AutismKB 2.0

Annotation Detail for LPHN1


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Basic Information Top
Gene Symbol:LPHN1 ( CIRL1,CL1,LEC2 )
Gene Full Name: latrophilin 1
Band: 19p13.2
Quick LinksEntrez ID:22859; OMIM: NA; Uniprot ID:LPHN1_HUMAN; ENSEMBL ID: ENSG00000072071; HGNC ID:
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D002713 Chlorine Chlorine results in decreased expression of LPHN1 mRNAdecreases expression 18636392
D002713 Chlorine [Ozone co-treated with Chlorine] results in increased expression of LPHN1 mRNAaffects cotreatment|increases expression 18636392
D004041 Dietary Fats Dietary Fats results in increased expression of LPHN1 mRNAincreases expression 18042831
D004317 Doxorubicin LPHN1 protein affects the susceptibility to Doxorubicinaffects response to substance 16217747
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of LPHN1 mRNAaffects cotreatment|increases expression 17942748
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of LPHN1 mRNAdecreases expression 17557909
D010126 Ozone [Ozone co-treated with Chlorine] results in increased expression of LPHN1 mRNAaffects cotreatment|increases expression 18636392
C041786 palm oil palm oil results in increased expression of LPHN1 mRNAincreases expression 18042831
D010269 Paraquat Paraquat affects the expression of LPHN1 mRNAaffects expression 15493455
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of LPHN1 mRNAaffects cotreatment|increases expression 17942748
D014635 Valproic Acid Valproic Acid results in increased expression of LPHN1 mRNAincreases expression 19101580
C025643 vinclozolin vinclozolin affects the expression of LPHN1 mRNAaffects expression 19015723
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 9.1111752688 14514962 15322242
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 9.118875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 4.1019490988
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.2117505938
MESH:D055371 Acute Lung Injury Chlorine 4.5120601635
MESH:D000230 Adenocarcinoma Doxorubicin 4.5217418594
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.5214692618
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.6116835633
MESH:D000382 Agricultural Workers' Diseases Paraquat 4.0011874814
MESH:D000419 Albuminuria Doxorubicin 4.7421441931
MESH:D000544 Alzheimer Disease Ozone 2.4715513908
MESH:D000550 Amblyopia Valproic Acid 5.5017688650
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.1111748828
MESH:D001008 Anxiety Disorders Valproic Acid 9.3217497229
MESH:D001008 Anxiety Disorders vinclozolin 9.3219015723
MESH:D001161 Arteriosclerosis Dietary Fats 10.6415238619
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 10.6411256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.7615885639
MESH:D001172 Arthritis, Rheumatoid Ozone 2.5915570426
MESH:D001249 Asthma Ozone 2.6817854713 16373670
MESH:D001321 Autistic Disorder Valproic Acid 1.9919460635 18985861 18775368 18316065 19232924 18558336 16609825 17507914 18396377 15238991 17157402 20603192 18940202 18177632 17688650
MESH:D001714 Bipolar Disorder Valproic Acid 3.1517594078 20046352
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.2112125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.0615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 8.3715746008
MESH:D001848 Bone Diseases, Developmental Valproic Acid 8.378888407
MESH:D019046 Bone Marrow Neoplasms Doxorubicin 4.9614601052
MESH:D001932 Brain Neoplasms Doxorubicin 3.9717150277
MESH:D001943 Breast Neoplasms Dietary Fats 1.8820435547
MESH:D001943 Breast Neoplasms Doxorubicin 1.8815634643 15136595 16935488 16264153 16826403 15939500 16595493 18695136 18382427 16096432 17983394 18234424 15993339 18628466 15994142 19526202 16115903 15668708 17369602 16322301 11325840 17426702 15567936 15692762
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.8820435547
MESH:D016535 Bronchial Hyperreactivity Ozone 3.8116777450 19059883 18417511 18315731 17626835 14754758 15516495
MESH:D002100 Cachexia Ozone 4.9816183385
MESH:D002276 Carcinoid Tumor Doxorubicin 5.0816051944
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9316835633
MESH:D006528 Carcinoma, Hepatocellular Doxorubicin 2.2518059187 17876044 16023760 16234567
MESH:D002292 Carcinoma, Renal Cell Doxorubicin 3.231485588 16201981
MESH:D002294 Carcinoma, Squamous Cell Doxorubicin 2.676189445
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4518670907 16120746 18850075
MESH:D009202 Cardiomyopathies Doxorubicin 3.6417308081 17351982 17519947 16651473 15476868 15792986 16364871 15811867 16731534 18627295 16109756 16278810 17131338 16242529 17329180 17928571 15505089 17974986 16269455 16612575 17007740 16952015 17924179 16455267 17382496
MESH:D002311 Cardiomyopathy, Dilated Doxorubicin 2.9917334414 16243910
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.7620734317
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.3116835633
MESH:D002779 Cholestasis Ethinyl Estradiol 3.0017333356 16919318 15861022 16105132 11677210 17681005 17110522
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.168697196 12621046 15340226 16354765 15668235
MESH:D015179 Colorectal Neoplasms Doxorubicin 2.1418259882 18802399
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.2114669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.5210048152 20055451 15322242
MESH:D019465 Craniofacial Abnormalities Valproic Acid 2.5216575769 8888407 17688650
MESH:D003456 Cryptorchidism vinclozolin 4.5414966744
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7017107852
MESH:D056486 Drug-Induced Liver Injury Doxorubicin 6.5217416283
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 6.5220420201
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 6.521733752 19641884
MESH:D004362 Drug Toxicity Doxorubicin 8.5318602426
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 8.5311462148
MESH:D050171 Dyslipidemias Dietary Fats 3.5718367378
MESH:D004417 Dyspnea Chlorine 4.8920016425
MESH:D004421 Dystonia Valproic Acid 4.231851702
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.5512711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.1715322242 18230668 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.3812538720
MESH:D016889 Endometrial Neoplasms Doxorubicin 3.5617359293
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.189294722 10568697
MESH:D004719 Endomyocardial Fibrosis Doxorubicin 5.4218037988
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 4.3717275665 3659116
MESH:D004828 Epilepsies, Partial Valproic Acid 4.183922381 16628512
MESH:D004827 Epilepsy Valproic Acid 3.0120417680 18234410
MESH:D004832 Epilepsy, Absence Valproic Acid 3.746254150 7562514 6426943
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.517750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 4.303659116
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1411564622
MESH:D005234 Fatty Liver Dietary Fats 14.1519551842 17967931 19004024 18296743
MESH:D005234 Fatty Liver Ethinyl Estradiol 14.1515345470
MESH:D005234 Fatty Liver Valproic Acid 14.1514986274 19224547
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.6711858732
MESH:D005315 Fetal Diseases Valproic Acid 5.1516575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.338888407 18558336
MESH:D018222 Fibromatosis, Aggressive Doxorubicin 4.8319069698
MESH:D005355 Fibrosis Dietary Fats 9.3518296743
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 9.3520067830
MESH:D005739 Gas Poisoning Chlorine 5.2720016425
MESH:D030342 Genetic Diseases, Inborn vinclozolin 5.1716973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.5716417039
MESH:D005909 Glioblastoma Doxorubicin 3.4517150277
MESH:D005911 Gliosis Paraquat 5.4311124998
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.8610696789
MESH:D006258 Head and Neck Neoplasms Doxorubicin 3.6415692506
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4111294989 10048152
MESH:D006331 Heart Diseases Doxorubicin 3.6014766674 16244371 16879835 17888722 17875725 12587719 18006777 16330681 16495754 16144979 16244372 18674790 16707910
MESH:D006333 Heart Failure Doxorubicin 3.4417481944
MESH:D006394 Hemangiosarcoma Doxorubicin 4.0715692506
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.5111000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.1115340226 16120746 12621046
MESH:D006689 Hodgkin Disease Doxorubicin 3.5615147373 18501091 17606976
MESH:D006849 Hydrocephalus Valproic Acid 5.1017688650
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.318697196 16354765 15340226 16959395 18606429
MESH:D006937 Hypercholesterolemia Dietary Fats 3.7621332399
MESH:D006949 Hyperlipidemias Dietary Fats 3.8021332399
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9618850075 18670907
MESH:D007021 Hypospadias Ethinyl Estradiol 4.0216569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.6512013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 11.9017937319
MESH:D007248 Infertility, Male Paraquat 11.904850670
MESH:D007248 Infertility, Male vinclozolin 11.9016467254
MESH:D007249 Inflammation Dietary Fats 5.1920412841
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.1912200463 12878042
MESH:D007333 Insulin Resistance Dietary Fats 3.2118457598 11836018
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.5116580747
MESH:D007674 Kidney Diseases Doxorubicin 3.1416775033 15369732 15699352
MESH:D007676 Kidney Failure, Chronic Doxorubicin 4.3316707910
MESH:D004915 Leukemia, Erythroblastic, Acute Doxorubicin 5.4216085563
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 2.1716294345 17596541
MESH:D007984 Leydig Cell Tumor vinclozolin 4.9716417039
MESH:D008103 Liver Cirrhosis Dietary Fats 2.9618296743
MESH:D008106 Liver Cirrhosis, Experimental Doxorubicin 2.4816439617 16595196
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.4812878042
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 1.7716984957
MESH:D008114 Liver Neoplasms, Experimental Doxorubicin 6.2516842330 17085340
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 6.2512151625
MESH:D008171 Lung Diseases Ozone 3.4919066396 8266340
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.5317228818
MESH:D055370 Lung Injury Ozone 4.0620417186
MESH:D008175 Lung Neoplasms Doxorubicin 3.5617418594 6189445
MESH:D008175 Lung Neoplasms Ozone 3.567614698 8597069
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.5619555203 11884234
MESH:D008223 Lymphoma Doxorubicin 3.5816098063
MESH:D008228 Lymphoma, Non-Hodgkin Doxorubicin 3.9317654614
MESH:D016399 Lymphoma, T-Cell Doxorubicin 4.7815621674
MESH:D008325 Mammary Neoplasms, Experimental Doxorubicin 3.1315458769
MESH:D008545 Melanoma Doxorubicin 2.3116827129
MESH:D008654 Mesothelioma Doxorubicin 3.1217638057
MESH:D008679 Metaplasia Ozone 5.3710496685
MESH:D008881 Migraine Disorders Valproic Acid 3.3118803445 18765137
MESH:D028361 Mitochondrial Diseases Doxorubicin 4.6715792986
MESH:D052016 Mucositis Doxorubicin 5.0317415656
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 4.208888407
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 3.2417596541
MESH:D009203 Myocardial Infarction Doxorubicin 3.0115857846 19429709
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1612213967
MESH:D009362 Neoplasm Metastasis Doxorubicin 3.0118259882
MESH:D009401 Nephrosis Doxorubicin 4.9816636307 16899518
MESH:D009404 Nephrotic Syndrome Doxorubicin 4.1515640375 16889571
MESH:D009410 Nerve Degeneration Paraquat 3.8516893418
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.4114600291
MESH:D009436 Neural Tube Defects Valproic Acid 3.2316359493 8888407
MESH:D009447 Neuroblastoma Doxorubicin 3.3415555623
MESH:D009765 Obesity Dietary Fats 2.3216723640 17217161 18457598 11836018 20518802 21332399 18674790 20132043 19632207
MESH:D012516 Osteosarcoma Doxorubicin 4.2515930896
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.8711578682
MESH:D010300 Parkinson Disease Paraquat 2.8715451049 15824117 11445065 12911755 16510128 11124998 16140633 11181820
MESH:D010302 Parkinson Disease, Secondary Paraquat 4.6516190885
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.5112520081
MESH:D010538 Peritonitis Ozone 4.3516369182
MESH:D003557 Phyllodes Tumor Doxorubicin 5.4217983394
MESH:D010997 Pleural Neoplasms Doxorubicin 5.4217638057
MESH:D011014 Pneumonia Ozone 11.8718381685 18929643 18007984
MESH:D011014 Pneumonia Paraquat 11.8712504350
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.7618163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 17.6911896295 11399792 11118676 11222880
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 17.6920603192
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 17.6918220299 18042343 19015723
MESH:D011469 Prostatic Diseases vinclozolin 5.1718220299
MESH:D011471 Prostatic Neoplasms Doxorubicin 3.5316729912 16888761 15897917 16868541 18437689 15749863
MESH:D011472 Prostatitis vinclozolin 5.1718629315
MESH:D011537 Pruritus Ethinyl Estradiol 3.5516919318 15861022
MESH:D019310 Pseudolymphoma Valproic Acid 4.8111422049 12752131
MESH:D011658 Pulmonary Fibrosis Paraquat 2.9716324872 17997886
MESH:D051437 Renal Insufficiency Doxorubicin 4.4417922066
MESH:D012120 Respiration Disorders Chlorine 5.4818579056
MESH:D012128 Respiratory Distress Syndrome, Adult Paraquat 4.0911700416
MESH:D012135 Respiratory Sounds Paraquat 4.2711874814
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.0418990726
MESH:D012162 Retinal Degeneration Paraquat 3.9916458197
MESH:D012208 Rhabdomyosarcoma Valproic Acid 4.3619155313
MESH:D012509 Sarcoma Doxorubicin 4.1518313854 15625365 17203757 16767912 17710206 15675481
MESH:D012512 Sarcoma, Ewing's Doxorubicin 4.4416326096 14601052
MESH:D012514 Sarcoma, Kaposi Doxorubicin 5.0317846226
MESH:D012559 Schizophrenia Valproic Acid 2.0915737665 19110320
MESH:D012640 Seizures Valproic Acid 2.8517978042 11044598 15475178 14763951 16876388 3137016 11738929 1511512
MESH:D012878 Skin Neoplasms Doxorubicin 5.9315692506
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.9316192470
MESH:D012983 Soft Tissue Neoplasms Doxorubicin 4.7816767912 17203757 15625365
MESH:D013088 Spermatocele Ethinyl Estradiol 4.2116709447
MESH:D016135 Spinal Dysraphism Valproic Acid 3.9119490988
MESH:D013226 Status Epilepticus Valproic Acid 4.8112833885
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.8011994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.3015669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.1712697716
MESH:D013964 Thyroid Neoplasms Doxorubicin 3.5016010429 17909728
MESH:D014178 Translocation, Genetic Valproic Acid 5.5017262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.763119515
MESH:D001749 Urinary Bladder Neoplasms Doxorubicin 2.8217653716
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.868888407
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.5014692618
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.8612125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.7114671159 15869587
MESH:D018487 Ventricular Dysfunction, Left Doxorubicin 4.4417334414 17638931 17678736 16364871
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.5115886252
MESH:D015430 Weight Gain Dietary Fats 3.8916723640
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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