.8812646999 15346721
MESH:D007249 Inflammation Diethylnitrosamine 4.7318785209
MESH:D007249 Inflammation Nickel 4.7316166738
MESH:D015212 Inflammatory Bowel Diseases Dextran Sulfate 4.4620423518 15339030
MESH:D007333 Insulin Resistance pirinixic acid 2.3616306350
MESH:D007410 Intestinal Diseases Tretinoin 3.3617994277
MESH:D007569 Jaw Abnormalities Tretinoin 3.5317551590 15992940
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.0115604871
MESH:D007642 Keratosis Arsenic 4.5712749816 16930632
MESH:D007674 Kidney Diseases Acetaminophen 12.4212587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 12.428314463 10903974 18776723
MESH:D007674 Kidney Diseases Furosemide 12.4211041285
MESH:D007674 Kidney Diseases sodium arsenite 12.4220008137
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 6.1516705839
MESH:D007680 Kidney Neoplasms Cyclosporine 6.1512371664
MESH:D007859 Learning Disorders Cholesterol 4.6917134702
MESH:D007938 Leukemia 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 5.9712970779
MESH:D007938 Leukemia Tretinoin 5.9717143497
MESH:D007951 Leukemia, Myeloid Tretinoin 3.3316482212 16932348 19285840
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.0017596541 19850784 16294345
MESH:D015473 Leukemia, Promyelocytic, Acute Arsenic 6.8317339181
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 6.8316823087 12679006 17294898 16766008 17107899 17506722 17339181 15748426 19075265 16331271 19642359 9834237 17649720 17368321 19035177 16140955 16788101 17217047 16891316 17712046 17361223 16935935 17301526 19225113 19029980
MESH:D017880 Limb Deformities, Congenital Dichlorodiphenyl Dichloroethylene 12.1812745335
MESH:D017880 Limb Deformities, Congenital Methylnitrosourea 12.1815526292
MESH:D017880 Limb Deformities, Congenital Tretinoin 12.189224671
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 5.8111408273 16221502 21278145 17334410 16943688 11903743 16239168 17174718 17157831
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 5.8120032147 18407596 18522880 19638242 18665156
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 7.9315818738 18205269 16248980 11481614 18376398 18339082 12649538 18187930 18251166 15362042 17557913 18166357 17761835 18429990 17900296 18481824 17922224 18263696 17805973 14716833 18412020 15052691 17823541 18420326 18006644 16192424 14620537 12632512 16638106 16116963 17708605 15057751 17698563 17631135 14716496 18317297 12666154 17944888 18210741 17565644 16097048 15996030 12445418 18705752 16033810 15893842 18472094 15650968 16015684 16027843 14512876 17721639 18277467 12586293 18054572 17976157 18395914 10355542 12389079 12741479 16136751 18395095 18472332 14724832 17714472 12609069 15338365 18279442 14748882 16011737 15931870 20821823 17869086 15123356 15370692 15959796 15925388 12632514 17481882 18156304 17640975 12898905 17525996 18418968 15876570 17766677 15673190 12445421 12667390 13678700 12546737 15730626 12958196
MESH:D008106 Liver Cirrhosis, Experimental Dimethylnitrosamine 7.9315492853 18364076 15067225 15081153 17348192 15763062 18210741 17432682 15298665 14568256 17881167 16627068 15842777 15577212 18672772 17203207 15942678 18637143 17196135 15383259 17640959 17201889 14659978 16603200 14709902 15591649 15479170 18239293 15099470 15571005 15339415 15369754 16042886 14643895 15733078 15504291 15366600 16009107 16270385 18629640 15161499 17534399 18095165 17724770 15864749 15793283 18237412 15723089 17465448 15744066 17666798 16169303 17719030 16570917 16544323 18567088 18371158 17198567 17036385 14726149 15086199 15138612 12925901 15798949 12918455
MESH:D008106 Liver Cirrhosis, Experimental Heparin 7.9316904936
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 7.9315474484
MESH:D008106 Liver Cirrhosis, Experimental Thioacetamide 7.9318295389 12557150 16248980 14739098 15288472 12679928 11172339 16489207 15095483 16511523 17629604 18395095 15316131 12531686 16126171 15465738 15474484 18263696 18031379 15288473 15078482 15075984 18032466 17127702 16343077 16098781 17355460 18416461 11682029 11481614 18380797 12175628 17050028 15362042 18458672 18615449 17292413 15334695 10677585 16097051 12891558 15716488 12085344 15158331 18606216
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 7.9318397230 16248980
MESH:D008107 Liver Diseases Acetaminophen 14.2416610002 11587558 19014921 16611625 19460945 12587719 12969438 19784758
MESH:D008107 Liver Diseases Arsenic 14.2411134558
MESH:D008107 Liver Diseases Carbon Tetrachloride 14.2415830285 16964402 17285989 16246199 15720792
MESH:D008107 Liver Diseases Chlorpyrifos 14.2415991261
MESH:D008107 Liver Diseases Diethylnitrosamine 14.2417034775
MESH:D008107 Liver Diseases Thioacetamide 14.2415158337 16337175 18374380
MESH:D017093 Liver Failure Carbon Tetrachloride 3.7515123358
MESH:D017114 Liver Failure, Acute Acetaminophen 20.2816871587 17185352
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 20.2816899240 14706259
MESH:D017114 Liver Failure, Acute Dimethylnitrosamine 20.2817457977
MESH:D017114 Liver Failure, Acute Thioacetamide 20.2815633222 12479984 17276928 15313186
MESH:D008113 Liver Neoplasms Aflatoxin B1 26.709163691 15890375 18177683 2125692
MESH:D008113 Liver Neoplasms Arsenic 26.7016368122
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 26.7020195826 21137059
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 26.7019294768
MESH:D008113 Liver Neoplasms Dieldrin 26.708742319 9539021
MESH:D008113 Liver Neoplasms Diethylnitrosamine 26.7019256749 19254457 21047994 18644402 19850985 15175105 20492335 12112319 10737359 18754104 20405173 12771043 19427195 18977376 20434301 20452335 2862719 19499222 19073162 19638242 15885732 18648771 19255062 20101389 19996281 16942905 19833225 19294768 20583210 19426721 21167192 20137499 21071580 19812893 9163691 19690152 19642983 21278145 19551842 20118626 2422723 19090486 20501860 18978307
MESH:D008113 Liver Neoplasms Dimethylnitrosamine 26.703113478 15890375
MESH:D008113 Liver Neoplasms pirinixic acid 26.7016377806 20007298 15890375
MESH:D008113 Liver Neoplasms sodium arsenite 26.7015276417 16712894
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 11.978603461
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 11.9715583823 12014681
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 11.9716267830 18308698 18775883 3124819 18544905 21159647 18079962 17942915 18164116 18253720 19009564 18282651 19126423 9362446 19539802 16842330 2563599 18093689 19004024 17854601 17174075 19519916
MESH:D008114 Liver Neoplasms, Experimental Dimethylnitrosamine 11.971848544 6150874 15603536
MESH:D038061 Lower Extremity Deformities, Congenital Methylnitrosourea 5.0516080182
MESH:D008171 Lung Diseases sodium arsenite 2.8919095001
MESH:D008175 Lung Neoplasms Aflatoxin B1 9.7414755239
MESH:D008175 Lung Neoplasms Arsenic 9.7417976673 19168569 17306315
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 9.7417053015 18569708 18520028 20464547 20869020 6695378 20064080 20135361 18816296
MESH:D008175 Lung Neoplasms Diethylnitrosamine 9.7420512841 20970405 21163286 6695378
MESH:D008175 Lung Neoplasms Dimethylnitrosamine 9.7416061637 19555203 11884234
MESH:D008175 Lung Neoplasms Methylnitrosourea 9.7418062963
MESH:D008175 Lung Neoplasms sodium arsenite 9.7415276417 17306315 16712894 17077188 19931552
MESH:D008223 Lymphoma Methylnitrosourea 3.7111418001 16257854
MESH:D016393 Lymphoma, B-Cell Methylnitrosourea 4.3914633661
MESH:D008325 Mammary Neoplasms, Experimental Methylnitrosourea 3.3216944150 16619500 14999141 10767621 17131329 11807958 17020996 15313902 15688392 15113128 19196723 10838139 12931682 11751437 16051031 16827153 14633655
MESH:D008527 Medulloblastoma Tretinoin 2.6117453147
MESH:D008545 Melanoma sodium arsenite 3.0719082730 16487513
MESH:D008545 Melanoma Tretinoin 3.0716752155
MESH:D008546 Melanoma, Experimental Acetaminophen 3.1619513568
MESH:D008591 Meningomyelocele Tretinoin 4.0216940565
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.3616801185
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 2.8716381670
MESH:D009135 Muscular Diseases pirinixic acid 3.1016239165
MESH:D009139 Musculoskeletal Abnormalities sodium arsenate 4.4818186108
MESH:D009190 Myelodysplastic Syndromes Tretinoin 2.8317596541
MESH:D009203 Myocardial Infarction pirinixic acid 1.9619151258
MESH:D017202 Myocardial Ischemia Arsenic 3.6515371236
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 2.6316411023
MESH:D009336 Necrosis 2,4-dinitrotoluene 3.4418551238
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.399029167 3581430
MESH:D009369 Neoplasms Benzo(a)pyrene 16.9611141357
MESH:D009369 Neoplasms Dieldrin 16.968820588
MESH:D009369 Neoplasms Methylnitrosourea 16.9615533788
MESH:D009369 Neoplasms pirinixic acid 16.9617405874
MESH:D009369 Neoplasms sodium arsenite 16.9611559025
MESH:D009369 Neoplasms Tretinoin 16.9616594593 16946489
MESH:D009374 Neoplasms, Experimental Methylnitrosourea 8.0512696579
MESH:D009374 Neoplasms, Experimental sodium arsenite 8.0520056578
MESH:D009397 Nephrocalcinosis Furosemide 5.4515086907
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.0117954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 2.9318481113 19348381
MESH:D009421 Nervous System Malformations Benomyl 9.0414502586
MESH:D009421 Nervous System Malformations Tretinoin 9.049125849
MESH:D009436 Neural Tube Defects Arsenic 15.1116620997
MESH:D009436 Neural Tube Defects sodium arsenate 15.1119446573 11749123 10525206 18186108
MESH:D009436 Neural Tube Defects sodium arsenite 15.1112854658
MESH:D009436 Neural Tube Defects Tretinoin 15.119142499
MESH:D009442 Neurilemmoma Methylnitrosourea 5.0711555667
MESH:D019636 Neurodegenerative Diseases Acetaminophen 7.0518514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 7.0520387270
MESH:D020078 Neurogenic Inflammation Arsenic 3.9917056641
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 4.6920387270
MESH:D020258 Neurotoxicity Syndromes Chlorpyrifos 3.8815081274
MESH:D052556 Niemann-Pick Disease, Type C Cholesterol 5.2920557099 9802331
MESH:D053206 Nocturnal Enuresis Furosemide 5.4517945291
MESH:D009765 Obesity pirinixic acid 1.7020558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 3.0716049721 12819281
MESH:D010051 Ovarian Neoplasms 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 10.1416211241
MESH:D010051 Ovarian Neoplasms Arsenic 10.1417306315
MESH:D010051 Ovarian Neoplasms sodium arsenite 10.1415276417 17306315
MESH:D010051 Ovarian Neoplasms Tretinoin 10.1416936753
MESH:D010146 Pain Acetaminophen 5.4816870215
MESH:D010146 Pain Tretinoin 5.4816870215
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 7.7616540662
MESH:D010190 Pancreatic Neoplasms Methylnitrosourea 7.7616965848
MESH:D010190 Pancreatic Neoplasms Tretinoin 7.7615976015
MESH:D010195 Pancreatitis Taurocholic Acid 4.8420035747
MESH:D010300 Parkinson Disease Cholesterol, Dietary 5.7119014385
MESH:D010300 Parkinson Disease Dieldrin 5.7111445065 11181820 16112328 17291500 16809432
MESH:D010523 Peripheral Nervous System Diseases Arsenic 3.7816093927
MESH:D016491 Peripheral Vascular Diseases Arsenic 4.5716905509 15371236 6392382
MESH:D011041 Poisoning Diazinon 3.9717603234
MESH:D011085 Polycystic Ovary Syndrome Flutamide 4.6315356085
MESH:D011141 Polyuria Furosemide 5.2317945291
MESH:D011230 Precancerous Conditions Cyclosporine 7.7812371664
MESH:D011230 Precancerous Conditions Diethylnitrosamine 7.782563599
MESH:D011471 Prostatic Neoplasms marker/mechanism 15448004
MESH:D011471 Prostatic Neoplasms Arsenic 1.9416140617
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 1.9417292933
MESH:D011471 Prostatic Neoplasms Flutamide 1.943169114
MESH:D011471 Prostatic Neoplasms Methylnitrosourea 1.9412376480 15682402
MESH:D011471 Prostatic Neoplasms sodium arsenite 1.9416039940
MESH:D011507 Proteinuria Arsenic 8.0021343184
MESH:D011507 Proteinuria Tretinoin 8.0016636307
MESH:D011565 Psoriasis Cyclosporine 2.0716882103
MESH:D011625 Pterygium Tretinoin 4.3716723453
MESH:D015427 Reperfusion Injury Furosemide 6.0916526316
MESH:D015427 Reperfusion Injury pirinixic acid 6.0919058328
MESH:D012128 Respiratory Distress Syndrome, Adult Furosemide 4.2315912074 16096441 12394941
MESH:D012135 Respiratory Sounds Chlorpyrifos 4.2317119214 16611668 11874814
MESH:D012140 Respiratory Tract Diseases Chlorpyrifos 4.4717119214 16611668
MESH:D012162 Retinal Degeneration Methylnitrosourea 4.1018155124 18172121
MESH:D012175 Retinoblastoma Methylnitrosourea 5.0711555667
MESH:D012208 Rhabdomyosarcoma Tretinoin 3.7116283617 16116481
MESH:D012640 Seizures 2,4-dinitrotoluene 2.2618551238
MESH:D012729 Sex Chromosome Aberrations Chlorpyrifos 5.666418539
MESH:D012851 Sinus Thrombosis, Intracranial Heparin 5.6512269725
MESH:D012871 Skin Diseases Arsenic 2.6316353154 17548696 17938729 19834688 15952646 16702368 17050553 6392382 17453740 16759981 18709164
MESH:D012878 Skin Neoplasms Arsenic 15.7417976673 15504454 17029826 16251483 17050553 19538983
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 15.7419755658 10029692
MESH:D012878 Skin Neoplasms Okadaic Acid 15.7412628509
MESH:D012878 Skin Neoplasms sodium arsenite 15.7419524636 18572023
MESH:D012878 Skin Neoplasms Tretinoin 15.7416467112
MESH:D016135 Spinal Dysraphism sodium arsenite 3.4712854658
MESH:D013158 Splenic Diseases Dimethylnitrosamine 4.8412587719
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 7.6320155912 2093021
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 7.6318456281
MESH:D013274 Stomach Neoplasms Dimethylnitrosamine 7.6316033868
MESH:D013274 Stomach Neoplasms Furosemide 7.6317052386
MESH:D013274 Stomach Neoplasms Methylnitrosourea 7.6318593901 15930296 16257854
MESH:D013274 Stomach Neoplasms Tretinoin 7.6317261132
MESH:D013276 Stomach Ulcer fucoidan 4.7415138204 18209962
MESH:D013921 Thrombocytopenia Heparin 5.0916893407 16651880
MESH:D013927 Thrombosis Heparin 4.9616893407
MESH:D013953 Thymus Neoplasms Methylnitrosourea 4.8111418001
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 10.257505956
MESH:D013964 Thyroid Neoplasms Methylnitrosourea 10.253078959 7505956
MESH:D013964 Thyroid Neoplasms Tretinoin 10.2516026305 17045167
MESH:D014062 Tongue Neoplasms Tretinoin 3.4316051514
MESH:D014376 Tuberculosis Tretinoin 2.9616040207
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 10.4616049721
MESH:D001749 Urinary Bladder Neoplasms Arsenic 10.4617306315 15987713 17976673 19429237 11144890 18640142 19322015
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 10.4617053015
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 10.4616712894 16452187 17306315 11723127
MESH:D014570 Urologic Diseases Diazinon 11.1616487989
MESH:D014570 Urologic Diseases Dichlorodiphenyl Dichloroethylene 11.1616487989
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 3.9010091137
MESH:D014581 Urticaria Acetaminophen 2.6010982225
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 8.2111813266
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 8.2116129372
MESH:D014594 Uterine Neoplasms sulindac sulfide 4.2618645019
MESH:D014604 Uveal Neoplasms Tretinoin 4.1816752155
MESH:D014605 Uveitis Cyclosporine 3.561336536
MESH:D014652 Vascular Diseases Arsenic 10.4517056641
MESH:D014652 Vascular Diseases sodium arsenite 10.4517056641
MESH:D014657 Vasculitis Heparin 5.6520337814
MESH:D014820 Vitiligo Tretinoin 3.6616761959
MESH:D009396 Wilms Tumor Tretinoin 3.6116287080
MESH:D014985 Xerophthalmia Cyclosporine 4.0117120751
Pathway ID Pathway Name
KEGG:04144 Endocytosis
KEGG:04010 MAPK signaling pathway
KEGG:04810 Regulation of actin cytoskeleton
REACT:9470 Signaling by FGFR
REACT:498 Signaling by Insulin receptor
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA28130
    • Releated gene ID Related gene Name
    PA28130FGFR4
    Releated disease ID Related disease Name
    PA443560Breast Neoplasms
    Releated drug ID Related drug Name
    PA449014cisplatin
    PA451581tamoxifen
    PA449165cyclophosphamide
    PA128406956fluorouracil
    PA450428methotrexate
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00039 - Palifermin Antimucositis Agents
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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