AutismKB 2.0

Annotation Detail for CLCA4


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Basic Information Top
Gene Symbol:CLCA4 ( CaCC,CaCC2,MGC142247,MGC142249 )
Gene Full Name: chloride channel accessory 4
Band: 1p22.3
Quick LinksEntrez ID:22802; OMIM: NA; Uniprot ID:CLCA4_HUMAN; ENSEMBL ID: ENSG00000016602; HGNC ID: 2018
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04972Pancreatic secretion
hsa04740Olfactory transduction
No data
No data
No data
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1826Cystic fibrosis
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D004958 Estradiol [Progesterone co-treated with Estradiol] results in decreased expression of CLCA4 mRNAaffects cotreatment|decreases expression 17404688
C006253 pirinixic acid pirinixic acid results in decreased expression of CLCA4 mRNAdecreases expression 17426115
D011374 Progesterone [Progesterone co-treated with Estradiol] results in decreased expression of CLCA4 mRNAaffects cotreatment|decreases expression 17404688
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D055371 Acute Lung Injury pirinixic acid 3.6418653653
MESH:D000230 Adenocarcinoma Estradiol 2.1811473722
MESH:D018248 Adenoma, Liver Cell pirinixic acid 4.2216434500
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.6319483382
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 6.2017868700
MESH:D001930 Brain Injuries Progesterone 4.9115845082 15380490 15665606
MESH:D001943 Breast Neoplasms Estradiol 2.1716675129 12948864 17018787 14630087 18497071 17289903 19861407 17261762
MESH:D001943 Breast Neoplasms Progesterone 2.1715562024 17614352 16175315
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 5.2116111702
MESH:D006528 Carcinoma, Hepatocellular Estradiol 1.7916924424
MESH:D002471 Cell Transformation, Neoplastic Estradiol 3.0618566989
MESH:D002779 Cholestasis pirinixic acid 3.1519176532
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5918249437
MESH:D003928 Diabetic Nephropathies Estradiol 3.8319279558
MESH:D003929 Diabetic Neuropathies Progesterone 5.1517187935
MESH:D004487 Edema pirinixic acid 2.9612083418
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 4.3617692515
MESH:D016889 Endometrial Neoplasms Estradiol 3.2518566989 19148513 11473722
MESH:D004715 Endometriosis Progesterone 4.2116134523
MESH:D005234 Fatty Liver pirinixic acid 3.2519236843 20131406
MESH:D006333 Heart Failure pirinixic acid 2.7820558911
MESH:D006529 Hepatomegaly pirinixic acid 3.6416221962 18467677 19176532 19772884
MESH:D006558 Herpes Genitalis Estradiol 5.9015709030
MESH:D019584 Hot Flashes Estradiol 4.6217088409
MESH:D006943 Hyperglycemia pirinixic acid 3.6320558911
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 5.0515869954
MESH:D007249 Inflammation Progesterone 2.7915869954
MESH:D007333 Insulin Resistance Estradiol 8.1016393666 16627594
MESH:D007333 Insulin Resistance pirinixic acid 8.1016306350
MESH:D007674 Kidney Diseases Estradiol 2.8015618244
MESH:D007680 Kidney Neoplasms Estradiol 3.3615610895
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 2.4014659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.4015474484
MESH:D008113 Liver Neoplasms pirinixic acid 1.9415890375 16377806 20007298
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 6.9511408345 11807958 17203775 16891317
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 6.9511408345 17203775
MESH:D020149 Manganese Poisoning Estradiol 5.3519453300
MESH:D009135 Muscular Diseases pirinixic acid 4.1616239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2919151258
MESH:D015428 Myocardial Reperfusion Injury Estradiol 9.4116810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 9.4116411023
MESH:D009369 Neoplasms pirinixic acid 2.1217405874
MESH:D009389 Neovascularization, Pathologic Estradiol 4.4717289903
MESH:D009421 Nervous System Malformations Estradiol 4.2311399458 16427766
MESH:D009765 Obesity pirinixic acid 1.8920558911
MESH:D010051 Ovarian Neoplasms Estradiol 5.2319401270
MESH:D010051 Ovarian Neoplasms Progesterone 5.2317393432 16525653
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 4.3720887781
MESH:D011471 Prostatic Neoplasms Estradiol 3.0216740699
MESH:D015427 Reperfusion Injury pirinixic acid 2.5619058328
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.9718045962
MESH:D013119 Spinal Cord Injuries Progesterone 5.0216503802 15862959
MESH:D013978 Tibial Fractures Estradiol 5.5519048282
Pathway ID Pathway Name
KEGG:04740 Olfactory transduction
KEGG:04972 Pancreatic secretion
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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