AutismKB 2.0

Annotation Detail for HSPA4L


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Basic Information Top
Gene Symbol:HSPA4L ( APG-1,Osp94 )
Gene Full Name: heat shock 70kDa protein 4-like
Band: 4q28.1
Quick LinksEntrez ID:22824; OMIM: NA; Uniprot ID:HS74L_HUMAN; ENSEMBL ID: ENSG00000164070; HGNC ID: 17041
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04141Protein processing in endoplasmic reticulum
No data
No data
No data
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C548651 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of HSPA4L mRNAincreases expression 19933214
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of HSPA4L mRNAaffects expression 21346803
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of HSPA4L mRNAincreases expression 18648102
C075773 4-phenylbutyric acid 4-phenylbutyric acid results in increased expression of HSPA4L mRNAincreases expression 14583596
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of HSPA4L proteinaffects expression 20106945
C015001 arsenite [arsenite co-treated with Benzo(a)pyrene] results in increased expression of HSPA4L mRNAaffects cotreatment|increases expression 15894712
C015001 arsenite arsenite results in increased expression of HSPA4L mRNAincreases expression 15894712
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of HSPA4L mRNAincreases expression 20106945
D001564 Benzo(a)pyrene [arsenite co-treated with Benzo(a)pyrene] results in increased expression of HSPA4L mRNAaffects cotreatment|increases expression 15894712
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of HSPA4L mRNAincreases expression 15894712
D016572 Cyclosporine Cyclosporine results in increased expression of HSPA4L mRNAincreases expression 20106945
D004041 Dietary Fats Dietary Fats results in decreased expression of HSPA4L mRNAdecreases expression 18042831
D004958 Estradiol Estradiol results in increased expression of HSPA4L mRNAincreases expression 20106945
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of HSPA4L mRNAaffects expression 17555576
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of HSPA4L mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of HSPA4L mRNAaffects cotreatment|increases expression 17942748
D019833 Genistein Genistein results in increased expression of HSPA4L mRNAincreases expression 18847459
C051890 irinotecan irinotecan metabolite results in decreased expression of HSPA4L mRNAdecreases expression 15956246
C051890 irinotecan irinotecan results in decreased expression of HSPA4L mRNAdecreases expression 15956246
C008493 methylselenic acid methylselenic acid results in increased expression of HSPA4L mRNAincreases expression 18548127
C041786 palm oil palm oil results in decreased expression of HSPA4L mRNAdecreases expression 18042831
D010634 Phenobarbital NR1I3 protein affects the reaction [Phenobarbital results in increased expression of HSPA4L mRNA]affects reaction|increases expression 19482888
D010634 Phenobarbital Phenobarbital results in increased expression of HSPA4L mRNAincreases expression 19482888
C006253 pirinixic acid pirinixic acid results in increased expression of HSPA4L mRNAincreases expression 18301758
20059764
C006253 pirinixic acid PPARA protein promotes the reaction [pirinixic acid results in increased expression of HSPA4L mRNA]increases expression|increases reaction 20059764
D011374 Progesterone Progesterone affects the expression of HSPA4L mRNAaffects expression 17251523
C045950 propiconazole propiconazole results in increased expression of HSPA4L mRNAincreases expression 16643972
C031280 pyrazole pyrazole results in increased expression of HSPA4L mRNAincreases expression 17945193
C009166 retinol acetate retinol acetate results in increased expression of HSPA4L mRNAincreases expression 16772331
C009277 sodium arsenate sodium arsenate results in increased expression of HSPA4L mRNAincreases expression 16882884
C017947 sodium arsenite sodium arsenite results in increased expression of HSPA4L mRNAincreases expression 16014739
C446685 systhane systhane results in decreased expression of HSPA4L mRNAdecreases expression 16643972
D013629 Tamoxifen Tamoxifen affects the expression of HSPA4L mRNAaffects expression 17555576
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of HSPA4L mRNAdecreases expression 20106945
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of HSPA4L mRNAaffects cotreatment|increases expression 17942748
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of HSPA4L mRNAincreases expression 18691609
19933214
C032910 triadimefon triadimefon results in decreased expression of HSPA4L mRNAdecreases expression 16643972
C025643 vinclozolin vinclozolin results in decreased expression of HSPA4L mRNAdecreases expression 18940246
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.3014745880
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 7.486195326
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 7.4815322242 14514962 11752688
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.6917505938
MESH:D055371 Acute Lung Injury pirinixic acid 2.8918653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 9.6220127859 20464547
MESH:D000230 Adenocarcinoma Estradiol 9.6211473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 9.6214692618
MESH:D000230 Adenocarcinoma Genistein 9.6211473722
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 6.133712494
MESH:D000236 Adenoma Benzo(a)pyrene 6.136695378
MESH:D018248 Adenoma, Liver Cell Phenobarbital 15.8517620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 15.8516434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 15.8516835633
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.4515276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 4.6516712894 17306315
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.7311748828
MESH:D001008 Anxiety Disorders vinclozolin 3.4519015723
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.8319183758
MESH:D001161 Arteriosclerosis Dietary Fats 9.1015238619
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 9.1011256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.5115885639
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 4.771440618 11289319
MESH:D001778 Blood Coagulation Disorders pirinixic acid 8.0419483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 8.0412125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.5415340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.6115746008
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.0917868700
MESH:D001930 Brain Injuries Progesterone 4.0215665606 15845082 15380490
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 3.6020146248 17474063
MESH:D001943 Breast Neoplasms Dietary Fats 3.6020435547
MESH:D001943 Breast Neoplasms Estradiol 3.6017261762 17289903 18497071 12948864 14630087 17018787 19861407 16675129
MESH:D001943 Breast Neoplasms Genistein 3.6016873071 16541309 17200150
MESH:D001943 Breast Neoplasms Progesterone 3.6017614352 15562024 16175315
MESH:D001943 Breast Neoplasms Tamoxifen 3.6019189212 21152245 19142967 17261762 16202921 17242785 19115204 19059307 18855134 19066611 19084267 18997820 19011961 19103187 18629630 18984771 18351453 20005174 19155303 20390343 18815881 16818667 11161223 18821012 20544844 20859285 20135344 16273361 17893378 16873071 15565566 18425577 19221464 17440819 19189210 19200415 15668708 19244106 19487384 19289846 19288272 20065188 19410462 21138602 17049068
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 3.6020435547
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.2216111702
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.6116835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.2619066611
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 16.1916705839
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 16.193581430 7296757
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 16.1912907637 21507988 12619106
MESH:D006528 Carcinoma, Hepatocellular Estradiol 16.1916924424
MESH:D006528 Carcinoma, Hepatocellular Genistein 16.1916924424
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 16.1917173139 20935162 6705139 1701930 20007298
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 16.1916507464 17306315 15276417
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 16.1916924424
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.567296757
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 4.3520419170
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 4.3518572023
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.4017572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.2318850075 18670907 16120746
MESH:D002318 Cardiovascular Diseases Genistein 3.1416332659
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 14.647505956
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 14.6412371664
MESH:D002471 Cell Transformation, Neoplastic Estradiol 14.6418566989
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 14.6420056578 19524636
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.014080065
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 2.9616835633
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 17.7419486331 9022650
MESH:D002779 Cholestasis Cyclosporine 17.7419486331
MESH:D002779 Cholestasis Ethinyl Estradiol 17.7416919318 17110522 16105132 11677210 17681005 17333356 15861022
MESH:D002779 Cholestasis pirinixic acid 17.7419176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.8115668235 8697196 16354765 15340226 12621046
MESH:D002972 Cleft Palate triadimefon 5.8116781842
MESH:D003110 Colonic Neoplasms arsenite 5.6815037631
MESH:D003110 Colonic Neoplasms Genistein 5.6817182828
MESH:D003110 Colonic Neoplasms irinotecan 5.6817287894 17725105
MESH:D015179 Colorectal Neoplasms irinotecan 2.3617159606 16303861 16391804 15273666 18259882 18509181 17454858
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.8517141729 14669216
MESH:D019465 Craniofacial Abnormalities sodium arsenate 3.8610525206
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 3.8610048152 20055451 15322242
MESH:D019465 Craniofacial Abnormalities triadimefon 3.8616875885 15834900
MESH:D003456 Cryptorchidism vinclozolin 4.1114966744
MESH:D003490 Cyanosis 2,4-dinitrotoluene 3.7718551238
MESH:D003711 Demyelinating Diseases Tamoxifen 4.1219031437
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 2.578156756 2524372 18759878 11906362 12868966 14531868 8970840 11298694
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.3118249437
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.263621924 2952479
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 4.1216647724
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.1217107852
MESH:D003928 Diabetic Nephropathies Estradiol 8.1619279558
MESH:D003928 Diabetic Nephropathies Tamoxifen 8.1619279558
MESH:D003929 Diabetic Neuropathies Progesterone 4.2517187935
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 11.2321346803 18551238
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 11.2318692083 1440618 18289764 9653073 9328219 9022650 6679447 7440962 11289319 18648102 6482804 8291058 16192314
MESH:D056486 Drug-Induced Liver Injury pyrazole 11.2312499123
MESH:D056486 Drug-Induced Liver Injury sodium arsenate 11.2318186108
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 11.2320420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.5811462148
MESH:D050171 Dyslipidemias Dietary Fats 3.2818367378
MESH:D004421 Dystonia Phenobarbital 3.781851702
MESH:D004487 Edema pirinixic acid 5.8212083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 5.8211000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.6518230668 15322242 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 13.9612538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 13.9617692515
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 13.9619031437
MESH:D004714 Endometrial Hyperplasia Genistein 4.3416402032
MESH:D016889 Endometrial Neoplasms Estradiol 11.5411473722 19148513 18566989
MESH:D016889 Endometrial Neoplasms Genistein 11.5411473722
MESH:D016889 Endometrial Neoplasms Tamoxifen 11.5417893378 19155303 20544844 16202921
MESH:D004715 Endometriosis Progesterone 8.2216134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 8.2210568697 9294722
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 3.873659116
MESH:D004828 Epilepsies, Partial Phenobarbital 3.623922381 11558140
MESH:D004827 Epilepsy Phenobarbital 2.7720417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.346401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.017750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 3.773659116
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 4.143581430
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.1416530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.8311564622
MESH:D005234 Fatty Liver arsenite 27.8418296743
MESH:D005234 Fatty Liver Cyclosporine 27.8419224547
MESH:D005234 Fatty Liver Dietary Fats 27.8417967931 19551842 19004024 18296743
MESH:D005234 Fatty Liver Ethinyl Estradiol 27.8415345470
MESH:D005234 Fatty Liver pirinixic acid 27.8420131406 19236843
MESH:D005234 Fatty Liver Tamoxifen 27.8419224547 14986274
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.0916709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.2111858732
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 4.776705139
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.2814745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 3.9419069698
MESH:D005355 Fibrosis arsenite 19.1718296743
MESH:D005355 Fibrosis Cyclosporine 19.1712639820 12168785
MESH:D005355 Fibrosis Dietary Fats 19.1718296743
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 19.1720067830
MESH:D030342 Genetic Diseases, Inborn vinclozolin 4.6916973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.0516417039
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.4316452187
MESH:D005885 Gingival Hyperplasia Cyclosporine 3.978708960
MESH:D005909 Glioblastoma Genistein 3.1016598420
MESH:D018149 Glucose Intolerance sodium arsenate 4.8519446573
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 3.817505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.3410696789
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.0220471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.0210048152 11294989
MESH:D006333 Heart Failure pirinixic acid 2.3920558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.1715720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.1211000095
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.286705139
MESH:D006529 Hepatomegaly Phenobarbital 30.6316109766
MESH:D006529 Hepatomegaly pirinixic acid 30.6319772884 16221962 19176532 18467677
MESH:D006529 Hepatomegaly propiconazole 30.6317178689 17178688
MESH:D006529 Hepatomegaly systhane 30.6317178689 17178688
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 30.6315340226 16120746 12621046
MESH:D006529 Hepatomegaly triadimefon 30.6317178688 17178689
MESH:D006558 Herpes Genitalis Estradiol 4.7815709030
MESH:D006689 Hodgkin Disease sodium arsenite 2.9512676792
MESH:D019584 Hot Flashes Estradiol 3.5017088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.8015340226 16354765 8697196 18606429 16959395
MESH:D006937 Hypercholesterolemia Dietary Fats 3.3721332399
MESH:D006943 Hyperglycemia pirinixic acid 2.9720558911
MESH:D006949 Hyperlipidemias Dietary Fats 3.3921332399
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 3.7015034207
MESH:D006973 Hypertension Cyclosporine 4.6310903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 4.6318670907 18850075
MESH:D007021 Hypospadias Ethinyl Estradiol 3.5716569931 16945680
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.1615869954
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.2312013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 10.2717937319
MESH:D007248 Infertility, Male sodium arsenite 10.2712646999 15346721
MESH:D007248 Infertility, Male vinclozolin 10.2716467254
MESH:D007249 Inflammation Dietary Fats 10.9020412841
MESH:D007249 Inflammation Progesterone 10.9015869954
MESH:D007249 Inflammation Tamoxifen 10.9019457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 10.9012200463 12878042
MESH:D007333 Insulin Resistance Dietary Fats 11.3718457598 11836018
MESH:D007333 Insulin Resistance Estradiol 11.3716393666 16627594
MESH:D007333 Insulin Resistance pirinixic acid 11.3716306350
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 4.778074119 9022650
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 9.5916580747
MESH:D007569 Jaw Abnormalities triadimefon 9.5915992940 15834900
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.1915604871
MESH:D007674 Kidney Diseases Cyclosporine 9.248314463 10903974 18776723
MESH:D007674 Kidney Diseases Estradiol 9.2415618244
MESH:D007674 Kidney Diseases sodium arsenite 9.2420008137
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 21.2216705839
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 21.226582329
MESH:D007680 Kidney Neoplasms Cyclosporine 21.2212371664
MESH:D007680 Kidney Neoplasms Estradiol 21.2215610895
MESH:D007680 Kidney Neoplasms Tamoxifen 21.2218625569
MESH:D007938 Leukemia Genistein 2.9017468513 18980019
MESH:D007984 Leydig Cell Tumor vinclozolin 4.4816417039
MESH:D008064 Lipidoses Tamoxifen 2.9817567588 15342952
MESH:D008103 Liver Cirrhosis arsenite 10.3318296743
MESH:D008103 Liver Cirrhosis Dietary Fats 10.3318296743
MESH:D008103 Liver Cirrhosis Phenobarbital 10.3321047994
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.049327722 15034207
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 6.3814716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Genistein 6.3817823541
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 6.3815474484
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 6.3818564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 6.3812878042
MESH:D008107 Liver Diseases Phenobarbital 6.4619363144
MESH:D008107 Liver Diseases propiconazole 6.4619363144
MESH:D008107 Liver Diseases triadimefon 6.4619363144
MESH:D008113 Liver Neoplasms Aflatoxin B1 28.319163691 15890375 2125692 18177683
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 28.3121137059 20195826
MESH:D008113 Liver Neoplasms Phenobarbital 28.3119812893 19073162 8742319 19482888 21047994 15975961
MESH:D008113 Liver Neoplasms pirinixic acid 28.3120007298 16377806 15890375
MESH:D008113 Liver Neoplasms propiconazole 28.3119028983
MESH:D008113 Liver Neoplasms sodium arsenite 28.3115276417 16712894
MESH:D008113 Liver Neoplasms Tamoxifen 28.3116684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 28.3116984957
MESH:D008113 Liver Neoplasms triadimefon 28.3119028983
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 25.95598648 6587162 1399818 3712494
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 25.958603461
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 25.952563599 17172636 18308698 1399818 6150874
MESH:D008114 Liver Neoplasms, Experimental propiconazole 25.9517178689
MESH:D008114 Liver Neoplasms, Experimental systhane 25.9517178689
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 25.9512151625
MESH:D008114 Liver Neoplasms, Experimental triadimefon 25.9517178689
MESH:D008171 Lung Diseases sodium arsenite 3.0119095001
MESH:D008175 Lung Neoplasms Aflatoxin B1 8.1414755239
MESH:D008175 Lung Neoplasms arsenite 8.1416809336
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 8.1418569708 6695378 18816296 20135361 20464547 18520028 17053015 20869020 20064080
MESH:D008175 Lung Neoplasms sodium arsenite 8.1416712894 19931552 17306315 15276417 17077188
MESH:D008175 Lung Neoplasms Tamoxifen 8.1418625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 8.1411884234 19555203
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.5119428831
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 12.9917203775 11807958 11408345 16891317
MESH:D008325 Mammary Neoplasms, Experimental Genistein 12.9914578162 12929590
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 12.9917203775 11408345
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 12.9919196723 11731420 19196722 14580682 16827153
MESH:D020149 Manganese Poisoning Estradiol 11.8119453300
MESH:D020149 Manganese Poisoning Tamoxifen 11.8119453300
MESH:D008545 Melanoma sodium arsenite 3.1716487513 19082730
MESH:D008545 Melanoma Tamoxifen 3.1712393984 19393235
MESH:D018328 Melanoma, Amelanotic Tamoxifen 3.9415990972
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.5416801185
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.0016381670
MESH:D052016 Mucositis irinotecan 4.7617159606
MESH:D009135 Muscular Diseases pirinixic acid 3.2716239165
MESH:D009139 Musculoskeletal Abnormalities sodium arsenate 4.6318186108
MESH:D009203 Myocardial Infarction Genistein 5.3317141266
MESH:D009203 Myocardial Infarction pirinixic acid 5.3319151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.8312213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 13.0916810080
MESH:D015428 Myocardial Reperfusion Injury Genistein 13.0917141266
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 13.0916411023
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.2317484760
MESH:D009336 Necrosis 2,4-dinitrotoluene 3.6118551238
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 8.963581430
MESH:D009362 Neoplasm Metastasis irinotecan 8.9618259882
MESH:D009362 Neoplasm Metastasis Tamoxifen 8.9619393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.4419410462
MESH:D009369 Neoplasms 4-phenylbutyric acid 10.9019116145
MESH:D009369 Neoplasms Benzo(a)pyrene 10.9011141357
MESH:D009369 Neoplasms pirinixic acid 10.9017405874
MESH:D009369 Neoplasms sodium arsenite 10.9011559025
MESH:D009374 Neoplasms, Experimental sodium arsenite 3.4320056578
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 3.7519200415 19189210 19196722
MESH:D009389 Neovascularization, Pathologic arsenite 9.3315738583
MESH:D009389 Neovascularization, Pathologic Estradiol 9.3317289903
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.1917954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.0818481113 19348381
MESH:D009421 Nervous System Malformations Estradiol 15.0011399458 16427766
MESH:D009421 Nervous System Malformations Genistein 15.0016427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 15.0014600291
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 11.336679447
MESH:D009436 Neural Tube Defects sodium arsenate 11.3310525206 11749123 18186108 19446573
MESH:D009436 Neural Tube Defects sodium arsenite 11.3312854658
MESH:D009447 Neuroblastoma irinotecan 3.358761367
MESH:D017599 Neuroectodermal Tumors irinotecan 4.488761367
MESH:D009765 Obesity Dietary Fats 4.2216723640 17217161 11836018 21332399 20518802 19632207 18457598 20132043 18674790
MESH:D009765 Obesity pirinixic acid 4.2220558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 8.1712819281 16049721
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 8.176482804 4026338
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 4.773988306
MESH:D010018 Osteomalacia Phenobarbital 4.1217016548
MESH:D010024 Osteoporosis Genistein 3.1019401787
MESH:D015663 Osteoporosis, Postmenopausal Genistein 3.8616169203
MESH:D010051 Ovarian Neoplasms Estradiol 10.6519401270
MESH:D010051 Ovarian Neoplasms Genistein 10.6519005980
MESH:D010051 Ovarian Neoplasms Progesterone 10.6516525653 17393432
MESH:D010051 Ovarian Neoplasms sodium arsenite 10.6517306315 15276417
MESH:D010190 Pancreatic Neoplasms Phenobarbital 2.4116965848
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.4611578682
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.247296757
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.0012520081
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.226228378
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.3218163543
MESH:D011230 Precancerous Conditions Cyclosporine 8.2912371664
MESH:D011230 Precancerous Conditions Phenobarbital 8.292563599
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 8.6711222880 11118676 11896295 11399792
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 8.6718042343 18220299 19015723
MESH:D011469 Prostatic Diseases vinclozolin 4.6918220299
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.6620887781
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 1.8817292933
MESH:D011471 Prostatic Neoplasms Estradiol 1.8816740699
MESH:D011471 Prostatic Neoplasms Genistein 1.8815256057 15378649 16925846
MESH:D011471 Prostatic Neoplasms methylselenic acid 1.8816205645
MESH:D011471 Prostatic Neoplasms sodium arsenite 1.8816039940
MESH:D011471 Prostatic Neoplasms Tamoxifen 1.8815067354
MESH:D011472 Prostatitis vinclozolin 4.6918629315
MESH:D011537 Pruritus Ethinyl Estradiol 3.0716919318 15861022
MESH:D019310 Pseudolymphoma Phenobarbital 4.2512752131
MESH:D011565 Psoriasis Cyclosporine 2.1416882103
MESH:D015427 Reperfusion Injury pirinixic acid 2.2719058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.6018990726
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.193692021
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.7718045962
MESH:D012640 Seizures 2,4-dinitrotoluene 5.3818551238
MESH:D012640 Seizures Phenobarbital 5.383137016 4039156 11442880 16876388
MESH:D003294 Seizures, Febrile Phenobarbital 4.576407741
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 8.7219755658 10029692
MESH:D012878 Skin Neoplasms sodium arsenite 8.7218572023 19524636
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 8.7216192470
MESH:D013088 Spermatocele Ethinyl Estradiol 10.7316709447
MESH:D013088 Spermatocele Tamoxifen 10.7316709447
MESH:D013119 Spinal Cord Injuries Progesterone 10.0516503802 15862959
MESH:D013119 Spinal Cord Injuries Tamoxifen 10.0519457130
MESH:D016135 Spinal Dysraphism sodium arsenite 3.6112854658
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 2.492093021 20155912
MESH:D013274 Stomach Neoplasms irinotecan 2.4915723263
MESH:D013733 Testicular Diseases pyrazole 4.576499806
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.3911994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.9515669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.6512697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 11.036587162 6582329 7505956 1399818 3712494
MESH:D013964 Thyroid Neoplasms Phenobarbital 11.031399818
MESH:D013964 Thyroid Neoplasms triadimefon 11.0317178689
MESH:D013978 Tibial Fractures Estradiol 4.4419048282
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 14.7516049721
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 14.758074119
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 14.7517053015
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 14.7516712894 16452187 17306315 11723127
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 14.7516712894 17572228 8653321
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.0710091137
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 3.5511813266
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.0614692618
MESH:D014605 Uveitis Cyclosporine 3.731336536
MESH:D014652 Vascular Diseases sodium arsenite 4.1817056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.3412125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.3214671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.0015886252
MESH:D015430 Weight Gain Dietary Fats 3.5316723640
MESH:D014985 Xerophthalmia Cyclosporine 4.1917120751
Pathway ID Pathway Name
KEGG:04141 Protein processing in endoplasmic reticulum
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Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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