AutismKB 2.0

Annotation Detail for XRN2


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Basic Information Top
Gene Symbol:XRN2 ( - )
Gene Full Name: 5'-3' exoribonuclease 2
Band: 20p11.22
Quick LinksEntrez ID:22803; OMIM: 608851; Uniprot ID:XRN2_HUMAN; ENSEMBL ID: ENSG00000088930; HGNC ID: 12836
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa03018RNA degradation
Pathway IDPathway Name
Metabolism of proteins
No data
Pathway IDPathway Name
P00017DNA replication
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of XRN2 mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of XRN2 mRNAaffects expression 21346803
C518576 2-methylbutyric acid 4-((1,3)dioxan-5-ylmethoxyimino)-8-(2-(4-hydroxy-6-oxo-tetrahydropyran-2-yl)ethyl -7-methyl-6-oxo-1,2,3,4,6,7,8,8a-octahydronaphthyl)heptanoate 2-methylbutyric acid 4-((1,3)dioxan-5-ylmethoxyimino)-8-(2-(4-hydroxy-6-oxo-tetrahydropyran-2-yl)ethyl -7-methyl-6-oxo-1,2,3,4,6,7,8,8a-octahydronaphthyl)heptanoate results in decreased expression of XRN2 mRNAdecreases expression 17327690
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in decreased expression of XRN2 mRNAdecreases expression 18648102
D000082 Acetaminophen Acetaminophen affects the expression of XRN2 mRNAaffects expression 17562736
C099555 CD 437 CD 437 results in decreased expression of XRN2 mRNAdecreases expression 12958071
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of XRN2 mRNAaffects expression 17555576
D013629 Tamoxifen Tamoxifen affects the expression of XRN2 mRNAaffects expression 17555576
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.9214745880
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.3217505938
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8614692618
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.883712494
MESH:D000799 Angioedema Acetaminophen 4.2210982225
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.7711256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.8015885639
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.401440618 11289319
MESH:D001943 Breast Neoplasms Tamoxifen 2.1819221464 19189212 17242785 19189210 11161223 19410462 19066611 17261762 19289846 19487384 20859285 17440819 19244106 17049068 18997820 21152245 19155303 21138602 18351453 20544844 18984771 20390343 18821012 15565566 16273361 19115204 18629630 16873071 20005174 19200415 17893378 19288272 18815881 19103187 19084267 16818667 19142967 20065188 18855134 19059307 15668708 19011961 20135344 18425577 16202921
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.8119066611
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 9.2116705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 9.2116705839
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 9.213581430 7296757
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 9.213084413
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 9.2116924424
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.777296757
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.8417572228
MESH:D002386 Cataract Acetaminophen 2.7110977129
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 7.196135515
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 7.197505956
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 8.459022650 19486331
MESH:D002779 Cholestasis Ethinyl Estradiol 8.4511677210 16105132 16919318 15861022 17681005 17333356 17110522
MESH:D003490 Cyanosis 2,4-dinitrotoluene 11.9418551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 11.9418551238
MESH:D003711 Demyelinating Diseases Tamoxifen 4.6719031437
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 3.1014531868 11298694 8156756 8970840 2524372 11906362 18759878 12868966
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.752952479 3621924
MESH:D003928 Diabetic Nephropathies Tamoxifen 3.6919279558
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 9.4718551238 21346803
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 9.4721346803 18551238
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 9.479328219 16192314 1440618 6679447 9653073 18289764 9022650 18692083 8291058 18648102 11289319 6482804 7440962
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 9.4710663392 11421492 11287661 12594235 14550746 16177239 11529661 19420014 10915739 10774834 12705907 19085960 18071297 15968718 11743745 2444490 11739529 17522070 18713872 16393943 12958197 19923254 11834606 12540782 17906064 16781746 19164858 12153990 16109766 14725611 16485898 16227642 19739265 19416960 17562736 19370779 15619225 12392966 11461765 16081117 14986274
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.4719426721
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 9.9012538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 9.9019031437
MESH:D016889 Endometrial Neoplasms Tamoxifen 3.1916202921 20544844 19155303 17893378
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 2.153581430
MESH:D005234 Fatty Liver Ethinyl Estradiol 8.5115345470
MESH:D005234 Fatty Liver Tamoxifen 8.5114986274 19224547
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.3716709447
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.406705139
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.8714745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.5219069698
MESH:D005756 Gastritis Acetaminophen 4.0516983495
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.307505956
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.796705139
MESH:D006930 Hyperalgesia Acetaminophen 2.8916870215
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.2515034207
MESH:D007021 Hypospadias Ethinyl Estradiol 4.1216945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.7212013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.6417937319
MESH:D007249 Inflammation Tamoxifen 2.4619457130
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.408074119 9022650
MESH:D007674 Kidney Diseases Acetaminophen 2.3215629191 12587719
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 19.4916705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 19.4916705839
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 19.496582329
MESH:D007680 Kidney Neoplasms Tamoxifen 19.4918625569
MESH:D008064 Lipidoses Tamoxifen 3.3217567588 15342952
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.3315034207 9327722
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 1.7518564211
MESH:D008107 Liver Diseases Acetaminophen 1.6716610002 19014921 11587558 19784758 12587719 12969438 19460945 16611625
MESH:D017114 Liver Failure, Acute Acetaminophen 3.4616871587 17185352
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 4.817678174
MESH:D008113 Liver Neoplasms Tamoxifen 4.8116684651
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 6.362876786 2876784 6135515
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 6.363712494 6587162 1399818 598648
MESH:D008175 Lung Neoplasms Tamoxifen 1.7418625569
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 4.1019428831
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 2.7614580682 16827153 11731420 19196723 19196722
MESH:D020149 Manganese Poisoning Tamoxifen 4.9219453300
MESH:D008545 Melanoma Tamoxifen 1.9119393235 12393984
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.5215990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.8719513568
MESH:D009336 Necrosis 2,4-dinitrotoluene 11.5018551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 11.5018551238 7678174
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 5.973581430
MESH:D009362 Neoplasm Metastasis Tamoxifen 5.9719393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.5819410462
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.3819196722 19189210 19200415
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 3.066679447
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.0718514411
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 16.4316049721 12819281
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 16.4316049721
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 16.434026338 6482804
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.403988306
MESH:D010051 Ovarian Neoplasms CD 437 3.3717474084
MESH:D010146 Pain Acetaminophen 2.5916870215
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.9511578682
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.797296757
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.856228378
MESH:D011471 Prostatic Neoplasms Tamoxifen 3.1115067354
MESH:D011537 Pruritus Ethinyl Estradiol 3.6515861022 16919318
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.553692021
MESH:D012640 Seizures 2,4-dinitrotoluene 6.3918551238
MESH:D012640 Seizures 2,6-dinitrotoluene 6.3918551238
MESH:D013088 Spermatocele Ethinyl Estradiol 12.8516709447
MESH:D013088 Spermatocele Tamoxifen 12.8516709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 4.3819457130
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.8811994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.3715669648
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 3.067505956 3712494 1399818 6587162 6582329
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 16.7016049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 16.7016049721
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 16.708074119
MESH:D001749 Urinary Bladder Neoplasms CD 437 16.7016720286
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 16.7016712894 17572228 8653321
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 13.1410091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 13.1410091137
MESH:D014581 Urticaria Acetaminophen 3.2410982225
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.5814692618
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.7815869587 14671159
Pathway ID Pathway Name
REACT:17015 Metabolism of proteins
KEGG:03008 Ribosome biogenesis in eukaryotes
KEGG:03018 RNA degradation
Pharmacogenomics Knowledge Base Top
Drug Bank Top

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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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