AutismKB 2.0

Annotation Detail for PLEKHA6


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Basic Information Top
Gene Symbol:PLEKHA6 ( KIAA0969,MGC176733,PEPP3 )
Gene Full Name: pleckstrin homology domain containing, family A member 6
Band: 1q32.1
Quick LinksEntrez ID:22874; OMIM: 607771; Uniprot ID:PKHA6_HUMAN; ENSEMBL ID: ENSG00000143850; HGNC ID: 17053
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of PLEKHA6 mRNAaffects expression 21346803
C472791 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in increased expression of PLEKHA6 mRNAincreases expression 16788091
C035207 4-amino-2,6-dinitrotoluene 4-amino-2,6-dinitrotoluene affects the expression of PLEKHA6 mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of PLEKHA6 mRNAaffects expression 17562736
D014212 Tretinoin Tretinoin results in increased expression of PLEKHA6 mRNAincreases expression 16788091
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced 4-amino-2,6-dinitrotoluene 4.497525203
MESH:D000505 Alopecia Tretinoin 3.9015955085
MESH:D000799 Angioedema Acetaminophen 4.4510982225
MESH:D001169 Arthritis, Experimental Tretinoin 3.2816412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.3316292516
MESH:D001249 Asthma Tretinoin 2.4316456186
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001471 Barrett Esophagus Tretinoin 4.8416935849
MESH:D001778 Blood Coagulation Disorders Tretinoin 3.9816197459 16206674
MESH:D001943 Breast Neoplasms Tretinoin 2.2316166294 16443354 16873071
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 5.1316813970
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.7716168501
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 4.7716705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.773084413
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 4.771917145
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 2.3716051514 16096774
MESH:D002386 Cataract 4-amino-2,6-dinitrotoluene 13.4714694615
MESH:D002386 Cataract Acetaminophen 13.4710977129
MESH:D002386 Cataract Tretinoin 13.4717460283
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 5.1316129372
MESH:D002822 Choriocarcinoma Tretinoin 5.7716461808
MESH:D002972 Cleft Palate Tretinoin 2.799407595
MESH:D003092 Colitis Tretinoin 4.1917035595
MESH:D000013 Congenital Abnormalities 4-amino-2,6-dinitrotoluene 4.4915095906
MESH:D019465 Craniofacial Abnormalities Tretinoin 1.8310589399 16925845 9125849 9224671 8800419 9142499 17551590 9211117 9664655 14991402
MESH:D003490 Cyanosis 2,4-dinitrotoluene 4.5018551238
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 6.7618551238 21346803
MESH:D056486 Drug-Induced Liver Injury 4-amino-2,6-dinitrotoluene 6.7621346803
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.7612392966 14986274 16393943 18071297 12540782 18713872 11529661 12153990 11739529 10663392 19085960 12958197 19420014 10915739 11743745 16227642 16109766 17522070 12594235 19416960 17562736 11421492 19164858 17906064 19370779 19739265 15968718 11287661 16081117 11834606 16485898 14725611 10774834 16781746 15619225 12705907 16177239 11461765 14550746 2444490 19923254
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.7119426721
MESH:D004489 Edema, Cardiac Tretinoin 5.0818230668
MESH:D016889 Endometrial Neoplasms Tretinoin 3.3216569247
MESH:D005124 Eye Abnormalities Tretinoin 3.8416938888 9664655
MESH:D005355 Fibrosis Tretinoin 3.9917994277
MESH:D005756 Gastritis Acetaminophen 4.2916983495
MESH:D005909 Glioblastoma Tretinoin 3.2217312396
MESH:D006258 Head and Neck Neoplasms Tretinoin 3.4116096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.7716084493
MESH:D006330 Heart Defects, Congenital Tretinoin 3.059664655 14991402
MESH:D006930 Hyperalgesia Acetaminophen 8.6016870215
MESH:D006930 Hyperalgesia Tretinoin 8.6016870215
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 5.0516778211
MESH:D007410 Intestinal Diseases Tretinoin 4.2517994277
MESH:D007569 Jaw Abnormalities Tretinoin 4.2715992940 17551590
MESH:D007674 Kidney Diseases Acetaminophen 2.3815629191 12587719
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 3.2816705839
MESH:D007938 Leukemia Tretinoin 2.9217143497
MESH:D007951 Leukemia, Myeloid Tretinoin 4.0716932348 16482212 19285840
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.1219850784 16294345 17596541
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.3716935935 17649720 17506722 16788101 15748426 17712046 16331271 16823087 17339181 17361223 19029980 17294898 17301526 19075265 16766008 16891316 19225113 9834237 17217047 17107899 16140955 19642359 19035177 17368321 12679006
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.559224671
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 1.8118397230 16248980
MESH:D008107 Liver Diseases Acetaminophen 1.6912969438 16611625 19460945 16610002 12587719 19014921 11587558 19784758
MESH:D017114 Liver Failure, Acute Acetaminophen 3.5817185352 16871587
MESH:D008527 Medulloblastoma Tretinoin 2.9017453147
MESH:D008545 Melanoma Tretinoin 1.9816752155
MESH:D008546 Melanoma, Experimental Acetaminophen 4.0519513568
MESH:D008591 Meningomyelocele Tretinoin 4.9116940565
MESH:D009190 Myelodysplastic Syndromes Tretinoin 3.2617596541
MESH:D009336 Necrosis 2,4-dinitrotoluene 4.4018551238
MESH:D009369 Neoplasms Tretinoin 2.5516594593 16946489
MESH:D009421 Nervous System Malformations Tretinoin 4.229125849
MESH:D009436 Neural Tube Defects Tretinoin 3.279142499
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.1818514411
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 10.3112819281 16049721
MESH:D009784 Occupational Diseases 4-amino-2,6-dinitrotoluene 10.3114694615
MESH:D010051 Ovarian Neoplasms Tretinoin 2.4316936753
MESH:D010146 Pain Acetaminophen 7.6116870215
MESH:D010146 Pain Tretinoin 7.6116870215
MESH:D010190 Pancreatic Neoplasms Tretinoin 2.5615976015
MESH:D011507 Proteinuria Tretinoin 4.0116636307
MESH:D011625 Pterygium Tretinoin 5.3316723453
MESH:D012208 Rhabdomyosarcoma Tretinoin 4.5016283617 16116481
MESH:D012640 Seizures 2,4-dinitrotoluene 2.7618551238
MESH:D012878 Skin Neoplasms Tretinoin 2.7516467112
MESH:D013274 Stomach Neoplasms Tretinoin 1.8017261132
MESH:D013964 Thyroid Neoplasms Tretinoin 3.2916026305 17045167
MESH:D014062 Tongue Neoplasms Tretinoin 4.1416051514
MESH:D014376 Tuberculosis Tretinoin 3.4316040207
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 2.3916049721
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.8610091137
MESH:D014581 Urticaria Acetaminophen 3.3810982225
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 4.0216129372
MESH:D014604 Uveal Neoplasms Tretinoin 5.2216752155
MESH:D014820 Vitiligo Tretinoin 4.5016761959
MESH:D009396 Wilms Tumor Tretinoin 4.2916287080
No data
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AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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