Annotation Detail for NLRP1
Basic Information
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| Gene Symbol: | NLRP1 ( CARD7,CLR17.1,DEFCAP,DEFCAP-L/S,DKFZp586O1822,KIAA0926,NAC,NALP1,PP1044,SLEV1,VAMAS1 ) |
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| Gene Full Name: | NLR family, pyrin domain containing 1 |
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| Band: | 17p13 |
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| Quick Links | Entrez ID:22861; OMIM: 606636; Uniprot ID:NALP1_HUMAN; ENSEMBL ID: ENSG00000091592; HGNC ID: 14374 |
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| Relate to Another Database: |
SFARIGene;
denovo-db |
| Pathway ID | Pathway Name |
|---|
| hsa04621 | NOD-like receptor signaling pathway |
| Pathway ID | Pathway Name |
|---|
| 200179 | Cellular roles of Anthrax toxin |
| Pathway ID | Pathway Name |
|---|
| P00020 | FAS signaling pathway |
| Desease Name |
|---|
| Vitiligo-associated multiple autoimmune disease susceptibility 1 |
| Chemical ID |
Chemical Name |
Interaction |
Interaction Action |
Publication |
|---|
| D015123 |
7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide |
7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of NLRP1 mRNA | increases expression | 20382639
|
| D002117 |
Calcitriol |
Calcitriol results in increased expression of NLRP1 mRNA | increases expression | 16002434
|
| D014635 |
Valproic Acid |
Valproic Acid results in increased expression of NLRP1 mRNA | increases expression | 19101580
|
| Disease ID |
Disease Name |
Direct Evidence |
Inference Chemical Name |
Inference Score |
Publication |
|---|
| MESH:D000014 |
Abnormalities, Drug-Induced |
|
Valproic Acid |
4.23 | 8875741 |
| MESH:D000015 |
Abnormalities, Multiple |
|
Valproic Acid |
4.41 | 19490988 |
| MESH:D000550 |
Amblyopia |
|
Valproic Acid |
6.10 | 17688650 |
| MESH:D001008 |
Anxiety Disorders |
|
Valproic Acid |
3.94 | 17497229 |
| MESH:D001321 |
Autistic Disorder |
|
Valproic Acid |
1.98 | 18940202 20603192 18177632 17157402 19232924 17507914 17688650 18316065 18558336 15238991 18985861 19460635 18396377 16609825 18775368 |
| MESH:D001714 |
Bipolar Disorder |
|
Valproic Acid |
3.26 | 20046352 17594078 |
| MESH:D001848 |
Bone Diseases, Developmental |
|
Valproic Acid |
3.66 | 8888407 |
| MESH:D001943 |
Breast Neoplasms |
|
Calcitriol |
2.56 | 11237771 |
| MESH:D002294 |
Carcinoma, Squamous Cell |
|
Calcitriol |
2.72 | 11237771 |
| MESH:D002471 |
Cell Transformation, Neoplastic |
|
7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide |
3.01 | 20889678 |
| MESH:D002659 |
Child Development Disorders, Pervasive |
|
Valproic Acid |
2.83 | 20734317 |
| MESH:D019465 |
Craniofacial Abnormalities |
|
Valproic Acid |
1.91 | 8888407 16575769 17688650 |
| MESH:D056486 |
Drug-Induced Liver Injury |
|
Valproic Acid |
2.26 | 1733752 19641884 |
| MESH:D004421 |
Dystonia |
|
Valproic Acid |
4.58 | 1851702 |
| MESH:D004681 |
Encephalomyelitis, Autoimmune, Experimental |
|
Calcitriol |
4.52 | 15138306 |
| MESH:D004831 |
Epilepsies, Myoclonic |
|
Valproic Acid |
4.81 | 17275665 3659116 |
| MESH:D004828 |
Epilepsies, Partial |
|
Valproic Acid |
4.78 | 3922381 16628512 |
| MESH:D004827 |
Epilepsy |
|
Valproic Acid |
3.12 | 20417680 18234410 |
| MESH:D004832 |
Epilepsy, Absence |
|
Valproic Acid |
4.00 | 6426943 6254150 7562514 |
| MESH:D017029 |
Epilepsy, Complex Partial |
|
Valproic Acid |
4.95 | 7750514 |
| MESH:D004830 |
Epilepsy, Tonic-Clonic |
|
Valproic Acid |
4.81 | 3659116 |
| MESH:D004938 |
Esophageal Neoplasms |
|
7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide |
2.15 | 20426865 |
| MESH:D005234 |
Fatty Liver |
|
Valproic Acid |
3.78 | 19224547 14986274 |
| MESH:D005315 |
Fetal Diseases |
|
Valproic Acid |
5.75 | 16575769 |
| MESH:D005317 |
Fetal Growth Retardation |
|
Valproic Acid |
4.71 | 18558336 8888407 |
| MESH:D006849 |
Hydrocephalus |
|
Valproic Acid |
5.61 | 17688650 |
| MESH:D015470 |
Leukemia, Myeloid, Acute |
|
Valproic Acid |
2.20 | 16294345 17596541 |
| MESH:D017563 |
Lung Diseases, Interstitial |
|
Valproic Acid |
5.13 | 17228818 |
| MESH:D008881 |
Migraine Disorders |
|
Valproic Acid |
3.50 | 18765137 18803445 |
| MESH:D009139 |
Musculoskeletal Abnormalities |
|
Valproic Acid |
4.51 | 8888407 |
| MESH:D009190 |
Myelodysplastic Syndromes |
|
Valproic Acid |
3.37 | 17596541 |
| MESH:D009436 |
Neural Tube Defects |
|
Valproic Acid |
3.39 | 16359493 8888407 |
| MESH:D011297 |
Prenatal Exposure Delayed Effects |
|
Valproic Acid |
4.57 | 20603192 |
| MESH:D011470 |
Prostatic Hyperplasia |
|
Calcitriol |
5.52 | 15572423 |
| MESH:D011471 |
Prostatic Neoplasms |
|
Calcitriol |
3.48 | 12479363 15754350 16289102 18247401 16644109 |
| MESH:D019310 |
Pseudolymphoma |
|
Valproic Acid |
5.41 | 12752131 11422049 |
| MESH:D012208 |
Rhabdomyosarcoma |
|
Valproic Acid |
4.70 | 19155313 |
| MESH:D012559 |
Schizophrenia |
|
Valproic Acid |
2.11 | 15737665 19110320 |
| MESH:D012640 |
Seizures |
|
Valproic Acid |
3.02 | 3137016 15475178 11044598 16876388 14763951 17978042 1511512 11738929 |
| MESH:D016135 |
Spinal Dysraphism |
|
Valproic Acid |
4.13 | 19490988 |
| MESH:D013226 |
Status Epilepticus |
|
Valproic Acid |
5.41 | 12833885 |
| MESH:D014178 |
Translocation, Genetic |
|
Valproic Acid |
6.10 | 17262798 |
| MESH:D020194 |
Unverricht-Lundborg Syndrome |
|
Valproic Acid |
5.26 | 3119515 |
| MESH:D014564 |
Urogenital Abnormalities |
|
Valproic Acid |
5.30 | 8888407 |
| OMIM:606579 |
VITILIGO-ASSOCIATED MULTIPLE AUTOIMMUNE DISEASE SUSCEPTIBILITY 1 |
marker/mechanism |
|
| |
| Pathway ID |
Pathway Name |
|---|
| KEGG:04621 |
NOD-like receptor signaling pathway |
PharmGKB Accession:PA162397797
| Releated disease ID |
Related disease Name |
| PA446047 | Vitiligo |
| Releated drug ID |
Related drug Name |
| PA450635 | nitric oxide |
Drug Bank