AutismKB 2.0

Annotation Detail for FHIT


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Basic Information Top
Gene Symbol:FHIT ( AP3Aase,FRA3B )
Gene Full Name: fragile histidine triad gene
Band: 3p14.2
Quick LinksEntrez ID:2272; OMIM: 601153; Uniprot ID:FHIT_HUMAN; ENSEMBL ID: ENSG00000189283; HGNC ID: 3701
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa00230Purine metabolism
hsa05223Non-small cell lung cancer
hsa05222Small cell lung cancer
No data
No data
No data
No data
Related Diseases/Disorders Top
Desease IDDesease Name
Cancers
H00014Non-small cell lung cancer
H00013Small cell lung cancer
Cancers of the lung and pleura
Desease IDDesease Name
1728Gastrointestinal tumor
1739Oral cancer
1832Congenital abnormality
1861Epstein-Barr virus infection
1934Cancer
1979Testicular dysfunction
2052Infection
1912Penile disease
Desease Name
ADHD
prostate cancer
CANCER
PSYCH
attention-deficit hyperactivity disorder
lung cancer and preneoplastic bronchial lesions
transcriptional inactivation of the FHIT gene
tumour kinetics and chromosomal instability
major depressive disorder
cervical cancer
smoking
Desease Name
Major depressive disorder
Attention deficit hyperactivity disorder
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C012277 1,2-diamino-4-nitrobenzene 1,2-diamino-4-nitrobenzene results in increased expression of FHIT mRNAincreases expression 17070881
C035314 1-nitropropane 1-nitropropane results in increased expression of FHIT mRNAincreases expression 17070881
C010914 2,4-diaminotoluene 2,4-diaminotoluene results in decreased expression of FHIT mRNAdecreases expression 17070881
C025235 2,6-diaminotoluene 2,6-diaminotoluene results in decreased expression of FHIT mRNAdecreases expression 17070881
C014706 2-nitro-4-phenylenediamine 2-nitro-4-phenylenediamine results in increased expression of FHIT mRNAincreases expression 17070881
C016617 2-nitropropane 2-nitropropane results in decreased expression of FHIT mRNAdecreases expression 17070881
C029955 2-nitrotoluene 2-nitrotoluene results in decreased expression of FHIT mRNAdecreases expression 15618236
C029955 2-nitrotoluene 2-nitrotoluene results in decreased expression of FHIT proteindecreases expression 15618236
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of FHIT mRNAincreases expression 18648102
C028676 4-acetylaminofluorene 4-acetylaminofluorene results in decreased expression of FHIT mRNAdecreases expression 17070881
D000082 Acetaminophen Acetaminophen affects the expression of FHIT mRNAaffects expression 17562736
D000111 Acetylcysteine Acetylcysteine inhibits the reaction [Tobacco Smoke Pollution results in decreased expression of FHIT protein]decreases expression|decreases reaction 16585223
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of FHIT proteinaffects expression 20106945
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of FHIT mRNAdecreases expression 20106945
D003513 Cycloheximide [Tetrachlorodibenzodioxin co-treated with Cycloheximide] results in increased expression of FHIT mRNAaffects cotreatment|increases expression 19684285
C014347 decitabine decitabine affects the methylation of FHIT promoteraffects methylation 17019711
C014347 decitabine [decitabine affects the methylation of FHIT promoter] which affects the expression of FHIT mRNAaffects expression|affects methylation 17019711
C014347 decitabine [decitabine co-treated with trichostatin A] affects the expression of FHIT proteinaffects cotreatment|affects expression 17019711
C014347 decitabine decitabine results in decreased methylation of FHIT promoterdecreases methylation 15937960
C014347 decitabine decitabine results in increased expression of FHIT mRNAincreases expression 15937960
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with Methylcholanthrene] results in decreased expression of FHIT proteinaffects cotreatment|decreases expression 20970405
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with Methylcholanthrene] results in increased methylation of FHIT promoteraffects cotreatment|increases methylation 20970405
D004052 Diethylnitrosamine Diethylnitrosamine results in decreased expression of FHIT proteindecreases expression 12112319
D015127 9,10-Dimethyl-1,2-benzanthracene 9,10-Dimethyl-1,2-benzanthracene results in decreased expression of FHIT mRNAdecreases expression 15937960
D015127 9,10-Dimethyl-1,2-benzanthracene 9,10-Dimethyl-1,2-benzanthracene results in decreased expression of FHIT proteindecreases expression 15937960
D015127 9,10-Dimethyl-1,2-benzanthracene 9,10-Dimethyl-1,2-benzanthracene results in increased methylation of FHIT intronincreases methylation 15937960
D015127 9,10-Dimethyl-1,2-benzanthracene 9,10-Dimethyl-1,2-benzanthracene results in increased methylation of FHIT promoterincreases methylation 15937960
D015073 2-Acetylaminofluorene 2-Acetylaminofluorene results in decreased expression of FHIT mRNAdecreases expression 17070881
D006830 Hydralazine Hydralazine results in decreased methylation of FHIT promoterdecreases methylation 15862127
D006830 Hydralazine Hydralazine results in increased expression of FHIT mRNAincreases expression 15862127
D008748 Methylcholanthrene [Diethylnitrosamine co-treated with Methylcholanthrene] results in decreased expression of FHIT proteinaffects cotreatment|decreases expression 20970405
D008748 Methylcholanthrene [Diethylnitrosamine co-treated with Methylcholanthrene] results in increased methylation of FHIT promoteraffects cotreatment|increases methylation 20970405
C005223 methyleugenol methyleugenol results in decreased expression of FHIT mRNAdecreases expression 15618236
C005223 methyleugenol methyleugenol results in decreased expression of FHIT proteindecreases expression 15618236
D008770 Methylnitrosourea Methylnitrosourea results in decreased expression of FHIT mRNAdecreases expression 15937960
17412507
D008770 Methylnitrosourea Methylnitrosourea results in decreased expression of FHIT proteindecreases expression 15937960
D008770 Methylnitrosourea Methylnitrosourea results in increased methylation of FHIT intronincreases methylation 15937960
D008770 Methylnitrosourea Methylnitrosourea results in increased methylation of FHIT promoterincreases methylation 15937960
C017558 nickel sulfide nickel sulfide results in decreased expression of FHIT mRNAdecreases expression 17044645
C017558 nickel sulfide nickel sulfide results in decreased expression of FHIT proteindecreases expression 17044645
C017558 nickel sulfide nickel sulfide results in increased mutagenesis of FHIT mRNAincreases mutagenesis 17044645
D010634 Phenobarbital Phenobarbital results in increased expression of FHIT mRNAincreases expression 19270015
C008999 ponasterone A ponasterone A affects the expression of FHIT proteinaffects expression 17019711
C004648 testosterone enanthate testosterone enanthate affects the expression of FHIT mRNAaffects expression 17440010
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Cycloheximide] results in increased expression of FHIT mRNAaffects cotreatment|increases expression 19684285
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of FHIT mRNAincreases expression 19684285
D014028 Tobacco Smoke Pollution Tobacco Smoke Pollution results in decreased expression of FHIT proteindecreases expression 16585223
D014028 Tobacco Smoke Pollution Acetylcysteine inhibits the reaction [Tobacco Smoke Pollution results in decreased expression of FHIT protein]decreases expression|decreases reaction 16585223
D014028 Tobacco Smoke Pollution Tobacco Smoke Pollution results in decreased expression of FHIT mRNAdecreases expression 16585223
D014028 Tobacco Smoke Pollution Tobacco Smoke Pollution results in decreased expression of FHIT proteindecreases expression 16585223
C012589 trichostatin A [decitabine co-treated with trichostatin A] affects the expression of FHIT proteinaffects cotreatment|affects expression 17019711
C017963 vinyl carbamate vinyl carbamate results in decreased expression of FHIT mRNAdecreases expression 17849452
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 7.376195326
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 7.3715322242 14514962 11752688
MESH:D000230 Adenocarcinoma 9,10-Dimethyl-1,2-benzanthracene 9.7612844480 10697514
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 9.7620464547 20127859
MESH:D000230 Adenocarcinoma Methylnitrosourea 9.7615688392 15113128
MESH:D000230 Adenocarcinoma vinyl carbamate 9.7616247444 17363558
MESH:D002282 Adenocarcinoma, Bronchiolo-Alveolar Tobacco Smoke Pollution 5.2515814487
MESH:D000236 Adenoma 2-Acetylaminofluorene 24.1810737359
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 24.183712494
MESH:D000236 Adenoma 9,10-Dimethyl-1,2-benzanthracene 24.1811376689
MESH:D000236 Adenoma Benzo(a)pyrene 24.186695378
MESH:D000236 Adenoma Diethylnitrosamine 24.1810737359 6695378
MESH:D000236 Adenoma Methylcholanthrene 24.186695378 10545420
MESH:D002759 Adenoma, Bile Duct 2-Acetylaminofluorene 5.726705139
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 22.6617620307 17162532 19052882 18056438 19061943 16434500
MESH:D018248 Adenoma, Liver Cell Phenobarbital 22.6617620307
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 22.6616835633
MESH:D018248 Adenoma, Liver Cell vinyl carbamate 22.6612371669
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.7111748828
MESH:D000799 Angioedema Acetaminophen 3.5610982225
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.8019183758
MESH:D001172 Arthritis, Rheumatoid Tobacco Smoke Pollution 3.1219898480
MESH:D050197 Atherosclerosis Methylcholanthrene 3.2911922910
MESH:D001321 Autistic Disorder Acetaminophen 1.4518445737
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 4.731440618 11289319
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 2.8012125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.5115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.5915746008
MESH:D001943 Breast Neoplasms 2,4-diaminotoluene 5.5411921183
MESH:D001943 Breast Neoplasms 9,10-Dimethyl-1,2-benzanthracene 5.5418840765 17127718 20435547 16153821 15565634
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 5.5417474063 20146248
MESH:D001943 Breast Neoplasms decitabine 5.5419208741 18320071
MESH:D001943 Breast Neoplasms Diethylnitrosamine 5.5417474063
MESH:D001943 Breast Neoplasms Methylcholanthrene 5.5417474063
MESH:D001943 Breast Neoplasms methyleugenol 5.5411921183
MESH:D001943 Breast Neoplasms Methylnitrosourea 5.5416253758 14633655 11306469
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 5.5420435547
MESH:D002277 Carcinoma marker/mechanism 16061637
MESH:D002277 Carcinoma Methylcholanthrene 7.6110545420
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 7.6116835633
MESH:D006528 Carcinoma, Hepatocellular 2-Acetylaminofluorene 13.343084413 3581430 6705139 17761372 10737359
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 13.343581430 7296757
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 13.343084413
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 13.3421507988 12619106 12907637
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 13.3420007298 18788625 19107877 19208518 20101231 17138121 20432363 16878318 18494052 17761372 16779866 17173139 18785209 18393292 18506893 20514400 16830150 19171122 16698587 16328049 17162532 19539802 21159647 16502159 19383236 20727157 19394651 16288022 16540662 18210153 3581430 19052882 20935162 17978847 19822196 3084413 19335982 18971187 17428255 20512989 19701751 20214788 20084675 10737359 19519916 17055752 18978308 19418558 16807293 18665156 20524982 10672840 18691550 16935385 18056438 19919837 16681979 16569478 11831363
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 13.341701930 20007298 17173139 6705139 20935162
MESH:D006528 Carcinoma, Hepatocellular vinyl carbamate 13.3412371669
MESH:D002289 Carcinoma, Non-Small-Cell Lung marker/mechanism 11788890
MESH:D002289 Carcinoma, Non-Small-Cell Lung Tobacco Smoke Pollution 6.0311212258
MESH:D002289 Carcinoma, Non-Small-Cell Lung vinyl carbamate 6.0316247446
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.547296757
MESH:D002294 Carcinoma, Squamous Cell 9,10-Dimethyl-1,2-benzanthracene 17.0111376689
MESH:D002294 Carcinoma, Squamous Cell Acetylcysteine 17.0117015178
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 17.0120419170
MESH:D002294 Carcinoma, Squamous Cell decitabine 17.0119215824
MESH:D002294 Carcinoma, Squamous Cell nickel sulfide 17.0117044645
MESH:D002294 Carcinoma, Squamous Cell Tobacco Smoke Pollution 17.0111212258
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.2116120746 18670907 18850075
MESH:D002386 Cataract Acetaminophen 7.0110977129
MESH:D002386 Cataract Methylnitrosourea 7.0112484553
MESH:D002430 Cecal Neoplasms 2-nitrotoluene 5.4314688030
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 19.127505956
MESH:D002471 Cell Transformation, Neoplastic Acetylcysteine 19.1218226522
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 19.122727394 17174075 21159647 7505956
MESH:D002471 Cell Transformation, Neoplastic Methylcholanthrene 19.1216192471
MESH:D002471 Cell Transformation, Neoplastic Methylnitrosourea 19.122727394 7505956
MESH:D002493 Central Nervous System Diseases Phenobarbital 3.984080065
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 8.5519052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 8.5516835633
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 2.9419486331 9022650
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 1.9915668235 8697196 12621046 15340226 16354765
MESH:D003110 Colonic Neoplasms decitabine 2.2917616700
MESH:D015179 Colorectal Neoplasms decitabine 2.1018981723
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.8317141729 14669216
MESH:D003328 Coronary Thrombosis methyleugenol 5.5316048847
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2420055451 10048152 15322242
MESH:D003550 Cystic Fibrosis Acetylcysteine 4.1419747007
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 2.5411298694 12868966 11906362 18759878 14531868 8156756 2524372 8970840
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.232952479 3621924
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 3.9820387270
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 3.9817107852
MESH:D056486 Drug-Induced Liver Injury 2-nitropropane 14.1315804453 16445897 20517888
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 14.1318692083 9328219 18289764 6679447 7440962 9653073 16192314 11289319 9022650 1440618 8291058 18648102 6482804
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 14.1318713872 16109766 18071297 11287661 11461765 15968718 19416960 2444490 12153990 16081117 11739529 17522070 12594235 11834606 16393943 19739265 11743745 19923254 11529661 17906064 12392966 14986274 19420014 16177239 16485898 12958197 17562736 19085960 19370779 16781746 10663392 10915739 19164858 12705907 14550746 16227642 10774834 14725611 12540782 11421492 15619225
MESH:D056486 Drug-Induced Liver Injury Acetylcysteine 14.1311287661
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 14.1319107877
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 14.1320420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.8119426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.5611462148
MESH:D004421 Dystonia Phenobarbital 3.751851702
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.1411000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.6218230668 15322242 16714409
MESH:D004701 Endocrine Gland Neoplasms decitabine 13.0819294695
MESH:D004701 Endocrine Gland Neoplasms trichostatin A 13.0819294695
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.7810568697 9294722
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 3.833659116
MESH:D004828 Epilepsies, Partial Phenobarbital 3.593922381 11558140
MESH:D004827 Epilepsy Phenobarbital 2.7520417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.316401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 3.987750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 3.743659116
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 4.8316302075
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 4.113581430
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.1116530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.8111564622
MESH:D005234 Fatty Liver Diethylnitrosamine 2.9420387270 21071580
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.1811858732
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 4.736705139
MESH:D005354 Fibrosarcoma Methylcholanthrene 11.2910962813 14633661
MESH:D005354 Fibrosarcoma Methylnitrosourea 11.2911555667
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 2.6820067830
MESH:D005756 Gastritis Acetaminophen 3.3916983495
MESH:D005909 Glioblastoma trichostatin A 3.6518801729
MESH:D005910 Glioma Methylnitrosourea 3.459825942
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 3.787505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.3110696789
MESH:D006258 Head and Neck Neoplasms decitabine 3.3019215824
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 5.9620471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 5.9611294989 10048152
MESH:D006390 Hemangioendothelioma 2-Acetylaminofluorene 5.036705139
MESH:D006394 Hemangiosarcoma 2-Acetylaminofluorene 9.016705139
MESH:D006394 Hemangiosarcoma 2-nitrotoluene 9.0113678655
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.0911000095
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.256705139
MESH:D006529 Hepatomegaly Phenobarbital 7.5316109766
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 7.5316120746 12621046 15340226
MESH:D019247 HIV Wasting Syndrome testosterone enanthate 5.4617440010
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.7616354765 15340226 16959395 8697196 18606429
MESH:D006930 Hyperalgesia Acetaminophen 2.4816870215
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 3.6715034207
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.8018850075 18670907
MESH:D046110 Hypertension, Pregnancy-Induced Hydralazine 4.3516612254
MESH:D007248 Infertility, Male decitabine 6.5917581917
MESH:D007248 Infertility, Male Methylnitrosourea 6.597193160
MESH:D007249 Inflammation Diethylnitrosamine 7.5518785209
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 7.5512200463 12878042
MESH:D007249 Inflammation Tobacco Smoke Pollution 7.5518590791
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 4.738074119 9022650
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.0916580747
MESH:D007674 Kidney Diseases Acetaminophen 2.0412587719 15629191
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 2.756582329
MESH:D007938 Leukemia decitabine 2.9318980019 19235587
MESH:D007951 Leukemia, Myeloid decitabine 3.7519117987 18454857 17236224
MESH:D015470 Leukemia, Myeloid, Acute decitabine 4.0918704418 19010910 18206229 17679729 19387464 18460780
MESH:D015470 Leukemia, Myeloid, Acute trichostatin A 4.0918206229
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 5.1818055864
MESH:D017880 Limb Deformities, Congenital Methylnitrosourea 4.0115526292
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 6.1319638242 18407596 18522880 20032147 18665156
MESH:D008103 Liver Cirrhosis Phenobarbital 6.1321047994
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.0215034207 9327722
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 1.2312878042
MESH:D008107 Liver Diseases Acetaminophen 6.0316611625 19784758 19014921 12969438 12587719 19460945 16610002 11587558
MESH:D008107 Liver Diseases Diethylnitrosamine 6.0317034775
MESH:D008107 Liver Diseases Phenobarbital 6.0319363144
MESH:D017114 Liver Failure, Acute Acetaminophen 2.9916871587 17185352
MESH:D008113 Liver Neoplasms marker/mechanism 12112319
MESH:D008113 Liver Neoplasms 2-Acetylaminofluorene 20.2310737359 11376686 10672840 14678523 18001218 16273603
MESH:D008113 Liver Neoplasms 9,10-Dimethyl-1,2-benzanthracene 20.239643874
MESH:D008113 Liver Neoplasms Aflatoxin B1 20.232125692 15890375 18177683 9163691
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 20.2320195826 21137059
MESH:D008113 Liver Neoplasms Diethylnitrosamine 20.2319254457 20492335 19850985 19996281 19551842 10737359 19090486 20583210 2422723 21047994 20434301 19499222 18977376 20501860 18644402 19256749 19690152 20118626 15175105 19426721 19812893 19833225 12112319 19427195 20452335 15885732 12771043 19073162 18648771 19638242 20101389 9163691 19294768 19642983 18754104 20405173 20137499 19255062 21167192 18978307 16942905 2862719 21278145 21071580
MESH:D008113 Liver Neoplasms Phenobarbital 20.238742319 15975961 19812893 19073162 21047994 19482888
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 20.2316984957
MESH:D008114 Liver Neoplasms, Experimental 2-Acetylaminofluorene 30.276150874 534488 1399818
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 30.273712494 6587162 598648 1399818
MESH:D008114 Liver Neoplasms, Experimental 9,10-Dimethyl-1,2-benzanthracene 30.271399818
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 30.278603461
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 30.2717854601 16842330 2563599 18164116 18544905 9362446 19539802 17942915 18079962 18282651 19009564 19004024 16267830 17174075 18775883 19126423 3124819 18308698 21159647 18253720 18093689 19519916
MESH:D008114 Liver Neoplasms, Experimental Methylcholanthrene 30.271399818 598648
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 30.2718308698 17172636 2563599 1399818 6150874
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 30.2712151625
MESH:D038061 Lower Extremity Deformities, Congenital Methylnitrosourea 5.1916080182
MESH:D008171 Lung Diseases Acetylcysteine 3.8712815614
MESH:D008175 Lung Neoplasms marker/mechanism 16061637
MESH:D008175 Lung Neoplasms 2-Acetylaminofluorene 17.1411376686
MESH:D008175 Lung Neoplasms 9,10-Dimethyl-1,2-benzanthracene 17.1411376689
MESH:D008175 Lung Neoplasms Aflatoxin B1 17.1414755239
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 17.1418520028 17053015 6695378 20464547 20135361 18569708 20869020 20064080 18816296
MESH:D008175 Lung Neoplasms Diethylnitrosamine 17.1420970405 21163286 20512841 6695378
MESH:D008175 Lung Neoplasms Methylcholanthrene 17.1415390079 20512841 16271038 21163286 20970405 6695378 16337739 17909032 1399818 11893704 9230183 10545420 7750092
MESH:D008175 Lung Neoplasms Methylnitrosourea 17.1418062963
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 17.1419555203 11884234
MESH:D008175 Lung Neoplasms Tobacco Smoke Pollution 17.1416288123 3440675 11091918 12111688
MESH:D008175 Lung Neoplasms vinyl carbamate 17.1415172992 17163412 12438228 16247444 17361011 12765245 11134547 14755239 15824018 17363558 12117777 16885199 11195469
MESH:D008223 Lymphoma 9,10-Dimethyl-1,2-benzanthracene 11.7411376689
MESH:D008223 Lymphoma decitabine 11.7419470736
MESH:D008223 Lymphoma Methylnitrosourea 11.7411418001 16257854
MESH:D016393 Lymphoma, B-Cell Methylnitrosourea 4.5114633661
MESH:D008325 Mammary Neoplasms, Experimental 2,4-diaminotoluene 13.0711921183
MESH:D008325 Mammary Neoplasms, Experimental 9,10-Dimethyl-1,2-benzanthracene 13.0716153821 8985016 11807958 1500032 12844480 16082771 10697514 18840765
MESH:D008325 Mammary Neoplasms, Experimental methyleugenol 13.0711921183
MESH:D008325 Mammary Neoplasms, Experimental Methylnitrosourea 13.0710767621 11751437 17131329 16619500 10838139 15313902 16827153 15113128 16051031 11807958 15688392 14999141 12931682 16944150 17020996 19196723 14633655
MESH:D008545 Melanoma decitabine 3.5616505122 17785578
MESH:D008545 Melanoma trichostatin A 3.5616505122
MESH:D008546 Melanoma, Experimental Acetaminophen 3.2919513568
MESH:D008654 Mesothelioma marker/mechanism 14569398 18038314
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 8.0916381670
MESH:D009062 Mouth Neoplasms Tobacco Smoke Pollution 8.0915006635
MESH:D009101 Multiple Myeloma decitabine 7.0018172295
MESH:D009101 Multiple Myeloma trichostatin A 7.0018172295
MESH:D019042 Muscle Neoplasms 2-nitrotoluene 6.4013678655
MESH:D009190 Myelodysplastic Syndromes decitabine 3.2218608210 19157545 16882708 19010910
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.8012213967
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.2017484760
MESH:D009336 Necrosis 2-nitropropane 5.2812195237
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 8.943581430
MESH:D009362 Neoplasm Metastasis Acetylcysteine 8.9414720322
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 8.943581430 9029167
MESH:D009369 Neoplasms 9,10-Dimethyl-1,2-benzanthracene 10.8511544531
MESH:D009369 Neoplasms Benzo(a)pyrene 10.8511141357
MESH:D009369 Neoplasms decitabine 10.8519470736 19116145 17925555
MESH:D009369 Neoplasms Methylnitrosourea 10.8515533788
MESH:D009374 Neoplasms, Experimental Methylnitrosourea 4.2012696579
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 2.9514600291
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 6.986679447
MESH:D009436 Neural Tube Defects Acetylcysteine 6.9819446573
MESH:D009442 Neurilemmoma Methylnitrosourea 5.2111555667
MESH:D019636 Neurodegenerative Diseases Acetaminophen 7.4318514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 7.4320387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 4.8320387270
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.186482804 4026338
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 4.733988306
MESH:D010018 Osteomalacia Phenobarbital 4.0817016548
MESH:D010051 Ovarian Neoplasms 9,10-Dimethyl-1,2-benzanthracene 7.7216891317
MESH:D010051 Ovarian Neoplasms decitabine 7.7219331143 19259094
MESH:D010051 Ovarian Neoplasms trichostatin A 7.7219331143
MESH:D010146 Pain Acetaminophen 2.1716870215
MESH:D010190 Pancreatic Neoplasms decitabine 15.2419294695
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 15.2416540662
MESH:D010190 Pancreatic Neoplasms Methylnitrosourea 15.2416965848
MESH:D010190 Pancreatic Neoplasms Phenobarbital 15.2416965848
MESH:D010190 Pancreatic Neoplasms trichostatin A 15.2419294695
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 8.857296757
MESH:D010212 Papilloma 9,10-Dimethyl-1,2-benzanthracene 8.8517234724 15173996 16517061
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.9612520081
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.196228378
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.2918163543
MESH:D011230 Precancerous Conditions Diethylnitrosamine 8.322563599
MESH:D011230 Precancerous Conditions Phenobarbital 8.322563599
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 2.9111118676 11222880 11399792 11896295
MESH:D055728 Primary Myelofibrosis decitabine 11.5117616702
MESH:D055728 Primary Myelofibrosis trichostatin A 11.5117616702
MESH:D011471 Prostatic Neoplasms marker/mechanism 17548701
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.8517292933
MESH:D011471 Prostatic Neoplasms Methylnitrosourea 2.8515682402 12376480
MESH:D011471 Prostatic Neoplasms trichostatin A 2.8518798265 19789329
MESH:D019310 Pseudolymphoma Phenobarbital 4.2112752131
MESH:D012128 Respiratory Distress Syndrome, Adult Acetylcysteine 4.2712210543
MESH:D012135 Respiratory Sounds Tobacco Smoke Pollution 4.3518410779
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.5718990726
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 8.433692021
MESH:D012162 Retinal Degeneration Methylnitrosourea 8.4318172121 18155124
MESH:D012175 Retinoblastoma Methylnitrosourea 5.2111555667
MESH:D012208 Rhabdomyosarcoma decitabine 4.1419155313
MESH:D012640 Seizures Phenobarbital 2.5116876388 3137016 4039156 11442880
MESH:D003294 Seizures, Febrile Phenobarbital 4.546407741
MESH:D012878 Skin Neoplasms 9,10-Dimethyl-1,2-benzanthracene 12.5716517061 11376689 8985016 15173996
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 12.5710029692 19755658
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 12.5716192470
MESH:D012878 Skin Neoplasms Tobacco Smoke Pollution 12.5718590791
MESH:D013274 Stomach Neoplasms marker/mechanism 12958204
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 4.5120155912 2093021
MESH:D013274 Stomach Neoplasms decitabine 4.5119037991
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 4.5118456281
MESH:D013274 Stomach Neoplasms Methylnitrosourea 4.5115930296 16257854 18593901
MESH:D013276 Stomach Ulcer Acetylcysteine 3.7517918041
MESH:D013953 Thymus Neoplasms Methylnitrosourea 4.9511418001
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.6212697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 20.263712494 6582329 6587162 1399818 7505956
MESH:D013964 Thyroid Neoplasms decitabine 20.2617967635
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 20.267505956
MESH:D013964 Thyroid Neoplasms Methylnitrosourea 20.263078959 7505956
MESH:D013964 Thyroid Neoplasms Phenobarbital 20.261399818
MESH:D001749 Urinary Bladder Neoplasms 2-Acetylaminofluorene 14.6415867355 1399818 15289314
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 14.648074119
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 14.6417053015
MESH:D001749 Urinary Bladder Neoplasms decitabine 14.6417616700 19087683
MESH:D001749 Urinary Bladder Neoplasms Tobacco Smoke Pollution 14.6412846360
MESH:D014581 Urticaria Acetaminophen 2.7210982225
MESH:D014604 Uveal Neoplasms decitabine 4.6317785578
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.3112125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.9615886252
Pathway ID Pathway Name
KEGG:05223 Non-small cell lung cancer
KEGG:00230 Purine metabolism
KEGG:05222 Small cell lung cancer
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA28140
    • No data
    Releated disease ID Related disease Name
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    No data
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB02373 - Adenosine Monotungstate
    DB04173 - Fructose
    DB04389 - Ado-P-Ch2-P-Ps-Ado
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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