AutismKB 2.0

Annotation Detail for FGG


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:FGG ( - )
Gene Full Name: fibrinogen gamma chain
Band: 4q32.1
Quick LinksEntrez ID:2266; OMIM: 134850; Uniprot ID:FIBG_HUMAN; ENSEMBL ID: ENSG00000171557; HGNC ID: 3694
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa05150Staphylococcus aureus infection
hsa04610Complement and coagulation cascades
Pathway IDPathway Name
Hemostasis
Integrin cell surface interactions
Pathway IDPathway Name
200124IL6-mediated signaling events
200077Glucocorticoid receptor regulatory network
Pathway IDPathway Name
P00050Plasminogen activating cascade
Pathway IDPathway Name
500303Common Pathway
Related Diseases/Disorders Top
Desease IDDesease Name
Circulatory system diseases
Hematologic diseases
H00223Inherited thrombophilia
H00222Afibrinogenemia
Desease IDDesease Name
1706Thrombophilia
1822Infectious lung disease
1831Prostate cancer
1858Hemorrhagic disorder
2120Rabies
2236Cardiovascular disease
Desease Name
HEMATOLOGICAL
CARDIOVASCULAR
fibrinogen
fibrinogen myocardial infarct
thrombosis, deep vein
No data
Desease Name
Thrombophilia, dysfibrinogenemic
Dysfibrinogenemia, gamma type
Hypofibrinogenemia, gamma type
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of FGG mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene results in decreased expression of FGG mRNAdecreases expression 20406850
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of FGG mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of FGG mRNAaffects expression 17562736
D000082 Acetaminophen Acetaminophen results in increased expression of FGG mRNAincreases expression 15800402
D000082 Acetaminophen Acetaminophen results in increased expression of FGG proteinincreases expression 15800402
D000643 Ammonium Chloride Ammonium Chloride affects the expression of FGG mRNAaffects expression 16483693
D017638 Asbestos, Crocidolite Asbestos, Crocidolite results in decreased expression of FGG mRNAdecreases expression 18687144
D001280 Atrazine [Atrazine co-treated with Diuron co-treated with isoproturon] results in decreased expression of FGG mRNAaffects cotreatment|decreases expression 16532367
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of FGG mRNAdecreases expression 18061397
C095105 bexarotene bexarotene results in decreased expression of FGG mRNAdecreases expression 16648578
C032036 bromobenzene bromobenzene results in decreased expression of FGG mRNAdecreases expression 12628495
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in increased expression of FGG mRNAincreases expression 12414654
C055494 caffeic acid phenethyl ester [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in increased expression of FGG mRNAaffects cotreatment|increases expression 20360939
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of FGG mRNAaffects expression 16239168
D002251 Carbon Tetrachloride Carbon Tetrachloride results in increased expression of FGG mRNAincreases expression 12921627
C030123 coumarin coumarin affects the expression of FGG mRNAaffects expression 16963487
C029892 cupric chloride cupric chloride results in increased expression of FGG mRNAincreases expression 16835292
D016572 Cyclosporine Cyclosporine results in decreased expression of FGG mRNAdecreases expression 20106945
C023635 dienogest [Ethinyl Estradiol co-treated with dienogest] results in increased expression of [FGA protein binds to FGB protein binds to FGG protein]affects binding|affects cotreatment|increases expression 15288212
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in increased expression of FGG mRNAaffects cotreatment|increases expression 20360939
D004237 Diuron [Atrazine co-treated with Diuron co-treated with isoproturon] results in decreased expression of FGG mRNAaffects cotreatment|decreases expression 16532367
C454300 estradiol valerate-dienogest [Ethinyl Estradiol co-treated with estradiol valerate-dienogest] results in increased expression of [FGA protein binds to FGB protein binds to FGG protein]affects binding|affects cotreatment|increases expression 15288212
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of FGG mRNAincreases expression 16954407
D004997 Ethinyl Estradiol [Ethinyl Estradiol co-treated with dienogest] results in increased expression of [FGA protein binds to FGB protein binds to FGG protein]affects binding|affects cotreatment|increases expression 15288212
D004997 Ethinyl Estradiol [Ethinyl Estradiol co-treated with estradiol valerate-dienogest] results in increased expression of [FGA protein binds to FGB protein binds to FGG protein]affects binding|affects cotreatment|increases expression 15288212
D004997 Ethinyl Estradiol [Ethinyl Estradiol co-treated with Gestodene] results in increased expression of [FGA protein binds to FGB protein binds to FGG protein]affects binding|affects cotreatment|increases expression 12618251
12616983
12616980
D004997 Ethinyl Estradiol [Ethinyl Estradiol co-treated with Levonorgestrel] results in increased expression of [FGA protein binds to FGB protein binds to FGG protein]affects binding|affects cotreatment|increases expression 15288212
12618251
D004997 Ethinyl Estradiol [Ethinyl Estradiol co-treated with Norethindrone] results in increased expression of [FGA protein binds to FGB protein binds to FGG protein]affects binding|affects cotreatment|increases expression 14561536
D004997 Ethinyl Estradiol [Ethinyl Estradiol co-treated with norgestimate] results in increased expression of [FGA protein binds to FGB protein binds to FGG protein]affects binding|affects cotreatment|increases expression 12618251
C442659 ethinyl estradiol-desogestrel combination ethinyl estradiol-desogestrel combination results in increased expression of [FGA protein binds to FGB protein binds to FGG protein]affects binding|increases expression 12616983
14981370
12618251
12616980
D005472 Fluorouracil FGG protein affects the susceptibility to Fluorouracilaffects response to substance 16217747
D005472 Fluorouracil Fluorouracil results in decreased expression of FGG mRNAdecreases expression 17039268
C056507 gemcitabine gemcitabine affects the expression of FGG mRNAaffects expression 17039268
C033273 Gestodene [Ethinyl Estradiol co-treated with Gestodene] results in increased expression of [FGA protein binds to FGB protein binds to FGG protein]affects binding|affects cotreatment|increases expression 12616983
12618251
12616980
D006854 Hydrocortisone Hydrocortisone results in increased expression of FGG mRNAincreases expression 16835292
D006861 Hydrogen Peroxide Hydrogen Peroxide results in increased expression of FGG mRNAincreases expression 12414654
C075954 indolo(3,2-b)carbazole indolo(3,2-b)carbazole results in decreased expression of FGG mRNAdecreases expression 18061397
C028904 isoproturon [Atrazine co-treated with Diuron co-treated with isoproturon] results in decreased expression of FGG mRNAaffects cotreatment|decreases expression 16532367
C004925 methylmercuric chloride methylmercuric chloride results in increased expression of FGG mRNAincreases expression 17961207
D009640 Norethindrone [Ethinyl Estradiol co-treated with Norethindrone] results in increased expression of [FGA protein binds to FGB protein binds to FGG protein]affects binding|affects cotreatment|increases expression 14561536
C017576 norgestimate [Ethinyl Estradiol co-treated with norgestimate] results in increased expression of [FGA protein binds to FGB protein binds to FGG protein]affects binding|affects cotreatment|increases expression 12618251
D016912 Levonorgestrel [Ethinyl Estradiol co-treated with Levonorgestrel] results in increased expression of [FGA protein binds to FGB protein binds to FGG protein]affects binding|affects cotreatment|increases expression 12618251
15288212
C023036 perfluorooctanoic acid perfluorooctanoic acid results in decreased expression of FGG mRNAdecreases expression 18467677
C023036 perfluorooctanoic acid PPARA protein promotes the reaction [perfluorooctanoic acid results in decreased expression of FGG mRNA]decreases expression|increases reaction 18467677
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of FGG mRNAaffects binding|decreases expression|increases activity 19710929
C006253 pirinixic acid pirinixic acid results in decreased expression of FGG mRNAdecreases expression 16940010
D010936 Plant Extracts Plant Extracts results in decreased expression of FGG mRNAdecreases expression 18061397
D012643 Selenium [Selenium deficiency co-treated with Vitamin E deficiency] results in increased expression of FGG mRNAaffects cotreatment|increases expression 11444866
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of FGG mRNAincreases expression 17884332
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of FGG mRNAdecreases expression 18061397
11489354
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin binds to AHR protein] which results in decreased expression of FGG mRNAaffects binding|decreases expression 16214954
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of FGG mRNAdecreases expression 18796159
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of FGG mRNAincreases expression 16267337
C496197 trans-10,cis-12-conjugated linoleic acid trans-10,cis-12-conjugated linoleic acid results in decreased expression of FGG mRNAdecreases expression 17951470
D014212 Tretinoin Tretinoin results in increased expression of FGG mRNAincreases expression 18230668
C025643 vinclozolin vinclozolin affects the expression of FGG mRNAaffects expression 19015723
D014810 Vitamin E [Selenium deficiency co-treated with Vitamin E deficiency] results in increased expression of FGG mRNAaffects cotreatment|increases expression 11444866
D014812 Vitamin K Vitamin K affects the expression of FGG mRNAaffects expression 16636460
D024483 Vitamin K 3 Vitamin K 3 results in increased expression of FGG mRNAincreases expression 12414654
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced methylmercuric chloride 7.276734493
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 7.2714514962 15322242 11752688
MESH:D000138 Acidosis Ammonium Chloride 3.1118287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 10.7817505938
MESH:D000152 Acne Vulgaris norgestimate 10.7817505938
MESH:D055371 Acute Lung Injury pirinixic acid 2.7018653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 6.2520127859 20464547
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 6.2514692618
MESH:D000230 Adenocarcinoma Fluorouracil 6.2517638652
MESH:D000236 Adenoma Benzo(a)pyrene 5.726695378
MESH:D000236 Adenoma Diethylnitrosamine 5.7210737359 6695378
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 14.6517620307 19052882 19061943 17162532 18056438 16434500
MESH:D018248 Adenoma, Liver Cell pirinixic acid 14.6516434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 14.6516835633
MESH:D000382 Agricultural Workers' Diseases Atrazine 3.7811874814
MESH:D000505 Alopecia Tretinoin 3.2615955085
MESH:D000544 Alzheimer Disease Plant Extracts 2.9116962711
MESH:D000740 Anemia Fluorouracil 7.3815504547 17963324 16511603
MESH:D000740 Anemia Tetrachlorodibenzodioxin 7.3811748828
MESH:D000799 Angioedema Acetaminophen 3.3810982225
MESH:D001008 Anxiety Disorders vinclozolin 3.2819015723
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.6319183758
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.0211256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 10.6615885639
MESH:D001169 Arthritis, Experimental Plant Extracts 10.6614686799
MESH:D001169 Arthritis, Experimental Tretinoin 10.6616412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.1516292516
MESH:D001249 Asthma Tretinoin 2.2016456186
MESH:D001321 Autistic Disorder Acetaminophen 1.4718445737
MESH:D001471 Barrett Esophagus Tretinoin 3.9716935849
MESH:D001778 Blood Coagulation Disorders pirinixic acid 12.9219483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 12.9212125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 12.9216206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.3315340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.4615746008
MESH:D002545 Brain Ischemia Plant Extracts 4.2816041641
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 3.4120146248 17474063
MESH:D001943 Breast Neoplasms bexarotene 3.4116818667 16344269
MESH:D001943 Breast Neoplasms Diethylnitrosamine 3.4117474063
MESH:D001943 Breast Neoplasms Fluorouracil 3.4116110121 18608205 19217205 16595493 15136595 16557594 18357371
MESH:D001943 Breast Neoplasms gemcitabine 3.4118382427 17039268
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 3.4120435547
MESH:D001943 Breast Neoplasms Tretinoin 3.4116166294 16443354 16873071
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.1416813970
MESH:D002057 Burns, Chemical Plant Extracts 4.879625245
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 8.4610355542 16011737 16227642 16192424 15721981 16124888 15673190 16097048 15700767 16050911 3786805 18705752
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 8.4616050911
MESH:D002276 Carcinoid Tumor Fluorouracil 4.2016051944
MESH:D002277 Carcinoma Fluorouracil 6.9917121937
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 6.9916835633
MESH:D018236 Carcinoma, Embryonal Tretinoin 4.6916168501
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 18.0916705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 18.0916705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 18.093084413
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 18.0918788625
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 18.0918788625 16569478 18056438 19052882 16878318 19919837 17162532 19701751 20101231 18210153 18691550 20214788 20514400 18506893 18494052 17055752 16502159 16935385 20432363 3084413 16681979 19208518 16328049 17761372 16540662 10672840 20512989 20727157 16288022 18393292 17428255 17173139 18785209 16779866 3581430 18971187 19394651 19335982 19822196 20935162 19383236 11831363 19539802 17138121 16830150 20084675 16698587 17978847 20007298 18978308 19171122 19519916 21159647 19418558 18665156 16807293 10737359 20524982 19107877
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 18.0918930000 17045692 17088986 16332177 17971768 16799960
MESH:D006528 Carcinoma, Hepatocellular Plant Extracts 18.0918834353
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 18.091917145
MESH:D006528 Carcinoma, Hepatocellular Vitamin K 18.0916328049
MESH:D002289 Carcinoma, Non-Small-Cell Lung bexarotene 3.0616247446
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 2.7918695887
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 6.6320419170
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 6.6316757204 17066447 18986760 16280240
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 6.6316051514 16096774
MESH:D006332 Cardiomegaly Plant Extracts 6.1017645561
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 6.1018670907 18850075 16120746
MESH:D002318 Cardiovascular Diseases Hydrogen Peroxide 3.2016936243
MESH:D002386 Cataract Acetaminophen 6.3010977129
MESH:D002386 Cataract Tretinoin 6.3017460283
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 9.316135515
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 9.3112371664
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 9.3121159647 2727394 17174075 7505956
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.1416129372
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 8.0519052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 8.0516835633
MESH:D002779 Cholestasis Cyclosporine 16.5219486331
MESH:D002779 Cholestasis Ethinyl Estradiol 16.5216919318 15861022 17681005 17110522 16105132 17333356 11677210
MESH:D002779 Cholestasis Levonorgestrel 16.5215861022
MESH:D002779 Cholestasis pirinixic acid 16.5219176532
MESH:D002822 Choriocarcinoma Tretinoin 4.6916461808
MESH:D002972 Cleft Palate Hydrocortisone 8.7715826874
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 8.7712621046 15668235 16354765 8697196 15340226
MESH:D002972 Cleft Palate Tretinoin 8.779407595
MESH:D003092 Colitis Selenium 8.0317936198
MESH:D003092 Colitis Tretinoin 8.0317035595
MESH:D003110 Colonic Neoplasms Fluorouracil 2.1518772588 15001691 17169374 17725105 17018589 16510598 17016597 17287894 16340194 17172411
MESH:D015179 Colorectal Neoplasms Fluorouracil 1.9916303861 20501625 18802399 14970324 18383874 17594712 16282729 16331619 17695437 16391804 16524972 17016601 17454858 18949393 15148649 17094418 17401013 17255274 18509181 18288408 15289873 18448328
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.6817141729 14669216
MESH:D019465 Craniofacial Abnormalities Hydrocortisone 4.9617728286
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 4.9620055451 10048152 15322242
MESH:D019465 Craniofacial Abnormalities Tretinoin 4.9616925845 17551590 14991402 10589399 9224671 9125849 9664655 9142499 8800419 9211117
MESH:D019465 Craniofacial Abnormalities Vitamin E 4.9619769572
MESH:D003456 Cryptorchidism vinclozolin 3.9114966744
MESH:D003490 Cyanosis 2,4-dinitrotoluene 9.4218551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 9.4218551238
MESH:D007644 Darier Disease Fluorouracil 4.3416733453
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.2018249437
MESH:D003924 Diabetes Mellitus, Type 2 coumarin 6.4219647726
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 6.4220387270
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 6.4217107852
MESH:D003928 Diabetic Nephropathies Plant Extracts 4.0319706694
MESH:D003967 Diarrhea Hydrocortisone 4.307237001
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 19.4721346803 18551238
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 19.4718551238 21346803
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 19.4711743745 17522070 14725611 11461765 12705907 16227642 11739529 15968718 14550746 19739265 16781746 10915739 11529661 19085960 16485898 19420014 12153990 16177239 10774834 14986274 15619225 17906064 2444490 19416960 12540782 11834606 12392966 16109766 10663392 16081117 16393943 12958197 18713872 19164858 19370779 11287661 17562736 11421492 19923254 18071297 12594235
MESH:D056486 Drug-Induced Liver Injury bromobenzene 19.4710092053 12628495
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 19.476623471 3732212 3786805 19336974 11566570 16177239 15998439 15027814 10092053 21278145 7120509 9327722 6884620 15968718 19085960 7179309 4309450 2869522 16227642 7440962 17522070 10915739
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 19.4719107877
MESH:D056486 Drug-Induced Liver Injury Selenium 19.4715131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 19.4720420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.6319426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.4211462148
MESH:C538011 Eales disease Vitamin E 4.249068938
MESH:D004487 Edema perfluorooctanoic acid 13.1812083418 17259670
MESH:D004487 Edema pirinixic acid 13.1812083418
MESH:D004487 Edema Plant Extracts 13.1812787963
MESH:D004487 Edema Tetrachlorodibenzodioxin 13.1812711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 10.4015322242 16714409 18230668
MESH:D004489 Edema, Cardiac Tretinoin 10.4018230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 2.7612538720
MESH:D016889 Endometrial Neoplasms Tretinoin 2.8116569247
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.639294722 10568697
MESH:D004719 Endomyocardial Fibrosis Plant Extracts 5.2215268973
MESH:D004827 Epilepsy Plant Extracts 3.4919700373 19439326
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 4.6516302075
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.0416530937
MESH:D004938 Esophageal Neoplasms Fluorouracil 4.0415173087 16785472 16337965 17638652 16481741
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 7.7011564622
MESH:D005124 Eye Abnormalities Tretinoin 7.709664655 16938888
MESH:D005234 Fatty Liver Carbon Tetrachloride 25.4619224547 12631006 17595544 12795759 61145 16239168 16045604 15959796
MESH:D005234 Fatty Liver Cyclosporine 25.4619224547
MESH:D005234 Fatty Liver Diethylnitrosamine 25.4621071580 20387270
MESH:D005234 Fatty Liver Ethinyl Estradiol 25.4615345470
MESH:D005234 Fatty Liver pirinixic acid 25.4620131406 19236843
MESH:D005234 Fatty Liver Plant Extracts 25.4615975614
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.0111858732
MESH:D005355 Fibrosis Carbon Tetrachloride 17.5018705752
MESH:D005355 Fibrosis Cyclosporine 17.5012639820 12168785
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 17.5020067830
MESH:D005355 Fibrosis Tretinoin 17.5017994277
MESH:D005756 Gastritis Acetaminophen 3.2116983495
MESH:D030342 Genetic Diseases, Inborn vinclozolin 4.4816973722
MESH:D005832 Genital Diseases, Male vinclozolin 4.8416417039
MESH:D005885 Gingival Hyperplasia Cyclosporine 3.768708960
MESH:D005909 Glioblastoma Tretinoin 2.7117312396
MESH:D005910 Glioma Fluorouracil 2.6816145905
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.1310696789
MESH:D006258 Head and Neck Neoplasms Fluorouracil 6.7515162350 18337622 15102660
MESH:D006258 Head and Neck Neoplasms Tretinoin 6.7516096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 4.6916084493
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 13.8920471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 13.8911294989 10048152
MESH:D006330 Heart Defects, Congenital Tretinoin 13.899664655 14991402
MESH:D006330 Heart Defects, Congenital Vitamin E 13.8916080930
MESH:D006333 Heart Failure pirinixic acid 10.2020558911
MESH:D006333 Heart Failure Plant Extracts 10.2018097624
MESH:D006333 Heart Failure Selenium 10.2017162251
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 3.9715720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 2.9311000095
MESH:D006505 Hepatitis Carbon Tetrachloride 3.1719900420 19110552
MESH:D006529 Hepatomegaly perfluorooctanoic acid 11.913609246
MESH:D006529 Hepatomegaly pirinixic acid 11.9119772884 18467677 19176532 16221962
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 11.9112621046 15340226 16120746
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.5316863852 16490937
MESH:D006561 Herpes Simplex Plant Extracts 4.1710715843
MESH:D015658 HIV Infections Plant Extracts 3.4312878215
MESH:D019584 Hot Flashes Plant Extracts 8.8817454163 16566672 14716179
MESH:D019584 Hot Flashes Vitamin E 8.8814716179
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.5815340226 18606429 16354765 16959395 8697196
MESH:D006930 Hyperalgesia Acetaminophen 11.0116870215
MESH:D006930 Hyperalgesia perfluorooctanoic acid 11.0112083418
MESH:D006930 Hyperalgesia Tretinoin 11.0116870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.0816899240
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.1216778211
MESH:D006943 Hyperglycemia pirinixic acid 2.7920558911
MESH:D020138 Hyperhomocysteinemia Plant Extracts 4.0816484555
MESH:D006949 Hyperlipidemias Plant Extracts 4.0615268973 15975614
MESH:D006973 Hypertension Cyclosporine 4.3110903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 4.3118850075 18670907
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.6415338365
MESH:D007021 Hypospadias Ethinyl Estradiol 3.3716945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.0412013081
MESH:D007248 Infertility, Male Atrazine 9.5112948887
MESH:D007248 Infertility, Male Ethinyl Estradiol 9.5117937319
MESH:D007248 Infertility, Male vinclozolin 9.5116467254
MESH:D007249 Inflammation Diethylnitrosamine 9.9618785209
MESH:D007249 Inflammation perfluorooctanoic acid 9.9612083418
MESH:D007249 Inflammation Plant Extracts 9.9619332304 12787963 16366677 15997105
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 9.9612200463 12878042
MESH:D007251 Influenza, Human Selenium 9.4216624496
MESH:D007251 Influenza, Human Vitamin E 9.4216624496
MESH:D007333 Insulin Resistance pirinixic acid 2.3316306350
MESH:D007410 Intestinal Diseases Tretinoin 3.3317994277
MESH:D007414 Intestinal Neoplasms caffeic acid phenethyl ester 8.9410783313
MESH:D007414 Intestinal Neoplasms Plant Extracts 8.9412584176 12351151 12628509
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 8.5816580747
MESH:D007569 Jaw Abnormalities Tretinoin 8.5815992940 17551590
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 3.9815604871
MESH:D007674 Kidney Diseases Acetaminophen 12.2215629191 12587719
MESH:D007674 Kidney Diseases caffeic acid phenethyl ester 12.2215369732
MESH:D007674 Kidney Diseases Cyclosporine 12.2218776723 10903974 8314463
MESH:D007674 Kidney Diseases Vitamin E 12.2212488133
MESH:D007676 Kidney Failure, Chronic Hydrogen Peroxide 8.6816518626
MESH:D007676 Kidney Failure, Chronic Selenium 8.6816518626
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 14.7316705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 14.7316705839
MESH:D007680 Kidney Neoplasms Cyclosporine 14.7312371664
MESH:D007680 Kidney Neoplasms Fluorouracil 14.7316985049
MESH:D007938 Leukemia Tretinoin 2.5317143497
MESH:D007951 Leukemia, Myeloid Tretinoin 3.2916932348 16482212 19285840
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 1.9917596541 16294345 19850784
MESH:D015473 Leukemia, Promyelocytic, Acute caffeic acid phenethyl ester 6.9116766008
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 6.9117361223 16766008 16331271 17217047 19075265 16140955 17107899 17301526 16788101 17506722 17294898 12679006 17712046 17368321 19642359 16935935 17339181 16891316 15748426 19225113 9834237 19029980 19035177 17649720 16823087
MESH:D007984 Leydig Cell Tumor perfluorooctanoic acid 11.428812269
MESH:D007984 Leydig Cell Tumor vinclozolin 11.4216417039
MESH:D017880 Limb Deformities, Congenital Tretinoin 2.989224671
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 9.6111903743 21278145 11408273 17157831 16943688 16239168 17174718 17334410 16221502
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 9.6120032147 19638242 18522880 18407596 18665156
MESH:D008103 Liver Cirrhosis Plant Extracts 9.6117157831
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 7.8212632514 14724832 17698563 18277467 18210741 15123356 17922224 15650968 18054572 17944888 16248980 15052691 17714472 14716833 16015684 11481614 12445418 18472094 17805973 17900296 16638106 17869086 17708605 17631135 15931870 12632512 18376398 17525996 18251166 18705752 15673190 16097048 15370692 18187930 14512876 12586293 17823541 16033810 12666154 18156304 15338365 15876570 14716496 16136751 17761835 18481824 15925388 12741479 12649538 15959796 15730626 18420326 18006644 16027843 14620537 18429990 12389079 12667390 12898905 12609069 18279442 15996030 12546737 14748882 18205269 16116963 15818738 17481882 18395914 16011737 18412020 18263696 10355542 17976157 17721639 12958196 13678700 17640975 17557913 15362042 18395095 16192424 15893842 18317297 18166357 18472332 20821823 17766677 18339082 17565644 18418968 12445421 15057751
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 7.8215474484
MESH:D008106 Liver Cirrhosis, Experimental Plant Extracts 7.8215479170
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 7.8212878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 7.8216248980 18397230
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 7.8216169303
MESH:D008107 Liver Diseases Acetaminophen 8.2619784758 16611625 19014921 11587558 12969438 12587719 19460945 16610002
MESH:D008107 Liver Diseases Carbon Tetrachloride 8.2616246199 15720792 17285989 16964402 15830285
MESH:D008107 Liver Diseases Diethylnitrosamine 8.2617034775
MESH:D008107 Liver Diseases Plant Extracts 8.2617034775
MESH:D017093 Liver Failure Carbon Tetrachloride 3.7215123358
MESH:D017114 Liver Failure, Acute Acetaminophen 8.1016871587 17185352
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 8.1016899240 14706259
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 26.347678174
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 26.3420195826 21137059
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 26.3419294768
MESH:D008113 Liver Neoplasms Diethylnitrosamine 26.3419427195 15885732 9163691 18978307 20492335 20501860 21047994 20118626 19551842 20452335 19073162 18754104 19090486 19499222 21167192 18977376 19690152 18644402 2422723 15175105 19642983 19294768 12112319 19426721 20434301 19254457 19996281 19812893 21071580 19638242 19850985 20101389 16942905 18648771 12771043 21278145 19833225 19255062 20137499 2862719 10737359 20405173 19256749 20583210
MESH:D008113 Liver Neoplasms Fluorouracil 26.3418383874 15113037 17045692 16603448
MESH:D008113 Liver Neoplasms perfluorooctanoic acid 26.3414757943 18709148
MESH:D008113 Liver Neoplasms pirinixic acid 26.3416377806 20007298 15890375
MESH:D008113 Liver Neoplasms Plant Extracts 26.3419168119
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 26.3416984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 11.702876784 2876786 6135515
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 11.7012014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 11.7018308698 18775883 9362446 18544905 18253720 18079962 21159647 19009564 18282651 16267830 18164116 19004024 18093689 19539802 16842330 2563599 19519916 17854601 17174075 3124819 19126423 17942915
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 11.7012151625
MESH:D008171 Lung Diseases Vitamin E 2.8716863852
MESH:D055370 Lung Injury Asbestos, Crocidolite 3.5917365036
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 9.6218520028 6695378 18816296 17053015 18569708 20869020 20464547 20135361 20064080
MESH:D008175 Lung Neoplasms bexarotene 9.6217849452
MESH:D008175 Lung Neoplasms Diethylnitrosamine 9.6220512841 20970405 21163286 6695378
MESH:D008175 Lung Neoplasms Fluorouracil 9.6215246190
MESH:D008175 Lung Neoplasms Plant Extracts 9.6220869020
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 9.6211884234 19555203
MESH:D008175 Lung Neoplasms Vitamin E 9.6211062179
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 4.3415086387
MESH:D016410 Lymphoma, T-Cell, Cutaneous bexarotene 4.7011161223
MESH:D008325 Mammary Neoplasms, Experimental bexarotene 5.3519196723 19196722 15591091
MESH:D008325 Mammary Neoplasms, Experimental Selenium 5.3515318939
MESH:D008527 Medulloblastoma Tretinoin 2.5917453147
MESH:D008545 Melanoma Tretinoin 3.4616752155
MESH:D008545 Melanoma Vitamin K 3 3.4619082730
MESH:D008546 Melanoma, Experimental Acetaminophen 3.1219513568
MESH:D008591 Meningomyelocele Tretinoin 3.9816940565
MESH:D008654 Mesothelioma Asbestos, Crocidolite 9.1618303189 16966607 16166281
MESH:D008654 Mesothelioma Atrazine 9.161916698
MESH:D008654 Mesothelioma Selenium 9.1615107826
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.3216801185
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 7.3716381670
MESH:D009062 Mouth Neoplasms Fluorouracil 7.3718986760 16757204
MESH:D009135 Muscular Diseases pirinixic acid 3.0616239165
MESH:D009190 Myelodysplastic Syndromes Tretinoin 2.8117596541
MESH:D009203 Myocardial Infarction pirinixic acid 1.9419151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.6612213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 2.6016411023
MESH:D009336 Necrosis 2,4-dinitrotoluene 8.8418551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 8.8418551238 7678174
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.379029167 3581430
MESH:D009369 Neoplasms Benzo(a)pyrene 9.8711141357
MESH:D009369 Neoplasms Fluorouracil 9.8718600527 16928823 18239605
MESH:D009369 Neoplasms pirinixic acid 9.8717405874
MESH:D009369 Neoplasms Tretinoin 9.8716946489 16594593
MESH:D009376 Neoplasms, Hormone-Dependent bexarotene 4.3219196722
MESH:D009402 Nephrosis, Lipoid Cyclosporine 3.9817954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 2.9019348381 18481113
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 8.0814600291
MESH:D009421 Nervous System Malformations Tretinoin 8.089125849
MESH:D009436 Neural Tube Defects Tretinoin 2.759142499
MESH:D019954 Neurobehavioral Manifestations Plant Extracts 4.7417168769
MESH:D019636 Neurodegenerative Diseases Acetaminophen 6.9518514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 6.9520387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 4.6520387270
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.1316436463
MESH:D052556 Niemann-Pick Disease, Type C perfluorooctanoic acid 4.519802331
MESH:D009765 Obesity pirinixic acid 4.3120558911
MESH:D009765 Obesity Plant Extracts 4.3120132043 19056576
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 7.5812819281 16049721
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 7.5816049721
MESH:D010024 Osteoporosis Levonorgestrel 4.3812665316
MESH:D010051 Ovarian Neoplasms Tretinoin 2.2016936753
MESH:D010146 Pain Acetaminophen 5.3816870215
MESH:D010146 Pain Tretinoin 5.3816870215
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 10.8816540662
MESH:D010190 Pancreatic Neoplasms Fluorouracil 10.8815113037 16929163 16500647 19003803
MESH:D010190 Pancreatic Neoplasms gemcitabine 10.8818383843 16929163 17440100 18992248 11504793
MESH:D010190 Pancreatic Neoplasms Tretinoin 10.8815976015
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.2711578682
MESH:D010212 Papilloma Hydrogen Peroxide 8.2212065085
MESH:D010212 Papilloma Plant Extracts 8.2216517061 15173996
MESH:D010300 Parkinson Disease Atrazine 3.1017218051
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.7812520081
MESH:D010954 Plasmacytoma Selenium 4.4215087411
MESH:D010995 Pleural Diseases Asbestos, Crocidolite 4.4510923243
MESH:D011085 Polycystic Ovary Syndrome ethinyl estradiol-desogestrel combination 5.2017105841
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.1318163543
MESH:D011230 Precancerous Conditions Cyclosporine 7.6712371664
MESH:D011230 Precancerous Conditions Diethylnitrosamine 7.672563599
MESH:D011297 Prenatal Exposure Delayed Effects perfluorooctanoic acid 13.6917132714
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 13.6911118676 11222880 11896295 11399792
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 13.6918042343 18220299 19015723
MESH:D011469 Prostatic Diseases vinclozolin 4.4818220299
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.2217292933
MESH:D011471 Prostatic Neoplasms Fluorouracil 2.2218626508 19082440
MESH:D011471 Prostatic Neoplasms Plant Extracts 2.2214666653 17804756
MESH:D011471 Prostatic Neoplasms Vitamin E 2.2215084515
MESH:D011472 Prostatitis vinclozolin 4.4818629315
MESH:D011507 Proteinuria Tretinoin 3.1916636307
MESH:D011537 Pruritus Ethinyl Estradiol 8.5015861022 16919318
MESH:D011537 Pruritus Levonorgestrel 8.5015861022
MESH:D011565 Psoriasis Cyclosporine 2.0616882103
MESH:D011625 Pterygium Tretinoin 4.3416723453
MESH:D011658 Pulmonary Fibrosis Asbestos, Crocidolite 2.8417975199 17365031 15814490 17322281
MESH:D012004 Rectal Neoplasms Fluorouracil 3.6318286688 15538739 16160472 18722050
MESH:D015427 Reperfusion Injury pirinixic acid 2.1519058328
MESH:D012135 Respiratory Sounds Atrazine 4.0811874814
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.4118990726
MESH:D012208 Rhabdomyosarcoma Tretinoin 3.6816283617 16116481
MESH:D012640 Seizures 2,4-dinitrotoluene 4.8418551238
MESH:D012640 Seizures 2,6-dinitrotoluene 4.8418551238
MESH:D012871 Skin Diseases Vitamin E 2.3118709164
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 19.5019755658 10029692
MESH:D012878 Skin Neoplasms Hydrogen Peroxide 19.5012065085
MESH:D012878 Skin Neoplasms Plant Extracts 19.5015173996 16517061
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 19.508532709
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 19.5016192470
MESH:D012878 Skin Neoplasms Tretinoin 19.5016467112
MESH:D013088 Spermatocele Ethinyl Estradiol 3.4816709447
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 4.252093021 20155912
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 4.2518456281
MESH:D013274 Stomach Neoplasms Fluorouracil 4.2515786421 18396642 17172411 16424979 19084572 17522103 17498489 18567086 16951190 19015929
MESH:D013274 Stomach Neoplasms Tretinoin 4.2517261132
MESH:D013276 Stomach Ulcer Plant Extracts 3.5118237397 18193104 15255614 12787963 17135157
MESH:D020521 Stroke Vitamin E 3.1616517955
MESH:D013705 Temporomandibular Joint Disorders Plant Extracts 5.0217997062
MESH:D019851 Thrombophilia Ethinyl Estradiol 16.0511994571
MESH:D019851 Thrombophilia ethinyl estradiol-desogestrel combination 16.0511994571
MESH:D019851 Thrombophilia Gestodene 16.0511994571
MESH:D013927 Thrombosis Ethinyl Estradiol 8.2815669648
MESH:D013927 Thrombosis Gestodene 8.2815669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.4412697716
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 6.027505956
MESH:D013964 Thyroid Neoplasms Tretinoin 6.0216026305 17045167
MESH:D014062 Tongue Neoplasms Fluorouracil 8.5216280240
MESH:D014062 Tongue Neoplasms Tretinoin 8.5216051514
MESH:D014376 Tuberculosis Tretinoin 2.9416040207
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 7.1216049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 7.1216049721
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 7.1217053015
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 10.4810091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 10.4810091137
MESH:D014581 Urticaria Acetaminophen 2.5610982225
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 8.1416803524
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 8.1416129372
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 2.8714692618
MESH:D014604 Uveal Neoplasms Tretinoin 4.1516752155
MESH:D014605 Uveitis Cyclosporine 3.521336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.1312125929
MESH:D014689 Venous Insufficiency coumarin 5.3112708602
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 15.5815869587 14671159
MESH:D020246 Venous Thrombosis ethinyl estradiol-desogestrel combination 15.5815869587
MESH:D020246 Venous Thrombosis Levonorgestrel 15.5815869587
MESH:D018487 Ventricular Dysfunction, Left Plant Extracts 4.3018097624
MESH:D020257 Ventricular Remodeling Plant Extracts 4.8618097624
MESH:D014820 Vitiligo Tretinoin 3.6316761959
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.7815886252
MESH:D009396 Wilms Tumor Tretinoin 3.5816287080
MESH:D014947 Wounds and Injuries Plant Extracts 3.8820213670 19894650
MESH:D014985 Xerophthalmia Cyclosporine 3.9817120751
Pathway ID Pathway Name
KEGG:04610 Complement and coagulation cascades
REACT:604 Hemostasis
REACT:13552 Integrin cell surface interactions
KEGG:05150 Staphylococcus aureus infection
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA430
    • No data
    No data
    Releated drug ID Related drug Name
    PA452347glucocorticoids
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00364 antagonist Sucralfate Anti-Ulcer Agents
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


    Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved