AutismKB 2.0

Annotation Detail for FGL1


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Basic Information Top
Gene Symbol:FGL1 ( HFREP1,HP-041,LFIRE1,MGC12455 )
Gene Full Name: fibrinogen-like 1
Band: 8p22
Quick LinksEntrez ID:2267; OMIM: 605776; Uniprot ID:FGL1_HUMAN; ENSEMBL ID: ENSG00000104760; HGNC ID: 3695
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of FGL1 mRNAaffects expression 17562736
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of FGL1 proteinaffects expression 20106945
D000643 Ammonium Chloride Ammonium Chloride affects the expression of FGL1 mRNAaffects expression 16483693
C032036 bromobenzene bromobenzene results in decreased expression of FGL1 mRNAdecreases expression 12628495
D016572 Cyclosporine Cyclosporine affects the expression of FGL1 mRNAaffects expression 20106945
D004041 Dietary Fats Dietary Fats affects the expression of FGL1 mRNAaffects expression 17086191
D004041 Dietary Fats resveratrol inhibits the reaction [Dietary Fats affects the expression of FGL1 mRNA]affects expression|decreases reaction 17086191
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of FGL1 mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of FGL1 mRNAaffects cotreatment|increases expression 17942748
C042763 olive oil olive oil analog affects the expression of FGL1 mRNAaffects expression 17349074
D010634 Phenobarbital Phenobarbital results in decreased expression of FGL1 mRNAdecreases expression 19270015
C059514 resveratrol resveratrol inhibits the reaction [Dietary Fats affects the expression of FGL1 mRNA]affects expression|decreases reaction 17086191
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of FGL1 mRNAaffects cotreatment|increases expression 17942748
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of FGL1 mRNAdecreases expression 16611356
C032910 triadimefon triadimefon results in increased expression of FGL1 mRNAincreases expression 16730040
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 8.816195326
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 8.8115322242 11752688 14514962
MESH:D000138 Acidosis Ammonium Chloride 3.7118287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.1217505938
MESH:D058186 Acute Kidney Injury resveratrol 3.9616538975
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8314692618
MESH:D000236 Adenoma resveratrol 3.3815688382
MESH:D018248 Adenoma, Liver Cell Phenobarbital 10.6017620307
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 10.6016835633
MESH:D000544 Alzheimer Disease resveratrol 2.5916162502 16183991
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.0511748828
MESH:D000799 Angioedema Acetaminophen 4.0210982225
MESH:D001161 Arteriosclerosis Dietary Fats 10.3815238619
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 10.3811256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 7.5815885639
MESH:D001169 Arthritis, Experimental resveratrol 7.5817115116
MESH:D050197 Atherosclerosis olive oil 7.5016216721
MESH:D050197 Atherosclerosis resveratrol 7.5017967414 16873680
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.1512125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.9615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8315746008
MESH:D002545 Brain Ischemia resveratrol 4.4417600658
MESH:D001943 Breast Neoplasms Dietary Fats 1.8920435547
MESH:D001943 Breast Neoplasms resveratrol 1.8916393696 17651959 17534123
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.8920435547
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.8916835633
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 6.723084413
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 6.7221507988 12619106 12907637
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 6.721701930 17173139 20007298 6705139 20935162
MESH:D006528 Carcinoma, Hepatocellular resveratrol 6.7216227395 19321006
MESH:D018827 Carcinoma, Lewis Lung resveratrol 4.7516675471
MESH:D002294 Carcinoma, Squamous Cell resveratrol 2.7416227395
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4216120746 18670907 18850075
MESH:D002318 Cardiovascular Diseases olive oil 8.2216216721
MESH:D002318 Cardiovascular Diseases resveratrol 8.2215458977
MESH:D002386 Cataract Acetaminophen 2.6410977129
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 2.6012371664
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.394080065
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.2616835633
MESH:D002779 Cholestasis Cyclosporine 8.0519486331
MESH:D002779 Cholestasis Ethinyl Estradiol 8.0516919318 15861022 16105132 17110522 17681005 17333356 11677210
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 6.298697196 12621046 15340226 16354765 15668235
MESH:D002972 Cleft Palate triadimefon 6.2916781842
MESH:D003092 Colitis resveratrol 4.2716474422
MESH:D003110 Colonic Neoplasms resveratrol 2.4716338953
MESH:D015179 Colorectal Neoplasms resveratrol 2.2216550006
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1617141729 14669216
MESH:D003327 Coronary Disease resveratrol 3.8216507316
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.8610048152 20055451 15322242
MESH:D019465 Craniofacial Abnormalities triadimefon 2.8616875885 15834900
MESH:D003921 Diabetes Mellitus, Experimental resveratrol 3.8616873680
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6917107852
MESH:D003928 Diabetic Nephropathies resveratrol 4.0616286809
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.4516781746 12958197 10663392 14986274 11743745 10915739 2444490 16081117 10774834 19416960 14725611 19739265 15619225 18071297 17562736 11287661 19923254 16227642 16485898 16109766 19370779 19085960 12153990 17906064 16393943 11834606 11529661 16177239 18713872 11461765 12540782 17522070 12392966 11421492 14550746 15968718 12705907 12594235 11739529 19164858 19420014
MESH:D056486 Drug-Induced Liver Injury bromobenzene 6.4512628495 10092053
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 6.4520420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.2719426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8411462148
MESH:D050171 Dyslipidemias Dietary Fats 3.5318367378
MESH:D004421 Dystonia Phenobarbital 4.121851702
MESH:D004487 Edema resveratrol 7.238985016
MESH:D004487 Edema Tetrachlorodibenzodioxin 7.2311000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.0815322242 18230668 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 9.5512538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental resveratrol 9.5517872969
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.129294722 10568697
MESH:D020345 Enterocolitis, Necrotizing resveratrol 4.9917923197
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 4.253659116
MESH:D004828 Epilepsies, Partial Phenobarbital 4.0411558140 3922381
MESH:D004827 Epilepsy Phenobarbital 2.9420417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.646401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.397750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 4.173659116
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0911564622
MESH:D005234 Fatty Liver Cyclosporine 13.7219224547
MESH:D005234 Fatty Liver Dietary Fats 13.7217967931 19004024 18296743 19551842
MESH:D005234 Fatty Liver Ethinyl Estradiol 13.7215345470
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.5911858732
MESH:D005355 Fibrosis Cyclosporine 15.5612168785 12639820
MESH:D005355 Fibrosis Dietary Fats 15.5618296743
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 15.5620067830
MESH:D005756 Gastritis Acetaminophen 3.8516983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.378708960
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.7710696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.3811294989 10048152
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.5815720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.4411000095
MESH:D006529 Hepatomegaly Phenobarbital 15.4316109766
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 15.4316120746 15340226 12621046
MESH:D006529 Hepatomegaly triadimefon 15.4317178688 17178689
MESH:D006561 Herpes Simplex resveratrol 4.3316876885
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.2218606429 8697196 16959395 15340226 16354765
MESH:D006930 Hyperalgesia Acetaminophen 2.7916870215
MESH:D006937 Hypercholesterolemia Dietary Fats 9.5821332399
MESH:D006937 Hypercholesterolemia resveratrol 9.5817188708
MESH:D006949 Hyperlipidemias Dietary Fats 9.6921332399
MESH:D006949 Hyperlipidemias resveratrol 9.6916873680
MESH:D006973 Hypertension Cyclosporine 5.0710903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.0718850075 18670907
MESH:D017379 Hypertrophy, Left Ventricular resveratrol 4.4117488730
MESH:D007021 Hypospadias Ethinyl Estradiol 3.9516945680 16569931
MESH:D020244 Infarction, Middle Cerebral Artery resveratrol 4.7817600658
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.5812013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.5617937319
MESH:D007249 Inflammation Dietary Fats 8.6620412841
MESH:D007249 Inflammation resveratrol 8.6616366677
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 8.6612200463 12878042
MESH:D007251 Influenza, Human resveratrol 4.7216624496
MESH:D007333 Insulin Resistance Dietary Fats 3.1718457598 11836018
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 10.6916580747
MESH:D007569 Jaw Abnormalities triadimefon 10.6915992940 15834900
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.6215604871
MESH:D007674 Kidney Diseases Acetaminophen 5.9912587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 5.9918776723 10903974 8314463
MESH:D007680 Kidney Neoplasms Cyclosporine 2.8212371664
MESH:D015473 Leukemia, Promyelocytic, Acute resveratrol 3.6416087638
MESH:D008103 Liver Cirrhosis Dietary Fats 6.8518296743
MESH:D008103 Liver Cirrhosis Phenobarbital 6.8521047994
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 1.2412878042
MESH:D008107 Liver Diseases Acetaminophen 6.7912969438 16611625 19784758 16610002 19014921 12587719 19460945 11587558
MESH:D008107 Liver Diseases Phenobarbital 6.7919363144
MESH:D008107 Liver Diseases triadimefon 6.7919363144
MESH:D017114 Liver Failure, Acute Acetaminophen 3.3417185352 16871587
MESH:D008113 Liver Neoplasms Aflatoxin B1 14.692125692 15890375 9163691 18177683
MESH:D008113 Liver Neoplasms Phenobarbital 14.698742319 19812893 21047994 19482888 19073162 15975961
MESH:D008113 Liver Neoplasms resveratrol 14.6920405173 19812893 19321006 19073162
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 14.6916984957
MESH:D008113 Liver Neoplasms triadimefon 14.6919028983
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 14.738603461
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 14.731399818 2563599 18308698 6150874 17172636
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 14.7312151625
MESH:D008114 Liver Neoplasms, Experimental triadimefon 14.7317178689
MESH:D008175 Lung Neoplasms Aflatoxin B1 2.3214755239
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.3211884234 19555203
MESH:D016393 Lymphoma, B-Cell resveratrol 4.4217088997
MESH:D008228 Lymphoma, Non-Hodgkin resveratrol 3.9614749477
MESH:D015674 Mammary Neoplasms, Animal resveratrol 4.4015688416
MESH:D008325 Mammary Neoplasms, Experimental resveratrol 3.1811606380 8985016
MESH:D008545 Melanoma resveratrol 2.3817992120
MESH:D008546 Melanoma, Experimental Acetaminophen 3.7119513568
MESH:D008659 Metabolic Diseases resveratrol 4.4917112576
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.9616801185
MESH:D009101 Multiple Myeloma resveratrol 3.5417164350 16490592 16267019 17049120 17935668 14749477
MESH:D009134 Muscular Atrophy, Spinal resveratrol 5.0217962980
MESH:D009203 Myocardial Infarction resveratrol 3.0716317513 16525036 16456233 17188708 17125593 17015251
MESH:D017202 Myocardial Ischemia resveratrol 9.3117125593 17015251
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 9.3112213967
MESH:D009205 Myocarditis resveratrol 4.9117322642
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.6317484760
MESH:D009374 Neoplasms, Experimental resveratrol 4.148985016
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.6217954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.3818481113 19348381
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.3414600291
MESH:D019636 Neurodegenerative Diseases Acetaminophen 8.6618514411
MESH:D019636 Neurodegenerative Diseases resveratrol 8.6617652729
MESH:D020078 Neurogenic Inflammation resveratrol 4.5217929310
MESH:D009765 Obesity Dietary Fats 2.3119632207 17217161 20518802 21332399 18457598 20132043 18674790 16723640 11836018
MESH:D010018 Osteomalacia Phenobarbital 4.5217016548
MESH:D015663 Osteoporosis, Postmenopausal resveratrol 4.3717513867
MESH:D010146 Pain Acetaminophen 2.4816870215
MESH:D010190 Pancreatic Neoplasms Phenobarbital 2.5316965848
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.8011578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.4212520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.6918163543
MESH:D011230 Precancerous Conditions Cyclosporine 9.3012371664
MESH:D011230 Precancerous Conditions Phenobarbital 9.302563599
MESH:D011297 Prenatal Exposure Delayed Effects resveratrol 10.1116679765
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 10.1111896295 11118676 11222880 11399792
MESH:D011471 Prostatic Neoplasms resveratrol 3.6217718901 15767336 17804756 16731767 17675339 17636462
MESH:D011537 Pruritus Ethinyl Estradiol 3.4715861022 16919318
MESH:D019310 Pseudolymphoma Phenobarbital 4.6712752131
MESH:D011565 Psoriasis Cyclosporine 2.2616882103
MESH:D051436 Renal Insufficiency, Chronic resveratrol 5.7616325855
MESH:D015427 Reperfusion Injury resveratrol 3.3217520802 16314181 17058453 15827377 16317513
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.9618990726
MESH:D012640 Seizures Phenobarbital 2.7616876388 3137016 11442880 4039156
MESH:D003294 Seizures, Febrile Phenobarbital 4.986407741
MESH:D012878 Skin Neoplasms resveratrol 5.8815837718 8985016
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.8816192470
MESH:D013088 Spermatocele Ethinyl Estradiol 4.1216709447
MESH:D013276 Stomach Ulcer olive oil 4.6212498302 16252198
OMIM:601367 STROKE, ISCHEMIC resveratrol 4.5816321402
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.7411994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.2515669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.0812697716
MESH:D013964 Thyroid Neoplasms Phenobarbital 7.871399818
MESH:D013964 Thyroid Neoplasms triadimefon 7.8717178689
MESH:D014062 Tongue Neoplasms resveratrol 4.3116227395
MESH:D014581 Urticaria Acetaminophen 3.0910982225
MESH:D002583 Uterine Cervical Neoplasms resveratrol 4.2017473185
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 9.9314692618
MESH:D014594 Uterine Neoplasms resveratrol 9.9317044934
MESH:D014605 Uveitis Cyclosporine 4.161336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.7712125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.6514671159 15869587
MESH:D018487 Ventricular Dysfunction, Left resveratrol 4.4417488730
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.4215886252
MESH:D015430 Weight Gain Dietary Fats 3.8316723640
MESH:D014985 Xerophthalmia Cyclosporine 4.6217120751
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA28133
    • Releated gene ID Related gene Name
    PA28133FGL1
    No data
    No data
    Drug Bank Top

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    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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