AutismKB 2.0

Annotation Detail for MTF2


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Basic Information Top
Gene Symbol:MTF2 ( M96,PCL2,RP5-976O13.1,dJ976O13.2 )
Gene Full Name: metal response element binding transcription factor 2
Band: 1p22.1
Quick LinksEntrez ID:22823; OMIM: 609882; Uniprot ID:MTF2_HUMAN; ENSEMBL ID: ENSG00000143033; HGNC ID: 29535
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of MTF2 mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of MTF2 mRNAaffects expression 21346803
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in decreased expression of MTF2 mRNAdecreases expression 18648102
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of MTF2 mRNAdecreases expression 19150397
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of MTF2 mRNAaffects expression 17484886
C029938 nickel sulfate nickel sulfate affects the expression of MTF2 mRNAaffects expression 12718980
C058305 phenethyl isothiocyanate phenethyl isothiocyanate results in decreased expression of MTF2 mRNAdecreases expression 17616710
D011374 Progesterone Progesterone results in increased expression of MTF2 mRNAincreases expression 18070364
D012643 Selenium Selenium results in decreased expression of MTF2 mRNAdecreases expression 19244175
D014810 Vitamin E Vitamin E results in decreased expression of MTF2 mRNAdecreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D055371 Acute Lung Injury nickel sulfate 4.4919131640 11954676 12718980 16100012
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.843712494
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.281440618 11289319
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.6017868700
MESH:D001930 Brain Injuries Progesterone 4.4715665606 15845082 15380490
MESH:D001943 Breast Neoplasms Progesterone 2.4316175315 15562024 17614352
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 10.6616227642 15700767 16124888 16097048 16011737 16050911 15673190 15721981 18705752 16192424 3786805 10355542
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 10.6616050911
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 6.7616705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 6.7616705839
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 6.767296757 3581430
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 6.7618788625
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.757296757
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 11.856135515
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 11.857505956
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 11.8520889678
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 3.279022650 19486331
MESH:D003092 Colitis Selenium 3.9917936198
MESH:D003093 Colitis, Ulcerative phenethyl isothiocyanate 3.6920423518
MESH:D019465 Craniofacial Abnormalities Vitamin E 1.9219769572
MESH:D003490 Cyanosis 2,4-dinitrotoluene 11.6318551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 11.6318551238
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 7.8611298694 8156756 8970840 18759878 11906362 12868966 14531868 2524372
MESH:D017449 Dermatitis, Allergic Contact nickel sulfate 7.8611298694 16780908 16823706
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.673621924 2952479
MESH:D003929 Diabetic Neuropathies Progesterone 4.7117187935
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 12.5218551238 21346803
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 12.5221346803 18551238
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 12.529328219 8291058 18289764 18648102 18692083 9653073 6482804 1440618 16192314 6679447 7440962 9022650 11289319
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 12.5215027814 4309450 6623471 2869522 10092053 21278145 3786805 16227642 11566570 7440962 7179309 15968718 9327722 17522070 7120509 10915739 19336974 19085960 3732212 16177239 6884620 15998439
MESH:D056486 Drug-Induced Liver Injury Selenium 12.5215131321
MESH:C538011 Eales disease Vitamin E 4.979068938
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 3.9817692515
MESH:D004715 Endometriosis Progesterone 3.9316134523
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 4.513581430
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.5120426865
MESH:D005234 Fatty Liver Carbon Tetrachloride 3.3416239168 12795759 19224547 15959796 17595544 12631006 61145 16045604
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.286705139
MESH:D005355 Fibrosis Carbon Tetrachloride 3.6718705752
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.227505956
MESH:D006330 Heart Defects, Congenital Vitamin E 3.0716080930
MESH:D006333 Heart Failure Selenium 3.1717162251
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 9.896705139
MESH:D006505 Hepatitis Carbon Tetrachloride 9.8919900420 19110552
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.7516490937 16863852
MESH:D019584 Hot Flashes Vitamin E 4.2414716179
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.7716899240
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.1515034207
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.3015338365
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.6215869954
MESH:D007249 Inflammation Progesterone 2.6815869954
MESH:D007251 Influenza, Human Selenium 11.8616624496
MESH:D007251 Influenza, Human Vitamin E 11.8616624496
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.288074119 9022650
MESH:D007674 Kidney Diseases Vitamin E 2.8912488133
MESH:D007676 Kidney Failure, Chronic Selenium 4.0616518626
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 13.2516705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 13.2516705839
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 13.256582329
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.8916943688 17174718 17157831 17334410 11408273 11903743 16221502 21278145 16239168
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.3015034207 9327722
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 2.5718205269 15673190 18166357 18251166 15650968 17761835 14512876 18376398 17698563 16248980 17900296 14716496 12445418 18210741 18420326 15123356 16116963 17823541 14724832 12666154 20821823 15931870 16027843 18395914 15925388 16015684 15876570 17805973 17525996 17631135 14620537 12632512 15057751 15338365 16011737 18472332 17944888 15818738 17976157 17922224 12741479 18187930 13678700 14748882 15052691 16638106 17565644 17766677 18263696 15362042 16097048 17557913 12667390 18412020 18429990 18277467 15959796 16192424 18705752 17714472 12609069 12898905 17869086 12632514 17721639 15730626 18279442 17708605 17481882 12546737 11481614 18339082 12958196 18472094 18006644 12649538 12586293 16136751 18395095 17640975 15893842 12389079 18481824 15996030 15370692 18418968 12445421 14716833 10355542 18317297 18054572 16033810 18156304
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 2.5716169303
MESH:D008107 Liver Diseases Carbon Tetrachloride 2.1216246199 15720792 16964402 17285989 15830285
MESH:D017093 Liver Failure Carbon Tetrachloride 4.3815123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.8516899240 14706259
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 4.757678174
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 4.7519294768
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 10.442876784 2876786 6135515
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 10.443712494 598648 1399818 6587162
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 10.4412014681 15583823
MESH:D008171 Lung Diseases Vitamin E 3.2916863852
MESH:D008175 Lung Neoplasms Vitamin E 1.9011062179
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 6.4811408345 17203775
MESH:D008325 Mammary Neoplasms, Experimental Selenium 6.4815318939
MESH:D008654 Mesothelioma Selenium 2.8515107826
MESH:D009336 Necrosis 2,4-dinitrotoluene 11.1518551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 11.1518551238 7678174
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.533581430
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 3.026679447
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 16.0316049721 12819281
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 16.0316049721
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 16.036482804 4026338
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.283988306
MESH:D010051 Ovarian Neoplasms Progesterone 2.5716525653 17393432
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.707296757
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.736228378
MESH:D010954 Plasmacytoma Selenium 5.1515087411
MESH:D011471 Prostatic Neoplasms Vitamin E 3.2815084515
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.503692021
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.9118045962
MESH:D012640 Seizures 2,4-dinitrotoluene 6.2518551238
MESH:D012640 Seizures 2,6-dinitrotoluene 6.2518551238
MESH:D012871 Skin Diseases Vitamin E 2.4818709164
MESH:D013119 Spinal Cord Injuries Progesterone 4.5216503802 15862959
MESH:D020521 Stroke Vitamin E 3.6616517955
MESH:D013733 Testicular Diseases phenethyl isothiocyanate 5.1815864552
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 3.011399818 3712494 6587162 7505956 6582329
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 8.6316049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 8.6316049721
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 8.638074119
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 12.8010091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 12.8010091137
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA128394586
    • No data
    Releated disease ID Related disease Name
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    No data
    Drug Bank Top

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    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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