AutismKB 2.0

Annotation Detail for FHL2


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Basic Information Top
Gene Symbol:FHL2 ( AAG11,DRAL,FHL-2,SLIM-3,SLIM3 )
Gene Full Name: four and a half LIM domains 2
Band: 2q12.2
Quick LinksEntrez ID:2274; OMIM: 602633; Uniprot ID:FHL2_HUMAN; ENSEMBL ID: ENSG00000115641; HGNC ID: 3703
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
No data
Pathway IDPathway Name
Metabolism of lipids and lipoproteins
Pathway IDPathway Name
200038Coregulation of Androgen receptor activity
200020Signaling events mediated by HDAC Class III
No data
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1829Gastrointestinal cancer
1831Prostate cancer
1848Embryoma
1944Breast cancer
2025Polyarthritis
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of FHL2 mRNAincreases expression 18648102
D000082 Acetaminophen Acetaminophen affects the expression of FHL2 mRNAaffects expression 17562736
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of FHL2 proteinaffects expression 20106945
D013196 Dihydrotestosterone AHR protein inhibits the reaction [[FHL2 protein co-treated with Tetrachlorodibenzodioxin] inhibits the reaction [Dihydrotestosterone results in increased activity of AR protein]]affects cotreatment|decreases reaction|increases activity 19815066
D013196 Dihydrotestosterone FHL2 protein affects the reaction [[Dihydrotestosterone co-treated with Tetrachlorodibenzodioxin] results in increased activity of AR protein]affects cotreatment|affects reaction|increases activity 19815066
D013196 Dihydrotestosterone [FHL2 protein co-treated with Tetrachlorodibenzodioxin] inhibits the reaction [Dihydrotestosterone results in increased activity of AR protein]affects cotreatment|decreases reaction|increases activity 19815066
D013196 Dihydrotestosterone FHL2 protein inhibits the reaction [AHR protein promotes the reaction [Dihydrotestosterone results in increased activity of AR protein]]decreases reaction|increases activity|increases reaction 19815066
D013196 Dihydrotestosterone FHL2 protein promotes the reaction [Dihydrotestosterone results in increased activity of AR protein]increases activity|increases reaction 19815066
D000643 Ammonium Chloride Ammonium Chloride affects the expression of FHL2 mRNAaffects expression 16483693
D017638 Asbestos, Crocidolite Asbestos, Crocidolite affects the expression of FHL2 mRNAaffects expression 17331233
D019324 beta-Naphthoflavone [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of FHL2 mRNAaffects cotreatment|increases expression 18164116
C006780 bisphenol A bisphenol A affects the expression of FHL2 mRNAaffects expression 20170705
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in increased expression of FHL2 mRNAincreases expression 15336504
D002251 Carbon Tetrachloride Carbon Tetrachloride results in increased expression of FHL2 mRNAincreases expression 17484886
D002251 Carbon Tetrachloride Carbon Tetrachloride results in increased expression of FHL2 mRNAincreases expression 16239168
D016572 Cyclosporine Cyclosporine results in increased expression of FHL2 mRNAincreases expression 20106945
C014347 decitabine [decitabine co-treated with vorinostat] affects the expression of FHL2 mRNAaffects cotreatment|affects expression 17330099
D004041 Dietary Fats Dietary Fats results in increased expression of FHL2 mRNAincreases expression 18042831
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of FHL2 mRNAaffects cotreatment|increases expression 18164116
D004054 Diethylstilbestrol Diethylstilbestrol results in increased expression of FHL2 mRNAincreases expression 19371625
D004317 Doxorubicin FHL2 protein affects the reaction [Doxorubicin results in increased expression of CDKN1A protein]affects reaction|increases expression 17682292
D004317 Doxorubicin TP53 protein affects the reaction [FHL2 protein affects the reaction [Doxorubicin results in increased expression of CDKN1A protein]]affects reaction|increases expression 17682292
D004958 Estradiol Estradiol affects the expression of FHL2 mRNAaffects expression 14699072
D004958 Estradiol [Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of FHL2 mRNAaffects cotreatment|decreases expression 19619570
D004958 Estradiol Estradiol promotes the reaction [FHL2 protein binds to ESR1 protein]affects binding|increases reaction 15666801
D004958 Estradiol Estradiol results in increased expression of FHL2 mRNAincreases expression 19619570
20106945
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of FHL2 mRNAaffects expression 20170705
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of FHL2 mRNAaffects expression 17555576
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of FHL2 mRNAaffects cotreatment|increases expression 17942748
D005472 Fluorouracil FHL2 protein affects the susceptibility to Fluorouracilaffects response to substance 16217747
C029424 hydrazine hydrazine results in decreased expression of FHL2 mRNAdecreases expression 15282401
D007657 Ketone Bodies Ketone Bodies results in increased expression of FHL2 mRNAincreases expression 16807920
C008493 methylselenic acid methylselenic acid results in increased expression of FHL2 mRNAincreases expression 18548127
C041786 palm oil palm oil results in increased expression of FHL2 mRNAincreases expression 18042831
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of FHL2 mRNAaffects binding|increases activity|increases expression 19710929
C006253 pirinixic acid pirinixic acid results in decreased expression of FHL2 mRNAdecreases expression 17426115
D020849 Raloxifene Raloxifene affects the expression of FHL2 mRNAaffects expression 14699072
D020849 Raloxifene [Raloxifene co-treated with ESR1 protein] results in increased expression of FHL2 mRNAaffects cotreatment|increases expression 19059307
D020849 Raloxifene [Raloxifene co-treated with ESR2 protein] results in decreased expression of FHL2 mRNAaffects cotreatment|decreases expression 19059307
C064116 S-(1,1,2,2-tetrafluoroethyl)cysteine S-(1,1,2,2-tetrafluoroethyl)cysteine results in increased expression of FHL2 mRNAincreases expression 16678137
D013467 Sulindac Sulindac results in increased expression of FHL2 mRNAincreases expression 11906190
D013629 Tamoxifen Tamoxifen affects the expression of FHL2 mRNAaffects expression 14699072
D013629 Tamoxifen [Tamoxifen co-treated with ESR1 protein] results in increased expression of FHL2 mRNAaffects cotreatment|increases expression 19059307
D013629 Tamoxifen [Tamoxifen co-treated with ESR2 protein] results in decreased expression of FHL2 mRNAaffects cotreatment|decreases expression 19059307
D013629 Tamoxifen Tamoxifen affects the expression of FHL2 mRNAaffects expression 17555576
D013749 Tetrachlorodibenzodioxin AHR protein inhibits the reaction [[FHL2 protein co-treated with Tetrachlorodibenzodioxin] inhibits the reaction [Dihydrotestosterone results in increased activity of AR protein]]affects cotreatment|decreases reaction|increases activity 19815066
D013749 Tetrachlorodibenzodioxin [Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of FHL2 mRNAaffects cotreatment|decreases expression 19619570
D013749 Tetrachlorodibenzodioxin FHL2 protein affects the reaction [[Dihydrotestosterone co-treated with Tetrachlorodibenzodioxin] results in increased activity of AR protein]affects cotreatment|affects reaction|increases activity 19815066
D013749 Tetrachlorodibenzodioxin [FHL2 protein co-treated with Tetrachlorodibenzodioxin] inhibits the reaction [Dihydrotestosterone results in increased activity of AR protein]affects cotreatment|decreases reaction|increases activity 19815066
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of FHL2 mRNAincreases expression 19619570
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of FHL2 mRNAaffects cotreatment|increases expression 17942748
C111237 vorinostat [decitabine co-treated with vorinostat] affects the expression of FHL2 mRNAaffects cotreatment|affects expression 17330099
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Sulindac 12.0714745880
MESH:D000008 Abdominal Neoplasms Tamoxifen 12.0714745880
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.5711752688 14514962 15322242
MESH:D000138 Acidosis Ammonium Chloride 3.2818287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.6617505938
MESH:D058186 Acute Kidney Injury Sulindac 4.077897758
MESH:D055371 Acute Lung Injury pirinixic acid 2.8618653653
MESH:D000230 Adenocarcinoma Doxorubicin 12.7617418594
MESH:D000230 Adenocarcinoma Estradiol 12.7611473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 12.7614692618
MESH:D000230 Adenocarcinoma Fluorouracil 12.7617638652
MESH:D000230 Adenocarcinoma Sulindac 12.7611910360
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 14.713712494
MESH:D000236 Adenoma beta-Naphthoflavone 14.7119389873
MESH:D000236 Adenoma Diethylnitrosamine 14.7110737359 6695378
MESH:D000236 Adenoma Sulindac 14.7110223192
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 15.6519061943 18056438 19052882 17162532 17620307 16434500
MESH:D018248 Adenoma, Liver Cell pirinixic acid 15.6516434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 15.6516835633
MESH:D011125 Adenomatous Polyposis Coli Sulindac 4.3619003578 11874996 16460482 11535846 15623613 17611924 12394442
MESH:D000419 Albuminuria Doxorubicin 10.5721441931
MESH:D000419 Albuminuria Raloxifene 10.5717308373 17451421
MESH:D000544 Alzheimer Disease Raloxifene 2.4815800139
MESH:D000686 Amyloidosis Diethylstilbestrol 4.2115469931
MESH:D000740 Anemia Fluorouracil 7.8815504547 17963324 16511603
MESH:D000740 Anemia Tetrachlorodibenzodioxin 7.8811748828
MESH:D000799 Angioedema Acetaminophen 3.5610982225
MESH:D001161 Arteriosclerosis Dietary Fats 9.0015238619
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 9.0011256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.4915885639
MESH:D001321 Autistic Disorder Acetaminophen 1.4518445737
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 4.731440618 11289319
MESH:D001778 Blood Coagulation Disorders pirinixic acid 7.9419483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 7.9412125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.5115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.5915746008
MESH:D019046 Bone Marrow Neoplasms Doxorubicin 4.4214601052
MESH:D001862 Bone Resorption bisphenol A 3.6111985600
MESH:D001913 Bowen's Disease Sulindac 5.0711207687
MESH:D001930 Brain Injuries Raloxifene 4.2016580743
MESH:D001932 Brain Neoplasms Doxorubicin 3.5717150277
MESH:D001943 Breast Neoplasms marker/mechanism 17682292
MESH:D001943 Breast Neoplasms bisphenol A 10.7617123778
MESH:D001943 Breast Neoplasms decitabine 10.7618320071 19208741
MESH:D001943 Breast Neoplasms Dietary Fats 10.7620435547
MESH:D001943 Breast Neoplasms Diethylnitrosamine 10.7617474063
MESH:D001943 Breast Neoplasms Diethylstilbestrol 10.7617129689 15324884
MESH:D001943 Breast Neoplasms Doxorubicin 10.7618695136 15634643 19526202 17426702 15136595 16595493 16096432 15994142 16264153 17369602 15939500 15993339 18628466 16322301 16935488 11325840 16826403 15692762 18234424 15567936 18382427 15668708 16115903 17983394
MESH:D001943 Breast Neoplasms Estradiol 10.7617261762 16675129 12948864 14630087 17289903 18497071 17018787 19861407
MESH:D001943 Breast Neoplasms Fluorouracil 10.7619217205 16110121 18357371 16595493 16557594 18608205 15136595
MESH:D001943 Breast Neoplasms Raloxifene 10.7617893378 17440819 15758505 17261762 16912660 17595753 15572757 16837676 17049068 17952589 15775269 17242785
MESH:D001943 Breast Neoplasms Sulindac 10.7616642371
MESH:D001943 Breast Neoplasms Tamoxifen 10.7616818667 19189212 19103187 19221464 19410462 19189210 19288272 16202921 19289846 19155303 18425577 11161223 20859285 15565566 19059307 18351453 20005174 18629630 17242785 18821012 19244106 20065188 18984771 20135344 21138602 19142967 16273361 19084267 19487384 20544844 20390343 18815881 17261762 17893378 17049068 19115204 19200415 19066611 16873071 19011961 17440819 18855134 21152245 18997820 15668708
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 10.7620435547
MESH:D001943 Breast Neoplasms vorinostat 10.7616144943
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.1816111702
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.5116011737 16227642 16124888 15721981 10355542 15700767 16097048 15673190 18705752 16050911 16192424 3786805
MESH:D002276 Carcinoid Tumor Doxorubicin 11.4116051944
MESH:D002276 Carcinoid Tumor Fluorouracil 11.4116051944
MESH:D002277 Carcinoma Fluorouracil 7.4617121937
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 7.4616835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.2319066611
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 21.947296757 3581430
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 21.943084413
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 21.9421507988 12619106 12907637
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 21.9418788625
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 21.9419822196 20727157 16830150 18788625 18978308 18393292 20007298 19052882 16698587 18210153 19418558 16935385 18971187 19701751 19335982 20214788 18785209 3084413 16807293 16878318 17428255 20514400 21159647 17761372 3581430 16328049 19107877 16502159 20935162 18506893 17978847 16681979 10737359 19208518 20512989 18056438 17173139 19919837 17138121 16569478 19394651 10672840 11831363 18494052 16779866 20432363 19539802 18691550 16540662 17162532 16288022 20101231 19171122 17055752 19519916 18665156 20084675 20524982 19383236
MESH:D006528 Carcinoma, Hepatocellular Diethylstilbestrol 21.9416924424 15948411
MESH:D006528 Carcinoma, Hepatocellular Doxorubicin 21.9416234567 17876044 18059187 16023760
MESH:D006528 Carcinoma, Hepatocellular Estradiol 21.9416924424
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 21.9418930000 17045692 17088986 16332177 16799960 17971768
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 21.9416924424
MESH:D002278 Carcinoma in Situ bisphenol A 4.7117123778
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 10.027296757
MESH:D002292 Carcinoma, Renal Cell Doxorubicin 10.021485588 16201981
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 10.0218695887
MESH:D002294 Carcinoma, Squamous Cell decitabine 7.1419215824
MESH:D002294 Carcinoma, Squamous Cell Doxorubicin 7.146189445
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 7.1416757204 17066447 18986760 16280240
MESH:D002295 Carcinoma, Transitional Cell Raloxifene 8.7017572228
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 8.7017572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.2118850075 18670907 16120746
MESH:D009202 Cardiomyopathies Doxorubicin 3.3516242529 17329180 15811867 16269455 16612575 16364871 17007740 17308081 15792986 17131338 17382496 16731534 16455267 15476868 16952015 17519947 17928571 15505089 17924179 16651473 17974986 16109756 16278810 17351982 18627295
MESH:D002311 Cardiomyopathy, Dilated Doxorubicin 2.8516243910 17334414
MESH:D002318 Cardiovascular Diseases Raloxifene 3.2615775269
MESH:D002386 Cataract Acetaminophen 2.4210977129
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 14.447505956
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 14.4412371664
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 14.442727394 7505956 21159647 17174075
MESH:D002471 Cell Transformation, Neoplastic Estradiol 14.4418566989
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 8.5519052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 8.5516835633
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 17.5319486331 9022650
MESH:D002779 Cholestasis Cyclosporine 17.5319486331
MESH:D002779 Cholestasis Ethinyl Estradiol 17.5316919318 17110522 17681005 11677210 16105132 15861022 17333356
MESH:D002779 Cholestasis pirinixic acid 17.5319176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 1.9912621046 15668235 16354765 15340226 8697196
MESH:D003072 Cognition Disorders Raloxifene 4.3415800139
MESH:D003110 Colonic Neoplasms decitabine 5.6417616700
MESH:D003110 Colonic Neoplasms Fluorouracil 5.6415001691 18772588 16510598 17169374 17725105 17172411 17018589 16340194 17016597 17287894
MESH:D003110 Colonic Neoplasms Sulindac 5.6412902858 12458338
MESH:D015179 Colorectal Neoplasms decitabine 4.6118981723
MESH:D015179 Colorectal Neoplasms Doxorubicin 4.6118259882 18802399
MESH:D015179 Colorectal Neoplasms Fluorouracil 4.6118288408 16282729 17094418 16524972 16391804 15148649 17594712 18509181 17016601 18383874 18448328 17695437 15289873 20501625 18949393 18802399 14970324 17454858 17255274 17401013 16331619 16303861
MESH:D015179 Colorectal Neoplasms Sulindac 4.6118059344 11076880 10666051 11197048
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.8317141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2415322242 20055451 10048152
MESH:D003456 Cryptorchidism Diethylstilbestrol 4.2912952375 16002989
MESH:D007644 Darier Disease Fluorouracil 4.5116733453
MESH:D003711 Demyelinating Diseases Tamoxifen 4.0919031437
MESH:D003865 Depressive Disorder, Major Raloxifene 3.9317474826
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 2.5412868966 8970840 8156756 11298694 2524372 11906362 18759878 14531868
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.3018249437
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.233621924 2952479
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 3.9820387270
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 3.9817107852
MESH:D003928 Diabetic Nephropathies Estradiol 13.6719279558
MESH:D003928 Diabetic Nephropathies Raloxifene 13.6717308373 17451421 15920148
MESH:D003928 Diabetic Nephropathies Tamoxifen 13.6719279558
MESH:D003930 Diabetic Retinopathy Sulindac 4.9112861449 17621415
MESH:D003967 Diarrhea vorinostat 4.2420479100
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 14.111440618 6482804 18289764 6679447 8291058 9022650 9653073 11289319 9328219 18692083 7440962 16192314 18648102
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 14.1116485898 10915739 14550746 19739265 15619225 14986274 10774834 11287661 12153990 19420014 11529661 11834606 11739529 19085960 12540782 19164858 11743745 11461765 2444490 19416960 12392966 11421492 16393943 12958197 17562736 17522070 19923254 16109766 19370779 15968718 14725611 16081117 10663392 16227642 12705907 17906064 18713872 12594235 16781746 16177239 18071297
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 14.1111566570 10915739 16177239 2869522 7120509 7440962 19336974 15968718 6623471 4309450 10092053 16227642 15998439 21278145 3786805 7179309 6884620 9327722 3732212 17522070 19085960 15027814
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 14.1119107877
MESH:D056486 Drug-Induced Liver Injury Doxorubicin 14.1117416283
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 14.1120420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.8119426721
MESH:D004362 Drug Toxicity Doxorubicin 7.4318602426
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 7.4311462148
MESH:D050171 Dyslipidemias Dietary Fats 3.2618367378
MESH:D004487 Edema pirinixic acid 10.0012083418
MESH:D004487 Edema Raloxifene 10.0015860553
MESH:D004487 Edema Tetrachlorodibenzodioxin 10.0012711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.6218230668 16714409 15322242
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 13.8112538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Raloxifene 13.8115845917
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 13.8119031437
MESH:D004701 Endocrine Gland Neoplasms decitabine 4.8319294695
MESH:D004714 Endometrial Hyperplasia Diethylstilbestrol 4.4116402032
MESH:D016889 Endometrial Neoplasms Diethylstilbestrol 16.3115700306 16804899
MESH:D016889 Endometrial Neoplasms Doxorubicin 16.3117359293
MESH:D016889 Endometrial Neoplasms Estradiol 16.3111473722 18566989 19148513
MESH:D016889 Endometrial Neoplasms Tamoxifen 16.3116202921 20544844 19155303 17893378
MESH:D004715 Endometriosis Sulindac 8.3915652904
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 8.3910568697 9294722
MESH:D004719 Endomyocardial Fibrosis Doxorubicin 4.8718037988
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 4.8316302075
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 6.943581430
MESH:D004938 Esophageal Neoplasms Fluorouracil 6.9416785472 15173087 17638652 16337965 16481741
MESH:D004938 Esophageal Neoplasms Sulindac 6.9412235107
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.8111564622
MESH:D005221 Fatigue vorinostat 5.3220479100
MESH:D005234 Fatty Liver Carbon Tetrachloride 38.9815959796 12795759 16239168 12631006 17595544 19224547 61145 16045604
MESH:D005234 Fatty Liver Cyclosporine 38.9819224547
MESH:D005234 Fatty Liver Dietary Fats 38.9817967931 19551842 18296743 19004024
MESH:D005234 Fatty Liver Diethylnitrosamine 38.9821071580 20387270
MESH:D005234 Fatty Liver Ethinyl Estradiol 38.9815345470
MESH:D005234 Fatty Liver pirinixic acid 38.9820131406 19236843
MESH:D005234 Fatty Liver Raloxifene 38.9817473493
MESH:D005234 Fatty Liver Tamoxifen 38.9814986274 19224547
MESH:D052776 Female Urogenital Diseases Diethylstilbestrol 7.6516534752 16513791 16611131 15751030 16002989
MESH:D052776 Female Urogenital Diseases Tamoxifen 7.6516709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.1811858732
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 4.736705139
MESH:D018221 Fibromatosis, Abdominal Sulindac 12.0214745880
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 12.0214745880
MESH:D018222 Fibromatosis, Aggressive Doxorubicin 17.9219069698
MESH:D018222 Fibromatosis, Aggressive Sulindac 17.9219069698
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 17.9219069698
MESH:D005355 Fibrosis Carbon Tetrachloride 18.8818705752
MESH:D005355 Fibrosis Cyclosporine 18.8812639820 12168785
MESH:D005355 Fibrosis Dietary Fats 18.8818296743
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 18.8820067830
MESH:D005756 Gastritis Acetaminophen 3.3916983495
MESH:D005764 Gastroesophageal Reflux Sulindac 4.7411910360
MESH:D005833 Genital Neoplasms, Female Diethylstilbestrol 4.6716452187
MESH:D005885 Gingival Hyperplasia Cyclosporine 3.948708960
MESH:D005909 Glioblastoma Doxorubicin 3.1717150277
MESH:D005910 Glioma Fluorouracil 2.7616145905
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 3.787505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.3110696789
MESH:D006258 Head and Neck Neoplasms decitabine 11.9419215824
MESH:D006258 Head and Neck Neoplasms Doxorubicin 11.9415692506
MESH:D006258 Head and Neck Neoplasms Fluorouracil 11.9415162350 15102660 18337622
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.1810048152 11294989
MESH:D006331 Heart Diseases Doxorubicin 7.2016144979 16244372 12587719 16879835 18674790 17875725 16707910 14766674 16244371 16330681 17888722 16495754 18006777
MESH:D006331 Heart Diseases Raloxifene 7.2011110106
MESH:D006333 Heart Failure Doxorubicin 6.4817481944
MESH:D006333 Heart Failure pirinixic acid 6.4820558911
MESH:D006394 Hemangiosarcoma Doxorubicin 3.6515692506
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.1415720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.0911000095
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 8.346705139
MESH:D006505 Hepatitis Carbon Tetrachloride 8.3419110552 19900420
MESH:D006529 Hepatomegaly pirinixic acid 7.3518467677 19176532 16221962 19772884
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 7.3515340226 16120746 12621046
MESH:D006558 Herpes Genitalis Estradiol 4.7515709030
MESH:D006689 Hodgkin Disease Doxorubicin 3.1817606976 15147373 18501091
MESH:D019584 Hot Flashes Estradiol 3.4717088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.7615340226 16959395 16354765 18606429 8697196
MESH:D006930 Hyperalgesia Acetaminophen 2.4816870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.2516899240
MESH:D006937 Hypercholesterolemia Dietary Fats 3.3421332399
MESH:D006943 Hyperglycemia pirinixic acid 2.9420558911
MESH:D006949 Hyperlipidemias Dietary Fats 3.3621332399
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 9.9215034207
MESH:D006965 Hyperplasia Diethylstilbestrol 9.9212960047 14722030
MESH:D006973 Hypertension Cyclosporine 7.9410903974
MESH:D006973 Hypertension Raloxifene 7.9417577099 15787275
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 7.9418670907 18850075
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.8115338365
MESH:D007021 Hypospadias Diethylstilbestrol 10.3316002989
MESH:D007021 Hypospadias Ethinyl Estradiol 10.3316569931 16945680
MESH:D007246 Infertility Diethylstilbestrol 4.0915036965
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.2012013081
MESH:D007248 Infertility, Male decitabine 6.1117581917
MESH:D007248 Infertility, Male Ethinyl Estradiol 6.1117937319
MESH:D007249 Inflammation Dietary Fats 14.3120412841
MESH:D007249 Inflammation Diethylnitrosamine 14.3118785209
MESH:D007249 Inflammation Sulindac 14.313291741
MESH:D007249 Inflammation Tamoxifen 14.3119457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 14.3112200463 12878042
MESH:D007333 Insulin Resistance bisphenol A 16.1516393666
MESH:D007333 Insulin Resistance Dietary Fats 16.1511836018 18457598
MESH:D007333 Insulin Resistance Estradiol 16.1516393666 16627594
MESH:D007333 Insulin Resistance pirinixic acid 16.1516306350
MESH:D007414 Intestinal Neoplasms Sulindac 4.3910223192 12628509 12663524 10213222 12584176 12351151
MESH:D007417 Intestinal Polyps Sulindac 4.7311245490 12394442
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 4.738074119 9022650
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.0916580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.1615604871
MESH:D007674 Kidney Diseases Acetaminophen 13.1012587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 13.1018776723 10903974 8314463
MESH:D007674 Kidney Diseases Doxorubicin 13.1015699352 15369732 16775033
MESH:D007674 Kidney Diseases Estradiol 13.1015618244
MESH:D007676 Kidney Failure, Chronic Doxorubicin 3.9016707910
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 26.186582329
MESH:D007680 Kidney Neoplasms Cyclosporine 26.1812371664
MESH:D007680 Kidney Neoplasms Diethylstilbestrol 26.1815003126 16762066 14681315
MESH:D007680 Kidney Neoplasms Estradiol 26.1815610895
MESH:D007680 Kidney Neoplasms Fluorouracil 26.1816985049
MESH:D007680 Kidney Neoplasms Tamoxifen 26.1818625569
MESH:D007859 Learning Disorders Diethylstilbestrol 3.7917184923
MESH:D007889 Leiomyoma Raloxifene 4.2416973256
MESH:D007938 Leukemia decitabine 2.9318980019 19235587
MESH:D004915 Leukemia, Erythroblastic, Acute Doxorubicin 4.8716085563
MESH:D007951 Leukemia, Myeloid decitabine 3.7519117987 17236224 18454857
MESH:D015470 Leukemia, Myeloid, Acute marker/mechanism 17330099
MESH:D015470 Leukemia, Myeloid, Acute decitabine 2.3319387464 18704418 19010910 17679729 18206229 18460780
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 5.1818055864
MESH:D008064 Lipidoses Tamoxifen 2.9617567588 15342952
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 10.1216943688 17174718 11903743 17157831 11408273 16221502 16239168 17334410 21278145
MESH:D008103 Liver Cirrhosis Dietary Fats 10.1218296743
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 10.1218407596 18665156 19638242 18522880 20032147
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 7.939327722 15034207
MESH:D008105 Liver Cirrhosis, Biliary Sulindac 7.9312468960
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 8.2417698563 18279442 12389079 17805973 12898905 13678700 18054572 18205269 17557913 18210741 12649538 12632514 18412020 15338365 17714472 17708605 12445418 16248980 16015684 17721639 17922224 17761835 18251166 15673190 18376398 15730626 14512876 10355542 15370692 15123356 12666154 17525996 17823541 18156304 15818738 15650968 14716496 15893842 12546737 14748882 14620537 15362042 15931870 18395095 18395914 20821823 18006644 11481614 15925388 18263696 16638106 18481824 18317297 17869086 14716833 14724832 18472332 12632512 17766677 16027843 17640975 18339082 18705752 15052691 17481882 12445421 16033810 16011737 18420326 16116963 12741479 18166357 15996030 15057751 17900296 18187930 17944888 12586293 18429990 12667390 15959796 15876570 12609069 17976157 12958196 18472094 16097048 18418968 17565644 16136751 17631135 18277467 16192424
MESH:D008106 Liver Cirrhosis, Experimental Doxorubicin 8.2416439617 16595196
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 8.2414716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 8.2415474484
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 8.2418564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 8.2412878042
MESH:D008107 Liver Diseases Acetaminophen 8.7712969438 16611625 19784758 12587719 19014921 16610002 11587558 19460945
MESH:D008107 Liver Diseases Carbon Tetrachloride 8.7717285989 15720792 16964402 16246199 15830285
MESH:D008107 Liver Diseases Diethylnitrosamine 8.7717034775
MESH:D008107 Liver Diseases Sulindac 8.7714986274 16867024
MESH:D017093 Liver Failure Carbon Tetrachloride 3.8915123358
MESH:D017114 Liver Failure, Acute Acetaminophen 8.6116871587 17185352
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 8.6114706259 16899240
MESH:D008113 Liver Neoplasms Aflatoxin B1 28.0215890375 18177683 2125692 9163691
MESH:D008113 Liver Neoplasms beta-Naphthoflavone 28.0219389873 21295105
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 28.0219294768
MESH:D008113 Liver Neoplasms Diethylnitrosamine 28.0219090486 20452335 10737359 18977376 20405173 21278145 21167192 18754104 19642983 19294768 19255062 18644402 20583210 19499222 20434301 19426721 19551842 19812893 19833225 19638242 2422723 15175105 20118626 20501860 19073162 18648771 20137499 20101389 20492335 19254457 19427195 15885732 19690152 16942905 2862719 12771043 19850985 19256749 12112319 9163691 21047994 19996281 18978307 21071580
MESH:D008113 Liver Neoplasms Diethylstilbestrol 28.0215890375 16712894
MESH:D008113 Liver Neoplasms Fluorouracil 28.0217045692 15113037 18383874 16603448
MESH:D008113 Liver Neoplasms pirinixic acid 28.0220007298 15890375 16377806
MESH:D008113 Liver Neoplasms Tamoxifen 28.0216684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 28.0216984957
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 25.611399818 598648 6587162 3712494
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 25.618603461
MESH:D008114 Liver Neoplasms, Experimental beta-Naphthoflavone 25.6118164116
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 25.6112014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 25.6118308698 18079962 17854601 16267830 17942915 18775883 19519916 19009564 18253720 18544905 17174075 19539802 18282651 21159647 19126423 19004024 18093689 16842330 3124819 2563599 9362446 18164116
MESH:D008114 Liver Neoplasms, Experimental Doxorubicin 25.6116842330 17085340
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 25.6112151625
MESH:D055370 Lung Injury Asbestos, Crocidolite 3.7517365036
MESH:D008175 Lung Neoplasms Aflatoxin B1 10.1314755239
MESH:D008175 Lung Neoplasms Diethylnitrosamine 10.1320512841 21163286 6695378 20970405
MESH:D008175 Lung Neoplasms Doxorubicin 10.136189445 17418594
MESH:D008175 Lung Neoplasms Fluorouracil 10.1315246190
MESH:D008175 Lung Neoplasms Sulindac 10.1315713900 19359593
MESH:D008175 Lung Neoplasms Tamoxifen 10.1318625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 10.1311884234 19555203
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 4.5115086387
MESH:D008181 Lupus Nephritis Diethylstilbestrol 4.8715166399
MESH:D008223 Lymphoma decitabine 11.4919470736
MESH:D008223 Lymphoma Diethylstilbestrol 11.4915700306
MESH:D008223 Lymphoma Doxorubicin 11.4916098063
MESH:D008228 Lymphoma, Non-Hodgkin Doxorubicin 3.5717654614
MESH:D016399 Lymphoma, T-Cell Doxorubicin 4.2915621674
MESH:D016410 Lymphoma, T-Cell, Cutaneous vorinostat 5.4120479100
MESH:D052801 Male Urogenital Diseases Diethylstilbestrol 5.2316002989
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.4819428831
MESH:D008325 Mammary Neoplasms, Experimental Doxorubicin 8.9615458769
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 8.9611807958 11408345 17203775 16891317
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 8.9616827153 11731420 19196723 14580682 19196722
MESH:D020149 Manganese Poisoning Estradiol 11.7019453300
MESH:D020149 Manganese Poisoning Tamoxifen 11.7019453300
MESH:D008545 Melanoma decitabine 6.9116505122 17785578
MESH:D008545 Melanoma Doxorubicin 6.9116827129
MESH:D008545 Melanoma Sulindac 6.9116642371
MESH:D008545 Melanoma Tamoxifen 6.9112393984 19393235
MESH:D018328 Melanoma, Amelanotic Tamoxifen 3.9015990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.2919513568
MESH:D008654 Mesothelioma Asbestos, Crocidolite 6.0616966607 16166281 18303189
MESH:D008654 Mesothelioma Doxorubicin 6.0617638057
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.5016801185
MESH:D028361 Mitochondrial Diseases Doxorubicin 4.2515792986
MESH:D018200 Mixed Tumor, Mullerian Raloxifene 5.2715863610
MESH:D009062 Mouth Neoplasms Fluorouracil 3.4216757204 18986760
MESH:D052016 Mucositis Doxorubicin 4.5117415656
MESH:D009101 Multiple Myeloma decitabine 6.8518172295
MESH:D009101 Multiple Myeloma Raloxifene 6.8516497877
MESH:D009135 Muscular Diseases pirinixic acid 3.2316239165
MESH:D009190 Myelodysplastic Syndromes decitabine 3.2219157545 16882708 19010910 18608210
MESH:D009203 Myocardial Infarction Doxorubicin 5.3215857846 19429709
MESH:D009203 Myocardial Infarction pirinixic acid 5.3219151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.8012213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 7.5516810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 7.5516411023
MESH:D009232 Myxoma Raloxifene 5.2716343187
MESH:D009325 Nausea vorinostat 5.2420479100
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 12.643581430
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 12.643581430 9029167
MESH:D009362 Neoplasm Metastasis Doxorubicin 12.6418259882
MESH:D009362 Neoplasm Metastasis Tamoxifen 12.6419393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.4219410462
MESH:D009369 Neoplasms decitabine 10.7417925555 19470736 19116145
MESH:D009369 Neoplasms Diethylstilbestrol 10.7415313581
MESH:D009369 Neoplasms Fluorouracil 10.7418600527 16928823 18239605
MESH:D009369 Neoplasms pirinixic acid 10.7417405874
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 3.7219189210 19200415 19196722
MESH:D009389 Neovascularization, Pathologic Estradiol 3.4517289903
MESH:D009401 Nephrosis Doxorubicin 4.4916899518 16636307
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.1617954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 8.5218481113 19348381
MESH:D009404 Nephrotic Syndrome Doxorubicin 8.5216889571 15640375
MESH:D009421 Nervous System Malformations bisphenol A 21.2611399458 16427766
MESH:D009421 Nervous System Malformations Diethylstilbestrol 21.2611399458
MESH:D009421 Nervous System Malformations Estradiol 21.2616427766 11399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 21.2614600291
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 2.736679447
MESH:D009447 Neuroblastoma Doxorubicin 3.1215555623
MESH:D019636 Neurodegenerative Diseases Acetaminophen 12.8118514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 12.8120387270
MESH:D019636 Neurodegenerative Diseases Sulindac 12.8116850258 17266991
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 4.8320387270
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.2516436463
MESH:D009765 Obesity Dietary Fats 4.1921332399 18674790 17217161 19632207 20132043 20518802 16723640 11836018 18457598
MESH:D009765 Obesity pirinixic acid 4.1920558911
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.186482804 4026338
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 4.733988306
MESH:D010024 Osteoporosis Raloxifene 3.2217882678 15775268 19059307
MESH:D015663 Osteoporosis, Postmenopausal Raloxifene 3.9717823083 17893378 15758505 15579764
MESH:D012516 Osteosarcoma Doxorubicin 3.8915930896
MESH:D010049 Ovarian Diseases bisphenol A 4.7111985600
MESH:D010051 Ovarian Neoplasms decitabine 4.6119331143 19259094
MESH:D010051 Ovarian Neoplasms Estradiol 4.6119401270
MESH:D010146 Pain Acetaminophen 6.1816870215
MESH:D010146 Pain Sulindac 6.183291741
MESH:D010190 Pancreatic Neoplasms decitabine 11.5419294695
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 11.5416540662
MESH:D010190 Pancreatic Neoplasms Fluorouracil 11.5415113037 16929163 16500647 19003803
MESH:D010190 Pancreatic Neoplasms Sulindac 11.5411504793 16820089
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.4311578682
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.217296757
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.9612520081
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.196228378
MESH:D003557 Phyllodes Tumor Doxorubicin 4.8717983394
MESH:D010900 Pituitary Diseases Diethylstilbestrol 4.8914722030
MESH:D010911 Pituitary Neoplasms Diethylstilbestrol 4.4015687265 16977796
MESH:D010995 Pleural Diseases Asbestos, Crocidolite 4.6210923243
MESH:D010997 Pleural Neoplasms Doxorubicin 4.8717638057
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.2918163543
MESH:D011230 Precancerous Conditions Cyclosporine 8.1712371664
MESH:D011230 Precancerous Conditions Diethylnitrosamine 8.172563599
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 14.6610548101
MESH:D011297 Prenatal Exposure Delayed Effects Diethylstilbestrol 14.6617184923
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 14.6611222880 11399792 11118676 11896295
MESH:D055728 Primary Myelofibrosis decitabine 4.4517616702
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 9.7220887781
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 9.7220887781
MESH:D011471 Prostatic Neoplasms bisphenol A 2.8516740699
MESH:D011471 Prostatic Neoplasms Diethylstilbestrol 2.8515046698 17136230 15846301
MESH:D011471 Prostatic Neoplasms Doxorubicin 2.8516888761 15897917 15749863 18437689 16729912 16868541
MESH:D011471 Prostatic Neoplasms Estradiol 2.8516740699
MESH:D011471 Prostatic Neoplasms Fluorouracil 2.8518626508 19082440
MESH:D011471 Prostatic Neoplasms methylselenic acid 2.8516205645
MESH:D011471 Prostatic Neoplasms Raloxifene 2.8516220300 16536755 15731164
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.8515067354
MESH:D011471 Prostatic Neoplasms vorinostat 2.8517218635
MESH:D011537 Pruritus Ethinyl Estradiol 3.0316919318 15861022
MESH:D011565 Psoriasis Cyclosporine 2.1316882103
MESH:D011629 Puberty, Precocious bisphenol A 4.5110548101
MESH:D011658 Pulmonary Fibrosis Asbestos, Crocidolite 2.9215814490 17365031 17975199 17322281
MESH:D011693 Purpura Raloxifene 5.2715770314
MESH:D012004 Rectal Neoplasms Fluorouracil 3.7818286688 15538739 16160472 18722050
MESH:D051437 Renal Insufficiency Doxorubicin 3.9517922066
MESH:D015427 Reperfusion Injury pirinixic acid 2.2519058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.5718990726
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.173692021
MESH:D012208 Rhabdomyosarcoma decitabine 4.1419155313
MESH:D012509 Sarcoma Doxorubicin 3.7516767912 15625365 17710206 18313854 17203757 15675481
MESH:D012512 Sarcoma, Ewing's Doxorubicin 3.9814601052 16326096
MESH:D012514 Sarcoma, Kaposi Doxorubicin 4.5117846226
MESH:D012878 Skin Neoplasms Doxorubicin 8.7015692506
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 8.708532709
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 8.7016192470
MESH:D012983 Soft Tissue Neoplasms Doxorubicin 4.2915625365 17203757 16767912
MESH:D013088 Spermatocele Diethylstilbestrol 18.4816709447 16002989
MESH:D013088 Spermatocele Ethinyl Estradiol 18.4816709447
MESH:D013088 Spermatocele Tamoxifen 18.4816709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 3.7619457130
MESH:D013274 Stomach Neoplasms decitabine 3.2719037991
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 3.2718456281
MESH:D013274 Stomach Neoplasms Fluorouracil 3.2717172411 17522103 19015929 16424979 15786421 18567086 17498489 18396642 16951190 19084572
MESH:D020521 Stroke Raloxifene 3.6016837676
MESH:D019966 Substance-Related Disorders bisphenol A 3.7116684133 16045194
MESH:D013921 Thrombocytopenia vorinostat 4.7320479100
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.3611994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.9215669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.6212697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 15.403712494 6587162 7505956 1399818 6582329
MESH:D013964 Thyroid Neoplasms decitabine 15.4017967635
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 15.407505956
MESH:D013964 Thyroid Neoplasms Doxorubicin 15.4016010429 17909728
MESH:D013978 Tibial Fractures Estradiol 12.7619048282
MESH:D013978 Tibial Fractures Raloxifene 12.7619048282
MESH:D014062 Tongue Neoplasms Fluorouracil 3.7516280240
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 18.438074119
MESH:D001749 Urinary Bladder Neoplasms decitabine 18.4317616700 19087683
MESH:D001749 Urinary Bladder Neoplasms Diethylstilbestrol 18.4317306315 16712894 16452187
MESH:D001749 Urinary Bladder Neoplasms Doxorubicin 18.4317653716
MESH:D001749 Urinary Bladder Neoplasms Raloxifene 18.4317572228
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 18.4316712894 17572228 8653321
MESH:D014581 Urticaria Acetaminophen 2.7210982225
MESH:D002583 Uterine Cervical Neoplasms Diethylstilbestrol 8.7816175088
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 8.7816803524
MESH:D014591 Uterine Diseases bisphenol A 12.8714652134
MESH:D014591 Uterine Diseases Diethylstilbestrol 12.8714652134
MESH:D014594 Uterine Neoplasms Diethylstilbestrol 14.5915809267 16690809
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 14.5914692618
MESH:D014594 Uterine Neoplasms Sulindac 14.5918645019
MESH:D014604 Uveal Neoplasms decitabine 4.6317785578
MESH:D014605 Uveitis Cyclosporine 3.701336536
MESH:D014625 Vaginal Neoplasms Diethylstilbestrol 4.1616513791 16002989
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.3112125929
MESH:D054556 Venous Thromboembolism Raloxifene 4.9216837676
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.2914671159 15869587
MESH:D018487 Ventricular Dysfunction, Left Doxorubicin 3.9517678736 16364871 17638931 17334414
MESH:D014846 Vulvar Neoplasms Raloxifene 5.2716343187
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.9615886252
MESH:D015430 Weight Gain Dietary Fats 3.5016723640
MESH:D014985 Xerophthalmia Cyclosporine 4.1617120751
Pathway ID Pathway Name
REACT:22258 Metabolism of lipids and lipoproteins
KEGG:04380 Osteoclast differentiation
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA164
    • No data
    Releated disease ID Related disease Name
    PA444807Long QT Syndrome
    Releated drug ID Related drug Name
    PA452249antiarrhythmics, class i and iii
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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